JPS61193669A - Serum treatment apparatus - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to a processing device for serum and blood that can be systematized by connecting a batch type centrifugal separator and a transient membrane module. Such a system can efficiently remove pathogen-related substances and harmful substances such as immune complexes, immunoglobulin aggregates, and nucleic acids contained in the blood.

(Conventional technology and its problems) In recent years, an abnormal increase in high molecular weight substances in the blood has been associated with autoimmune diseases such as rheumatism, 8LE, myasthenia gravis, Gutpasschair syndrome, and idiopathic thrombocytopenic purpura. It has become clear that these high molecular weight substances are deeply involved in the onset and pathology of various diseases such as multiple myeloma, metabolic disorders such as macroglobulinemia, and hyperviscosity syndrome. Plasma separation methods have become widely practiced. The blood streak separation method first separates blood into plasma components and blood cell components, removes harmful high molecular weight substances from the separated plasma components, and separates the plasma components in the dish thus treated and the previously separated blood cells. It is a method of returning the ingredients to corporal punishment.

Conventional methods for separating blood into plasma components and blood cell components include a membrane separation method using a transient membrane module and a centrifugation method using a centrifugal separator. The plasma separation method using the membrane separation method described above is as follows: (1) After separating blood into plasma components and blood cell components through a membrane, the plasma components containing harmful substances are removed, and new plasma in an amount equivalent to the plasma components is added to the blood cells. A method of mixing with ingredients and returning it to the body.

(2) After separating blood into plasma components and blood cell components through a plasma separation membrane, the plasma components containing harmful substances are brought into contact with an adsorbent to adsorb and remove the harmful substances, and then the plasma components are recombined with blood cell components. Method of mixing and returning to the body (3) After separating blood into plasma components and blood cell components through a plasma separation membrane, the plasma components are roughly separated into low molecular weight substances including fulbumin and high molecular weight substances using a plasma processing membrane. A method of separating purified blood a from which high molecular weight substances including harmful substances have been removed is mixed with blood cell components and returned to the body (Japanese Patent Laid-Open No. 56-7416
(No. 4, No. 56-145860, etc.) (4) After separating blood into plasma components and blood cell components through a plasma separation membrane, the plasma components are cooled to gel high molecular weight substances containing harmful substances, A method is known in which this gel is removed with a temporary membrane, and only the low molecular weight substances that have passed through the membrane are mixed with blood cell components and returned to the body (Japanese Patent Application Laid-open No. 31869/1983).

On the other hand, the plasma processing method using centrifugation is as follows: (1) After separating blood into blood cell components and plasma components using a centrifugal separator, the plasma components containing harmful substances are removed, and new plasma in an amount equivalent to the blood cell components is added to the blood cells. Method of mixing blood with other components and returning it to the body (2) After separating blood into plasma components and blood cell components using a centrifugal separator, the plasma components are separated into high molecular weight substances and low molecular weight substances using a filtration error module. A method in which purified plasma from which only molecular weight substances have been removed is returned to the body together with blood cell components (
JP-A-57-64058 and JP-A-59-8967) are known.

Among the plasma processing methods mentioned above, plasmapheresis therapy, in which separated plasma is exchanged with new plasma, has problems in securing plasma from healthy people who are transfused to treat breathing problems. Because of side effects such as infection by pathogens and serum sickness, it is considered desirable to purify one's own plasma before transfusion. Among them, the method of separating blood into blood cell components and plasma components using a centrifugal separator and then processing the separated plasma components using a transient membrane module is a safe method because there is no need to worry about a drop in separation efficiency or hemolysis. This is an excellent method. However, at present, there are almost no plasma processing methods in which plasma is processed using a combination of a centrifugal separator and a filtration membrane module. The reason for this is that the conventional centrifugal separator and filtration membrane module are connected through a dedicated closed circuit, and the control system of the centrifugal separator controls the pumps etc. connected to the filtration membrane module. This is thought to be because it was difficult to connect the separator to the existing centrifugal separator, as it required modifying the control circuit of the centrifugal separator when connecting the separation device and the filtration membrane module.

