JPS6239156B2 - - Google Patents
Info
- Publication number
- JPS6239156B2 JPS6239156B2 JP54118859A JP11885979A JPS6239156B2 JP S6239156 B2 JPS6239156 B2 JP S6239156B2 JP 54118859 A JP54118859 A JP 54118859A JP 11885979 A JP11885979 A JP 11885979A JP S6239156 B2 JPS6239156 B2 JP S6239156B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- hydrogen
- general formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical group 0.000 claims description 88
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- -1 silver halide Chemical class 0.000 claims description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 229910052709 silver Inorganic materials 0.000 claims description 14
- 239000004332 silver Substances 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical group 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 150000002391 heterocyclic compounds Chemical class 0.000 claims description 4
- 150000002431 hydrogen Chemical group 0.000 claims description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 4
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 18
- 239000000243 solution Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000010410 layer Substances 0.000 description 12
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000002844 melting Methods 0.000 description 9
- 230000008018 melting Effects 0.000 description 9
- 239000000843 powder Substances 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 5
- 235000019341 magnesium sulphate Nutrition 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000012044 organic layer Substances 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical compound NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 description 2
- JECYUBVRTQDVAT-UHFFFAOYSA-N 2-acetylphenol Chemical compound CC(=O)C1=CC=CC=C1O JECYUBVRTQDVAT-UHFFFAOYSA-N 0.000 description 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- 229940001584 sodium metabisulfite Drugs 0.000 description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- GVEYRUKUJCHJSR-UHFFFAOYSA-N (4-azaniumyl-3-methylphenyl)-ethyl-(2-hydroxyethyl)azanium;sulfate Chemical compound OS(O)(=O)=O.OCCN(CC)C1=CC=C(N)C(C)=C1 GVEYRUKUJCHJSR-UHFFFAOYSA-N 0.000 description 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 1
- NQIKPINVDBMJHG-UHFFFAOYSA-N 1-benzyl-2-phenyl-1,2,4-triazolidine-3,5-dione Chemical compound C=1C=CC=CC=1CN1C(=O)NC(=O)N1C1=CC=CC=C1 NQIKPINVDBMJHG-UHFFFAOYSA-N 0.000 description 1
- KOFZTCSTGIWCQG-UHFFFAOYSA-N 1-bromotetradecane Chemical compound CCCCCCCCCCCCCCBr KOFZTCSTGIWCQG-UHFFFAOYSA-N 0.000 description 1
- WCVONAZWPPWVOD-UHFFFAOYSA-N 1-tert-butyl-4-methylsulfanyltriazole Chemical compound CSC1=CN(C(C)(C)C)N=N1 WCVONAZWPPWVOD-UHFFFAOYSA-N 0.000 description 1
- 229940002520 2'-hydroxyacetophenone Drugs 0.000 description 1
- KBLAMUYRMZPYLS-UHFFFAOYSA-N 2,3-bis(2-methylpropyl)naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(O)(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 KBLAMUYRMZPYLS-UHFFFAOYSA-N 0.000 description 1
- UOMQUZPKALKDCA-UHFFFAOYSA-K 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]acetate;iron(3+) Chemical compound [Fe+3].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UOMQUZPKALKDCA-UHFFFAOYSA-K 0.000 description 1
- ZVTFHTFPSHCQEH-UHFFFAOYSA-N 2-bromo-1-(2-tetradecoxyphenyl)ethanone Chemical compound CCCCCCCCCCCCCCOC1=CC=CC=C1C(=O)CBr ZVTFHTFPSHCQEH-UHFFFAOYSA-N 0.000 description 1
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 1
- ZNBNBTIDJSKEAM-UHFFFAOYSA-N 4-[7-hydroxy-2-[5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-2-methyl-3-propanoyloxypentanoic acid Chemical compound C1C(O)C(C)C(C(C)C(OC(=O)CC)C(C)C(O)=O)OC11OC(C)(C2OC(C)(CC2)C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CC1 ZNBNBTIDJSKEAM-UHFFFAOYSA-N 0.000 description 1
- GJKUZDYIYKJZOB-UHFFFAOYSA-N 5,6-dinitro-1h-benzimidazole Chemical compound C1=C([N+]([O-])=O)C([N+](=O)[O-])=CC2=C1NC=N2 GJKUZDYIYKJZOB-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 101100494262 Caenorhabditis elegans best-12 gene Proteins 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
- XYXNTHIYBIDHGM-UHFFFAOYSA-N ammonium thiosulfate Chemical compound [NH4+].[NH4+].[O-]S([O-])(=O)=S XYXNTHIYBIDHGM-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000009034 developmental inhibition Effects 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008098 formaldehyde solution Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 230000002140 halogenating effect Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229910000378 hydroxylammonium sulfate Inorganic materials 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000004848 polyfunctional curative Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- ADZWSOLPGZMUMY-UHFFFAOYSA-M silver bromide Chemical compound [Ag]Br ADZWSOLPGZMUMY-UHFFFAOYSA-M 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C7/00—Multicolour photographic processes or agents therefor; Regeneration of such processing agents; Photosensitive materials for multicolour processes
