JPS6119607B2 - - Google Patents
Info
- Publication number
- JPS6119607B2 JPS6119607B2 JP1084976A JP1084976A JPS6119607B2 JP S6119607 B2 JPS6119607 B2 JP S6119607B2 JP 1084976 A JP1084976 A JP 1084976A JP 1084976 A JP1084976 A JP 1084976A JP S6119607 B2 JPS6119607 B2 JP S6119607B2
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- mink
- oep
- protease
- toxoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000772415 Neovison vison Species 0.000 claims description 29
- 229960005486 vaccine Drugs 0.000 claims description 29
- 108091005804 Peptidases Proteins 0.000 claims description 22
- 239000004365 Protease Substances 0.000 claims description 22
- 108010067372 Pancreatic elastase Proteins 0.000 claims description 21
- 102000016387 Pancreatic elastase Human genes 0.000 claims description 21
- 208000015181 infectious disease Diseases 0.000 claims description 13
- 230000003449 preventive effect Effects 0.000 claims description 7
- 101710194807 Protective antigen Proteins 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 description 21
- 241001465754 Metazoa Species 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 9
- 206010035664 Pneumonia Diseases 0.000 description 8
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 8
- 230000002008 hemorrhagic effect Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 238000009395 breeding Methods 0.000 description 6
- 230000001488 breeding effect Effects 0.000 description 6
- 229940001442 combination vaccine Drugs 0.000 description 6
- 230000034994 death Effects 0.000 description 6
- 231100000517 death Toxicity 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 241000589516 Pseudomonas Species 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 229940124597 therapeutic agent Drugs 0.000 description 5
- 229960004279 formaldehyde Drugs 0.000 description 4
- 244000144972 livestock Species 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 235000011126 aluminium potassium sulphate Nutrition 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 101000980463 Treponema pallidum (strain Nichols) Chaperonin GroEL Proteins 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 201000007717 corneal ulcer Diseases 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 235000019256 formaldehyde Nutrition 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229940050271 potassium alum Drugs 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000272201 Columbiformes Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 108010022461 Pseudomonas aeruginosa pseudolysin Proteins 0.000 description 1
- 108010011176 Pseudomonas serine proteinase Proteins 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 206010038687 Respiratory distress Diseases 0.000 description 1
- 206010040893 Skin necrosis Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047924 Wheezing Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- UCWUTEPZFGIUIA-UHFFFAOYSA-N oxomethanesulfinic acid Chemical compound OS(=O)C=O UCWUTEPZFGIUIA-UHFFFAOYSA-N 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 231100000654 protein toxin Toxicity 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1084976A JPS5296730A (en) | 1976-02-05 | 1976-02-05 | Preventing and treating agent for mink pseudomonas phyocyaneum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1084976A JPS5296730A (en) | 1976-02-05 | 1976-02-05 | Preventing and treating agent for mink pseudomonas phyocyaneum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5296730A JPS5296730A (en) | 1977-08-13 |
| JPS6119607B2 true JPS6119607B2 (enrdf_load_stackoverflow) | 1986-05-17 |
Family
ID=11761788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1084976A Granted JPS5296730A (en) | 1976-02-05 | 1976-02-05 | Preventing and treating agent for mink pseudomonas phyocyaneum |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5296730A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105779358A (zh) * | 2016-04-19 | 2016-07-20 | 青岛农业大学 | 一种水貂绿脓杆菌sd17株及其应用 |
| CN108441457B (zh) * | 2018-06-20 | 2021-04-13 | 中国农业科学院特产研究所 | 一种水貂源d型绿脓杆菌及其应用、其灭活疫苗以及该灭活疫苗的制备方法 |
-
1976
- 1976-02-05 JP JP1084976A patent/JPS5296730A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5296730A (en) | 1977-08-13 |
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