JPS61500224A - 腫瘍性組織を放射線に対して増感する医薬組成物 - Google Patents
腫瘍性組織を放射線に対して増感する医薬組成物Info
- Publication number
- JPS61500224A JPS61500224A JP59504070A JP50407084A JPS61500224A JP S61500224 A JPS61500224 A JP S61500224A JP 59504070 A JP59504070 A JP 59504070A JP 50407084 A JP50407084 A JP 50407084A JP S61500224 A JPS61500224 A JP S61500224A
- Authority
- JP
- Japan
- Prior art keywords
- deoxycytidine
- chloro
- fluoro
- tetrahydrouridine
- deamination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 230000006824 pyrimidine synthesis Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54569383A | 1983-10-26 | 1983-10-26 | |
| US545693 | 1983-10-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61500224A true JPS61500224A (ja) | 1986-02-06 |
| JPH0586376B2 JPH0586376B2 (enExample) | 1993-12-10 |
Family
ID=24177186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59504070A Granted JPS61500224A (ja) | 1983-10-26 | 1984-10-26 | 腫瘍性組織を放射線に対して増感する医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0160079B1 (enExample) |
| JP (1) | JPS61500224A (enExample) |
| AU (1) | AU583801B2 (enExample) |
| DE (1) | DE3481172D1 (enExample) |
| WO (1) | WO1985001871A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4815447A (en) * | 1985-03-19 | 1989-03-28 | Mills Randell L | Mossbauer cancer therapy |
| WO1988009152A1 (en) | 1985-03-19 | 1988-12-01 | Mills Randell L | Apparatus providing diagnosis and selective tissue necrosis |
| US4815448A (en) * | 1985-03-19 | 1989-03-28 | Mills Randell L | Mossbauer cancer therapy |
| NZ330360A (en) * | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| EP0882734B1 (en) * | 1997-06-02 | 2009-08-26 | F. Hoffmann-La Roche Ag | 5'-Deoxy-cytidine derivatives |
| US6417168B1 (en) * | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
| US6933287B1 (en) | 1999-03-01 | 2005-08-23 | Sheldon B. Greer | Dramatic simplification of a method to treat neoplastic disease by radiation |
| AU3354500A (en) * | 1999-03-01 | 2000-09-21 | Halogenetics, Inc. | Dramatic simplification of a method to treat neoplastic disease by radiation |
| JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain Compounds, Compositions and Methods |
| US8609631B2 (en) | 2009-04-06 | 2013-12-17 | Eisai Inc. | Compositions and methods for treating cancer |
| EP2417146B1 (en) * | 2009-04-06 | 2016-07-13 | Otsuka Pharmaceutical Co., Ltd. | (2'-deoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3)diazepin-2-one derivatives for treating cancer |
| ES2628609T3 (es) | 2009-04-06 | 2017-08-03 | Otsuka Pharmaceutical Co., Ltd. | Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer |
| WO2010118010A1 (en) | 2009-04-06 | 2010-10-14 | Eisai Inc. | Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3870700A (en) * | 1973-05-29 | 1975-03-11 | Miles Lab | 2-halogeno-2-deoxy-5-(substituted)uridines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4017606A (en) * | 1973-10-04 | 1977-04-12 | The Upjohn Company | Organic compounds and process |
| CS184526B1 (en) * | 1976-02-19 | 1978-08-31 | Dieter Cech | 2'-halogen-2'-deoxy-5-fluoruridine,3',5-di-o-benzoyl-derivatives and process for preparing thereof |
| US4210638A (en) * | 1978-03-17 | 1980-07-01 | Pcr, Inc. | Antiviral composition and method of treating virus diseases |
-
1984
- 1984-10-26 DE DE8484904049T patent/DE3481172D1/de not_active Expired - Lifetime
- 1984-10-26 JP JP59504070A patent/JPS61500224A/ja active Granted
- 1984-10-26 AU AU36107/84A patent/AU583801B2/en not_active Ceased
- 1984-10-26 WO PCT/US1984/001735 patent/WO1985001871A1/en not_active Ceased
- 1984-10-26 EP EP84904049A patent/EP0160079B1/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3870700A (en) * | 1973-05-29 | 1975-03-11 | Miles Lab | 2-halogeno-2-deoxy-5-(substituted)uridines |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1985001871A1 (en) | 1985-05-09 |
| AU3610784A (en) | 1985-05-22 |
| EP0160079B1 (en) | 1990-01-31 |
| AU583801B2 (en) | 1989-05-11 |
| JPH0586376B2 (enExample) | 1993-12-10 |
| DE3481172D1 (de) | 1990-03-08 |
| EP0160079A4 (en) | 1986-05-14 |
| EP0160079A1 (en) | 1985-11-06 |
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