- G03C7/30—Colour processes using colour-coupling substances; Materials therefor; Preparing or processing such materials
- G03C7/305—Substances liberating photographically active agents, e.g. development-inhibiting releasing couplers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S430/00—Radiation imagery chemistry: process, composition, or product thereof
- Y10S430/156—Precursor compound
- Y10S430/158—Development inhibitor releaser, DIR
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Description
æ¬çºæã¯æ°èŠã®ååŠååç©é¡ããã³ãããã®å
ççŸåæå¶ç©è³ªæŸåºæ§ååç©é¡ã«é¢ããã æ¬çºæã«ããäžè¬åŒ(1)ïŒ ãåŒäžãR1ã¯ããããªãã·åã¯ã¢ã«ã³ãªãã·ã§ã
ããïœã¯ïŒã§ããïŒR2ã¯æ°ŽçŽ ã§ããïŒR3ã¯ã¢ã«
ãã«ã§ããïŒïŒ¹ã¯æ°ŽçŽ ãããã²ã³ãããšãã«ãå
ã¯åŒ
ççŸåæå¶ç©è³ªæŸåºæ§ååç©é¡ã«é¢ããã æ¬çºæã«ããäžè¬åŒ(1)ïŒ ãåŒäžãR1ã¯ããããªãã·åã¯ã¢ã«ã³ãªãã·ã§ã
ããïœã¯ïŒã§ããïŒR2ã¯æ°ŽçŽ ã§ããïŒR3ã¯ã¢ã«
ãã«ã§ããïŒïŒ¹ã¯æ°ŽçŽ ãããã²ã³ãããšãã«ãå
ã¯åŒ
ãåŒããããã¯
ãåŒãã®è€çŽ ç°åºã§ã
ããã§ç€ºãããååç©é¡ãæäŸãããã
ãã®ååç©äžã«é·éã¢ã«ãã«å®å®ååºãããã
ãšã奜ãŸããããã®åºã¯R1äžã«ãã€ãŠãããå
ã¯ïŒ¹ãäžèšã®è€çŽ ç°åºã§ããå Žåã¯ïŒ¹äžã«ãã€ãŠ
ãããåã¯ãããR3ã§ãã€ãŠãããã 奜ãŸããR1ã¯ããããªãã·ãåã¯ççŽ ååïŒ
ä¹è³18ããã€ã¢ã«ã³ãªãã·ã§ããã 奜ãŸããã¯æ°ŽçŽ ãããã²ã³ïŒå¡©çŽ ãèçŽ ïŒã
ããšãã«åã¯äžã«å®çŸ©ããæ§ãªè€çŽ ç°åºã§ããã åŒ(1)ããã€ååç©é¡ã®å¥œãŸããçš®é¡ã¯åŒ(2)ïŒ ã«ãããŠïŒ¹ãR2ããã³R3ã¯äžã«å®çŸ©ãããšãã
ãšããã€Râ²1ã¯ããããªãã·ãåã¯ççŽ ååïŒä¹
è³18ã奜ãŸããã¯ïŒä¹è³18ãæè¯ã¯12ä¹è³18ãã
ã€ã¢ã«ã³ãªãã·ãè¡šããæ§ãªäžèšåŒïŒããã€åå
ç©ã§ããã ã¢ã«ã³ãªãã·åºã¯äŸ¿å©ãªããšã«å°ãªããïŒççŽ
ååããã€ã¢ã«ãã«éšåããã¡ãããã¯ååç©ã
被èŠããå±€äžã§ååç©ãå®åšããã®ãå©ããŸãã
ããæ²¹ã«æº¶è§£æ§ãšãªãã®ãå©ããã ãŸãåŒ(2)ããã€ååç©äžãR2ãæ°ŽçŽ ã§ããã
ã€R3ãççŽ ååïŒä¹è³12ããã€ã¢ã«ãã«ã§ãã
ããšã奜ãŸããã åŒ(2)ããã€ååç©é¡ã®ç¹ã«å¥œãŸããçš®é¡ã¯äžè¬
åŒ(3)ïŒ ïŒåŒäžRâ²3ã¯ççŽ ååïŒä¹è³12ããã€ã¢ã«ãã«ãè¡š
ããïŒããã€ååç©é¡ã§ããã åŒ(1)ãååç©é¡ã¯ãã©ããšãã¬ã³ãžã¢ãã³åã®
ã«ã©ãŒçŸåæ§ååç©ã®é žåçæç©ãšã«ããã«ãç¡
è²ã«ãã©ãŒãçæãã¢ã«ãã«ããªããªãŸãŒã«åºã
éé¢ãããããã®åºã¯D.I.ååç©ã§ããã æ¬çºæã®ä»ã®åœ¢æ ã«ããåçæ¯æäœäžã«è¢«èŠã
ããå°ãªããïŒããã²ã³åéä¹³å€å±€ããã¡ããã®
å±€ãŸãã¯ããã«é£ãå±€ã«äžè¬åŒ(1)ããã€ååç©ã
å«ãæå æ§åçææãæäŸãããã åŒ(1)ããã€ååç©ã¯ããã²ã³åéä¹³å€å±€ã«å«ãŸ
ããŠããã®ãããã åŒ(1)ããã€ååç©ãšé žåãããã«ã©ãŒçŸåå€ãš
ã®ã«ãããªã³ã°ã¯äžå®å®ååç©ãçæãååç©ã
ãã¢ã«ãã«ããªããªã¢ãŸãŒã«åºãæŸåºãããã åŒ(1)ããã€ååç©ããã®ã¢ã«ãã«ããªããªã¢ãŸ
ãŒã«ã®æŸåºã¯ãŸãã¯åŒ(1)äžã®ïŒ¹ãæ°ŽçŽ ã§ããå Žå
é žåãããã«ã©ãŒçŸåå€ãšã®ã«ããªã³ã°åå¿ã§ã
ããããåŒ(3)ããã€ååç©é¡ã«ãããŠã¯ãã容æ
ã«èµ·ããªãã ãããã²ã³ã§ããå Žåã¢ã«ãã«ããªããªã¢ãŸ
ãŒã«ã®æŸåºã¯å®¹æã«èµ·ãããæå æ§ããã²ã³åé
ä¹³å€ã®åçæ床ã幟åèœã¡ãããšãèªããããã
R2ãæ°ŽçŽ ã§ãããã€R3ãççŽ ååïŒä¹è³12ãã
ã€ã¢ã«ãã«ã§ããå Žåã¢ã«ãã«ããªããªã¢ãŸãŒã«
ã¯D.I.ååç©ãšããŠããæå¹ã§ããã ãããã€ãŠåŒ(1)ããã€ååç©äžR2ã¯æ°ŽçŽ ã§ã
ããã€R3ã¯ççŽ ååïŒä¹è³12ããã€ã¢ã«ãã«ã§
ããããšã奜ãŸããã ãåèšã®è€çŽ ç°åºã§ããå Žåã¢ã«ãã«ããªã
ãªã¢ãŸãŒã«ã¯é žåãããã«ã©ãŒçŸåå€ãšã®ã«ããª
ã³ã°åå¿äžå®¹æã«æŸåºããããããã«ããä¹³å€æ
床ã¯å šãèœã¡ãªãã ãããã€ãŠåŒ(1)ããã€ååç©ã®ïŒ¹ã¯åèšã®è€çŽ
ç°åºã奜ãŸããããŸãå®å®ååºã¯R1ã®äžéšã§ã
ãããšãããã å®å®æ§ã¢ã«ãã«åºãšã¯ççŽ ååå°ãªããšãïŒã
ãã€ä»»æã«çœ®æãããçŽéåã¯åæéã¢ã«ãã«åº
ãæå³ãããD.I.R.ååç©äžã®å®å®æ§ã¢ã«ãã«åº
ã®ååšã¯ãã®ååç©ã被èŠãããå±€äžã§ãã®åå
ç©ãå®åšãããã äžèšåŒ(1)ããã€ååç©é¡ã¯äžè¬åŒ(6)ïŒ ããã€ååç©æº¶æ¶²ãäžè¬åŒ(7)ïŒ ïŒäžïŒåŒäžR1ãR2ããã³R3ã¯äžã«å®çŸ©ãããšãã
ãšãããïŒããã€ã¢ã«ãã«ããªããªã¢ãŸãŒã«ãšå
å¿ãããŠåŒ(8)ïŒ ïŒåŒäžR1ãR2ãR3ããã³ïœã¯äžã«å®çŸ©ãããšãã
ãšããïŒããã€ååç©ãçæããŠè£œé ã§ãããã
ãã¯ïŒ¹ãæ°ŽçŽ ã§ããå Žåã®åŒ(1)ããã€ååç©ã§ã
ãã ãããšãã«ã§ããåŒ(1)ã®ååç©ã¯äžè¬åŒ(6)ã®
ååç©ã®ä»£ãã«
ãšã奜ãŸããããã®åºã¯R1äžã«ãã€ãŠãããå
ã¯ïŒ¹ãäžèšã®è€çŽ ç°åºã§ããå Žåã¯ïŒ¹äžã«ãã€ãŠ
ãããåã¯ãããR3ã§ãã€ãŠãããã 奜ãŸããR1ã¯ããããªãã·ãåã¯ççŽ ååïŒ
ä¹è³18ããã€ã¢ã«ã³ãªãã·ã§ããã 奜ãŸããã¯æ°ŽçŽ ãããã²ã³ïŒå¡©çŽ ãèçŽ ïŒã
ããšãã«åã¯äžã«å®çŸ©ããæ§ãªè€çŽ ç°åºã§ããã åŒ(1)ããã€ååç©é¡ã®å¥œãŸããçš®é¡ã¯åŒ(2)ïŒ ã«ãããŠïŒ¹ãR2ããã³R3ã¯äžã«å®çŸ©ãããšãã
ãšããã€Râ²1ã¯ããããªãã·ãåã¯ççŽ ååïŒä¹
è³18ã奜ãŸããã¯ïŒä¹è³18ãæè¯ã¯12ä¹è³18ãã
ã€ã¢ã«ã³ãªãã·ãè¡šããæ§ãªäžèšåŒïŒããã€åå
ç©ã§ããã ã¢ã«ã³ãªãã·åºã¯äŸ¿å©ãªããšã«å°ãªããïŒççŽ
ååããã€ã¢ã«ãã«éšåããã¡ãããã¯ååç©ã
被èŠããå±€äžã§ååç©ãå®åšããã®ãå©ããŸãã
ããæ²¹ã«æº¶è§£æ§ãšãªãã®ãå©ããã ãŸãåŒ(2)ããã€ååç©äžãR2ãæ°ŽçŽ ã§ããã
ã€R3ãççŽ ååïŒä¹è³12ããã€ã¢ã«ãã«ã§ãã
ããšã奜ãŸããã åŒ(2)ããã€ååç©é¡ã®ç¹ã«å¥œãŸããçš®é¡ã¯äžè¬
åŒ(3)ïŒ ïŒåŒäžRâ²3ã¯ççŽ ååïŒä¹è³12ããã€ã¢ã«ãã«ãè¡š
ããïŒããã€ååç©é¡ã§ããã åŒ(1)ãååç©é¡ã¯ãã©ããšãã¬ã³ãžã¢ãã³åã®
ã«ã©ãŒçŸåæ§ååç©ã®é žåçæç©ãšã«ããã«ãç¡
è²ã«ãã©ãŒãçæãã¢ã«ãã«ããªããªãŸãŒã«åºã
éé¢ãããããã®åºã¯D.I.ååç©ã§ããã æ¬çºæã®ä»ã®åœ¢æ ã«ããåçæ¯æäœäžã«è¢«èŠã
ããå°ãªããïŒããã²ã³åéä¹³å€å±€ããã¡ããã®
å±€ãŸãã¯ããã«é£ãå±€ã«äžè¬åŒ(1)ããã€ååç©ã
å«ãæå æ§åçææãæäŸãããã åŒ(1)ããã€ååç©ã¯ããã²ã³åéä¹³å€å±€ã«å«ãŸ
ããŠããã®ãããã åŒ(1)ããã€ååç©ãšé žåãããã«ã©ãŒçŸåå€ãš
ã®ã«ãããªã³ã°ã¯äžå®å®ååç©ãçæãååç©ã
