JPS61201612A - カルシウム−リン系アパタイトの製法 - Google Patents
カルシウム−リン系アパタイトの製法Info
- Publication number
- JPS61201612A JPS61201612A JP3865585A JP3865585A JPS61201612A JP S61201612 A JPS61201612 A JP S61201612A JP 3865585 A JP3865585 A JP 3865585A JP 3865585 A JP3865585 A JP 3865585A JP S61201612 A JPS61201612 A JP S61201612A
- Authority
- JP
- Japan
- Prior art keywords
- water
- apatite
- solvent
- calcium
- phosphorus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052586 apatite Inorganic materials 0.000 title claims abstract description 42
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 title claims abstract description 42
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 239000002994 raw material Substances 0.000 claims abstract description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000002904 solvent Substances 0.000 claims abstract description 21
- 239000003960 organic solvent Substances 0.000 claims abstract description 20
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- 239000002253 acid Substances 0.000 claims abstract description 8
- 230000002378 acidificating effect Effects 0.000 claims abstract description 5
- 238000005507 spraying Methods 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims description 32
- 239000011575 calcium Substances 0.000 claims description 22
- 229910052698 phosphorus Inorganic materials 0.000 claims description 18
- 239000011574 phosphorus Substances 0.000 claims description 18
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 14
- 229910052791 calcium Inorganic materials 0.000 claims description 12
- 238000005979 thermal decomposition reaction Methods 0.000 claims description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 11
- ZQBZAOZWBKABNC-UHFFFAOYSA-N [P].[Ca] Chemical compound [P].[Ca] ZQBZAOZWBKABNC-UHFFFAOYSA-N 0.000 claims description 10
- 229910010272 inorganic material Inorganic materials 0.000 claims description 8
- 239000012046 mixed solvent Substances 0.000 claims description 7
- -1 phosphorus compound Chemical class 0.000 claims description 7
- 229940043430 calcium compound Drugs 0.000 claims description 5
- 150000001674 calcium compounds Chemical class 0.000 claims description 5
- 150000002484 inorganic compounds Chemical class 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 abstract description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract description 9
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract description 6
- 229910017604 nitric acid Inorganic materials 0.000 abstract description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract description 4
- 239000003463 adsorbent Substances 0.000 abstract description 4
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 abstract description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract description 2
- 239000001110 calcium chloride Substances 0.000 abstract description 2
- 229910001628 calcium chloride Inorganic materials 0.000 abstract description 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 2
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 abstract 1
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 abstract 1
- 235000011148 calcium chloride Nutrition 0.000 abstract 1
- 235000019837 monoammonium phosphate Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 description 48
- 239000000243 solution Substances 0.000 description 44
- 239000000203 mixture Substances 0.000 description 16
- 239000000047 product Substances 0.000 description 15
- 238000001308 synthesis method Methods 0.000 description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 8
- 239000000460 chlorine Substances 0.000 description 8
- 229910052801 chlorine Inorganic materials 0.000 description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
- 239000002244 precipitate Substances 0.000 description 8
- 238000005118 spray pyrolysis Methods 0.000 description 8
- 238000002441 X-ray diffraction Methods 0.000 description 7
- 239000012071 phase Substances 0.000 description 7
- 238000002485 combustion reaction Methods 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000000919 ceramic Substances 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000001704 evaporation Methods 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000002194 synthesizing effect Effects 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 3
- 229910052589 chlorapatite Inorganic materials 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 3