(Means for Solving the Problems) Therefore, an object of the present invention is to separate the control system of the plasma processing device from the control system of the centrifugal separator and perform it separately, and to systemize it by continuously connecting it with the centrifugal separator. The object of the present invention is to provide a plasma processing device that can perform the following steps.

The present invention continuously connects a batch-type centrifugal separator provided in an extracorporeal circulation circuit, and filters plasma components separated by the centrifugal separator into a filtration membrane module for high-molecular weight substances and low-molecular weight substances including albumin. In a plasma processing device that returns purified plasma from which high molecular weight substances have been removed into the body, a plasma supply circuit is provided that connects a centrifugal separator and a filtration and membrane module in the extracorporeal circulation circuit. A plasma storage bag with an inlet opening into the upper space is provided, and a means for sensing the liquid level in the plasma storage bag is provided, and the liquid level is controlled within a set range by interlocking control with the liquid level sensing means. A plasma supply pump is provided that can adjust the flow rate so that the flow rate is within the filtration membrane module, and a circuit is provided for returning purified plasma containing albumin from which high molecular weight substances have been removed by the filtration membrane module to the body, and a purified plasma storage tank is provided in the circuit. At the same time, a purified plasma delivery pump is provided, which is set so that the flow ratio between the amount of plasma introduced into the filtration membrane module and the amount of purified plasma output from the filtration membrane module becomes a predetermined value by interlocking control with the plasma supply pump; A concentrated plasma discharge pump set so that the discharge amount of high molecular weight substances is a predetermined value is installed in the concentrated plasma discharge circuit, and a fluid replacement pump is installed upstream of the purified plasma discharge pump installed in the circuit that returns purified plasma to the body. This plasma processing apparatus is characterized in that a circuit is connected to the purified plasma return circuit, and a circuit for bypassing the purified plasma delivery pump is provided in the filtration membrane module.

The plasma processing device of the present invention is used in a system in which it is continuously connected to a centrifugal separator, and the plasma components separated by the centrifugal separator are separated into high molecular weight substances and low molecular weight substances including albumin using a filtration membrane module. The present invention relates to a plasma processing device that separates purified plasma from which high molecular weight substances have been removed and returns it to the body.

A batch type centrifugal separator connected to the plasma processing apparatus of the present invention supplies blood into a centrifugal bowl from one side, continuously extracts only plasma components from the bowl from the other, and accumulates blood cell components in the bowl. , a device [1 (Haemoneti
cS V-50 type device and PEX type device, etc.).

As a filtration membrane module for separating plasma in a plasma processing apparatus, a module having a built-in flat membrane or hollow fiber membrane can be used. In particular, it is preferable to use a module containing a hollow fiber membrane from the viewpoint of ease of production and miniaturization. The transient membrane used in the above-mentioned membrane module selectively separates plasma components into high molecular weight substances and low molecular weight substances,
The molecular weight cutoff can be set arbitrarily depending on the purpose.

For example, in the case of autoimmune diseases, which are one of the main target diseases for treatment using the device of the present invention, the molecular weight cutoff can be set at 1-100,000. This is because the pathogenic substances of autoimmune diseases often exist in a form bound to r-globulin, which has a molecular weight of about 160,000, so substances with a larger molecular weight are removed, and substances with a lower molecular weight and which are harmful to the living body are removed. Useful molecules 1lk67oo.

It is desirable to reflux albumin, etc. Therefore, if the molecular weight cutoff is 100,000, the above-mentioned r-globulin and albumin can be sharply fractionated. The molecular weight cutoff of the filtration membrane should be set depending on the molecular weight of the target pathogenic substance. set between As such a filtration membrane, any membrane may be used as long as it can fractionate and separate plasma components under pressure, and in this sense, filtration membranes with ultrafiltration properties can be widely used. Therefore, the structure of the membrane is not particularly limited, and a homogeneous microporous membrane or an asymmetric membrane can be used. Materials for such membranes include polyvinyl alcohol (PVA), ethylene-vinyl alcohol (EV) copolymers, cellulose derivatives such as cellulose acetate, polyolefins, polyacrylonitrile, polyamides, and polyesters. Polysulfone or the like is used. Among these, P which has excellent biocompatibility
It is desirable to use VA type, ETA type, cellulose derivatives, polysulfone, etc.

