JPS6156201B2 - - Google Patents
Info
- Publication number
- JPS6156201B2 JPS6156201B2 JP17018883A JP17018883A JPS6156201B2 JP S6156201 B2 JPS6156201 B2 JP S6156201B2 JP 17018883 A JP17018883 A JP 17018883A JP 17018883 A JP17018883 A JP 17018883A JP S6156201 B2 JPS6156201 B2 JP S6156201B2
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- perfusion
- organ
- vein
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000010412 perfusion Effects 0.000 claims description 77
- 210000000056 organ Anatomy 0.000 claims description 68
- 239000007788 liquid Substances 0.000 claims description 46
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 30
- 210000004369 blood Anatomy 0.000 claims description 20
- 239000008280 blood Substances 0.000 claims description 20
- 210000003462 vein Anatomy 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 18
- 238000007710 freezing Methods 0.000 claims description 15
- 230000008014 freezing Effects 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 210000001367 artery Anatomy 0.000 claims description 13
- 239000002577 cryoprotective agent Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 9
- 210000003240 portal vein Anatomy 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 7
- 239000002504 physiological saline solution Substances 0.000 claims description 7
- 239000003130 blood coagulation factor inhibitor Substances 0.000 claims description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 4
- 230000023555 blood coagulation Effects 0.000 claims description 4
- 230000036760 body temperature Effects 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 229960002897 heparin Drugs 0.000 claims description 4
- 229920000669 heparin Polymers 0.000 claims description 4
- 230000008081 blood perfusion Effects 0.000 claims 3
- 239000011259 mixed solution Substances 0.000 claims 3
- 230000007613 environmental effect Effects 0.000 description 13
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 10
- 239000012530 fluid Substances 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 7
- 230000006378 damage Effects 0.000 description 5
- 238000002054 transplantation Methods 0.000 description 5
- 238000004321 preservation Methods 0.000 description 4
- 239000003507 refrigerant Substances 0.000 description 4
- 239000007798 antifreeze agent Substances 0.000 description 3
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000082 organ preservation Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17018883A JPS6061501A (ja) | 1983-09-14 | 1983-09-14 | 臓器の保存方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17018883A JPS6061501A (ja) | 1983-09-14 | 1983-09-14 | 臓器の保存方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6061501A JPS6061501A (ja) | 1985-04-09 |
| JPS6156201B2 true JPS6156201B2 (de) | 1986-12-01 |
Family
ID=15900310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17018883A Granted JPS6061501A (ja) | 1983-09-14 | 1983-09-14 | 臓器の保存方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6061501A (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63191822U (de) * | 1987-05-28 | 1988-12-09 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0688881B2 (ja) * | 1985-09-17 | 1994-11-09 | 久則 内田 | 移植器官の保存方法 |
| ATE197530T1 (de) * | 1993-05-07 | 2000-12-15 | Chugai Pharmaceutical Co Ltd | Organkonservierungsmittel |
| KR950030791A (ko) * | 1994-01-25 | 1995-12-18 | 아키요 시게마주 | 생물조직 보존방법 및 그를 위한 관류액 |
| US6364907B1 (en) | 1998-10-09 | 2002-04-02 | Qlt Inc. | Method to prevent xenograft transplant rejection |
| JP2013075888A (ja) * | 2011-09-15 | 2013-04-25 | Tokyo Metropolitan Univ | 臓器保存装置 |
| WO2014038473A1 (ja) * | 2012-09-08 | 2014-03-13 | 株式会社オーガンテクノロジーズ | 移植のための臓器又は組織の長期維持方法 |
-
1983
- 1983-09-14 JP JP17018883A patent/JPS6061501A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63191822U (de) * | 1987-05-28 | 1988-12-09 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6061501A (ja) | 1985-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1200507A (en) | Method of preserving organ and apparatus for preserving the same | |
| US4688387A (en) | Method for preservation and storage of viable biological materials at cryogenic temperatures | |
| US4471629A (en) | Method of freezing and transplant of kidneys and apparatus | |
| US4462215A (en) | Method of preserving organ and apparatus for preserving the same | |
| US9314015B2 (en) | Method and apparatus for prevention of thermo-mechanical fracturing in vitrified tissue using rapid cooling and warming by persufflation | |
| WO2000018226A3 (en) | Apparatus and method for maintaining and/or restoring viability of organs | |
| JP2004503473A (ja) | 高温凍結を使用した生物活性材料の低温保存 | |
| US5879876A (en) | Continuous-multi-step dilution process and apparatus, for the removal of cryoprotectants from cryopreserved tissues | |
| US7780712B2 (en) | Laparoscopic kidney cooling device | |
| JPS6156201B2 (de) | ||
| Ishine et al. | A histological analysis of liver injury in freezing storage | |
| Ishine et al. | Transplantation of mammalian livers following freezing: vascular damage and functional recovery | |
| JPS6156202B2 (de) | ||
| JP2632531B2 (ja) | 臓器の保存方法 | |
| JPS6061502A (ja) | 臓器保存処理のための潅流方法と潅流装置 | |
| JPS6155881B2 (de) | ||
| JP3239418B2 (ja) | 生体臓器保存再生方法およびその装置 | |
| Karow Jr et al. | Survival of dog kidneys subjected to high pressures: necrosis of kidneys after freezing | |
| Martin et al. | Experimental renal preservation | |
| Schimmel et al. | Freezing of whole rat and dog kidney by perfusion of liquid nitrogen through the renal artery | |
| JPS6155882B2 (de) | ||
| WO2023106036A1 (ja) | 臓器保存装置および臓器保存方法 | |
| Jacob | Studies in organ preservation by actual freezing and reduction of the freezing point | |
| Das et al. | In situ flushing of donor kidneys: its technique and rationale | |
| Calne et al. | Organ Preservation |