- 238000001027 hydrothermal synthesis Methods 0.000 description 3
- 239000006104 solid solution Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 229920001222 biopolymer Polymers 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000000197 pyrolysis Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 238000003746 solid phase reaction Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treating Waste Gases (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3865585A JPS61201612A (ja) | 1985-03-01 | 1985-03-01 | カルシウム−リン系アパタイトの製法 |
| US06/893,324 US4711769A (en) | 1984-12-18 | 1985-12-18 | Calcium-phosphorus-apatite having novel properties and process for preparing the same |
| EP86900255A EP0205622B1 (en) | 1984-12-18 | 1985-12-18 | Calcium-phosphorus type apatite having novel properties and process for its production |
| DE1986900255 DE205622T1 (de) | 1984-12-18 | 1985-12-18 | Apatit von kalzium-phosphor-typ mit neuen eigenschaften und herstellungsverfahren. |
| DE86900255T DE3587573T2 (de) | 1984-12-18 | 1985-12-18 | Apatit vom kalzium-phosphor-typ mit neuen eigenschaften und herstellungsverfahren. |
| PCT/JP1985/000693 WO1986003733A1 (en) | 1984-12-18 | 1985-12-18 | Calcium-phosphorus type apatite having novel properties and process for its production |
| US07/095,222 US4836994A (en) | 1984-12-18 | 1987-09-11 | Calcium-phosphorus-apatite having novel properties and process for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3865585A JPS61201612A (ja) | 1985-03-01 | 1985-03-01 | カルシウム−リン系アパタイトの製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61201612A true JPS61201612A (ja) | 1986-09-06 |
| JPH0415166B2 JPH0415166B2 (enrdf_load_stackoverflow) | 1992-03-17 |
Family
ID=12531269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3865585A Granted JPS61201612A (ja) | 1984-12-18 | 1985-03-01 | カルシウム−リン系アパタイトの製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61201612A (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62148529U (enrdf_load_stackoverflow) * | 1986-03-13 | 1987-09-19 | ||
| US5205928A (en) * | 1988-03-11 | 1993-04-27 | Kanto Kagaku Kabushiki Kaisha | Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite |
| JP2007529399A (ja) * | 2004-03-15 | 2007-10-25 | アイトゲネシッシェ テヒニッシェ ホーホシューレ チューリッヒ | 金属塩ナノ粒子、特にナノ粒子を有するカルシウムとホスフェートのフレーム合成 |
| JP2008050260A (ja) * | 1997-01-16 | 2008-03-06 | Orthovita Inc | 新規なミネラル類とその製造及び使用方法 |
| JP2011502667A (ja) * | 2007-11-12 | 2011-01-27 | エイチケーピービー サイエンティフィック リミテッド | リン酸カルシウムおよびリン酸カルシウム複合粒子を製造するための燃焼方法 |
| US8287915B2 (en) | 2004-02-03 | 2012-10-16 | Orthovita, Inc. | Bone restorative carrier mediums |
| US8303976B2 (en) | 1999-01-26 | 2012-11-06 | Orthovita, Inc. | Inorganic shaped bodies and methods for their production and use |
| US8303967B2 (en) | 2006-06-29 | 2012-11-06 | Orthovita, Inc. | Bioactive bone graft substitute |
| JP2014172794A (ja) * | 2013-03-11 | 2014-09-22 | Shalom:Kk | リン酸カルシウム系化合物 |
| US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
-
1985
- 1985-03-01 JP JP3865585A patent/JPS61201612A/ja active Granted
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62148529U (enrdf_load_stackoverflow) * | 1986-03-13 | 1987-09-19 | ||
| US5205928A (en) * | 1988-03-11 | 1993-04-27 | Kanto Kagaku Kabushiki Kaisha | Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite |
| JP2008050260A (ja) * | 1997-01-16 | 2008-03-06 | Orthovita Inc | 新規なミネラル類とその製造及び使用方法 |
| US8303976B2 (en) | 1999-01-26 | 2012-11-06 | Orthovita, Inc. | Inorganic shaped bodies and methods for their production and use |
| US8287915B2 (en) | 2004-02-03 | 2012-10-16 | Orthovita, Inc. | Bone restorative carrier mediums |
| JP2007529399A (ja) * | 2004-03-15 | 2007-10-25 | アイトゲネシッシェ テヒニッシェ ホーホシューレ チューリッヒ | 金属塩ナノ粒子、特にナノ粒子を有するカルシウムとホスフェートのフレーム合成 |
| US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
| US9789225B2 (en) | 2004-06-23 | 2017-10-17 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
| US10441683B2 (en) | 2004-06-23 | 2019-10-15 | Orthovita, Inc. | Method for restoring bone using shapeable bone graft substitute and instruments for delivery thereof |
| US8303967B2 (en) | 2006-06-29 | 2012-11-06 | Orthovita, Inc. | Bioactive bone graft substitute |
| JP2011502667A (ja) * | 2007-11-12 | 2011-01-27 | エイチケーピービー サイエンティフィック リミテッド | リン酸カルシウムおよびリン酸カルシウム複合粒子を製造するための燃焼方法 |
| JP2014172794A (ja) * | 2013-03-11 | 2014-09-22 | Shalom:Kk | リン酸カルシウム系化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0415166B2 (enrdf_load_stackoverflow) | 1992-03-17 |
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