JPS61501571A - Ｎｍｒ造影剤 - Google Patents

Ｎｍｒ造影剤

Info

Publication number
JPS61501571A
JPS61501571A JP60502468A JP50246885A JPS61501571A JP S61501571 A JPS61501571 A JP S61501571A JP 60502468 A JP60502468 A JP 60502468A JP 50246885 A JP50246885 A JP 50246885A JP S61501571 A JPS61501571 A JP S61501571A
Authority
JP
Japan
Prior art keywords
dtpa
polysaccharide
complexing agent
hours
paramagnetic metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60502468A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0563453B2 (en, 2012
Inventor
サドラー，ピーター・ジヨン
ハーデイング，チヤールズ・トマス
Original Assignee
ゲルベ・ソシエテ・アノニム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ゲルベ・ソシエテ・アノニム filed Critical ゲルベ・ソシエテ・アノニム
Publication of JPS61501571A publication Critical patent/JPS61501571A/ja
Publication of JPH0563453B2 publication Critical patent/JPH0563453B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP60502468A 1984-05-31 1985-05-31 Ｎｍｒ造影剤 Granted JPS61501571A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848413849A GB8413849D0 (en) 1984-05-31 1984-05-31 Nmr contrast agents
GB8413849 1985-05-31

Publications (2)

Publication Number Publication Date
JPS61501571A true JPS61501571A (ja) 1986-07-31
JPH0563453B2 JPH0563453B2 (en, 2012) 1993-09-10

Family

ID=10561731

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60502468A Granted JPS61501571A (ja) 1984-05-31 1985-05-31 Ｎｍｒ造影剤

Country Status (5)

Country Link
EP (1) EP0183760B1 (en, 2012)
JP (1) JPS61501571A (en, 2012)
DE (1) DE3585668D1 (en, 2012)
GB (1) GB8413849D0 (en, 2012)
WO (1) WO1985005554A1 (en, 2012)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61155337A (ja) * 1984-11-01 1986-07-15 ニユエガ−ド・アンド・コンパニ−・アクシエ／セルカペト 診断剤

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
EP0330801A1 (en) * 1983-02-08 1989-09-06 Schering Aktiengesellschaft Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
EP0184899B1 (en) * 1984-11-01 1990-04-18 Nycomed As Paramagnetic contrast agents for use in "in vivo" diagnostic methods using nmr, and their preparation
US5746999A (en) * 1984-11-23 1998-05-05 Schering Aktiengesellschaft Magnetic particles for diagnostic purposes
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
GB8522535D0 (en) * 1985-09-11 1985-10-16 Amersham Int Plc Contrast agent
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
ATE90879T1 (de) * 1985-11-18 1993-07-15 Access Pharma Inc Polychelierende stoffe fuer abbildung- und spektralerhoehung (und spektrale verschiebung).
US5102652A (en) * 1986-07-03 1992-04-07 Advanced Magnetics Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US5342607A (en) * 1986-07-03 1994-08-30 Advanced Magnetics, Inc. Receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US5352432A (en) * 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5248492A (en) * 1986-07-03 1993-09-28 Advanced Magnetics, Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US5284646A (en) * 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
DE3709851A1 (de) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te Nmr-diagnostische fluessigkeitszusammensetzungen
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US4935518A (en) * 1987-05-08 1990-06-19 Salutar, Inc. Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
GB8813144D0 (en) * 1988-06-03 1988-07-06 Nycomed As Compositions
US5213788A (en) * 1988-09-29 1993-05-25 Ranney David F Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement
US5260050A (en) * 1988-09-29 1993-11-09 Ranney David F Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5494655A (en) * 1990-03-09 1996-02-27 The Regents Of The University Of California Methods for detecting blood perfusion variations by magnetic resonance imaging
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
IT1246380B (it) * 1990-04-12 1994-11-18 Bracco Spa Sali insolubili di lantanidi per la visualizzazione in risonanza magnetica nucleare del tratto gastro-intestinale
US5310539A (en) * 1991-04-15 1994-05-10 Board Of Regents, The University Of Texas System Melanin-based agents for image enhancement
JP2901787B2 (ja) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 核磁気共鳴造影剤
JP2894879B2 (ja) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 診断用造影剤
US5756688A (en) * 1992-10-14 1998-05-26 Sterling Winthrop Inc. MR imaging compositions and methods
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
JPH09500365A (ja) 1993-05-20 1997-01-14 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 磁気共鳴映像法に用いる巨大分子造影剤
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
FR2725618B1 (fr) 1994-10-17 1997-04-04 France Bloc Prothese femorale d'articulation du genou
NZ280272A (en) * 1994-10-21 1996-11-26 Nihon Mediphysics Co Ltd Diagnostic imaging agent comprising a metal ion and bifunctional ligand bonded to an amino- or dialdehyde- oligosaccharide
TW319763B (en, 2012) 1995-02-01 1997-11-11 Epix Medical Inc
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
JP3037298U (ja) * 1996-10-29 1997-05-16 亨 原 内部に洗浄粒を充填したたわし
NO20035745D0 (no) 2003-12-19 2003-12-19 Amersham Health As Prosess
CN101098854B (zh) 2004-07-23 2012-12-05 恩多塞特公司 二价连接体及其轭合物
WO2006124726A2 (en) 2005-05-12 2006-11-23 The General Hospital Corporation Novel biotinylated compositions
WO2008112873A2 (en) 2007-03-14 2008-09-18 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
JP5690589B2 (ja) 2007-06-25 2015-03-25 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 親水性スペーサーリンカーを含有する結合体
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
US9655977B2 (en) 2012-08-31 2017-05-23 The General Hospital Corporation Biotin complexes for treatment and diagnosis of alzheimer's disease
KR20150070318A (ko) 2012-10-16 2015-06-24 엔도사이트, 인코포레이티드 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61155337A (ja) * 1984-11-01 1986-07-15 ニユエガ−ド・アンド・コンパニ−・アクシエ／セルカペト 診断剤

