JPS60222410A - Shampoo composition - Google Patents

Abstract

PURPOSE:The titled composition, containing an acylation product of a peptide, having a specific molecular weight, and obtained by treating protein with protease, and having improved foaming, good color, odor and appearance and high safety with little irritation to the scalp. CONSTITUTION:A hair shampoo composition containing 5-20wt% acylated peptide obtained by treating protein with protease, preferably neutral protease derived from molds at 30-60 deg.C, deaerating the resultant peptide, and acylating the resultant aqueous solution of the peptide having 200-1,000 average molecular weight in 50-90wt% concentration (solid) with an 8-22C fatty acid halide at 8-12pH in the presence of a mono- or dihydric alcohol. Preferably, 0.5-10wt% trialkylamine oxide of formula I (R1 is 8-14C alkyl; R2 and R3 are 1-2C alkyl or hydroxyethyl) or an alkylbetaine based surfactant of formula II(R4 is 10-20C alkyl or 10-20C alkenyl; R5 and R6 are 1-4C alkyl; p is an integer 1-3; X is COO<->) is contained therein.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to shampoo compositions, and particularly to mild shampoo compositions that have excellent foaming properties and are less irritating to the scalp.

[Conventional technology]

In recent years, the number of times people use shampoo has increased as people have become more aware of their appearance. At this time, highly safe
A shampoo that does not irritate the skin is desired. Conventional shampoo active agents are higher alcohol ethoxy sulfates, but these are undesirable as they cause protein denaturation and skin irritation.In addition, the amount of foam and its persistence are important for shampoos because they do not allow dirt to enter the foam. This is very important when considering the effect of soaking in and rinsing away.

[Problem that the invention seeks to solve]

As a result of intensive research to improve the drawbacks of conventional shampoo active agents, the present inventors have discovered a shampoo composition that is highly safe, does not cause skin irritation, and has good lathering properties, resulting in the present invention.

[Means for solving problems]

The shampoo composition of the present invention contains 5 to 20% (by weight) acylated peptides obtained by acylating peptides with an average molecular weight of 200 to 1,000 obtained by treating proteins with protease with a fatty acid halide having 8 to 22 carbon atoms. , hereinafter the same)).

Preferred shampoo compositions of the present invention include, in addition to the above-mentioned acylated peptides.

General formula % Formula % (1) (In the formula, R1 is an alkyl group having 8 to 16 carbon atoms, R2゜R3
represents an alkyl group or hydroxyethyl group having 1 to 2 carbon atoms, and R, , R, may be the same or different. ) trialkylamine oxide represented by 0.5~
10%, or the general formula (wherein R6 represents an alkyl group having 10 to 20 carbon atoms or alkenyl ah R,, R6 represents an alkyl group having 1 to 4 carbon atoms, and R, , R6 are the same) %p is an integer of 1 to 3, and X represents a coo'' group).
It contains 10%.

[Effect]

The method for producing the acylated peptide of the present invention will be described in detail below.

Examples of proteins used in the present invention include collagen, keratin, casein, gelatin, soybean protein, wheat protein, albumin, etc., and partially decomposed products thereof can also be used.

Proteases used in the present invention include alkaline, neutral, and acidic proteases derived from Bacillus subtilis, actinomycetes, and filamentous fungi, and may be used alone or in combination of two or more. The protease used in the present invention is more preferably a neutral protease derived from filamentous fungi.

In the present invention, it is desirable that the amount of the protease used varies depending on the potency of each protease.

Desirably soo to ioO, CoO units per 1007 proteins, more preferably 1.000 to soo, oo
o unit is good.

In the present invention, the pH at the time of proteolysis is preferably 3 to 12, and it is desirable to carry out the proteolysis within the range that provides the best activity of each protease. When using a neutral protease derived from filamentous fungi, the pH is preferably 5 to 8.

In the present invention, the temperature during proteolysis is preferably 30 to 60°C, and when using a neutral protease derived from filamentous fungi, 40 to 50°C.

In the present invention, the time for proteolysis is determined by the predetermined molecular weight (20
0 to 1000), but it is industrially disadvantageous to do so for more than 100 hours, so adjusting the amount of enzyme, temperature, etc.
It is desirable to do this within ~48 hours. Furthermore, it is desirable to add preservatives such as paraben and DHA to prevent bacterial contamination during protein decomposition.

In the present invention, after protein decomposition, the protein is degassed to a concentration of 5.
Obtain a 0 to 90% aqueous solution of veptide, and adjust the aqueous solution to pH 8 to 12 in the presence of a monohydric or dihydric alcohol with a carbon number of 8 to 90%.
It is desirable to react with No. 22 fatty acid halide.

