JPS6016879A - Porous ceramic material - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION TECHNICAL FIELD The present invention relates to porous ceramic materials and methods of manufacturing the same. More specifically, the present invention has a large number of holes with specific dimensions and a large number of capillary cavity passages with specific dimensions that communicate at least these holes with an external space, and the present invention has a plurality of holes with specific dimensions and a large number of capillary cavity passages with specific dimensions that communicate at least the holes with an external space. This invention relates to a porous ceramic material useful as a material used in medical applications, an electronic material, and a material for genetic engineering, and a method for producing the same. It has a good affinity for , and is useful as a medical material, for example, a substitute material for bones or tooth roots, or a prosthetic material.

For example, Japanese Unexamined Patent Application Publication No. 56-54841 discloses a bone defect and void filling material using a calcium phosphate compound powder having an amyl-4-tite crystal structure.

Further, Japanese Patent Application Laid-Open No. 166843/1984 discloses a bone defect and cavity filler made of a porous body of a calcium phosphate compound. The pores contained in this porous body of calcium phosphate compound have a maximum pore diameter of 3.00 m.
m+minimum pore diameter of 0.05 mm, the shape and dimensions are such that bone-forming components of the living body can easily enter, and a substantially continuous three-dimensional network structure is completely formed.

Conventional calcium phosphate compound ceramic materials, such as those described above, may cause deformation noise over time after undergoing surgical procedures such as fillings or prosthetics, or may promote hardening of soft tissue near the filling or prosthesis. However, because of this, there was a safety problem in that the tissue in which the abnormality occurred had to be removed.

Generally, in the treatment of defects in the hard tissues of living bodies, such as excision of the bony insula or defects caused by external bone damage, it is most preferable to promote natural healing, and artificial replacements and prostheses are That's not necessarily a good thing. parable,
Artificial substances fill the living body 2. Or even if it is prosthetic,
It is most desirable that such artifacts are eventually consumed within the body, and that natural tissue regenerates in its place, thereby healing the defective area. In this case, it is important that the rate at which the artificial body is replaced by the living tissue (turnover rate) is appropriate; if the turnover rate is too fast, it may cause local irritation and other disturbances. Other complications may occur, such as the development of cancer.

In addition, if the turnover rate is low and the artifact remains in the body for a long period of time, deformation of the local tissue (bone) of the body and hardening of the soft tissue in the vicinity may occur, which may require excision surgery. There are things you need to do.

In order to address the problems mentioned in Section 2, it is essential that the filling material or prosthetic material inserted into the living body satisfy the requirements for inducing and replacing living tissue at the cellular level. That is, the activation of pre-archaeocytes (osteoclasts) against living tissue properly promotes the infiltration of bone-destructive cells (osteoclasts), and collagen fibers, which promotes the hardening of soft tissues. It is important to suppress the development and hardening of bone tissue, and not to inhibit the entry of blood, red blood cells, body fluids, etc., or the development of capillaries.

In order to meet the above requirements, the filling material or prosthetic material inserted into the living body must have good affinity for the living body,
In particular, it is necessary to have bioresponsiveness and to be able to maintain a good population and growth capacity for the activation of the desired M)Jf'7.

The purpose of the present invention is to provide a porous ceramic material useful for in vivo bone tissue regeneration, i.e., induction of new bone, other medical applications, electronic materials, genetic engineering materials, and a method for producing the same. The goal is to provide the following.

Structure of the Invention The porous ceramic material of the present invention comprises a sintered porous body of a calcium phosphate compound, and the porous body has a large number of capillary voids extending in the form of passages and a large number of 1 to 600 micron pores. pores having a pore diameter of 1 to 30 microns are formed,
At least the pores and the external space of the porous body are in communication with each other through at least a part of the plurality of capillary void passages. It is.

A portion of the plurality of capillary void passages may communicate with the plurality of pores.

The above-mentioned porous ceramic material can be manufactured by the method described in 1 above.