Also Published As

Publication number Publication date
WO1985005554A1 (en) 1985-12-19
EP0183760B1 (en) 1992-03-18
EP0183760A1 (en) 1986-06-11
GB8413849D0 (en) 1984-07-04
JPH0563453B2 (en, 2012) 1993-09-10
DE3585668D1 (de) 1992-04-23

Similar Documents

Publication Publication Date Title
JPS61501571A (ja) Ｎｍｒ造影剤
US5250672A (en) Contrast agent for NMR imaging
US5208324A (en) Paramagnetic compounds
EP0430863B1 (de) Kaskadenpolymer-gebundene Komplexbildner, deren Komplexe und Konjugate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US4986980A (en) Water-soluble, carrier-bound paramagnetic metal containing diagnostic agents
US6048515A (en) Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
Vitha et al. Lanthanide (III) complexes of bis (phosphonate) monoamide analogues of DOTA: bone-seeking agents for imaging and therapy
Rebizak et al. Polymeric conjugates of Gd3+− diethylenetriaminepentaacetic acid and dextran. 1. Synthesis, characterization, and paramagnetic properties
JP2894879B2 (ja) 診断用造影剤
JP3683584B2 (ja) 樹枝状高分子の金属錯体、これを含有する診断剤、及びこれら錯体及び診断剤の製法
NO169525B (no) Diagnostisk preparat
DE3853415T2 (de) Makrocyclische Chelatisierungsmittel und daraus hergestellte Chelate.
Rebizak et al. Polymeric conjugates of Gd3+− diethylenetriaminepentaacetic acid and dextran. 2. Influence of spacer arm length and conjugate molecular mass on the paramagnetic properties and some biological parameters
JPH05504125A (ja) マルチサイト金属キレート化剤
CN102336838B (zh) 一种顺磁性金属配合物和合成方法及应用
RU2197495C2 (ru) Комплексы каскадных полимеров, содержащее их диагностическое контрастное средство и промежуточные соединения
Ndiaye et al. Comparison of MRI properties between multimeric DOTAGA and DO3A Gadolinium-Dendron conjugates
JP2901787B2 (ja) 核磁気共鳴造影剤
US5886169A (en) Iodinated polymers, processes for preparing them and their applications as contrast media
CN101642579A (zh) 壳聚糖修饰顺磁性金属离子磁共振成像对比剂的制备方法
Champagne et al. Synthesis and Unprecedented Complexation Properties of β-Cyclodextrin-Based Ligand for Lanthanide Ions
US5401491A (en) NMR contrast agents
CN104189924A (zh) 一种以碳基材料为支架的磁共振造影剂及其制备方法
US20210236661A1 (en) Cyclodextrin-linked polyvalent ligands for complexation of metal ions
JPH05504343A (ja) Ｍｒ―診断用の遷移金属錯体