, FIG. 1 is a system diagram of a system that combines a patch type centrifugal separator and the plasma processing apparatus of the present invention.

Sterile air flows into and out of the bowl during the blood collection and blood return process in a patch-type centrifugal separator. In other words, the sterile air initially filled in the centrifuge bowl is expelled by the blood introduced into the bowl during blood collection, but when blood is returned, the sterile air causes the blood cell components accumulated in the bowl to flow into the bowl. They are now being kicked out. Therefore, the volume must be distributed so that plasma components containing high molecular weight substances do not mix with the sterile air flowing into the bowl during the blood return process. In addition, patch-type centrifugal separators allow for blood collection and blood return (
(or plasma return) T - In addition to the 2A5 method performed using a separate needle, 1 mix purified plasma and blood cell components and return the blood from the blood introduction port.
There is an arm method. FIG. 1 shows an example of a system using the 27-me method in which the plasma processing device 60 of the present invention is combined with a patch-type centrifugal separator 50.The configuration will be explained according to the flow of blood. First, blood is introduced into the bowl 3 of the centrifugal separator 50 by a pump such as a roller pump as necessary from the blood introduction part 1 (a part that can be connected to a normal blood collection device or blood storage device such as a shunt or a syringe needle) through the blood introduction circuit 10. Then, the sterile air filled in the centrifugal bowl is expelled by the blood supplied under pressure by the pump 2, and first the sterile air and then the separated plasma components are transferred from the plasma inlet 80 to the plasma supply circuit 16.
The plasma is then transported to the plasma storage bag 4 through the following steps. On the other hand, the separated blood cell components are accumulated as they are in the centrifuge bowl.

The blood cell detector 43 detects that the blood cell components accumulated in the centrifugal bowl overflow from the centrifugal bowl and flow into the plasma supply circuit.
When detected, the device is stopped and the blood collection process is completed, followed by the blood return process. At the time of blood collection, the separated plasma is processed by the plasma processing device of the present invention. That is, the plasma components separated by the centrifugal separator 50 are transferred from the plasma inlet 80 to the plasma supply circuit 16 using the gee pump 14 built into the centrifugal separator.
and stored in the plasma storage bag 4 provided in the circuit. The plasma storage bag 4 is provided with means 21 for sensing the liquid level in the bag.

When more than a certain amount of plasma accumulates in the plasma storage bag, a plasma supply pump 5 such as a roller pump, which is controlled in conjunction with the liquid level sensing means, operates to take out the plasma from the bag and transfer it to the filtration membrane module 6. send. The plasma supply circuit 16 is provided with a drip chamber 22 to which a pressure gauge 23 is connected, and monitors abnormal pressure caused by clogging of the filtration membrane module 6 or other factors. The plasma sent to the filtration membrane module 6 is separated into high molecular weight substances and low molecular weight substances including fulbumin in this module. The purified plasma consisting of low molecular weight substances separated by the filtration membrane module 6 is sent to a purified plasma storage tank 8 provided in a purified plasma return circuit 17 by an adulterated plasma delivery pump 7 which is controlled in conjunction with the plasma supply pump 5. The purified plasma drawn from the purified plasma storage tank 8 is infused into the patient's body from a purified plasma outlet (a portion that can be connected to a shunt, an infusion set, etc.) provided in the purified plasma return circuit 17. On the other hand, the concentrated plasma containing high molecular weight substances separated by the filtration membrane module 6 is discharged to the drain tank 28 by the concentrated plasma discharge pump 26 provided in the concentrated plasma discharge circuit 27.

