JPS6244980Y2 - - Google Patents

Info

Publication number

JPS6244980Y2

JPS6244980Y2 JP20004483U JP20004483U JPS6244980Y2 JP S6244980 Y2 JPS6244980 Y2 JP S6244980Y2 JP 20004483 U JP20004483 U JP 20004483U JP 20004483 U JP20004483 U JP 20004483U JP S6244980 Y2 JPS6244980 Y2 JP S6244980Y2

Authority

JP

Japan

Prior art keywords

reactor

solvent

way solenoid

flow path

valve

Prior art date

1983-12-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

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• 239000002904 solvent Substances 0.000 claims description 43
• 239000003153 chemical reaction reagent Substances 0.000 claims description 32
• 238000001035 drying Methods 0.000 claims description 17
• 238000001816 cooling Methods 0.000 claims description 12
• 230000000873 masking effect Effects 0.000 claims description 11
• 238000010438 heat treatment Methods 0.000 claims description 9
• 238000000034 method Methods 0.000 claims description 9
• 238000010511 deprotection reaction Methods 0.000 claims description 7
• 238000009833 condensation Methods 0.000 claims description 6
• 230000005494 condensation Effects 0.000 claims description 6
• 230000002194 synthesizing effect Effects 0.000 claims description 5
• 239000002773 nucleotide Substances 0.000 description 20
• 125000003729 nucleotide group Chemical group 0.000 description 20
• 108020004414 DNA Proteins 0.000 description 16
• 238000002360 preparation method Methods 0.000 description 15
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
• 229910001873 dinitrogen Inorganic materials 0.000 description 10
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
• 238000004140 cleaning Methods 0.000 description 9
• 230000006820 DNA synthesis Effects 0.000 description 8
• 238000005406 washing Methods 0.000 description 7
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
• 239000007810 chemical reaction solvent Substances 0.000 description 6
• 238000006243 chemical reaction Methods 0.000 description 5
• 239000003795 chemical substances by application Substances 0.000 description 5
• 125000006239 protecting group Chemical group 0.000 description 5
• YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 4
• WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
• 102000053602 DNA Human genes 0.000 description 3
• 238000006482 condensation reaction Methods 0.000 description 3
• 239000000203 mixture Substances 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
• XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• 230000015556 catabolic process Effects 0.000 description 2
• 238000006731 degradation reaction Methods 0.000 description 2
• 238000010586 diagram Methods 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 230000035484 reaction time Effects 0.000 description 2
• 238000009834 vaporization Methods 0.000 description 2
• 230000008016 vaporization Effects 0.000 description 2
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
• SFYDWLYPIXHPML-UHFFFAOYSA-N 3-nitro-1-(2,4,6-trimethylphenyl)sulfonyl-1,2,4-triazole Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1N=C([N+]([O-])=O)N=C1 SFYDWLYPIXHPML-UHFFFAOYSA-N 0.000 description 1
• 229910052786 argon Inorganic materials 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
• 150000005691 triesters Chemical class 0.000 description 1