That is, the method for manufacturing a porous ceramic material of the present invention involves foaming υlJ[l:I of 100 wt. The mixture was mixed with 120 parts of aroused calcium compound powder, and the mixture was molded by pouring it into a mold having the desired shape and size.
The egg white is heated to a temperature of 20-150°C to harden to a completely hard white.Then, the egg white is carbonized by heating to a temperature of 500-7001: 800-1350°C in an oxygen-containing atmosphere.
The method is characterized in that it is heated to a temperature of .degree. C. to burn off the carbide and sinter the calcium diphosphate compound powder.

Another manufacturing method for porous ceramic Hamura is to foam 100 parts by weight of egg white to form a large number of bubbles with pore diameters of 1 to 600 microns, and then mix this Ukron with organic fibers containing , the mixture was molded by pouring it into a mold of a desired shape and size, and the molded mixture was heated to 120 m
Harden the egg white by heating to a temperature of ~150°C, then 50°C
The egg white and ft+2 are heated to a temperature of 0 to 700°C.
The fibers are carbonized and then heated at 800°C to 13°C in an oxygen-containing atmosphere.
The method is characterized in that it is heated to a temperature of 50° C. to burn and remove the carbide and sinter the calcium phosphate compound powder.

Another method for producing the porous ceramic material of the present invention is to mix 20 to 300 parts by weight of sublimable solid material particles having a particle size of 1 to 600 microns with 100 parts by weight of calcium phosphate compound powder. This mixture was press-molded into a desired shape and size, the molded product was heated to a temperature of 300 to 500°C to remove all of the sublimable substance, and then 800°C
It is characterized in that the calcium phosphate compound powder is sintered by heating to a temperature of ~1350°C.

In still another method for producing the porous ceramic material of the present invention, 30 to 12 oztt of organic fibers are mixed with 100 parts by weight of calcium phosphate compound powder, and this mixture is shaped into a desired shape. The molded material is press-molded to a desired size, heated to a temperature of 300 to 500°C to remove the sublimable substance by sublimation, and completely carbonize the organic fiber, and then heated to a temperature of 800 to 1350°C in an oxygen-containing atmosphere. The method is characterized in that the carbide is burned off and the calcium phosphate compound powder is sintered.

In still another method for producing the porous ceramic material of the present invention, 25 to 380 parts by weight of organic synthetic resin particles having a total particle size of 1 to 600 microns are mixed with a calcium phosphate compound of 1,003 parts. The mixture is mixed into powder, press-molded into the desired shape and size, and the resulting molded product is
The above-mentioned synthetic resin particles are removed by thermal decomposition by heating to a temperature of 800 °C, and then heated to a temperature of 800 to 1350 °C in an oxygen-containing atmosphere.
The method is characterized in that the calcium phosphate compound powder is sintered by heating to a temperature of .degree.

Still another method for producing the porous ceramic material of the present invention is as follows:
25 to 380 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microns, and 1 to 5 parts by weight of organic fibers having a length of 1 to 5 mm and a diameter of 1 to 30 microns, were Mixed with part of calcium phosphate compound powder,
The obtained mixture is press-molded into a desired shape and size, and the obtained molded product is heated to a temperature of 200 to 800°C to thermally decompose and remove the synthetic resin and carbonize the organic fiber, and then placed in an oxygen-containing atmosphere. It is characterized in that it is heated to a temperature of 800 to 1350° C. to completely burn off the carbide and sinter the calcium phosphate compound powder.

Still another method for producing the porous material of the present invention includes 25 to 38
0 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microns and 2 to 2 g parts by weight of sublimable solid material particles having a particle size of 1 to 600 microns are combined with 100 parts by weight of phosphoric acid. The resulting mixture is press-molded into the desired shape and size, and the resulting molded product is heated to a temperature of 200 to 800°C to thermally decompose the synthetic resin particles. At the same time, all of the sublimable material particles are removed by sublimation, and then 800 to 135
The method is characterized in that the calcium phosphate compound powder is sintered by heating to a temperature of 0°C.