ãã¢ã«ãã«ããªããªã¢ãŸãŒã«åºãæŸåºãããã åŒ(1)ããã€ååç©ããã®ã¢ã«ãã«ããªããªã¢ãŸ
ãŒã«ã®æŸåºã¯ãŸãã¯åŒ(1)äžã®ïŒ¹ãæ°ŽçŽ ã§ããå Žå
é žåãããã«ã©ãŒçŸåå€ãšã®ã«ããªã³ã°åå¿ã§ã
ããããåŒ(3)ããã€ååç©é¡ã«ãããŠã¯ãã容æ
ã«èµ·ããªãã ãããã²ã³ã§ããå Žåã¢ã«ãã«ããªããªã¢ãŸ
ãŒã«ã®æŸåºã¯å®¹æã«èµ·ãããæå æ§ããã²ã³åé
ä¹³å€ã®åçæ床ã幟åèœã¡ãããšãèªããããã
R2ãæ°ŽçŽ ã§ãããã€R3ãççŽ ååïŒä¹è³12ãã
ã€ã¢ã«ãã«ã§ããå Žåã¢ã«ãã«ããªããªã¢ãŸãŒã«
ã¯D.I.ååç©ãšããŠããæå¹ã§ããã ãããã€ãŠåŒ(1)ããã€ååç©äžR2ã¯æ°ŽçŽ ã§ã
ããã€R3ã¯ççŽ ååïŒä¹è³12ããã€ã¢ã«ãã«ã§
ããããšã奜ãŸããã ãåèšã®è€çŽ ç°åºã§ããå Žåã¢ã«ãã«ããªã
ãªã¢ãŸãŒã«ã¯é žåãããã«ã©ãŒçŸåå€ãšã®ã«ããª
ã³ã°åå¿äžå®¹æã«æŸåºããããããã«ããä¹³å€æ
床ã¯å šãèœã¡ãªãã ãããã€ãŠåŒ(1)ããã€ååç©ã®ïŒ¹ã¯åèšã®è€çŽ
ç°åºã奜ãŸããããŸãå®å®ååºã¯R1ã®äžéšã§ã
ãããšãããã å®å®æ§ã¢ã«ãã«åºãšã¯ççŽ ååå°ãªããšãïŒã
ãã€ä»»æã«çœ®æãããçŽéåã¯åæéã¢ã«ãã«åº
ãæå³ãããD.I.R.ååç©äžã®å®å®æ§ã¢ã«ãã«åº
ã®ååšã¯ãã®ååç©ã被èŠãããå±€äžã§ãã®åå
ç©ãå®åšãããã äžèšåŒ(1)ããã€ååç©é¡ã¯äžè¬åŒ(6)ïŒ ããã€ååç©æº¶æ¶²ãäžè¬åŒ(7)ïŒ ïŒäžïŒåŒäžR1ãR2ããã³R3ã¯äžã«å®çŸ©ãããšãã
ãšãããïŒããã€ã¢ã«ãã«ããªããªã¢ãŸãŒã«ãšå
å¿ãããŠåŒ(8)ïŒ ïŒåŒäžR1ãR2ãR3ããã³ïœã¯äžã«å®çŸ©ãããšãã
ãšããïŒããã€ååç©ãçæããŠè£œé ã§ãããã
ãã¯ïŒ¹ãæ°ŽçŽ ã§ããå Žåã®åŒ(1)ããã€ååç©ã§ã
ãã ãããšãã«ã§ããåŒ(1)ã®ååç©ã¯äžè¬åŒ(6)ã®
ååç©ã®ä»£ãã«
ãåŒããªãå
åç©ã䜿çšããããšã«ãã€ãŠåæ§ã«è£œé ãããã
åŒ(8)ããã€ååç©é¡ã¯åŒ(8)ããã€ååç©ãã¯ã
ãããªã«ã äžãåã¯é ¢é žåªè³ªäžããã¥ããã§ãã
ã²ã³åããŠïŒ¹ãããã²ã³ã§ããåŒ(1)ããã€ååç©
é¡ã«è»¢åã§ãããäŸãã°ã¯ããããªã«ã åªè³ªäžã§
èçŽ åããã°äžè¬åŒ(9)ïŒ ããã€ååç©ãåŸãã åŒ(9)ããã€ååç©ã¯å¡©åºã®ååšã«ãããŠåŒ
ãããªã«ã äžãåã¯é ¢é žåªè³ªäžããã¥ããã§ãã
ã²ã³åããŠïŒ¹ãããã²ã³ã§ããåŒ(1)ããã€ååç©
é¡ã«è»¢åã§ãããäŸãã°ã¯ããããªã«ã åªè³ªäžã§
èçŽ åããã°äžè¬åŒ(9)ïŒ ããã€ååç©ãåŸãã åŒ(9)ããã€ååç©ã¯å¡©åºã®ååšã«ãããŠåŒ
ãåŒãããã€è€çŽ ç°ååç©ãšåå¿ããã
ãåã¯ã¢ã»ããããªã«äžã§åŒ
ãåŒããã
ã€è©²è€çŽ ç°ååç©ã«ãªãŠã å¡©ãšåå¿ãããŠïŒ¹ã
ãåŒãåºã§ããåŒ(1)ã®ååç©ã«è»¢åã§ã
ãããªã
ãåŒãåºã¯åèšè€çŽ ç°åºãè¡šã
ãã
äžèšè£œé æ³ã«çšããå¡©åºã¯æ°Žé
žåã«ãªãŠã 埮ç²
æ«ã奜ãŸããã åŒ(7)ããã€ã¢ã«ãã«ããªããªã¢ãŸãŒã«ååç©ã¯
D.I.ååç©ã§ãããç»åã®æ§ã«D.I.ååç©ãæŸåº
ããååç©é¡ã®äœ¿çšã¯æçšãªå±€éããã³å±€å å¹æ
ãåŸãçºåçæè¡åéã«ãããŠã¯ããç¥ãããŠã
ãã çš®ã ã®çŸåæå¶å€âæŸåºæ§ååç©é¡ãããè¿ã«
ã€ãããããããããã®ååç©é¡ã®æ®ãã©ã¯å å
ã«æºè¶³ããããã®ã§ãªããäŸãã°ã«ã©ãŒçŸåã®é
ææãçæããçŸåæå¶å€âæŸåºæ§ååç©ã®å Žå
D.I.R.ååç©ã®ã«ã©ãŒã«ãã©ãŒæ®æž£ã¯åŸãããæ
æã®å¿ èŠãªç¹å®åžåæ§ã®çºåçã«ã©ãŒç»åã®æ£ç¢º
ãªè²åè¡¡ãåŸãã«æ³šæããŠéžæããå¿ èŠãããã
æçšãªD.I.R.ã«ã©ãŒã«ãã©ãŒãçæããããšã¯ã
ã€ããããšããã€ãŠããã ããã«åããŠã«ã©ãŒçŸåå€ã®é žåçæç©ãšææ
ãçæããªãçŸåæå¶å€âæŸåºæ§ååç©é¡ã¯æ¥µã
ãŠäœãåå¿æ§ããã€ãåã¯çŸåäžéåžžã«æ床ãã
ã¡ãããã¥ããã§ããã ãããæ¬çºæã®ååç©é¡ã¯ã«ã©ãŒçŸåå€ã®é žå
çæç©ãšåå¿ããå Žåç¡è²ååç©é¡ãçæããã
ç¡è²æ®æž£ã¯åŸãããç»åã®ã©ã®éšåãæ§æããª
ããããã¯æ°èŠæŸåºæ§ååç©é¡ãåçææã®ã©ã®
å¿ èŠå±€ã«ã䜿çšã§ããå©ç¹ã§ãããæŽã«æ¬çºæã®
ååç©é¡ã¯ã«ã©ãŒçŸåå€ã®é žåçæç©ãšæ¥µããŠå€§
ããªåå¿æ§ããã€ããããã€ãŠé倧ãªæ床æ倱ãª
ãããç»åå ããã³ç»åéå¹æãåŸãã«å å°ã®å
åç©éã䜿ãã°ããã®ã§ããã æŽã«æ¬çºæã®ä»ã®åœ¢æ ã¯åçç»å圢ææ³ãæäŸ
ããããã®æ¹æ³ã¯å°ãªããïŒããã²ã³åé乳局å
åã¯ããã«é£æ¥ããå±€å ã«åŒ(1)ããã€ååç©ãå«
ãæå æ§ããã²ã³åéåçææãæ åé²åºãé²åº
ããããã²ã³åéããã©ããšãã¬ã³ãžã¢ãã³ã«ã©
ãŒçŸåå€ã§çŸåããŠåŒ(7)ããã€ã¢ã«ãã«ããªããª
ã¢ãŸãŒã«ååç©ãç»åã©ããéé¢ãããæ¹æ³ã§ã
ãã æ¬çºæã®D.I.R.ååç©é¡ã¯çºè²æ³ã«ãã€ãŠåŠç
ã§ããŸãç»åé®®é床ããã³ïŒåã¯ïŒäžéå±€å¹æã®
å¢å ãæãŸããã©ã®åç補åã«ã䜿çšã§ãããæ
ã«æ¬çºæã®D.I.R.ååç©é¡ã®æ倧çšéã¯ã«ã©ãŒå
çææã®åéãç¹ã«ã«ã©ãŒé°ç»ãã€ã«ã ææã«ã
ããšæåŸ ããããã«ã©ãŒãã€ã«ã ææäžã«äœ¿çšã
ãå Žåæ¬çºæã®D.I.Rååç©é¡ã¯å°ãªããšãïŒã«
ã©ãŒã«ãã©ãŒãå«ãã«ã©ãŒå¢æããããã²ã³åé
ä¹³å€å±€äžã«ãããšäºæ³ãããããã®æ§ãªããã²ã³
åéä¹³å€å±€äžã«ããD.I.R.ã®æçšéã¯ååšããã«
ã©ãŒã«ãã©ãŒã®ïŒä¹è³10ã¢ã«ïŒ ã§ããã ã«ããªã³ã°ã«éãçŸåæå¶å€ååç©ãæŸåºãã
æ¬çºæã«ããååç©é¡ã®ç¹å®äŸã¯æ¬¡ã®ãšããã§ã
ãã 次ã®å®æœäŸã«ãããéšããã³ããŒã»ã³ãã¯ãã¹
ãŠééåºæºã§ããã å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâ2â²â
ããã©ãã·ã«ãªãã·âã¢ã»ãããšãã³ïŒåŒ(10)ã®
ååç©ïŒã®è£œé ã¢ã»ããããªã«20mläžã«ïŒ(5)âãããã«ããªã
ãªã¢ãŸãŒã«ïŒïœãšããªãšãã«ã¢ãã³ïŒïœã®æº¶æ¶²äž
ã«æž©ã¢ã»ããããªã«30mläžã«ïŒâããã©ãã·ã«ãª
ãã·âããšãã·ã«èåç©10ïœã®æº¶æ¶²ãå ãããå
å¿æ··åç©ã宀枩ã§ïŒæéæ¹æããåŸèžçºãããæ®
枣ãé ¢é žãšãã«50mlã«ãšããææ©å±€ãæ°ŽïŒïŒÃ50
mlïŒã§æŽãMgSO4äžããšãã也ç¥ãéãèžçº
ãããæ®æž£ãã¡ã¿ããŒã«ããåæ¶åºãããŠåŒ(10)ã
ãã€çœè²åŸ®ç²æ«ååç©7.8ïœïŒ61ïŒ ïŒãåŸããè
ç¹61â62âã C31H51N3O2Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã70.27ïŒïŒšã9.70ïŒïŒ®ã7.93 枬å®å€ïŒïŒ£ã69.97ãã94.1ïŒïŒ®ã7.91 å®æœäŸ ïŒ ïŒâããã¢âãïŒ(5)âãããã«ããšããªã¢ãŸãª
ã«ãâ2â²âããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³
ïŒåŒïŒ14ïŒããã€ååç©ïŒã®è£œé ã¯ãããã«ã 75mläžã«ååç©(10)5.1ïœã®æº¶æ¶²ã
60âã§æ¹æããªããã¯ãããã«ã 10mläžã«èçŽ
1.6ïœã®æº¶æ¶²ãïŒæéã«ãããå ãããåå¿æ··å
ç©ãæŽã«ïŒæéç°æµããæ¹æããåŸèžçºãããæ®
ã€ãæ²¹ãïŒâã§ã¡ã¿ããŒã«äžã§ããã€ã¶ãåºäœç
æç©ãåŸããéããŠåŒïŒ14ïŒããã€çœè²åŸ®ç²æ«
ååç©5.4ïœïŒ92ïŒ ïŒãåŸããèç¹45â46âã C31H56BrN3O2Sã«å¯Ÿããåæå€ïŒ èšç®å€ïŒïŒ£ã61.11ïŒïŒšã8.27ïŒïŒ®ã6.9 枬å®å€ïŒïŒ£ã60.85ãã8.20ïŒïŒ®ã7.1 å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâïŒâ
ãïŒã»ïŒâãžããããã³ãºã€ãããŸãªã«ãâ2â²â
ããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³ïŒåŒïŒ15ïŒ
ããã€ååç©ïŒã®è£œé ã¢ã»ããããªã«50mläžã«ïŒã»ïŒâãžããããã³
