JPS62240608A - Hair tonic cosmetic containing diazoxide - Google Patents
Hair tonic cosmetic containing diazoxideInfo
- Publication number
- JPS62240608A JPS62240608A JP8327886A JP8327886A JPS62240608A JP S62240608 A JPS62240608 A JP S62240608A JP 8327886 A JP8327886 A JP 8327886A JP 8327886 A JP8327886 A JP 8327886A JP S62240608 A JPS62240608 A JP S62240608A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- diazoxide
- growth
- hair tonic
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 35
- 229960004042 diazoxide Drugs 0.000 title claims abstract description 12
- 239000002537 cosmetic Substances 0.000 title claims abstract description 11
- 230000001256 tonic effect Effects 0.000 title abstract description 5
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 title description 8
- GDLBFKVLRPITMI-UHFFFAOYSA-N diazoxide Chemical compound ClC1=CC=C2NC(C)=NS(=O)(=O)C2=C1 GDLBFKVLRPITMI-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000003779 hair growth Effects 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 11
- 206010020772 Hypertension Diseases 0.000 abstract description 2
- 230000001154 acute effect Effects 0.000 abstract description 2
- 230000017531 blood circulation Effects 0.000 abstract description 2
- 210000004204 blood vessel Anatomy 0.000 abstract description 2
- 230000001631 hypertensive effect Effects 0.000 abstract description 2
- 230000002093 peripheral effect Effects 0.000 abstract description 2
- 210000002460 smooth muscle Anatomy 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 230000003676 hair loss Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 5
- 231100000360 alopecia Toxicity 0.000 description 5
- 208000024963 hair loss Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 208000004631 alopecia areata Diseases 0.000 description 2
- 206010068168 androgenetic alopecia Diseases 0.000 description 2
- 201000002996 androgenic alopecia Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000004919 hair shaft Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000034557 congenital alopecia Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000003803 hair density Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000008311 hydrophilic ointment Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000003813 thin hair Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、優れた養毛・発毛効果を示す発毛促進養毛化
粧料に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a hair growth promoting cosmetic composition that exhibits excellent hair nourishing and hair growth effects.
脱毛症には先天性の無毛症やｍａ性脱毛症などは別とし
て、円形脱毛症や男性型脱毛症は身体が健康で、毛根が
皮膚中に存在するにもかかわらず毛を産生ずる機能が低
下あるいは停止してしまい、薄毛、ハゲが発症するのが
ほとんどである。それら脱毛症の原因として棟々の説が
あり、多くの研究がされてきたにもかかわらず。Apart from congenital alopecia and alopecia alopecia, alopecia areata and androgenetic alopecia are caused by the ability to produce hair even though the body is healthy and the hair roots are present in the skin. In most cases, hair loss decreases or stops, resulting in thinning hair and baldness. There are various theories as to the cause of hair loss, and even though many studies have been conducted.
その原因は明確にされてなく、予防や治療の方法が今だ
に確立していないのが現状である。今日の社会風俗にお
いて１毛髪の有する美容的な意味は大きいため、脱毛症
患者の精神的苦悩ははかりしれないものがある。The cause is not clear, and currently no methods of prevention or treatment have been established. In today's social customs, each hair has a great cosmetic meaning, and the mental suffering of alopecia patients is immeasurable.
本発明は、脱毛症でない人に対しては育毛・化粧効果が
あシ、また毛根の消失を伴わない各種脱毛症の治療に対
して有効である発毛促進養毛化粧料を開発することを目
的として行なったものである。The present invention aims to develop a hair growth-promoting hair nourishing cosmetic that has no hair growth and cosmetic effects on people without alopecia, and is effective for the treatment of various types of alopecia that do not involve loss of hair roots. This was done for a purpose.
本発明者らは、高血圧性急性症に対する治療注射薬とし
て用いられるジアゾ千シト（別名エンデミン）が優れた
養毛・発毛効果を有することを見い出して本発明を完成
するにいたった。The present inventors have completed the present invention by discovering that diazo-sensito (also known as Endemin), which is used as an injectable drug to treat acute hypertensive symptoms, has excellent hair-nourishing and hair-growth effects.