Another method for producing the porous ceramic material of the present invention is as follows:
~380 parts by weight of organic synthetic resin particles having a particle diameter of 1 to 600 microns; 1 to 9 parts by weight of sublimable solid material particles having a vertical diameter of 1 to 600 microns; 1 part of organic Ka paste having a length of 1 to 5 mm and a diameter of 1 to 30 microns and -i are mixed with 100 quantitative parts of calcium phosphate compound powder, and the resulting mixture is press-molded into a desired shape and size, The obtained molded product is heated to 200 to 800°C.
The organic synthetic resin particles are thermally decomposed and removed by heating to a temperature of
3. Detailed Description of the Invention The porous ceramic material of the present invention is characterized in that the porous ceramic material of the present invention is heated to a temperature of It is made of a sintered porous body.

The calcium phosphate compound used in the present invention is CaHP
The main components are Oa Ca3(PO4)2 Ca5(PO4), 0H Ca40(PO4)2 Ca1o(PO4)6(OH)2 CaP401゜c a (po3)2 C82P207 Ca(H2PO4) 2- H2O, etc. This includes some compounds called hydroxyapatite. Human numbing sheapatite has the composition formula Ca5(PO4)3OH or Ca10
(po4) Compound f having 6(OH) 2 @: This is the basic component, and a part of the Ca component is Sr + B
a + Mg r Fe r At r Y r La
, Na, KrH, etc. may be substituted with one or more glazes, and a part of the (PO4) component may be substituted with VO4+
BO5+ may be substituted with one or more of SO2, Co3.5in4, etc., and furthermore, a part of the (OH) component may be substituted with one or more of F, C7,0, Co3, etc. Hydroxyapatite may be a normal crystalline substance, or may be any of a isomorphic solid solution, a substitutional solid solution, and an interstitial solid solution, and may also contain non-compatristic lattice defects.

Generally, the Di(dicalcium compound used in the present invention) has an atomic ratio of calcium (Ca) to phosphorus (P) of 1.
Those within the range of 30 to 1,80 are preferable, and 1.6
Those within the range of 0 to 1.67 are more preferable.

Calcium phosphate compounds used in the present invention include tricalcium phosphate (Ca3(PO4)2), hydroxyapatite (Cas(PO4)3oH), and C
a1o(PO4)6(OH)2 is preferred, and one synthesized by the Zorgul method and freeze-dried is particularly preferred.

Moreover, it is preferable that the calcium phosphate compound is sintered at a temperature of 800 to 1350°C, and the sintering temperature is more preferably 850 to 1200°C.

In the porous ceramic material of the present invention, the calcium phosphorus compound is sintered in the form of a powder, so that there are fine voids between the powder particles that are sintered in contact with each other. ! l can have.

The calcium phosphate porous body of the porous ceramic material of the present invention may have any shape and dimensions, and has a large number of capillary voids extending in the form of passages and a diameter of 1 to 600 microns inside. , a large number of pores preferably having a pore diameter of 10 to 300 microns are formed, and the diameter of the capillary void passage is within the range of 1 to 30 microns, preferably 1 to 20 microns; At least the pores and the external space of the porous body communicate with each other through at least a portion of the plurality of capillary void passages. At this time, generally tllfmll mutually,
It communicates with a portion of a number of capillary void passages.

The sintered porous body preferably has a porosity of 40 to 90%, more preferably 60 to 70%.

It is preferable that the pores in the sintered porous body have a true sphere or a shape close to a true sphere, and it is preferable that the pores are uniformly distributed within the porous body. These pores are formed by the ceramic material.
When implanted in a living body, it biologically activates preconception cells, bone regeneration cells, etc. For this purpose, the pore diameter must be in the range of 1 to 600 microns.
Preferably it is 10 to 300 microns. The pore diameter is 1~
Pores outside the 600 micron range cannot provide good living space for the cells.

When the shape of the hole is a true sphere or a sphere close to this,
The resulting porous material has excellent mechanical strength.

Therefore, when this porous material is implanted in a living body, until it is returned over by new bone,
It maintains high mechanical strength and can prevent fractures during that time.