ãºã€ãããŸãŒã«ã®ã«ãªãŠã å¡©2.6ïœãšïŒâããã¢
âïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâ2â²â
ããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³5.3ïœã®æ··å
ç©ã40âã§ïŒæéæ¹æããåŸèžçºãããæ®æž£ãã¯
ãããã«ã ã«ãšããææ©å±€ãæ°ŽïŒïŒÃ50mlïŒã§æŽ
ãMgSO4äžããšãããŠä¹Ÿç¥ãéãèžçºããã
æ®æž£ãã¡ã¿ããŒã«ããåæ¶åºãããŠåŒïŒ15ïŒãã
ã€çœè²åºäœååç©4.4ïœïŒ68ïŒ ïŒãåŸããèç¹63
â64âã C38H53N7O6Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã62.01ïŒïŒšã7.25ïŒïŒ®ã13.04 枬å®å€ïŒïŒ£ã61.80ãã7.30ïŒïŒ®ã12.72 å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâïŒ
ãïŒâïœâããã«âïŒâã¡ãã«ããªããªã¢ãŸãª
ã«ãâ2â²âããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³
ïŒåŒïŒ16ïŒããã€ååç©ïŒã®è£œé ã¢ã»ããããªã«50mläžã«ïŒâããã¢âïŒâãïŒ
(5)âãããã«ããªããªã¢ãŸãªã«ãâ2â²âããã©ã
ã·ã«ãªãã·ã¢ã»ãããšãã³6.0ïœãå«ã液ã«ã¢ã»
ããããªã«ïŒmläžã«ïŒâïœâããã«âïŒâã¡ãã«
ããªããªã¢ãŸãŒã«ã®ã«ãªãŠã å¡©2.1ïœãå«ã溶液
ãå ãããåå¿æ··åç©ã45âã§3.5æéæ¹æãã
åŸèžçºãããæ®æž£ãã¯ãããã«ã ã«ãšããææ©å±€
ãæ°ŽæŽãMgSO4äžããšãã也ç¥ãéãèžçºã
ãããã®ååç©ãã«ã©ã ã¯ãããã°ã©ãæ³ã§ç²Ÿè£œ
ãããã¡ã¿ããŒã«ããåæ¶åºãããŠåŒïŒ16ïŒãã
ã€ååç©2.7ïœïŒ39ïŒ ïŒãçœè²åŸ®ç²æ«ãšããŠåŸ
ããèç¹63âã C38H62N6O2S2ã«å¯ŸããåæïŒ ïŒ èšç®å€ïŒïŒ£ã65.28ïŒïŒšã8.93ïŒïŒ®ã12.02 枬å®å€ïŒïŒ£ã65.36ãã8.91ïŒïŒ®ã11.91 å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâïŒâ
âãã³ãžã«ããšãã«ãŠã©ãŸãªã«ãâ2â²âãã
ã©ãã·ã«ãªãã·ã¢ã»ãããšãã³ïŒåŒïŒ17ïŒãã
ã€ååç©ïŒã®è£œé ã¢ã»ããããªã«35mläžã«ïŒâããã¢âïŒãïŒ(5)
âãããã«ããªããªã¢ãŸãªã«ãâ2â²âããã©ãã·
ã«ãªãã·ã¢ã»ãããšãã³3.0ïœãšãã³ãžã«ããšãš
ãã«ãŠã©ãŸãŒã«1.4ïœãå«ã溶液ã«æ°Žé žåãããª
ãŠã ãã¬ããç²æ«0.45ïœãå ãããåå¿æ··åç©ã
宀枩ã§ïŒæéæ¹æåŸéãèžçºãããæ®æž£ãã¡ã¿
ããŒã«ããåæ¶åºãããŠåŒïŒ17ïŒããã€ååç©ã®
çœè²åŸ®ç²2.3ïœïŒ58ïŒ ïŒãåŸããèç¹48â49âã C46H62N6O4Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã69.40ïŒïŒšã7.86ïŒïŒ®ã10.57 枬å®å€ïŒïŒ£ã69.17ãã7.80ïŒïŒ®ã10.41 å®æœäŸ ïŒ ïŒâãïŒ(5)âããã·ã«ããªããªã¢ãŸãªã«ãâïŒâ
ããšãã«4â²âããã©ãã·ã«ãªãã·ã¢ã»ãããšã
ã³ïŒåŒïŒ18ïŒããã€ååç©ïŒã®è£œé (a) ïŒâããã©ãã·ã«ãªãã·ããšãã«âãã³ãžã«
ã±ãã³ãšã¿ããŒã«100mläžã«æ°Žé žåã«ãªãŠã 3.0
ïœãå«ã液ã«ïŒâããããªãã·ããã«âãã³ãž
ã«ã±ãã³10.5ïœãå ãæŽã«ããã©ãã·ã«èåç©
16ïœãå ãããåå¿æ··åç©ãéæµæž©åºŠã§12æé
ãã¥ãã«æ¹æããåŸå·åŽãæ°Žäžã«æ³šå ¥ãããç
æç©ãã¯ãããã«ã äžã«æœåºãæŽã«æ°ŽæŽã
MgSO4äžããšãã也ç¥ãéãèžçºãããæ®
枣ãã¡ã¿ããŒã«ããåæ¶åºãããŠéŠé¡ååç©ã®
ç¡è²çµæ¶æ§åºäœ17.5ïœïŒ86ïŒ ïŒãåŸããèç¹72
â74âã (b) ïŒâããã¢âïŒâããšãã«â4â²âããã©ãã·
ã«ãªãã·ã¢ã»ãããã³ å¡©åäºé0.2ïœãå«ãã¯ãããã«ã 50mläžã«
äžèšã±ãã³8.0ïœãå«ã液ã«ã¯ãããã«ã 25ml
äžã«èçŽ 3.2ïœïŒ1.1mlïŒãå«ã液ãå ãããå
å¿æ··åç©ã35âã§3.5æéæ¹æãèžçºä¹Ÿåºã
ããæ®æž£ãã¡ã¿ããŒã«ããåæ¶åºãããŠïŒâã
ãã¢èªå°äœ8.1ïœïŒ85ïŒ ïŒãçœè²åŸ®ç²æ«ãšããŠ
åŸããèç¹62â65âã (c) ïŒâãïŒ(5)âããã·ã«ããªããªã¢ãŸãªã«ãâïŒ
âããã«â4â²âããã©ãã·ã«ãªãã·ã¢ã»ãããš
ãã³ïŒåŒïŒ18ïŒããã€ååç©ïŒ ã¢ã»ããããªã«35mläžã«äžèšïŒâããã¢åå
ç©4.9ïœãšïŒ(5)âããã·ã«ããªâïŒã»ïŒã»ïŒâ
ããªã¢ãŸãŒã«2.0ïœãå«ã液ã«æ°Žé žåã«ãªãŠã
ãã¬ããç²æ«0.6ïœãå ãããåå¿æ··åç©ã宀
æž©ã§ïŒæéæ¹æãéãèžçºãããæ®æž£ãã¡ã¿
ããŒã«äžïŒâã§ããã€ã¶ããåŒïŒ18ïŒããã€å
åç©2.7ïœïŒ46ïŒ ïŒãçœè²åºäœãšããŠåŸããè
ç¹54â58â C36H53N3O2Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã73.01ïŒïŒšã9.03ïŒïŒ®ã7.13 枬å®å€ïŒïŒ£ã72.86ãã9.00ïŒïŒ®ã7.10 å®æœäŸ ïŒ ïŒâãïŒ(5)âããã·ã«ããªããªã¢ãŸãªã«ãâ2â²â
ããããªãã·ã¢ã»ãããšãã³ïŒåŒïŒ13ïŒããã€
ååç©ïŒã®è£œé ïŒâãïŒ(5)âããã·ã«ããªããªã¢ãŸãªã«ãâ2â²â
ããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³ïŒåŒ(10)ããã€
ååç©ãšåæ§ã®æ¹æ³ã§è£œé ããïŒ5.2ïœãšèåæ°Ž
çŽ é žïŒ48ïŒ ïŒ60mlãéæµæž©åºŠã§ïŒæéãã¥ãã«æ¹
æãå·åŽåŸæ°Žäžã«æ³šå ¥ãããæ°Žæ§åªè³ªãæ°Žé žåã
ããªãŠã 溶液ã§äžåããšãŒãã«ã§æœåºããããšãŒ
ãã«æœåºæ¶²ãæ°ŽæŽãMgSO4äžããšãã也ç¥ã
éãèžçºããŠçµæ¶æ§çæç©ãåŸããæ®æž£ãç³æ²¹ãš
ãŒãã«ïŒ60â80âïŒãšããã€ã¶ããŠååç©ïŒ13ïŒ
ã®çœè²çµæ¶2.3ïœïŒ69ïŒ ïŒãåŸããèç¹62â65
âã C16H21N3O2Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã60.16ïŒïŒšã6.63ïŒïŒ®ã13.16 枬å®å€ïŒïŒ£ã60.25ãã6.64ïŒïŒ®ã13.2 å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâïŒâ
ãïŒã»ïŒâãžãããâãã³ãºã€ãããŸã€ã«ãâ
2â²âããããªãã·ã¢ã»ãããšãã³ïŒåŒïŒ19ïŒã
ãã€ååç©ïŒã®è£œé åŒïŒ13ïŒããã€ååç©ã®è£œé ãåæ§ã®æ¹æ³ã§å®
æœäŸïŒã«ã«ãããŠèåæ°ŽçŽ é žãšéæµç¶æ ã§ïŒæé
åå¿ãããŠçæãããšããåŒïŒ15ïŒããã€ååç©
ããåŒïŒ19ïŒããã€ååç©ã補é ããã å®æœäŸ ïŒïŒäœ¿çšå®æœäŸïŒ ããªã¯ã¬ãžã«ããé žå¡©10ïœãšé ¢é žãšãã«10ïœã®
溶液ïŒã«ãã©ãŒä¹³å液ïŒã«ïŒâïŒïŒã»ïŒã»ïŒâã
ãªã¯ããããšãã«ïŒâïŒâïŒïŒâãïŒïŒã»ïŒâãžâïœ
âã¢ãã«ããšããªãã·ïŒã¢ã»ãã¢ãããâãã³ãº
ã¢ããïŒâïŒâãã©ãŸãã³10ïœã溶解ããããŒã©
ãã³æº¶æ¶²80ïœãå ããåŸæ°Ž20mlãšæ¹¿æœ€å€ïŒãžã€ãœ
ããã«ããã¿ã¬ã³ã¹ã«ãã³é žã®ãããªãŠã å¡©ã®10
ïŒ æ°Žæº¶æ¶²ïŒ20mlãé 次å ãããå šäœãè¶ é³æ³¢æ··å
æ©ãçšããŠåæ£ãããã äžèšã«ãã©ãŒä¹³å液24ïœã4.9ïœã®éå«éãš8.8
ã¢ã«ïŒ å¹³åããåç©å«éããã€ããåèåéä¹³å€
40ïœã«å ããããŒã©ãã³æº¶æ¶²48ïœãšæŽã«æ¹¿æœ€å€
3.8mlãå ããåŸæ°Žãå ããŠå šéã200ïœãšããã ãã®æ··åç©ãäžå¡ãããããªã¢ã»ãã€ãæ¯æã
ã€ã«ã äžã«å¡ã20mgïŒïœm2ã®éèééãš6.4mgïŒ
ïœm2ã®ã«ãã©ãŒèééãšããããã®äžã«ããªã¢ãž
ã³ç¡¬åå€ãå«ããŒã©ãã³å±€20mgïŒïœm2ãã€ããã ãã®èãé£ç¶çãŠãšããžã«é²åºãããåŸ37.8â
ã§æ¬¡ã®é åºã«åŠçããã ïŒ ã«ã©ãŒçŸåå€ 3.25å ïŒ æŒçœ 6.50å ïŒ æ°ŽæŽ 3.25å ïŒ å®ç 6.50å ïŒ æ°ŽæŽ 3.25å ïŒ å®å®å 1.50å åŠç济ã¯æ¬¡ã®çµæã®ãã®ã§ãã€ãã ïŒ çŸåå€ çé žã«ãªãŠã 37.5ïœ ç¡æ°Žã¡ã¿éäºç¡«é žãããªãŠã 4.25ïœ ããåã«ãªãŠã 2.0mg èåãããªãŠã 1.3ïœ ç¡«é žããããã·ã«ã¢ãã³ 2.0ïœ ïŒâïŒïŒ®âãšãã«ââβâããããªãã·âãš