The flow rate of this pump 26 is normally set to 115 to 1/10 of the flow rate of the plasma supply pump 5. Further, the pump 26 may be controlled in conjunction with the plasma supply pump 5 so that the flow rate ratio between the plasma volume supplied to the filtration module and the concentrated plasma volume derived from the module is always a predetermined value. In this case, when the flow rate of the plasma supply pump 5 is set to 300 c/min, the flow rate of the concentrated plasma discharge pump is
A~1/10 or less, i.e. 6 CC/min~3
It is automatically adjusted to below CC/min. Further, the purified plasma delivery pump 7 adjusts the flow rate ratio between the amount of plasma delivered to the filtration membrane module 6 and the amount of purified plasma sent out from the filtration membrane module to a predetermined value by interlocking control with the plasma supply pump 5. It is something that For example, if the flow rate f of the plasma supply pump 5 is set to 30 cc/min, the purified plasma delivery pump will be controlled to 24 to 30 cc/min. When the entire amount of plasma is filtered by the membrane module, the flow rates of the plasma supply pump and the purified plasma delivery pump are set to be equal. The concentrated plasma evacuation pump is then stopped.

In the blood return process, the roller pump 2 that introduces blood into the centrifugal bowl is rotated in the opposite direction. Then, the blood cell components accumulated in the bowl are sucked into the blood introduction circuit 10 and returned to the blood introduction section 1 and into the body through the circuit. This blood return operation is performed using a centrifugal separator. When the blood cell components in the bowl are taken out, the inside of the bowl becomes negative pressure, so the sterilized air accumulated in the upper part of the plasma storage bag 4 is sucked into the bowl from the plasma supply circuit 16. When the blood cells in the bowl are sucked in, the blood cell components in the bowl flow out and are completely replaced with sterile air, and this sterile air is further sucked by the roller pump 2 and flows out into the blood introduction circuit 10. The air bubble detector 42 installed in the pump is activated to stop the pump 2, and the blood return process is also completed. The above two steps of blood collection and blood return are considered as one cycle, and this is repeated as many times as necessary. In a batch-type centrifugal separator, when the sterile air in the plasma storage bag is sucked into the centrifuge bowl during the blood return process, it is necessary to prevent plasma components from flowing into the bowl together with the sterile air. In the present invention, the plasma inlet to the plasma storage bag 4 is designed to prevent plasma components from flowing into the bowl. That is, the inlet for plasma into the plasma storage bag 4 is opened at a position higher than the liquid level of the plasma collected in the plasma storage bag, in other words, the opening for the upper space of the bag, and the outlet for plasma is opened at the bottom of the bag. Examples of the plasma introduction port to the plasma storage bag include one where the plasma introduction port opens from above the bag into the upper space of the bag, one where the introduction port of a pipe inserted from below the bag opens into the upper space of the bag, Alternatively, a bag having an independent plasma inlet channel within the bag can be used. A commercially available blood bag can be used as this bag by modifying the blood introduction part to have a plasma introduction port.

A circuit 13t for replenishing purified plasma with a replacement fluid such as flutumin or hydroxyethyl starch (ELE8) from the replacement fluid bag 12 to supplement the concentrated plasma removed by the filtration membrane module 6 - upstream of the purified plasma delivery pump of the purified plasma return circuit 17 May be connected to the side.

In this case, the flow rate tp of the purified plasma delivery pump 7 is adjusted so that the amount of plasma supplied to the membrane module 6 and the amount of purified plasma, which is obtained by adding replacement fluid to the purified plasma sent from the membrane module, are equal. When set, a replacement fluid equivalent to the amount of concentrated plasma discharged by the concentrated plasma discharge pump 26 will be injected into the purified plasma storage tank 8. When a fluid replacement circuit is provided, it is preferable to provide a bypass circuit 24 that bypasses the purified plasma delivery pump. In this bypass circuit, due to clogging of the filtration membrane module 60, trouble occurred to the extent that the membrane module had to be replaced, and all pumps of the plasma processing device were stopped.When the valve 25 was opened, the replacement fluid was transferred to the purified plasma storage tank 8. It is intended to be transported by bypass. When the trouble is resolved, the valve 25 can be closed and normal operation can be resumed. Therefore, even when the device is stopped, continuous infusion to the patient can be performed without interruption, resulting in higher safety.

