JPS62281956A - Blood component removing apparatus - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial Application Field> The present invention relates to a blood component removal device that selectively removes harmful components such as cholesterol contained in blood.

<Prior art> As a blood component removal device as described above, for example, Japanese Patent Application Laid-open No. 5
A removal device disclosed in Japanese Patent No. 9-197255 is known. This removal device includes a first pump that sends blood collected from a donor, a plasma separation section that separates the blood into plasma and blood cells, and specific components (such as lipoproteins) contained in the plasma. a selective removal section that selectively removes the plasma; a @2 pump that sends the plasma separated in the plasma separation section to the selective removal section; A mixing unit is provided to mix the plasma from which blood has been selectively removed, and the speed of the first and second pumps is manually controlled to remove the specific components contained in the blood. .

However, in the above-mentioned conventional example, the speed of the first and second pumps is controlled manually, which not only lacks speed but also poses a safety problem as it is not possible to ensure blood flow in accordance with the donor's condition. <Problems to be solved by the invention> The present invention was made in view of the above-mentioned situation, and its purpose is to maintain blood flow that is compatible with the condition of the blood donor while safely and To provide a blood component remover capable of quickly and selectively removing harmful components from blood.

Means for Solving the Problems> A feature of the present invention that solves the above-mentioned problems is that in a blood component removal device, a first pump for delivering collected blood and a first pump for transporting plasma separated from the blood are provided. The liquid feeding flow rate of the second pump, which feeds the liquid, is controlled using drive signals calculated based on pressure signals detected by a plurality of pressure gauges.

<Example> Hereinafter, the present invention will be described in detail using the drawings. The figure is an explanatory diagram of the configuration of an embodiment of the present invention. In the figure, la is a blood collection part that collects blood from the donor's arm, etc. (not shown), and 1b is K blood from the donor's arm, etc. (not shown). Blood return section, 2a~
2d is the blood (or plasma) chamber, 33 to 3e are the first
~Fifth pressure gauge, 4a is the first pump that pumps blood, 4
Reference numeral b denotes a second pump for pumping plasma; 5, the interior is partitioned into an inner chamber 5b and an outer chamber 5c by, for example, a tube-shaped membrane 5aK; the inner nuclear chamber 5b is provided with an inlet 5d and an outlet 5e; In the chamber 5c, there is a sowing device, 7 is a mixing section, and 8 is a motor drive which receives pressure signals 81 to S5 from the first to fifth pressure gauges 3a to 3e, performs predetermined calculation processing, and drives a motor based on the calculation results. The signals ml and m2 are transmitted to the first and second pumps 4a, respectively.
This is a control unit that sends out 4bK.

In the embodiment of the present invention having such a configuration, first, the motor drive signals rn1 and ff12 corresponding to the set values set in advance in the control unit 8 are sent to the first
and the second pumps 4a, 4b according to the drive signals m1+m2.
4b is being driven. By driving the first pump 4a, blood is collected from the donor's arm or the like (not shown) through the blood collection section 1a, and the blood is transferred to the blood chamber 2a and the first pump.
It reaches the plasma separator 5 via the pump 4a and the blood chamber 2b. In the plasma separator 5, plasma in the blood is led to the outer chamber 5c via the membrane 5a, and the remaining blood cells are led to the mixing section 7 from the outlet 5e. Also, outside room 5C
The plasma in
, the second pump 4b, and the blood chamber 20 to the selective remover 6. In the remover 6, harmful components (for example, fresterol) in the plasma are adsorbed by the adsorbent and removed, and the plasma from which the harmful components have been removed is led to the mixing section 7 from the outlet 6b. The plasma is mixed in the mixing section 7 with the blood cell components introduced from the outlet 5e of the plasma separator 5, and is returned to the donor's arm or the like from the blood return section 1b via the blood chamber 2C. .

On the other hand, the blood pressure (Pl) in the blood chamber 2a is
It is detected by the pressure gauge 3a, and the detection signal is the pressure signal S1.
The signal is input to the control unit 8 and monitored. When the donor's blood pressure decreases due to deterioration of the donor's condition, etc., the decrease in blood pressure is detected by the first pressure gauge 33, and the first pump 4a is activated to send fluid according to a command from the control unit 8 in accordance with the detection signal. Flow rate is reduced. Therefore, the amount of blood collected from the donor's arm or the like via the blood collection unit 1a is reduced, and the safety of the blood donor can be maintained.