ãã«ã¢ããïŒâïŒâã¡ãã«ã¢ããªã³ç¡«é žå¡©
4.75ïœ æ°Žãå ãïŒãšããã ïŒ æŒçœæµŽ èåã¢ã³ã¢ããŠã 150ïœ ã¢ã³ã¢ããŠã 第ïŒéãšãã¬ã³ãžã¢ãã³ããã©â
é ¢é ž 175ml æ°·é ¢é ž 10.5ml ç¡é žãããªãŠã 35ïœ æ°Žãå ïŒãšããã ïŒ å®ç济 ããªç¡«é žã¢ã³ã¢ããŠã ïŒ50ïŒ ïŒ 162ml ãžãšãã¬ã³ããªã¢ãã³ãã³ã¿âé ¢é ž 1.25ïœ ç¡æ°Žã¡ã¿éäºç¡«é žãããªãŠã 12.4ïœ æ°Žé žåãããªãŠã 2.4ïœ æ°Žãå ãïŒãšããã å®å®å€ 35ïŒ ãã«ã ã¢ã«ããã溶液 5.0ml æ°Žãå ãïŒãšããã äžèšæ¹æ³ïŒå¯Ÿç §ïŒã¯æ倧ã³ã³ãã©ã¹ãïŒÎ³ïœïŒ
ãšã³ã³ãã©ã¹ããã調æŽæ床ïŒïŒ³ γïŒïŒïŒã«å¯Ÿ
ã次ã®åççµæãçããã 察 ç § Î³ïœ ïŒ³ γïŒïŒïŒlogEå
äœïŒ ãã©ãŸãã³ ã«ãã©ãŒåç¬ 1.30 ãããã¹ããŒãã«å¯Ÿããã³ã³ãã©ã¹ãã®å¹æã
èæ ®ããçºïŒ³ γïŒïŒå€ãèŠç©ã€ããããã¯æ¬¡ã®
æ§ã«å®çŸ©ãããã  γïŒïŒïŒïŒãã¶ãæ¿åºŠæ°Žæºã«ãããæ床ïŒïŒ
γïŒïŒ 次ãã§äžèšè¢«èŠæ³ãåèŠããããã©ãŸãã³ã«ã
ã©ãŒã®ä»ã«åã ã«ïŒåã¯10ã¢ã«ïŒ ã®D.I.R.ååç©
é¡ãå ããèãã€ãããγïœäœäžïŒ ããã³ïŒ³
γïŒïŒã«ãããå€åãå¯Ÿç §ãšæ¯èŒæž¬å®ããã
æ«ã奜ãŸããã åŒ(7)ããã€ã¢ã«ãã«ããªããªã¢ãŸãŒã«ååç©ã¯
D.I.ååç©ã§ãããç»åã®æ§ã«D.I.ååç©ãæŸåº
ããååç©é¡ã®äœ¿çšã¯æçšãªå±€éããã³å±€å å¹æ
ãåŸãçºåçæè¡åéã«ãããŠã¯ããç¥ãããŠã
ãã çš®ã ã®çŸåæå¶å€âæŸåºæ§ååç©é¡ãããè¿ã«
ã€ãããããããããã®ååç©é¡ã®æ®ãã©ã¯å å
ã«æºè¶³ããããã®ã§ãªããäŸãã°ã«ã©ãŒçŸåã®é
ææãçæããçŸåæå¶å€âæŸåºæ§ååç©ã®å Žå
D.I.R.ååç©ã®ã«ã©ãŒã«ãã©ãŒæ®æž£ã¯åŸãããæ
æã®å¿ èŠãªç¹å®åžåæ§ã®çºåçã«ã©ãŒç»åã®æ£ç¢º
ãªè²åè¡¡ãåŸãã«æ³šæããŠéžæããå¿ èŠãããã
æçšãªD.I.R.ã«ã©ãŒã«ãã©ãŒãçæããããšã¯ã
ã€ããããšããã€ãŠããã ããã«åããŠã«ã©ãŒçŸåå€ã®é žåçæç©ãšææ
ãçæããªãçŸåæå¶å€âæŸåºæ§ååç©é¡ã¯æ¥µã
ãŠäœãåå¿æ§ããã€ãåã¯çŸåäžéåžžã«æ床ãã
ã¡ãããã¥ããã§ããã ãããæ¬çºæã®ååç©é¡ã¯ã«ã©ãŒçŸåå€ã®é žå
çæç©ãšåå¿ããå Žåç¡è²ååç©é¡ãçæããã
ç¡è²æ®æž£ã¯åŸãããç»åã®ã©ã®éšåãæ§æããª
ããããã¯æ°èŠæŸåºæ§ååç©é¡ãåçææã®ã©ã®
å¿ èŠå±€ã«ã䜿çšã§ããå©ç¹ã§ãããæŽã«æ¬çºæã®
ååç©é¡ã¯ã«ã©ãŒçŸåå€ã®é žåçæç©ãšæ¥µããŠå€§
ããªåå¿æ§ããã€ããããã€ãŠé倧ãªæ床æ倱ãª
ãããç»åå ããã³ç»åéå¹æãåŸãã«å å°ã®å
åç©éã䜿ãã°ããã®ã§ããã æŽã«æ¬çºæã®ä»ã®åœ¢æ ã¯åçç»å圢ææ³ãæäŸ
ããããã®æ¹æ³ã¯å°ãªããïŒããã²ã³åé乳局å
åã¯ããã«é£æ¥ããå±€å ã«åŒ(1)ããã€ååç©ãå«
ãæå æ§ããã²ã³åéåçææãæ åé²åºãé²åº
ããããã²ã³åéããã©ããšãã¬ã³ãžã¢ãã³ã«ã©
ãŒçŸåå€ã§çŸåããŠåŒ(7)ããã€ã¢ã«ãã«ããªããª
ã¢ãŸãŒã«ååç©ãç»åã©ããéé¢ãããæ¹æ³ã§ã
ãã æ¬çºæã®D.I.R.ååç©é¡ã¯çºè²æ³ã«ãã€ãŠåŠç
ã§ããŸãç»åé®®é床ããã³ïŒåã¯ïŒäžéå±€å¹æã®
å¢å ãæãŸããã©ã®åç補åã«ã䜿çšã§ãããæ
ã«æ¬çºæã®D.I.R.ååç©é¡ã®æ倧çšéã¯ã«ã©ãŒå
çææã®åéãç¹ã«ã«ã©ãŒé°ç»ãã€ã«ã ææã«ã
ããšæåŸ ããããã«ã©ãŒãã€ã«ã ææäžã«äœ¿çšã
ãå Žåæ¬çºæã®D.I.Rååç©é¡ã¯å°ãªããšãïŒã«
ã©ãŒã«ãã©ãŒãå«ãã«ã©ãŒå¢æããããã²ã³åé
ä¹³å€å±€äžã«ãããšäºæ³ãããããã®æ§ãªããã²ã³
åéä¹³å€å±€äžã«ããD.I.R.ã®æçšéã¯ååšããã«
ã©ãŒã«ãã©ãŒã®ïŒä¹è³10ã¢ã«ïŒ ã§ããã ã«ããªã³ã°ã«éãçŸåæå¶å€ååç©ãæŸåºãã
æ¬çºæã«ããååç©é¡ã®ç¹å®äŸã¯æ¬¡ã®ãšããã§ã
ãã 次ã®å®æœäŸã«ãããéšããã³ããŒã»ã³ãã¯ãã¹
ãŠééåºæºã§ããã å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâ2â²â
ããã©ãã·ã«ãªãã·âã¢ã»ãããšãã³ïŒåŒ(10)ã®
ååç©ïŒã®è£œé ã¢ã»ããããªã«20mläžã«ïŒ(5)âãããã«ããªã
ãªã¢ãŸãŒã«ïŒïœãšããªãšãã«ã¢ãã³ïŒïœã®æº¶æ¶²äž
ã«æž©ã¢ã»ããããªã«30mläžã«ïŒâããã©ãã·ã«ãª
ãã·âããšãã·ã«èåç©10ïœã®æº¶æ¶²ãå ãããå
å¿æ··åç©ã宀枩ã§ïŒæéæ¹æããåŸèžçºãããæ®
枣ãé ¢é žãšãã«50mlã«ãšããææ©å±€ãæ°ŽïŒïŒÃ50
mlïŒã§æŽãMgSO4äžããšãã也ç¥ãéãèžçº
ãããæ®æž£ãã¡ã¿ããŒã«ããåæ¶åºãããŠåŒ(10)ã
ãã€çœè²åŸ®ç²æ«ååç©7.8ïœïŒ61ïŒ ïŒãåŸããè
ç¹61â62âã C31H51N3O2Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã70.27ïŒïŒšã9.70ïŒïŒ®ã7.93 枬å®å€ïŒïŒ£ã69.97ãã94.1ïŒïŒ®ã7.91 å®æœäŸ ïŒ ïŒâããã¢âãïŒ(5)âãããã«ããšããªã¢ãŸãª
ã«ãâ2â²âããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³
ïŒåŒïŒ14ïŒããã€ååç©ïŒã®è£œé ã¯ãããã«ã 75mläžã«ååç©(10)5.1ïœã®æº¶æ¶²ã
60âã§æ¹æããªããã¯ãããã«ã 10mläžã«èçŽ
1.6ïœã®æº¶æ¶²ãïŒæéã«ãããå ãããåå¿æ··å
ç©ãæŽã«ïŒæéç°æµããæ¹æããåŸèžçºãããæ®
ã€ãæ²¹ãïŒâã§ã¡ã¿ããŒã«äžã§ããã€ã¶ãåºäœç
æç©ãåŸããéããŠåŒïŒ14ïŒããã€çœè²åŸ®ç²æ«
ååç©5.4ïœïŒ92ïŒ ïŒãåŸããèç¹45â46âã C31H56BrN3O2Sã«å¯Ÿããåæå€ïŒ èšç®å€ïŒïŒ£ã61.11ïŒïŒšã8.27ïŒïŒ®ã6.9 枬å®å€ïŒïŒ£ã60.85ãã8.20ïŒïŒ®ã7.1 å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâïŒâ
ãïŒã»ïŒâãžããããã³ãºã€ãããŸãªã«ãâ2â²â
ããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³ïŒåŒïŒ15ïŒ
ããã€ååç©ïŒã®è£œé ã¢ã»ããããªã«50mläžã«ïŒã»ïŒâãžããããã³
ãºã€ãããŸãŒã«ã®ã«ãªãŠã å¡©2.6ïœãšïŒâããã¢
âïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâ2â²â
ããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³5.3ïœã®æ··å
ç©ã40âã§ïŒæéæ¹æããåŸèžçºãããæ®æž£ãã¯
ãããã«ã ã«ãšããææ©å±€ãæ°ŽïŒïŒÃ50mlïŒã§æŽ
ãMgSO4äžããšãããŠä¹Ÿç¥ãéãèžçºããã
æ®æž£ãã¡ã¿ããŒã«ããåæ¶åºãããŠåŒïŒ15ïŒãã
ã€çœè²åºäœååç©4.4ïœïŒ68ïŒ ïŒãåŸããèç¹63
â64âã C38H53N7O6Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã62.01ïŒïŒšã7.25ïŒïŒ®ã13.04 枬å®å€ïŒïŒ£ã61.80ãã7.30ïŒïŒ®ã12.72 å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâïŒ
ãïŒâïœâããã«âïŒâã¡ãã«ããªããªã¢ãŸãª
ã«ãâ2â²âããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³
ïŒåŒïŒ16ïŒããã€ååç©ïŒã®è£œé ã¢ã»ããããªã«50mläžã«ïŒâããã¢âïŒâãïŒ
(5)âãããã«ããªããªã¢ãŸãªã«ãâ2â²âããã©ã
ã·ã«ãªãã·ã¢ã»ãããšãã³6.0ïœãå«ã液ã«ã¢ã»
ããããªã«ïŒmläžã«ïŒâïœâããã«âïŒâã¡ãã«
ããªããªã¢ãŸãŒã«ã®ã«ãªãŠã å¡©2.1ïœãå«ã溶液
ãå ãããåå¿æ··åç©ã45âã§3.5æéæ¹æãã
åŸèžçºãããæ®æž£ãã¯ãããã«ã ã«ãšããææ©å±€