It is preferable that the means 21 for detecting the liquid level in the plasma storage bag 4 constantly monitor the liquid level because the setting of the liquid level can be easily changed. As the liquid level detection means, a method using a pressure sensor that detects the liquid level using pressure, a method that detects the liquid level using weight, a method that directly detects the liquid level using ultrasonic waves, etc. can be used. can.

FIG. 4 shows an example in which a pressure sensor is used as the liquid level sensing means 21, and a pressure detection hole 30 provided at the bottom of the plasma storage bag 4 has a tube 31 with an inner diameter of 1 mm or less, usually 0.8 mm.
is connected, and a pressure sensor 21 is attached to the end thereof. A diaphragm type pressure transducer is usually used as this pressure sensor. When plasma is supplied into the plasma storage bag and the liquid level changes, head pressure is applied to the air sealed in the thin tube, and this air pressure causes displacement of the diaphragm. This minute displacement of the diaphragm is detected by a metal wire strain gauge, a semiconductor strain gauge, etc., and the detection signal is transmitted to a control device 32 that controls the drive of each pump. The signal transmitted from the pressure sensor is amplified by an amplification circuit 33 and sent to a comparison circuit 34. The comparator circuit compares the liquid level with the liquid level set by the setting circuit 35, and the signal is sent to the drive circuit 36 to control the rotation of the pump 5.7.26. This liquid level detection means 21 senses the amount of plasma stored in the plasma storage bag 4, and the number of rotations of the plasma supply pump 5 is automatically changed or the switch is automatically turned ON by interlocking control with this detection means. - By turning it off, the liquid level in the plasma storage bag can be controlled to be within the set range. For example, if the liquid level falls below a set level, the rotation speed of the plasma supply pump 5 may be slowed down or temporarily stopped. In the case of a system based on the two-arm method, it is preferable that the purified plasma storage tank 8 is also provided with a liquid level detecting means 21t, and furthermore, a valve 82f that is controlled in conjunction with the liquid level detecting means 21 is provided in the purified plasma return circuit 17. This valve operates to open the circuit 17 when the liquid level in the purified plasma storage tank falls below a predetermined level and the circuit 17fc close level returns. Therefore, it is possible to prevent an accident in which air is returned to the body due to liquid shortage in the storage tank.

The means for controlling the flow rate of each pump 5.7.26 described above may be a method of electrically controlling the rotation speed of the pump. Alternatively, a two-barreled or double-barreled Geela pump may be used. In this case, the flow rate of liquid flowing through each circuit can be adjusted by changing the diameter of each tube. As the plasma storage bag 4, a flexible bag having a capacity of 50 to 3000 cC, such as a blood bag, can be used. Further, as the purified plasma storage tank 8, a flexible bag with a capacity of 200 to 50 cC is usually used, but when the purified plasma is returned to the body by the purified plasma delivery pump 7, a container with a capacity of 10 to 50 cC can be used. As this container, a drip chamber used in dialysis etc. may be used.In addition to the above device, a plasma warmer for warming the cooled plasma during extracorporeal circulation and a pre-filter for removing formed components in the plasma may be used. - It may be provided on the upstream side of the p-filter membrane module.

Further, as shown in FIG. 2, when the purified plasma outlet 81 of the purified plasma return circuit 17 and the blood inlet 1 of the blood introduction circuit 10 are connected to the one-shaped connector 45 connected to a shunt or the like, blood cells and purified plasma are transferred to the Y-shaped connector. It can be used as an L-arm device that mixes the mixture and returns it to the body. In this case, it is necessary to provide a switching valve 46 in the circuit connecting the purified plasma outlet 81 of the purified plasma return circuit 17 and the one-shaped connector 45 so that the purified plasma is not introduced into the centrifugal separator together with the blood during blood collection. This switching valve 46 is driven by a solenoid, a motor, air pressure, etc., and can be automatically controlled in conjunction with the blood cell detector 43 and air bubble detector 42 so that it is closed during the blood collection process and opened during the blood return process. can. If this switching valve 46 is further controlled in conjunction with the liquid level detection means 21 provided in the purified plasma storage tank 8, it is possible to prevent an accident of air intrusion into the body due to liquid shortage in the storage tank. The switching valve 46 is preferably a pinch valve that directly clamps or opens the circuit to avoid direct blood contact with the valve passage.