ジアゾキシドは、化学名が７−クロロ−３−メチル−２
）ｉ−１，２，４−ベンゾチアジアジン−１，１−ジオ
キシド、化学式ｃ、ｎ、ｅｔＲ，ｏ、ｓ 。Diazoxide has the chemical name 7-chloro-3-methyl-2
) i-1,2,4-benzothiadiazine-1,1-dioxide, chemical formula c, n, etR, o, s.
分子ｆｔ２５α７０の化合物で、次に示す構造式：０゜
を有する白色ないし類白色の無臭結晶性粉末で、融点は
３５０〜３３１℃である。It is a compound with a molecular weight of ft25α70, a white to almost white odorless crystalline powder having the following structural formula: 0°, and a melting point of 350 to 331°C.
このジアゾキシドは、水、クロロホルム、エーテルに殆
ど溶けず、アルコール、アルカリ溶液に可溶である。This diazoxide is almost insoluble in water, chloroform, and ether, and soluble in alcohol and alkaline solutions.
ジアゾキシドを皮ｊＭに投与することで１本薬剤のもつ
末梢動脈壁の平滑筋に対する直接的弛緩作用により血管
を拡張し、毛根周囲の血行をより盛んにし、また毛成長
に関する細胞群に対し分裂能を促進し、るるいは毛生成
に必要なタンパク合成作用を活性化することで養毛・発
毛に有効な＊きを示すものと考えられる。By administering diazoxide to the skin, the drug directly relaxes the smooth muscles of peripheral arterial walls, dilating blood vessels, increasing blood circulation around hair roots, and increasing the ability of cells involved in hair growth to divide. Rurui is thought to be effective for hair nourishment and hair growth by activating the protein synthesis action necessary for hair production.
以下に若干の実施例および試験例をあげて具体的に本発
明を説明するが１本発明はこれ等のみに限定されるもの
ではない。The present invention will be specifically explained below with reference to some Examples and Test Examples, but the present invention is not limited to these.
実施例１
次の処方により常法にて養毛効果の優れたゲル製剤を調
製した。Example 1 A gel preparation with excellent hair-nourishing effects was prepared in a conventional manner using the following formulation.
（重量％）
ジアゾキシド ＣＬ５
濃グリセリン 五〇
カルボキシビニルポリマー １．０トリエ
タノールアミン α４５エタノール
４［ＬＯ精製水 ５１０５
実施例２
次の処方により常法にて養毛効果の優れたヘアートニッ
クを調製した。(Weight %) Diazoxide CL5 Concentrated glycerin 50 carboxyvinyl polymer 1.0 Triethanolamine α45 ethanol
4 [LO Purified Water 5105 Example 2 A hair tonic with excellent hair nourishing effect was prepared according to the following formulation in a conventional manner.
ジアゾキシド ｃＬ５ｇサリチル酸
［Ｌｌｇｌ、３−ブデレングリコール
Ｓ０ｇｄｔ−メントール
１１ｇエタノール ７０ｄ精製水
適意
（以上全量１００−とする）
実施例３
次の処方により常法にて養毛効果の優れた軟膏製剤を調
製した。Diazoxide cL5g salicylic acid
[Llgl, 3-budelene glycol
S0gdt-menthol
11g ethanol 70d purified water
Adequacy (the total amount is 100 -) Example 3 An ointment preparation with excellent hair-nourishing effect was prepared according to the following formulation in a conventional manner.
ジアゾキシド １．０ｇ局方親水軟膏
９９．０ ｇ試験例
本発明養毛化粧料の養毛・発毛効果を以下のごとく試験
した。Diazoxide 1.0 g Pharmacopoeia hydrophilic ointment 99.0 g Test Example The hair nourishing and hair growth effects of the hair nourishing cosmetic of the present invention were tested as follows.
１、動物実験
第８週令の４Ｈマウス（♂＞１に用いて、１群を１１匹
として２群を作り、全マウスの背部毛をＺ５濡Ｘ五〇備
の範囲に抜毛し、一方の群を被検液塗布群としてシア／
キシド１１ｇ／７０％エタノール溶液１００ｄの被検液
を連日。1. Animal experiment: Use 8-week-old 4H mice (female > 1) to make 2 groups of 11 mice in each group, remove the hair from the backs of all mice to an area of Z5 wet x 50 Shear/
Test solution of 11 g of oxide/100 d of 70% ethanol solution was applied every day.