ãæ°ŽæŽãMgSO4äžããšãã也ç¥ãéãèžçºã
ãããã®ååç©ãã«ã©ã ã¯ãããã°ã©ãæ³ã§ç²Ÿè£œ
ãããã¡ã¿ããŒã«ããåæ¶åºãããŠåŒïŒ16ïŒãã
ã€ååç©2.7ïœïŒ39ïŒ ïŒãçœè²åŸ®ç²æ«ãšããŠåŸ
ããèç¹63âã C38H62N6O2S2ã«å¯ŸããåæïŒ ïŒ èšç®å€ïŒïŒ£ã65.28ïŒïŒšã8.93ïŒïŒ®ã12.02 枬å®å€ïŒïŒ£ã65.36ãã8.91ïŒïŒ®ã11.91 å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâïŒâ
âãã³ãžã«ããšãã«ãŠã©ãŸãªã«ãâ2â²âãã
ã©ãã·ã«ãªãã·ã¢ã»ãããšãã³ïŒåŒïŒ17ïŒãã
ã€ååç©ïŒã®è£œé ã¢ã»ããããªã«35mläžã«ïŒâããã¢âïŒãïŒ(5)
âãããã«ããªããªã¢ãŸãªã«ãâ2â²âããã©ãã·
ã«ãªãã·ã¢ã»ãããšãã³3.0ïœãšãã³ãžã«ããšãš
ãã«ãŠã©ãŸãŒã«1.4ïœãå«ã溶液ã«æ°Žé žåãããª
ãŠã ãã¬ããç²æ«0.45ïœãå ãããåå¿æ··åç©ã
宀枩ã§ïŒæéæ¹æåŸéãèžçºãããæ®æž£ãã¡ã¿
ããŒã«ããåæ¶åºãããŠåŒïŒ17ïŒããã€ååç©ã®
çœè²åŸ®ç²2.3ïœïŒ58ïŒ ïŒãåŸããèç¹48â49âã C46H62N6O4Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã69.40ïŒïŒšã7.86ïŒïŒ®ã10.57 枬å®å€ïŒïŒ£ã69.17ãã7.80ïŒïŒ®ã10.41 å®æœäŸ ïŒ ïŒâãïŒ(5)âããã·ã«ããªããªã¢ãŸãªã«ãâïŒâ
ããšãã«4â²âããã©ãã·ã«ãªãã·ã¢ã»ãããšã
ã³ïŒåŒïŒ18ïŒããã€ååç©ïŒã®è£œé (a) ïŒâããã©ãã·ã«ãªãã·ããšãã«âãã³ãžã«
ã±ãã³ãšã¿ããŒã«100mläžã«æ°Žé žåã«ãªãŠã 3.0
ïœãå«ã液ã«ïŒâããããªãã·ããã«âãã³ãž
ã«ã±ãã³10.5ïœãå ãæŽã«ããã©ãã·ã«èåç©
16ïœãå ãããåå¿æ··åç©ãéæµæž©åºŠã§12æé
ãã¥ãã«æ¹æããåŸå·åŽãæ°Žäžã«æ³šå ¥ãããç
æç©ãã¯ãããã«ã äžã«æœåºãæŽã«æ°ŽæŽã
MgSO4äžããšãã也ç¥ãéãèžçºãããæ®
枣ãã¡ã¿ããŒã«ããåæ¶åºãããŠéŠé¡ååç©ã®
ç¡è²çµæ¶æ§åºäœ17.5ïœïŒ86ïŒ ïŒãåŸããèç¹72
â74âã (b) ïŒâããã¢âïŒâããšãã«â4â²âããã©ãã·
ã«ãªãã·ã¢ã»ãããã³ å¡©åäºé0.2ïœãå«ãã¯ãããã«ã 50mläžã«
äžèšã±ãã³8.0ïœãå«ã液ã«ã¯ãããã«ã 25ml
äžã«èçŽ 3.2ïœïŒ1.1mlïŒãå«ã液ãå ãããå
å¿æ··åç©ã35âã§3.5æéæ¹æãèžçºä¹Ÿåºã
ããæ®æž£ãã¡ã¿ããŒã«ããåæ¶åºãããŠïŒâã
ãã¢èªå°äœ8.1ïœïŒ85ïŒ ïŒãçœè²åŸ®ç²æ«ãšããŠ
åŸããèç¹62â65âã (c) ïŒâãïŒ(5)âããã·ã«ããªããªã¢ãŸãªã«ãâïŒ
âããã«â4â²âããã©ãã·ã«ãªãã·ã¢ã»ãããš
ãã³ïŒåŒïŒ18ïŒããã€ååç©ïŒ ã¢ã»ããããªã«35mläžã«äžèšïŒâããã¢åå
ç©4.9ïœãšïŒ(5)âããã·ã«ããªâïŒã»ïŒã»ïŒâ
ããªã¢ãŸãŒã«2.0ïœãå«ã液ã«æ°Žé žåã«ãªãŠã
ãã¬ããç²æ«0.6ïœãå ãããåå¿æ··åç©ã宀
æž©ã§ïŒæéæ¹æãéãèžçºãããæ®æž£ãã¡ã¿
ããŒã«äžïŒâã§ããã€ã¶ããåŒïŒ18ïŒããã€å
åç©2.7ïœïŒ46ïŒ ïŒãçœè²åºäœãšããŠåŸããè
ç¹54â58â C36H53N3O2Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã73.01ïŒïŒšã9.03ïŒïŒ®ã7.13 枬å®å€ïŒïŒ£ã72.86ãã9.00ïŒïŒ®ã7.10 å®æœäŸ ïŒ ïŒâãïŒ(5)âããã·ã«ããªããªã¢ãŸãªã«ãâ2â²â
ããããªãã·ã¢ã»ãããšãã³ïŒåŒïŒ13ïŒããã€
ååç©ïŒã®è£œé ïŒâãïŒ(5)âããã·ã«ããªããªã¢ãŸãªã«ãâ2â²â
ããã©ãã·ã«ãªãã·ã¢ã»ãããšãã³ïŒåŒ(10)ããã€
ååç©ãšåæ§ã®æ¹æ³ã§è£œé ããïŒ5.2ïœãšèåæ°Ž
çŽ é žïŒ48ïŒ ïŒ60mlãéæµæž©åºŠã§ïŒæéãã¥ãã«æ¹
æãå·åŽåŸæ°Žäžã«æ³šå ¥ãããæ°Žæ§åªè³ªãæ°Žé žåã
ããªãŠã 溶液ã§äžåããšãŒãã«ã§æœåºããããšãŒ
ãã«æœåºæ¶²ãæ°ŽæŽãMgSO4äžããšãã也ç¥ã
éãèžçºããŠçµæ¶æ§çæç©ãåŸããæ®æž£ãç³æ²¹ãš
ãŒãã«ïŒ60â80âïŒãšããã€ã¶ããŠååç©ïŒ13ïŒ
ã®çœè²çµæ¶2.3ïœïŒ69ïŒ ïŒãåŸããèç¹62â65
âã C16H21N3O2Sã«å¯Ÿããåæå€ïŒ ïŒ èšç®å€ïŒïŒ£ã60.16ïŒïŒšã6.63ïŒïŒ®ã13.16 枬å®å€ïŒïŒ£ã60.25ãã6.64ïŒïŒ®ã13.2 å®æœäŸ ïŒ ïŒâãïŒ(5)âãããã«ããªããªã¢ãŸãªã«ãâïŒâ
ãïŒã»ïŒâãžãããâãã³ãºã€ãããŸã€ã«ãâ
2â²âããããªãã·ã¢ã»ãããšãã³ïŒåŒïŒ19ïŒã
ãã€ååç©ïŒã®è£œé åŒïŒ13ïŒããã€ååç©ã®è£œé ãåæ§ã®æ¹æ³ã§å®
æœäŸïŒã«ã«ãããŠèåæ°ŽçŽ é žãšéæµç¶æ ã§ïŒæé
åå¿ãããŠçæãããšããåŒïŒ15ïŒããã€ååç©
ããåŒïŒ19ïŒããã€ååç©ã補é ããã å®æœäŸ ïŒïŒäœ¿çšå®æœäŸïŒ ããªã¯ã¬ãžã«ããé žå¡©10ïœãšé ¢é žãšãã«10ïœã®
溶液ïŒã«ãã©ãŒä¹³å液ïŒã«ïŒâïŒïŒã»ïŒã»ïŒâã
ãªã¯ããããšãã«ïŒâïŒâïŒïŒâãïŒïŒã»ïŒâãžâïœ
âã¢ãã«ããšããªãã·ïŒã¢ã»ãã¢ãããâãã³ãº
ã¢ããïŒâïŒâãã©ãŸãã³10ïœã溶解ããããŒã©
ãã³æº¶æ¶²80ïœãå ããåŸæ°Ž20mlãšæ¹¿æœ€å€ïŒãžã€ãœ
ããã«ããã¿ã¬ã³ã¹ã«ãã³é žã®ãããªãŠã å¡©ã®10
ïŒ æ°Žæº¶æ¶²ïŒ20mlãé 次å ãããå šäœãè¶ é³æ³¢æ··å
æ©ãçšããŠåæ£ãããã äžèšã«ãã©ãŒä¹³å液24ïœã4.9ïœã®éå«éãš8.8
ã¢ã«ïŒ å¹³åããåç©å«éããã€ããåèåéä¹³å€
40ïœã«å ããããŒã©ãã³æº¶æ¶²48ïœãšæŽã«æ¹¿æœ€å€
3.8mlãå ããåŸæ°Žãå ããŠå šéã200ïœãšããã ãã®æ··åç©ãäžå¡ãããããªã¢ã»ãã€ãæ¯æã
ã€ã«ã äžã«å¡ã20mgïŒïœm2ã®éèééãš6.4mgïŒ
ïœm2ã®ã«ãã©ãŒèééãšããããã®äžã«ããªã¢ãž
ã³ç¡¬åå€ãå«ããŒã©ãã³å±€20mgïŒïœm2ãã€ããã ãã®èãé£ç¶çãŠãšããžã«é²åºãããåŸ37.8â
ã§æ¬¡ã®é åºã«åŠçããã ïŒ ã«ã©ãŒçŸåå€ 3.25å ïŒ æŒçœ 6.50å ïŒ æ°ŽæŽ 3.25å ïŒ å®ç 6.50å ïŒ æ°ŽæŽ 3.25å ïŒ å®å®å 1.50å åŠç济ã¯æ¬¡ã®çµæã®ãã®ã§ãã€ãã ïŒ çŸåå€ çé žã«ãªãŠã 37.5ïœ ç¡æ°Žã¡ã¿éäºç¡«é žãããªãŠã 4.25ïœ ããåã«ãªãŠã 2.0mg èåãããªãŠã 1.3ïœ ç¡«é žããããã·ã«ã¢ãã³ 2.0ïœ ïŒâïŒïŒ®âãšãã«ââβâããããªãã·âãš
ãã«ã¢ããïŒâïŒâã¡ãã«ã¢ããªã³ç¡«é žå¡©
4.75ïœ æ°Žãå ãïŒãšããã ïŒ æŒçœæµŽ èåã¢ã³ã¢ããŠã 150ïœ ã¢ã³ã¢ããŠã 第ïŒéãšãã¬ã³ãžã¢ãã³ããã©â
é ¢é ž 175ml æ°·é ¢é ž 10.5ml ç¡é žãããªãŠã 35ïœ æ°Žãå ïŒãšããã ïŒ å®ç济 ããªç¡«é žã¢ã³ã¢ããŠã ïŒ50ïŒ ïŒ 162ml ãžãšãã¬ã³ããªã¢ãã³ãã³ã¿âé ¢é ž 1.25ïœ ç¡æ°Žã¡ã¿éäºç¡«é žãããªãŠã 12.4ïœ æ°Žé žåãããªãŠã 2.4ïœ æ°Žãå ãïŒãšããã å®å®å€ 35ïŒ ãã«ã ã¢ã«ããã溶液 5.0ml æ°Žãå ãïŒãšããã äžèšæ¹æ³ïŒå¯Ÿç §ïŒã¯æ倧ã³ã³ãã©ã¹ãïŒÎ³ïœïŒ
ãšã³ã³ãã©ã¹ããã調æŽæ床ïŒïŒ³ γïŒïŒïŒã«å¯Ÿ
ã次ã®åççµæãçããã 察 ç § Î³ïœ ïŒ³ γïŒïŒïŒlogEå
äœïŒ ãã©ãŸãã³ ã«ãã©ãŒåç¬ 1.30 ãããã¹ããŒãã«å¯Ÿããã³ã³ãã©ã¹ãã®å¹æã
èæ ®ããçºïŒ³ γïŒïŒå€ãèŠç©ã€ããããã¯æ¬¡ã®
æ§ã«å®çŸ©ãããã  γïŒïŒïŒïŒãã¶ãæ¿åºŠæ°Žæºã«ãããæ床ïŒïŒ
γïŒïŒ 次ãã§äžèšè¢«èŠæ³ãåèŠããããã©ãŸãã³ã«ã
ã©ãŒã®ä»ã«åã ã«ïŒåã¯10ã¢ã«ïŒ ã®D.I.R.ååç©
é¡ãå ããèãã€ãããγïœäœäžïŒ ããã³ïŒ³
γïŒïŒã«ãããå€åãå¯Ÿç §ãšæ¯èŒæž¬å®ããã
ãè¡šã
è¡šïŒã¯æ¬çºæã®ååç©é¡ãé«ãγmaxäœäžå€ã
瀺ããšããçŸåæå¶ã«äœ¿çšã§ããããšãæããã«
瀺ããŠãããååç©é¡ã¯D.I.R.掻æ§ã®ç¯å²ãšäžã
ãæ§éžæã§ãããæŽã«æ¬çºæã®D.I.R.ååç©é¡ã¯
åŒïŒ14ïŒããã€ååç©ãé€å€ããŠãã¥ããæ£ã®ïŒ³
γïŒïŒå€ã瀺ããšããæ床æ倱ã瀺ããªãã å®æœäŸ 10ïŒäœ¿çšå®æœäŸïŒ å®æœäŸïŒã«ãããŠè£œé ãããšããã®èãæŽã«é²
åºç¯å²ã«ãããŠç·ãšç©ºéãã€ãŒãã«é²åºãåèšãš
åæ§ã®é åºã§åŠçããã ãã€ã¯ããã³ã·ãã¡ãŒã¿ãŒã䜿çšããŠåç·ãšç©º
éãã¬ã±ã³ã·ã€ã«å¯Ÿãããã³ã·ãã€å·®ãèšç®ã
ãã次ãã§åãã¬ã±ã³ã·ã€ã«ããããã³ã·ãã€å·®
ãæäœãã¬ã±ã³ã·ã€ã®ãããšåãããŠçžå¯Ÿã¬ã¹ã
ã³ãèšç®ããã çžå¯Ÿã¬ã¹ãã³ã¹ãé²åºã§å€åããããåºããçµ
æã¯é²åºç¯å²ã«ãããå¹³åããã
瀺ããšããçŸåæå¶ã«äœ¿çšã§ããããšãæããã«
瀺ããŠãããååç©é¡ã¯D.I.R.掻æ§ã®ç¯å²ãšäžã
ãæ§éžæã§ãããæŽã«æ¬çºæã®D.I.R.ååç©é¡ã¯
åŒïŒ14ïŒããã€ååç©ãé€å€ããŠãã¥ããæ£ã®ïŒ³
γïŒïŒå€ã瀺ããšããæ床æ倱ã瀺ããªãã å®æœäŸ 10ïŒäœ¿çšå®æœäŸïŒ å®æœäŸïŒã«ãããŠè£œé ãããšããã®èãæŽã«é²
åºç¯å²ã«ãããŠç·ãšç©ºéãã€ãŒãã«é²åºãåèšãš
åæ§ã®é åºã§åŠçããã ãã€ã¯ããã³ã·ãã¡ãŒã¿ãŒã䜿çšããŠåç·ãšç©º
éãã¬ã±ã³ã·ã€ã«å¯Ÿãããã³ã·ãã€å·®ãèšç®ã
ãã次ãã§åãã¬ã±ã³ã·ã€ã«ããããã³ã·ãã€å·®
ãæäœãã¬ã±ã³ã·ã€ã®ãããšåãããŠçžå¯Ÿã¬ã¹ã
ã³ãèšç®ããã çžå¯Ÿã¬ã¹ãã³ã¹ãé²åºã§å€åããããåºããçµ
æã¯é²åºç¯å²ã«ãããå¹³åããã
ãè¡šã
è¡šïŒã¯æ¬çºæã®D.I.R.ååç©é¡ã察ç
§èãšæ¯èŒ
ããå Žåé®®æ床ãå¢ãããšãæããã«ç€ºããŠã
ãã
ããå Žåé®®æ床ãå¢ãããšãæããã«ç€ºããŠã
ãã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ äžè¬åŒïŒ ãåŒäžãR1ã¯ããããªãã·åã¯ã¢ã«ã³ãªãã·ã§ã
ãïŒïœã¯ïŒã§ããïŒR2ã¯æ°ŽçŽ ã§ããïŒR3ã¯ã¢ã«
ãã«ã§ããïŒïŒ¹ã¯æ°ŽçŽ ãããã²ã³ãããšãã«ãå
ã¯åŒ ãåŒãããã㯠ãåŒãã®è€çŽ ç°åºã§ã ãã ã§ç€ºãããååç©ã ïŒ äžè¬åŒ ïŒåŒäžR2ãR3ããã³ïŒ¹ã¯ç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé ã«
å®çŸ©ãããšããã§ããïŒRâ²1ã¯ããããªãã·åã¯
ççŽ ååïŒä¹è³18ããã€ã¢ã«ã³ãªãã·ã§ããïŒã
ãã€ç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé ã«èšèŒã®ååç©ã ïŒ Râ²ãããããªãã·ãåã¯ççŽ ååïŒä¹è³18
ããã€ã¢ã«ã³ãªãã·ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé
ã«èšèŒã®ååç©ã ïŒ R2ãæ°ŽçŽ ã§ãããã€R3ãççŽ ååïŒä¹è³12
ããã€ã¢ã«ãã«ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé ãŸã
ã¯ç¬¬ïŒé ã«èšèŒã®ååç©ã ïŒ äžè¬åŒïŒ ïŒåŒäžRâ²3ã¯ççŽ ååïŒä¹è³12ããã€ã¢ã«ãã«ã§ã
ãïŒããã€ç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé ã«èšèŒã®åå
ç©ã ïŒ äžè¬åŒïŒ ïŒåŒäžR1ã¯ããããªãã·åã¯ã¢ã«ã³ãªãã·ã§ã
ãïŒïœã¯ïŒã§ããïŒããã€ååç©ã®æº¶æ¶²ãäžè¬
åŒïŒ ïŒåŒäžR2ã¯æ°ŽçŽ ã§ãããR3ã¯ã¢ã«ãã«ã§ããïŒã
ãã€ã¢ã«ãã«ããªããªã¢ãŸãŒã«ãšåå¿ãããŠåŒïŒ ããã€ååç©ã補é ããããšãç¹åŸŽãšããæ¹æ³ã ïŒ äžè¬åŒïŒ ïŒåŒäžR1ã¯ããããªãã·åã¯ã¢ã«ã³ãªãã·ã§ã
ãïŒïœã¯ïŒã§ããïŒããã€ååç©ã®æº¶æ¶²ãäžè¬
åŒïŒ ïŒåŒäžR2ã¯æ°ŽçŽ ã§ãããR3ã¯ã¢ã«ãã«ã§ããïŒã
ãã€ã¢ã«ãã«ããªããªã¢ãŸãŒã«ãšåå¿ãããŠåŒïŒ ããã€ååç©ã補é ããåŸã該ã¡ãã¬ã³åºããã
ã²ã³åããŠåŒ ïŒïŒžã¯ããã²ã³ã§ããïŒããã€ååç©ã補é ãã
ããšãç¹åŸŽãšããæ¹æ³ã ïŒ äžè¬åŒïŒ ïŒåŒäžR1ã¯ããããªãã·åã¯ã¢ã«ã³ãªãã·ã§ã
ãïŒïœã¯ïŒã§ããïŒããã€ååç©ã®æº¶æ¶²ãäžè¬
åŒïŒ ïŒåŒäžR2ã¯æ°ŽçŽ ã§ãããR3ã¯ã¢ã«ãã«ã§ããïŒã
ãã€ã¢ã«ãã«ããªããªã¢ãŸãŒã«ãšåå¿ãããŠåŒïŒ ããã€ååç©ã補é ããåŸã該ã¡ãã¬ã³åºããã
ã²ã³åããŠåŒ ïŒïŒžã¯ããã²ã³ã§ããïŒããã€ååç©ã補é ãã
次ãã§ãããåŒ ãåŒããŸã㯠ãåŒãããã€è€çŽ ç°å åç©ãšå¡©åºã®ååšã«ãããŠãåã¯è©²è€çŽ ç°ååç©
ã®ã«ãªãŠã å¡©ãšã¢ã»ããããªã«äžã«ãããŠåå¿ã
ããŠåŒ ãåŒäžãã¯ãåŒã ãåŒãããã㯠ãåŒãã®è€çŽ ç°åºã§ã ãã ããã€ååç©ã補é ããããšãç¹åŸŽãšããæ¹æ³ã ïŒ äžè¬åŒïŒ ïŒåŒäžR1ã¯ããããªãã·åã¯ã¢ã«ã³ãªãã·ã§ã
ãïŒïœã¯ïŒã§ããïŒããã€ååç©ã®æº¶æ¶²ãäžè¬
åŒïŒ ïŒåŒäžR2ã¯æ°ŽçŽ ã§ãããR3ã¯ã¢ã«ãã«ã§ããïŒã
ãã€ã¢ã«ãã«ããªããªã¢ãŸãŒã«ãšåå¿ãããŠåŒïŒ ããã€ååç©ã補é ããããšãç¹åŸŽãšããæ¹æ³ã ïŒïŒ æ¯æäœäžã«ã€ããå°ãªããšãïŒããã²ã³å
éä¹³å€å±€ããã¡ãã€ãã®å±€åã¯ãããšé£æ¥ããå±€
ãäžè¬åŒïŒ ïŒåŒäžR1ã¯ããããªãã·åã¯ã¢ã«ã³ãªãã·ã§ã
ãïŒïœã¯ïŒã§ããïŒR2ã¯æ°ŽçŽ ã§ããïŒR3ã¯ã¢ã«
ãã«ã§ããïŒïŒ¹ã¯æ°ŽçŽ ãããã²ã³ãããšãã«ãå
ã¯åŒ ãåŒã ãããã¯ãåŒãã®è€çŽ ç°åºã§ããïŒã§ç€ºãããååç©ãå«ãããšãç¹åŸŽ
ãšããæå æ§åçææã ïŒïŒ 該ååç©ãããã²ã³åéä¹³å€å±€äžã«ããç¹
èš±è«æ±ã®ç¯å²ç¬¬ïŒïŒé ã«èšèŒã®åçææã
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7837260 | 1978-09-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5555171A JPS5555171A (en) | 1980-04-22 |
| JPS6239156B2 true JPS6239156B2 (ja) | 1987-08-21 |
Family
ID=10499753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11885979A Granted JPS5555171A (en) | 1978-09-18 | 1979-09-18 | Development controlling agent release compounds and their use in photograph material |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US4259437A (ja) |
| JP (1) | JPS5555171A (ja) |
| BE (1) | BE878815A (ja) |
| CH (1) | CH646959A5 (ja) |
| DE (1) | DE2937127A1 (ja) |
| FR (1) | FR2436142A1 (ja) |
| GB (1) | GB2035302B (ja) |
| IT (1) | IT1120009B (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0044279A3 (en) * | 1980-07-16 | 1983-03-02 | Ciba-Geigy Ag | A method of processing monochrome silver halide material |
| US4404390A (en) * | 1980-12-12 | 1983-09-13 | Eastman Kodak Company | Mesoionic 1,2,4-triazolium silver halide stabilizer precursors |
| US4351896A (en) * | 1980-12-12 | 1982-09-28 | Eastman Kodak Company | Mesoionic silver halide stabilizer precursor and use in a heat developable and heat stabilizable photographic silver halide material and process |
| PT79031B (en) * | 1983-08-20 | 1986-08-22 | Boots Co Plc | Therapeutic agents |