Figure 3 shows blood cells mixed with purified plasma and returned to the body 2
This is another example of the arm method, in which a blood introduction circuit 10 and a purified plasma storage tank 8 are connected by a blood cell supply circuit 44. The blood cell supply circuit and the blood supply circuit can be appropriately switched by a flow path switching means. In FIG. 4, two switching valves 40 and 41 provided in each circuit are used to switch the flow paths.

Said purified plasma storage tank 8 (blood cell storage tank in a batch type centrifugal separator) circuit 10.20.44 and switching valve 40.41
is attached to a batch-type two-arm centrifugal separator 50. Therefore, by connecting the purified plasma return circuit 17 to the blood cell storage tank attached to the centrifugal separator, this blood cell storage tank can be used as a purified plasma storage tank. This device operates as follows. First, in the blood collection process, the switching valve 41 is closed and the switching valve 40 is opened, and the blood is introduced into the centrifugal separator to separate blood cell components and plasma components, and the sterile air expelled from the bowl enters the plasma storage bag. While being stocked, the separated plasma components are processed by the filtration membrane module, and the plasma from which high molecular weight substances have been removed is transported to the purified plasma storage tank 8. This purified plasma is then continuously returned to the body from the purified plasma storage tank. When blood cell components flow into the plasma supply circuit 16 and are detected by the blood cell detector 43, the blood collection step is completed and the next step of mixing purified plasma and blood cells is started. In the mixing process, the switching valve 40 is closed, and the switching valve 4
1 is opened, the pump 2 is reversed, and the blood cell components in the centrifugal bowl are sent from the blood cell supply circuit 44 to the purified plasma storage tank 8, where the blood cell components and purified plasma are mixed. The blood cell components in the bowl are replaced with sterilized air, and when this sterile air flows out of the bowl and is detected by the air bubble detector 42, the mixing process ends and the process returns to the blood sampling process described above. The purified blood mixed with blood cell components and purified plasma in the purified plasma storage tank 8 is returned to the patient at the same time as the next blood collection process. The purified blood return circuit 20 is controlled in conjunction with liquid level detection means installed in the purified plasma storage tank.
A switching valve may be provided to prevent air from entering the body due to liquid shortage in the storage tank.

Note that in FIG. 3, the same parts as in FIG. 1 are given the same numbers and their explanations will be omitted.

FIG. 5 is a perspective view of a part of the monitor constituting the plasma processing apparatus of the present invention, and plasma is supplied to a double pump 68 (used as pumps 5 and 7) provided in the front of the part of the monitor. A circuit 16 and a purified plasma delivery circuit 17 are attached. Further, a pipe 31 that leads the head pressure of the plasma storage bag 4 to a pressure sensor is connected to the connector 61, and a pipe that leads the pressure inside the drip chamber 22 provided in the plasma supply circuit to a pressure gauge is connected to the connector 62. 63 is a digital liquid level gauge that displays the liquid level of the plasma storage bag, and displays the head pressure (liquid level) in a t-bar graph. 7 is a switch for setting the plasma level, and the plasma level can be set arbitrarily by this switch. 6
4 is a pressure gauge that displays the pressure on the inlet side of the filtration membrane module. Reference numeral 71 is a knob for setting the flow rate of the plasma supply pump 5. The instantaneous flow rate of this pump is digitally displayed on a flow meter 67. The total amount of plasma supplied to the membrane module by the pump is displayed on the totalizer 70. 72 is a main switch. 73 is a changeover switch between automatic operation and manual operation. During automatic operation, when the plasma level in the plasma storage bag is above the set value, the lamp 74 lights up and the pump rotates. When the plasma level falls below the set value, the lamp goes out and the pump stops. 75 is an integration reset button. The monitor is provided with a lamp that indicates an abnormality when it occurs. 65 is a pressure alarm lamp that lights up when the pressure on the inlet side of the filtration membrane module exceeds the upper and lower limit alarm settings, 66 is a lamp that lights up when the cover of pump 68 is opened, and 67 is a pressure alarm lamp that lights up when the pressure on the inlet side of the filtration membrane module exceeds the upper and lower limit alarm settings. This lamp lights up when plasma is accumulated in the cell.