１日１回２００ｄずつ毛成長が終了するまで背部に塗布
投与した、また他方を対照群として溶媒のみを同様に塗
布投与した。両群のマウスの再生する背部毛の長さく１
匹当り１回１５本）および太さく１匹当り１００本）に
ついて測定した結果を表Ｉおよび…に示す。The mice were applied once a day for 200 days to the back until hair growth was completed.The other group was treated as a control group, and only the solvent was applied in the same manner. The length of the regenerated dorsal hair in both groups of mice was 1.
The results of the measurements were shown in Table I and...
表−Ｉ 毛成長の長さの測定（単位ｍ＋）λ臨床試験
試験液としてジアゾキシドα５ｇ／エタノール１０〇−
浴液を用い、本試料液を１回約０．５ｄ１日２回頭部脱
毛部分にｍＲＸし、約５ケ月間継続使用を行ない、塗擦
部位の新宅の発生・発育等を単位面積当たりの硬毛の毛
幹数を計測する毛密度測定法と、写真撮影を行い判定す
る５ｃｏｒｅ判定法にて評価した。Table-I Measurement of hair growth length (unit: m+) λ Diazoxide α 5g/ethanol 100- as test solution for clinical trials
Using a bath solution, mRX this sample solution to the bald area of the head for about 0.5 d twice a day, and continue to use it for about 5 months to check the occurrence and growth of new hair at the application site. Evaluation was made using the hair density measurement method, which measures the number of hair shafts, and the 5core judgment method, which uses photography to determine the number of hair shafts.
５ｃｏｒｅ判定法の判定基準は次の通りとした。The criteria for the 5core judgment method were as follows.
ｃｏｒｅ
１、 毛はほとんどなく、僅かに軟毛が見られるのみで
ある。core 1, there is almost no hair, only a few soft hairs are seen.
２ 脱毛部位に多数の軟毛と僅かに硬毛が見られる。2. A large number of vellus hairs and a few terminal hairs are seen at the hair removal site.
五 脱毛部位に密集して軟毛があり半数程度の硬毛が見
られる。(5) There is dense vellus hair in the area of hair loss, and about half of the hair is terminal.
４、 硬毛で全体が覆われているが頭皮がすけて見える
。4. The entire scalp is covered with terminal hair, but the scalp is visible.
＆ 脱毛斑、博毛の状態がまったく見られない。& There are no signs of hair loss or hair loss.
被検者ノ版１と２は円形脱毛症患者の脱毛斑部位を用い
、４３と４は男性型脱毛患者の脱毛部位で行なった。次
表−世に試験結果を示す。Tests 1 and 2 were performed on the bald spots of patients with alopecia areata, and tests 43 and 4 were performed on the bald areas of patients with androgenetic alopecia. The following table shows the test results.
表−■
上記両試験例に示すごとく、本発明養毛化粧料は明らか
な養毛・発毛効果を有し、優れた養毛化粧料であること
がわかる。Table 1 As shown in both of the above test examples, the hair nourishing cosmetic of the present invention has clear hair nourishing and hair growth effects, and is found to be an excellent hair nourishing cosmetic.
Claims (1)
キシド）を含有することを特徴とする養毛化粧料。[Scope of Claims] A hair nourishing cosmetic containing diazoxide (7-chloro-3-methyl-2H-1,2,4-benzothiadiazine-1,1-dioxide).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8327886A JPS62240608A (en) | 1986-04-11 | 1986-04-11 | Hair tonic cosmetic containing diazoxide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8327886A JPS62240608A (en) | 1986-04-11 | 1986-04-11 | Hair tonic cosmetic containing diazoxide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS62240608A true JPS62240608A (en) | 1987-10-21 |
Family
ID=13797893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8327886A Pending JPS62240608A (en) | 1986-04-11 | 1986-04-11 | Hair tonic cosmetic containing diazoxide |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62240608A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0840894A (en) * | 1994-03-15 | 1996-02-13 | L'oreal Sa | Alpha-pyrone-based composition for inducing and acceleratinggrowth of hair and/or retarding decrease of hair |
-
1986
- 1986-04-11 JP JP8327886A patent/JPS62240608A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0840894A (en) * | 1994-03-15 | 1996-02-13 | L'oreal Sa | Alpha-pyrone-based composition for inducing and acceleratinggrowth of hair and/or retarding decrease of hair |
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