JPS6137784A - 免疫調整剤としての２‐ベンジル‐４‐（４‐ピリジル）チアゾール類及びその誘導体 - Google Patents

免疫調整剤としての２‐ベンジル‐４‐（４‐ピリジル）チアゾール類及びその誘導体

Info

Publication number
JPS6137784A
JPS6137784A JP16308885A JP16308885A JPS6137784A JP S6137784 A JPS6137784 A JP S6137784A JP 16308885 A JP16308885 A JP 16308885A JP 16308885 A JP16308885 A JP 16308885A JP S6137784 A JPS6137784 A JP S6137784A
Authority
JP
Japan
Prior art keywords
alkyl
halogen
independently
halo
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16308885A
Other languages
English (en)
Japanese (ja)
Inventor
デイヴイツド　エー．ブールトン
ヴアーノン　エル．ムーア
イホール　イー．コプカ
アルセニオ　エー．ペツソラーノ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS6137784A publication Critical patent/JPS6137784A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP16308885A 1984-07-25 1985-07-25 免疫調整剤としての２‐ベンジル‐４‐（４‐ピリジル）チアゾール類及びその誘導体 Pending JPS6137784A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/634,094 US4697012A (en) 1984-07-25 1984-07-25 Morpholino pyridyl thiazole compound
US634094 1984-07-25

Publications (1)

Publication Number Publication Date
JPS6137784A true JPS6137784A (ja) 1986-02-22

Family

ID=24542414

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16308885A Pending JPS6137784A (ja) 1984-07-25 1985-07-25 免疫調整剤としての２‐ベンジル‐４‐（４‐ピリジル）チアゾール類及びその誘導体

Country Status (12)

Country Link
US (1) US4697012A (US20100223739A1-20100909-C00005.png)
EP (1) EP0169502B1 (US20100223739A1-20100909-C00005.png)
JP (1) JPS6137784A (US20100223739A1-20100909-C00005.png)
KR (1) KR860001105A (US20100223739A1-20100909-C00005.png)
AU (1) AU575666B2 (US20100223739A1-20100909-C00005.png)
DE (1) DE3580317D1 (US20100223739A1-20100909-C00005.png)
DK (1) DK336685A (US20100223739A1-20100909-C00005.png)
ES (1) ES8700255A1 (US20100223739A1-20100909-C00005.png)
GR (1) GR851809B (US20100223739A1-20100909-C00005.png)
IL (1) IL75823A0 (US20100223739A1-20100909-C00005.png)
PT (1) PT80833B (US20100223739A1-20100909-C00005.png)
ZA (1) ZA855581B (US20100223739A1-20100909-C00005.png)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149884B1 (en) * 1983-09-09 1992-12-16 Takeda Chemical Industries, Ltd. 5-pyridyl-1,3-thiazole derivatives, their production and use
GB9201692D0 (en) * 1992-01-27 1992-03-11 Smithkline Beecham Intercredit Compounds
HUP9801057A3 (en) * 1995-05-26 2000-06-28 Bayer Ag Pyridyl-thiazoles and their use to protect plants against infections by micro-organisms
JP4662764B2 (ja) 2002-06-14 2011-03-30 メルク セローノ ソシエテ アノニム アゾールメチリデンシアニド誘導体およびそれらのタンパク質キナーゼモジュレーターとしての使用
SA04250288B1 (ar) * 2003-09-19 2008-07-19 سولفاي فارماسوتيكالز بي . في مشتقات ثيازول thiazole كمعدلات لمستقبل المكونات الكيميائية للقنب cannabinoid
US7294640B2 (en) 2004-02-06 2007-11-13 Merck & Co., Inc. Mitotic kinesin inhibitors
EP2616441B1 (en) * 2010-09-17 2019-08-07 Purdue Pharma L.P. Pyridine compounds and the uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1112128A (en) * 1965-12-22 1968-05-01 Bellon Labor Sa Roger New thiazolyl-diphenylmethane derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL28803A (en) * 1966-11-18 1974-05-16 Wyeth John & Brother Ltd Oxazole and thiazole compounds,their preparation and pharmaceutical compositions containing them
CA962269A (en) * 1971-05-05 1975-02-04 Robert E. Grahame (Jr.) Thiazoles, and their use as insecticides
US4153703A (en) * 1977-06-30 1979-05-08 Uniroyal, Inc. Method of controlling insects and acarids with certain aryl-substituted thiazoles
EP0149884B1 (en) * 1983-09-09 1992-12-16 Takeda Chemical Industries, Ltd. 5-pyridyl-1,3-thiazole derivatives, their production and use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1112128A (en) * 1965-12-22 1968-05-01 Bellon Labor Sa Roger New thiazolyl-diphenylmethane derivatives
FR1601733A (en) * 1965-12-22 1970-09-14 2-thiazolyl diphenylmethane derivs laxatives