The control system of the plasma processing apparatus of the present invention is all housed in a part of the monitor. Therefore, when the apparatus of the present invention and the centrifugal separator are connected in series to form a system, the control of the centrifugal separator and the apparatus of the present invention can be performed completely separately.

(Effects) As described above, the device of the present invention is equipped with a plasma storage bag and a purified plasma storage tank, and by interlocking and controlling the liquid level detection means of the plasma storage bag, the plasma supply pump, and the purified plasma delivery pump, it can be used with existing equipment. A blood processing system can be provided that is connected in series with a continuous centrifugal separator. This system allows for efficient and safe removal of harmful substances from the blood without damage or loss of red blood cells or platelets or loss of serum proteins.

[Brief explanation of drawings]

The drawing shows one embodiment of the plasma processing apparatus of the present invention, and shows the first embodiment of the plasma processing apparatus of the present invention.
3 and 3 are system diagrams of a 27-arm method system that combines a batch-type centrifugal separator and the plasma processing device of the present invention, and FIG. 2 is a system diagram of a 1-arm method system. . FIG. 4 is an electric circuit diagram of the liquid level detection means of the plasma storage bag, and FIG. 5 is a perspective view of the plasma processing apparatus of the present invention. 1...Blood inlet 3...Centrifugal bowl 4
... Plasma storage bag 5 ... Plasma supply pump 6 ... Filtration membrane module 7 ... Purified plasma delivery pump 8 ... Purified plasma storage tank 50 ... Centrifugal separator 60 ... Plasma processing Device

Claims (1)

[Scope of Claims] 1. Continuously connected to a batch type centrifugal separator provided in an extracorporeal circulation circuit, plasma components separated by the centrifugal separator are passed through a filtration membrane module containing high molecular weight substances and albumin. In a plasma processing device that returns purified plasma from which low molecular weight substances have been separated and high molecular weight substances have been removed to the body, a plasma supply circuit is provided that connects a centrifugal separator and a filtration membrane module in the extracorporeal circulation circuit, A plasma storage bag having a plasma inlet opening into the upper space is provided in the circuit, and a means for sensing a liquid level in the bag is provided, and the liquid level is set by interlocking control with the liquid level sensing means. A plasma supply pump capable of adjusting the flow rate within the range is provided, and a circuit is provided for returning purified plasma containing albumin from which high molecular weight substances have been removed by the filtration membrane module to the body, and a purified plasma storage tank is provided in the circuit. In addition, a purified plasma delivery pump is provided, which is set so that the flow rate ratio between the amount of plasma introduced into the filtration membrane module and the amount of purified plasma taken out is a predetermined value by interlocking control with the plasma supply pump. The concentrated plasma discharge circuit is equipped with a concentrated plasma discharge pump that is set so that the discharge amount of high molecular weight substances is a predetermined value, and the purified plasma discharge pump is installed in the circuit that returns purified plasma to the body. 1. A plasma processing apparatus, characterized in that the purified plasma return circuit is provided with a circuit that bypasses the purified plasma delivery pump. 2. The purified plasma storage tank is provided with a means for sensing the liquid level in the storage tank, and by interlocking control with this liquid level sensing means, a switching valve that closes when the liquid level falls below a set value is installed in the purified plasma storage tank. A plasma processing device according to claim 1, which is provided in a purified plasma return circuit on the downstream side of the plasma processing device. 3. Connecting the purified plasma storage tank and the circuit for introducing blood into the centrifugal separator through a blood cell supply circuit, and closing the blood cell supply circuit between the blood introduction circuit and the blood cell supply circuit when blood is collected;
The plasma processing device according to claim 1, further comprising a switching valve for closing the blood introduction circuit during mixing and blood return. 4. Claim No. 4, characterized in that the purified plasma return circuit and the circuit for introducing blood into the centrifugal separator are connected to a Y-shaped connector, and the purified plasma return circuit is provided with a switching valve that closes when blood is collected. The plasma processing device according to item 1.