JPS6158781B2 - - Google Patents
Info
- Publication number
- JPS6158781B2 JPS6158781B2 JP53131992A JP13199278A JPS6158781B2 JP S6158781 B2 JPS6158781 B2 JP S6158781B2 JP 53131992 A JP53131992 A JP 53131992A JP 13199278 A JP13199278 A JP 13199278A JP S6158781 B2 JPS6158781 B2 JP S6158781B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- blood collection
- salt
- reagent
- collection tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004369 blood Anatomy 0.000 claims description 73
- 239000008280 blood Substances 0.000 claims description 73
- 239000003153 chemical reaction reagent Substances 0.000 claims description 33
- 230000034659 glycolysis Effects 0.000 claims description 26
- 150000004673 fluoride salts Chemical class 0.000 claims description 17
- 230000002401 inhibitory effect Effects 0.000 claims description 14
- 239000003146 anticoagulant agent Substances 0.000 claims description 13
- 229940127219 anticoagulant drug Drugs 0.000 claims description 13
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 10
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 claims description 5
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 44
- 235000013024 sodium fluoride Nutrition 0.000 description 22
- 239000011775 sodium fluoride Substances 0.000 description 22
- 229920000669 heparin Polymers 0.000 description 8
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 7
- 229960001008 heparin sodium Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 206010018910 Haemolysis Diseases 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- 230000008588 hemolysis Effects 0.000 description 6
- 238000011068 loading method Methods 0.000 description 6
- QLBHNVFOQLIYTH-UHFFFAOYSA-L dipotassium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O QLBHNVFOQLIYTH-UHFFFAOYSA-L 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 230000002429 anti-coagulating effect Effects 0.000 description 4
- 230000023555 blood coagulation Effects 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 238000004220 aggregation Methods 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- PQMFVUNERGGBPG-UHFFFAOYSA-N (6-bromopyridin-2-yl)hydrazine Chemical compound NNC1=CC=CC(Br)=N1 PQMFVUNERGGBPG-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- -1 EDTA salt Chemical class 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000011206 morphological examination Methods 0.000 description 1
- 230000017570 negative regulation of blood coagulation Effects 0.000 description 1
- 230000019261 negative regulation of glycolysis Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000004992 toluidines Chemical class 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13199278A JPS5558462A (en) | 1978-10-26 | 1978-10-26 | Blood-collecting pipe for obstructing glycolysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13199278A JPS5558462A (en) | 1978-10-26 | 1978-10-26 | Blood-collecting pipe for obstructing glycolysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5558462A JPS5558462A (en) | 1980-05-01 |
| JPS6158781B2 true JPS6158781B2 (fr) | 1986-12-13 |
Family
ID=15071015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13199278A Granted JPS5558462A (en) | 1978-10-26 | 1978-10-26 | Blood-collecting pipe for obstructing glycolysis |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5558462A (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK150403C (da) * | 1983-07-15 | 1987-07-13 | Radiometer As | Blodproevetagningsudstyr |
| CA2154117C (fr) * | 1994-08-09 | 1999-11-16 | Tatsuhiko Ikeda | Appareillage servant a inhiber la glycolyse dans les echantillons de sang |
| CN105286885A (zh) * | 2015-09-17 | 2016-02-03 | 安徽信灵检验医学科技有限公司 | 一种用于医学临床检验的采血管及其制备方法 |
| EP3427833A1 (fr) * | 2017-07-10 | 2019-01-16 | Victor Lind | Dispositif de préparation de test du sang pour déterminer la concentration de glucose dans le plasma sanguin |
-
1978
- 1978-10-26 JP JP13199278A patent/JPS5558462A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5558462A (en) | 1980-05-01 |
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