Also Published As

Publication number Publication date
EP0169502B1 (en) 1990-10-31
DE3580317D1 (en) 1990-12-13
DK336685A (da) 1986-01-26
ZA855581B (en) 1986-03-26
IL75823A0 (en) 1985-11-29
EP0169502A3 (en) 1987-02-25
ES545439A0 (es) 1986-10-01
US4697012A (en) 1987-09-29
AU575666B2 (en) 1988-08-04
PT80833B (en) 1987-05-27
DK336685D0 (da) 1985-07-24
AU4532085A (en) 1986-01-30
KR860001105A (ko) 1986-02-22
ES8700255A1 (es) 1986-10-01
EP0169502A2 (en) 1986-01-29
GR851809B (US20100223739A1-20100909-C00005.png) 1985-11-26
PT80833A (en) 1985-08-01

Similar Documents

Publication Publication Date Title
US5073562A (en) Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US4175127A (en) Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
US4476137A (en) [1-(2-Benzoxazolyl)hydrazino]alkyl nitrile derivatives
HU203228B (en) Process for producing new thiazole derivatives and leukotriene-antagonist pharmaceutical compositions comprising same as active ingredient
US20040198768A1 (en) Method for inhibiting 5-lipoxygenase using a benzoxazole derivative or an analogue thereof
JPS61197554A (ja) 新規アニリド
KR20220004013A (ko) 벤조티오펜 화합물, 이의 제조 방법 및 용도
US4767766A (en) Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
JPS6137784A (ja) 免疫調整剤としての２‐ベンジル‐４‐（４‐ピリジル）チアゾール類及びその誘導体
US4746669A (en) Substituted thiazoles as immunoregulants
KR900006118B1 (ko) 4-퀴놀론 유도체의 제법
EP1142885A1 (en) Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives
US4689331A (en) Substituted 2-pyridinyl benzimidazoles, and their use for inhibiting gastric acid secretion
JPS61246183A (ja) 置換１，８‐ナフチリジノン類、それらの製造方法およびそれらを含む医薬組成物
JPS6350353B2 (US20100223739A1-20100909-C00005.png)
DE2950095A1 (de) Benzothiazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
JPS5944370A (ja) 融合環４ｈ−１，４−ベンゾチアジン、その製法及び医薬としての使用
EP0099122B1 (en) Compositions comprising pepstatin and an histamine h2-receptor antagonist having an enhanced antiulcer activity
US4725606A (en) 2-benzyl-4-(4-pyridyl)thiazoles and derivatives thereof as immunoregulants and compositions
JPH01186881A (ja) リポキシゲナーゼ阻害剤としてのアリール置換チオフエン−３−オール類、誘導体及び類縁体
JPH072737B2 (ja) ５−リポキシゲナ−ゼ経路の抑制
US4760086A (en) N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors
EP0177927A1 (en) 3-Hydroxybenzo[b]thiophene-2-sulfide derivatives as specific-5-lipoxygenase inhibitors
US5212198A (en) Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5192782A (en) Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof