JPS6090880A - リン酸カルシウム多孔体およびその製造方法 - Google Patents
リン酸カルシウム多孔体およびその製造方法Info
- Publication number
- JPS6090880A JPS6090880A JP58198214A JP19821483A JPS6090880A JP S6090880 A JPS6090880 A JP S6090880A JP 58198214 A JP58198214 A JP 58198214A JP 19821483 A JP19821483 A JP 19821483A JP S6090880 A JPS6090880 A JP S6090880A
- Authority
- JP
- Japan
- Prior art keywords
- porous body
- calcium
- crystals
- needle
- calcium phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000001506 calcium phosphate Substances 0.000 title claims description 45
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims description 44
- 235000011010 calcium phosphates Nutrition 0.000 title claims description 44
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims description 7
- 239000013078 crystal Substances 0.000 claims description 52
- -1 calcium phosphate compound Chemical class 0.000 claims description 41
- 239000011148 porous material Substances 0.000 claims description 39
- 239000000843 powder Substances 0.000 claims description 29
- 239000002002 slurry Substances 0.000 claims description 24
- 239000002994 raw material Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 229940043430 calcium compound Drugs 0.000 claims description 10
- 150000001674 calcium compounds Chemical class 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- 238000005245 sintering Methods 0.000 claims description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 8
- 239000011575 calcium Substances 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 7
- 229910052698 phosphorus Inorganic materials 0.000 claims description 7
- 239000011574 phosphorus Substances 0.000 claims description 7
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 5
- 239000000920 calcium hydroxide Substances 0.000 claims description 5
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 5
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 4
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims description 2
- 229910001634 calcium fluoride Inorganic materials 0.000 claims description 2
- 239000000292 calcium oxide Substances 0.000 claims description 2
- 235000012255 calcium oxide Nutrition 0.000 claims description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 9
- 102000008186 Collagen Human genes 0.000 description 6
- 108010035532 Collagen Proteins 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 210000002449 bone cell Anatomy 0.000 description 6
- 229920001436 collagen Polymers 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000007547 defect Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000001172 regenerating effect Effects 0.000 description 4
- 239000003463 adsorbent Substances 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000006104 solid solution Substances 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000010478 bone regeneration Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 241000190020 Zelkova serrata Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012776 electronic material Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000001599 osteoclastic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Porous Artificial Stone Or Porous Ceramic Products (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58198214A JPS6090880A (ja) | 1983-10-25 | 1983-10-25 | リン酸カルシウム多孔体およびその製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58198214A JPS6090880A (ja) | 1983-10-25 | 1983-10-25 | リン酸カルシウム多孔体およびその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6090880A true JPS6090880A (ja) | 1985-05-22 |
| JPH0429630B2 JPH0429630B2 (enrdf_load_stackoverflow) | 1992-05-19 |
Family
ID=16387385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58198214A Granted JPS6090880A (ja) | 1983-10-25 | 1983-10-25 | リン酸カルシウム多孔体およびその製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6090880A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6242837U (enrdf_load_stackoverflow) * | 1985-09-02 | 1987-03-14 | ||
| JPS62158175A (ja) * | 1986-01-07 | 1987-07-14 | 住友大阪セメント株式会社 | 代替骨用多孔質セラミツク成形体およびその製造方法 |
| JPH021285A (ja) * | 1988-01-11 | 1990-01-05 | Asahi Optical Co Ltd | 固着可能な歯科用及び医科用顆粒状骨補填材、その固着方法及び骨補填物 |
| WO2003035576A1 (fr) * | 2001-10-21 | 2003-05-01 | National Institute Of Advanced Industrial Science And Technology | Article poreux de phosphate de calcium fritte, procede de production de celui-ci, ainsi qu'os artificiel et echafaudae histomorphologique faisant appel a cet article |
| JP2004284933A (ja) * | 2003-03-25 | 2004-10-14 | Mamoru Aizawa | 繊維状リン酸カルシウム |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
-
1983
- 1983-10-25 JP JP58198214A patent/JPS6090880A/ja active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6242837U (enrdf_load_stackoverflow) * | 1985-09-02 | 1987-03-14 | ||
| JPS62158175A (ja) * | 1986-01-07 | 1987-07-14 | 住友大阪セメント株式会社 | 代替骨用多孔質セラミツク成形体およびその製造方法 |
| JPH021285A (ja) * | 1988-01-11 | 1990-01-05 | Asahi Optical Co Ltd | 固着可能な歯科用及び医科用顆粒状骨補填材、その固着方法及び骨補填物 |
| WO2003035576A1 (fr) * | 2001-10-21 | 2003-05-01 | National Institute Of Advanced Industrial Science And Technology | Article poreux de phosphate de calcium fritte, procede de production de celui-ci, ainsi qu'os artificiel et echafaudae histomorphologique faisant appel a cet article |
| JP2004284933A (ja) * | 2003-03-25 | 2004-10-14 | Mamoru Aizawa | 繊維状リン酸カルシウム |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0429630B2 (enrdf_load_stackoverflow) | 1992-05-19 |
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