Also, when the donor's condition recovers and his blood pressure returns to normal,
The blood pressure is detected by the first pressure gauge 33, and the liquid delivery IT of the first pump 4a is increased by the command (driving signal mx) of the control unit 8 output in response to the detection signal S1, and a steady state is reached. . By the way, the blood led to the plasma separator 5 is separated into plasma and blood cell components by the plasma separator 5, but the pressure drop in the plasma separator 5 may increase due to clogging of the plasma separator 5a. In this case, if blood is continued to be supplied into the plasma separator S, there is a risk that the membrane 5a may be damaged or other dangerous situations may occur.For this reason, the second pressure gauge 3b and the third pressure gauge 3C may Detected pressure signal S2-83
The control unit 8 calculates (p2-p3) based on , and the calculated value does not exceed the constant pressure value C1, and the pressure detected by the third pressure gauge 3c reaches the constant pressure value 0□ (these values 01 .0
2 are preset in the control unit 8), the control unit 8 controls the liquid feeding flow rate of the first pump 4a. In addition, the liquid feeding flow rate of the second pump 4b is controlled by the control unit 80 command (i.e., drive signal m2) so as to satisfy the following conditions (a) to (!).

0) Blood flow rate Q2 calculated within the control unit 8 based on the drive signal m1 sent from the control unit 8 to the first pump 4a.
The control unit 8 controls the second pump 4 so that the following formula (1) is satisfied.
Control the liquid feeding flow rate of b.

Q: 2≦kQl (1) Such flow rate control makes it possible to prevent the membrane 5a from being clogged due to too much plasma being taken in the plasma separation 55.

(b) Second. Third. and fifth pressure gauges 3b, 3c,
Pressure P2 detected at 3e. P3. The control unit 8 controls the second pump 4b so that the following formula (2) holds between P5 and P5.
Controls the liquid flow rate.

Such flow rate control makes it possible to prevent hemolysis, in which blood cell components enter the pores of the membrane 5a and are destroyed. Note that the above 03 is, for example, 50 (
rrrnHg).

(c) Pressure P3 detected by the third and fourth pressure gauges 3C+ 3d. The control unit 8 controls the second
Controls the flow rate of the pump 4b.

(p4-p3)≦04 (3) Such flow rate control causes negative effects such as excessive pressure of plasma flowing into the selective remover 6 and deterioration of adsorbent performance in the selective remover 6. can be prevented from occurring.

<Effects of the Invention> According to the present invention as described in detail above, the blood pressure is monitored by the first pressure gauge 33, and when the donor's condition worsens, the first pump 4a is activated by a command from the control unit 8. Since the structure is such that the flow rate of blood is reduced, there is an advantage that blood can be collected in accordance with the condition of the blood donor. In addition, since the configuration is configured to perform predetermined calculations based on the pressure signals 82 to S5 detected by the second to fifth pressure gauges 3b to 3e and control the flow rate of the second pump 4b to achieve the optimum condition, plasma Another advantage is that harmful components inside can be removed safely and efficiently.

[Brief explanation of the drawing]

The figure is a configuration explanatory diagram of an embodiment of the present invention. la...Blood collection section, 1b...Blood return section, 2a-2d...
・Chamber, 38-3e...Pressure gauge, 4a, 4b
Pump, 5 Plasma separator, 6 Selective remover, 7 Mixing section, 8 Control section. Do1,\

Claims (3)

[Claims] (1) A first pump that sends blood collected from a donor; the inside is partitioned into an inner chamber and an outer chamber by a membrane, and when the blood is led into the inner chamber, it is separated into plasma and blood cells. a plasma separator, a second pump that pumps the plasma in the outer chamber, and a selective remover that is filled with an adsorbent and selectively removes harmful components from the plasma when the plasma is introduced. ,
A first pressure gauge that detects the upstream pressure P_1 of the first pump, a second pressure gauge that detects the inlet pressure P_2 of the plasma separator, and a third pressure gauge that detects the pressure P_3 of blood returned to the donor. Pressure gauge and inlet side pressure P_ of the selective remover
A fourth pressure gauge detects the pressure P_5 in the outer chamber of the plasma separator, and a fifth pressure gauge detects the pressure P_5 in the outer chamber of the plasma separator. A blood component removal device comprising: a control section that sends a drive signal to the first and second pumps; and the drive signal controls the flow rate of liquid delivered by the first and second pumps. (2) In response to the decrease in the upstream pressure P_1, the liquid delivery flow rate of the first pump is reduced, and the difference between the inlet pressure P_2 and the return pressure P_3 does not exceed a constant pressure value C_1. The blood component removal device according to claim 1, wherein the fluid flow rate of the first pump is controlled so that blood pressure P_3 does not exceed a constant pressure value C_2. (3) Based on the inlet side pressure P_2, return pressure P_3, and outer chamber pressure P_5 ((P_2+P_3)/2−
P_5) does not exceed the constant pressure value C_3, and the difference between the input side pressure P_4 and the return pressure P_3 is the constant pressure value C_4.
The blood component removal device according to claim 1 or 2, wherein the flow rate of liquid sent by the second pump is controlled so that the flow rate does not exceed .