In the present invention, degassing of peptide is performed under reduced pressure of 30 to 1
It is desirable to carry out at 00°C. At temperatures below 30°C, deaeration efficiency is poor, and at temperatures above 100°C, deterioration of quality occurs due to decomposition of peptides, etc. In the present invention, degassing of peptides is preferably carried out under reduced pressure, and more preferably carried out at a degree of vacuum of 200% Hg or less. Further, the degassed Bebutide has a concentration (solid content) of 50 to 90%.

If the concentration is less than 50%, the raw material for the acylated peptide is too pure, so even if it is acylated, it will not be possible to obtain an acylated peptide with a high concentration. If it is 90% or more, the concentration is too high, resulting in high viscosity, which is disadvantageous in terms of handling, and is undesirable because there is a risk of separation due to the alcohol solvent during acylation.

In the present invention, alcohols used in the S-combination of peptide acylation include monohydric alcohols such as ethanol, and propylene glycol.

Dihydric alcohols such as 1,3-butanediol are preferred, and these may be used alone or in combination of two or more. It is also possible to further blend polyhydric alcohols such as glycerin with these alcohols, but if used in large quantities, thickening and gelation will occur, making it unsuitable for S. Although methanol, n-butanol, and the like provide a preferable yield in the reaction as the -hydric alcohol, their use is not preferred due to safety concerns. These alcohols are contained in the acylated bebutide reaction composition in an amount of 5 to 50%.
However, if the content is less than 5%, there is not only no anti-gelling effect, but also no antiseptic effect, and soap and the like are produced due to side reactions. If it is more than 30%, the solubility of the peptide becomes poor during one reaction and the peptide separates, resulting in non-uniformity, resulting in a poor yield, which is not desirable.

As the fatty acid halide having 8 to 22 carbon atoms, lauroyl chloride, coconut oil fatty acid chloride, beef tallow fatty acid chloride, rapeseed oil fatty acid chloride, etc. can be used.

Examples of the trialkylamine oxide represented by the general formula (1) used in the present invention include lauryl dimethylamine oxide, lauryl diethylamine oxide, lauryl methylethylamine oxide, lauryl dihydroxy diethylamine oxide, and the like.

Examples of the alkyl betaine surfactant represented by the general formula (2) used in the present invention include betaine lauryl aminoacetate, pemaine lauryl aminopropionate, betaine lauryl amino butyrate, and the like.

In the shampoo of the present invention, the amount of acylated peptide blended is preferably 5 to 20%; less than that will result in less foaming, and more than that will cause problems in low-temperature stability.

The formulation of the acylated peptide amine oxide-containing shampoo of the present invention is 5-20% and 0.5-10%, respectively.
is desirable; if the latter is less than 0.5%, the texture is poor;
The effect remains the same even if the percentage is exceeded.

The formulation of the shampoo containing acylated peptide alkyl betaine of the present invention is 5-20% and 0.5-10%, respectively.
% is desirable; if the latter is less than 0.5%, the texture will be poor;
The effect remains unchanged even if it exceeds 0%.

Furthermore, humectants such as glycols and glycerin, fragrances, pigments, and the like can be added to the shampoo of the present invention, if necessary.

〔Effect of the invention〕

The shampoo composition of the present invention, which contains acylated peptides obtained by treating proteins with protease and having an average molecular weight of 200 to 1,000 and acylating them with fatty acids having 8 to 22 carbon atoms, does not cause skin irritation. , good color, odor, and appearance. In contrast, the average molecular weight of proteins obtained by alkali treatment is 200 to 100.
A shampoo composition containing acylated bebutide, which is obtained by converting 0 peptide to a fatty acid having 8 to 22 carbon atoms, is irritating to the skin and has poor color, odor, and appearance.

The acylated peptide amine oxide-containing shampoo composition of the present invention not only exhibits a remarkable synergistic foaming effect in the presence of dirt, but also has a strong foam stabilizing effect.
The suppleness of the hair after washing is also noticeably increased.

Also, conventional diuryl ether sulfate sodium salt -
Amine oxide-containing shampoo compositions have excellent foaming properties and a good texture.

Furthermore, the shampoo composition containing the acylated beptide alkyl betaine of the present invention exhibits a better texture than the conventional shampoo composition containing lauryl ether sulfate sodium salt-furkyl betaine.

Furthermore, it is surprising that the acylated peptide amine oxide-containing shampoo compositions of the present invention, which contain amine oxides that are mildly irritating to the skin, do not cause any skin irritation.

〔Example〕

Examples of the present invention are shown below.

Examples 1-5. Comparative Examples 1 to 4 Shampoo compositions having the compositions shown in Table 1 were prepared, and the effects of adding each essential ingredient were investigated. Table 1 shows the results.

The evaluation method is as follows.