| DE3412948A1 (de) * | 1984-04-06 | 1985-10-17 | Agfa-Gevaert Ag, 5090 Leverkusen | Fotografisches aufzeichnungsmaterial, verfahren zur stabilisierung fotografischer aufzeichnungsmaterialien und neue triazole |
| JPS61269143A (ja) * | 1985-05-24 | 1986-11-28 | Fuji Photo Film Co Ltd | å ç±å·¥çšãæããç»å圢ææ¹æ³ |
| DE3711418A1 (de) * | 1987-04-04 | 1988-10-20 | Agfa Gevaert Ag | Farbfotografisches aufzeichnungsmaterial mit einem kuppler, der eine fotografisch wirksame verbindung freisetzt |
| US5385815A (en) | 1992-07-01 | 1995-01-31 | Eastman Kodak Company | Photographic elements containing loaded ultraviolet absorbing polymer latex |
| EP0686873B1 (en) | 1994-06-08 | 2000-04-19 | Eastman Kodak Company | Color photographic element containing new epoxy scavengers for residual magenta coupler |
| JPH08101477A (ja) | 1994-08-01 | 1996-04-16 | Eastman Kodak Co | æ°Žæ§åççšã³ãŒãã£ã³ã°çµæç© |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3869291A (en) * | 1970-12-08 | 1975-03-04 | Agfa Gevaert Ag | Silver halide light-sensitive color photographic material containing color coupler masking compound and development inhibitor releasing compound |
| DE2336721A1 (de) * | 1973-07-19 | 1975-02-06 | Agfa Gevaert Ag | Farbphotographisches mehrschichtenmaterial mit verbesserter farbdichte |
| JPS5223344A (en) * | 1975-08-15 | 1977-02-22 | Konishiroku Photo Ind Co Ltd | Silver halide photographic light sensitive material |
| US4079143A (en) * | 1975-08-26 | 1978-03-14 | Imperial Chemical Industries Limited | Fungicidal 1H-1,2,4-triazoles |
| JPS537232A (en) * | 1976-07-07 | 1978-01-23 | Fuji Photo Film Co Ltd | Silver halide photographic photosensitive material |
-
1979
- 1979-09-05 US US06/072,735 patent/US4259437A/en not_active Expired - Lifetime
- 1979-09-12 FR FR7922816A patent/FR2436142A1/fr active Granted
- 1979-09-13 DE DE19792937127 patent/DE2937127A1/de active Granted
- 1979-09-14 IT IT50273/79A patent/IT1120009B/it active
- 1979-09-14 CH CH834479A patent/CH646959A5/de not_active IP Right Cessation
- 1979-09-17 BE BE0/197167A patent/BE878815A/fr not_active IP Right Cessation
- 1979-09-18 JP JP11885979A patent/JPS5555171A/ja active Granted
- 1979-09-18 GB GB7932288A patent/GB2035302B/en not_active Expired
-
1980
- 1980-06-12 US US06/158,979 patent/US4362878A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4259437A (en) | 1981-03-31 |
| FR2436142B1 (ja) | 1983-03-11 |
| IT7950273A0 (it) | 1979-09-14 |
| CH646959A5 (de) | 1984-12-28 |
| GB2035302B (en) | 1983-01-19 |
| GB2035302A (en) | 1980-06-18 |
| US4362878A (en) | 1982-12-07 |
| IT1120009B (it) | 1986-03-19 |
| FR2436142A1 (fr) | 1980-04-11 |
| DE2937127A1 (de) | 1980-03-27 |
| BE878815A (fr) | 1980-03-17 |
| DE2937127C2 (ja) | 1988-10-13 |
| JPS5555171A (en) | 1980-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4421845A (en) | Silver halide photographic light-sensitive material | |
| US4046575A (en) | Color photographic material containing 2-equivalent yellow couplers | |
| JP2656924B2 (ja) | åçèŠçŽ | |
| EP0246766B1 (en) | The stabilization of dye images produced in photographic materials | |
| DE2811025A1 (de) | Silbersalze von 3-amino-1,2,4-mercaptotriazolderivaten | |
| JPH0823673B2 (ja) | ããã²ã³åéåçèŠçŽ | |
| US4009035A (en) | Process for forming cyan dye photographic images | |
| US4438193A (en) | Silver halide photosensitive color photographic material | |
| JPS59218439A (ja) | ããã²ã³åéåçæå ææ | |
| JPS6239156B2 (ja) | ||
| US4728601A (en) | Tetra-aza indene compounds | |
| US4049458A (en) | Photographic silver halide material containing 2-equivalent yellow couplers | |
| US4500636A (en) | Silver halide photographic light-sensitive material | |
| US4286054A (en) | Light sensitive, color photographic silver halide compositions with DIR-couplers | |
| JPS6326377B2 (ja) | ||
| US4387159A (en) | Light sensitive, color photographic silver halide compositions with DIR-couplers | |
| US4609620A (en) | Pyrazolone compounds and a process for their manufacture | |
| US4226934A (en) | Light sensitive photographic material containing development inhibitor releasing compounds | |
| US4341864A (en) | Photographic elements containing cyan-forming couplers | |
| JP2002229166A (ja) | ã«ã©ãŒåçããªã³ãææ | |
| US5206379A (en) | α-acylmethoxycarbonylbenzotriazoles | |
| DE2850626A1 (de) | Photographisches material | |
| SU1062640A1 (ru) | СвеÑПÑÑвÑÑвОÑелÑÐœÑй ÑвеÑПÑПÑПгÑаÑОÑеÑкОй галПгеМÑеÑÐµÐ±Ñ ÐœÑй ЌаÑеÑОал Ñ ÐÐÐ -кПЌпПМеМÑаЌО | |
| US4148657A (en) | Silver halide photographic emulsions reactively associated with antifog agents, and photographic elements containing said emulsions | |
| GB2032914A (en) | Heterocyclyl-substituted phenacyl thioether derivatives for use as photographic development inhibitors |