Appearance The shampoo compositions were kept at -5°C and 40°C and stored for one month, and the appearance was visually judged.

Appearance evaluation is based on two levels:

○: Uniform ×: Unrestricted Odor The shampoo composition was kept at 40°C and stored for one month, and then the odor was determined by a sensory test.

○: No change ×: Unusual foaming In a test using the Weθko method, a graduated cylinder was placed in a constant temperature bath (40°C), and an aqueous solution 1001 of a shampoo composition with a concentration of 1% heated to 40°C was placed in the cylinder. When the liquid temperature in the cylinder reaches 40℃, the dirt heated to 40℃ (
Triolein:) IJ Sue 7 Aline: Cholesterol: Co1/sterol ester: Nystear oleate
Jy acid: palmitic acid, liquid halafine (viscosity 1'20
seconds) : Squalene: Polypropylene glycol alkyl ether (viscosity 1500 cps 25°C) = 10
:10 :2.5 :7.5 :2.5:5 :
2.5:s:5:511 (weight ratio)) to 1
After stirring for 3 minutes using a constant speed stirrer at a rotational speed of 2800 rpm to create foam, the mixture was allowed to stand for 5 minutes; 7. Then, the volume of the remaining foam was measured.

Cleaning power: Dissolve the above stains in chloroform at a rate of 10 (5f per lt), soak a 5v bundle of hair with a length of 10-7 in this solution for 1 minute, air dry, and measure the weight to remove the stains. I measured the amount of hair.Next, I added 40 strands of hair.
℃ in a 10% shampoo composition aqueous solution, move the hair up and down 20 times for 20 seconds to wash the hair, rinse with pure water, air dry, and measure the weight of the hair.The finished product is 2.5ml. Apply the shampoo composition to either the right or left half of the hair, and apply 2.5 ynl of a commercially available conventional shampoo composition to the other half.
After washing the hair, rinsing it with warm water, and drying it with a hair dryer, the results of both were combed and compared in terms of softness.The evaluation of the finish was based on the following four levels.

◎: Very superior to commercially available products.

O: Superior to commercially available products.

△: Equivalent to commercially available products.

×: Inferior to commercially available products.

As shown in Table 1, the acylated peptide ■-amine oxide shampoo composition and the acylated peptide ■-alkyl betaine shampoo composition have no odor, no foaming,
Although it can satisfy all of the cleaning power and finish, acylated peptide ■ cannot satisfy all of them.

Examples 6-9. Comparative Examples 5 to 8 Shampoo compositions having the compositions shown in Table 2 were prepared, and the effects of each essential component on skin irritation were examined. Table 2 shows the results.

Test method: Apply the undiluted solution of the sample test solution and 1 to the left forearm of 20 normal healthy people.
0 times diluted 0.5-50 m/m x 50 m/
After drying, it was covered with Sumitomo 3M micropore surgical tape, and after 24 hours, the presence or absence of erythema was determined using physiological saline applied in the same manner to the corresponding area of the right arm.

Judgment criteria - Non-reactive soil False positive + Erythema test 1 The numerical values on the judgment result shelf are 100 percent corresponding to the judgment results of 20 panelists.

As shown in Table 2, the shampoo composition containing the acylated peptide (■) of the present invention causes significantly less skin irritation than the shampoo composition containing the acylated peptide (Example 6, Comparative Example 5). The skin irritation of shampoo compositions containing amine oxide is significantly reduced, and is less irritating than those containing only amine oxide (Examples 7 and 8; Comparative Example 6). Furthermore, the acylated peptide-amine oxide-containing shampoo composition of the present invention causes less skin irritation than the conventional lauryl ether sulfate sodium salt-amine oxide-containing shampoo composition (Examples 7 and 8; Comparative Examples 6 and 7). 8).

Applicant's agent Kaoru Furutani

Claims (1)

[Scope of Claims] 1. A peptide having an average molecular weight of 200 to 1000 obtained by multiple treatment of a protein with a protease and having a carbon number of 8 to 22.
A shampoo composition comprising 5 to 20% by weight of an acylated peptide acylated with a fatty acid halide. 2 General formula (1) %Formula% (In the formula, R1 is an alkyl group having 8 to 16 carbon atoms, R2゜R3
represents an alkyl group or hydroxyethyl group having 1 to 2 carbon atoms, and R, , R, ti may be the same or different. ) trialkylamine oxide represented by 0.5~
The shampoo composition according to claim 1, containing 10% by weight. 3 General formula (2) (In the formula, R11 represents an alkyl group or alkenyl group having 10 to 20 carbon atoms, R,, R6 represents an alkyl group having 1 to 4 carbon atoms, and R1 and R6 are the same or different. p is an integer of 1 to 3, and X represents a -coo group.
The shampoo composition according to claim 1, containing 10% by weight.