The capillary-like void passages in the sintered porous body are at least ##
The pores communicate with the external space of the porous body, and through these passages, the bone cells, prearchaeocytic cells, red blood cell fluid, etc. can freely enter the porous body. ,
And the development of capillaries is promoted. However, since the diameter of this capillary void passage is in the range of 1 to 30 microns, preferably in the range of 1 to 20 microns, bone destructive cells and collagen fibers enter the capillary void passage in the porous body and leave. , can prevent abnormal development of collagen fibers and hardening of bone tissue. That is, in the porous body of the present invention, the capillary-like void passages also function as a biofilter.

When the diameter of the capillary-like cavity passage becomes as small as 1 micron, it becomes difficult for bone cells, prearchaeocytic cells, and red blood cell fluid to enter the porous chamber, and when it becomes as large as 30 microns, broken cells and collagen become difficult to enter. The invasion and development of fibers is completely allowed, which inhibits bone regeneration and leads to hardening of the regenerated bone tissue and the surrounding tissues.

In the porous ceramic material of the present invention, the pores in the porous body may communicate with each other through some of the multiple capillary void passages, thereby allowing the exhaustion of the porous body and the formation of biological tissue. It is possible to promote return-over.

The porous ceramic material of the present invention can be easily and freely formed into a shape and size corresponding to the shape and size of the defect or void to be filled or prosthetized. Further, the ceramic material of the present invention may be formed into granules having a particle size of 0.05 to 5 mm.

When the porous ceramic material of the present invention is implanted in a living body as a dental implant or a prosthetic material, blood can be removed.

Body fluids, bone cells, and bone regenerating cells enter through the capillary-like pore passages and are consumed by the bone cells that proliferate in the pores, and at the same time, bone tissue is regenerated by prepalaeozoic cells. The opening ceremony will be held on the following month. At this time, the capillary-like void passageway that connects the pores to the external space of the porous body has a diameter of 1 to 30 microns, so bone destruction cells and collagen fibers are It is difficult to enter the capillary void passageway, and can prevent abnormal development of collagen fibers and their hardening. Therefore, the soft tissue of the regenerated bone is not destroyed and hardened by collagen fibers. Therefore, the porous ceramic material of the present invention induces new bone formation and is imbued with normal bone tissue grown in vivo.

As mentioned above, a porous ceramic material that can be returned over by normal bone tissue is novel and could be realized for the first time with the present invention.

The porous ceramic material of the present invention can be produced by various methods.

The first method for producing the porous ceramic material of the present invention is to whisk 100 parts by weight of egg white, and then
Form a large number of bubbles of 600 microns to form egg white bubbles,
Mixing with 30 to 120 parts by weight of calcium phosphate compound powder, pouring and molding this mixture into a mold of desired shape and size, heating the molded mixture to a temperature of 120 to 150 ° C. to harden the egg white, The egg white is then carbonized by heating to a temperature of 500-700°C, and then heated to a temperature of 500-700°C, and then
The method includes heating to a temperature of 00°C to 1350°C to burn off the carbide and sinter the calcium phosphate compound powder.

Generally, the calcium phosphate compound powder used for producing the porous ceramic material of the present invention is 0.
Those having a particle size of 0.05 to 10 microns are preferred. A particularly preferable calcium phosphate compound powder preferably contains a crystalline portion developed into a plate shape, and according to a preliminary measurement result based on an SEM (scanning electron microscope), less than 30% of the powder particles have a particle size of 1 μ or more. It is preferable to have a particle size distribution such that 7.70 cm or more has a particle size of 1 μm or less.

Any method to form bubbles of desired pore size in egg white,
For example, egg white is whipped using an emulsifying mixer, a sample of egg white foam is collected on a slide glass by lightly stroking the liquid surface, and the pore size of the foam is measured by observing tL with a microscope. This operation is repeated until the desired pore size is obtained.

Next, calcium phosphate compound powder of a predetermined M1 is added and mixing is repeated again. At this time, a small amount of a suitable pore control agent, such as fatty acids such as oleic acid and maleic acid, and/or aliphatic alcohols such as high-soprobyl alcohol and isopropyl alcohol may be added.

The resulting mixture is shaped into the desired shape and dimensions. Any molding method and device used in the sintering molding process can be used, but generally casting using a mold is used.

The resulting molded product is heated to a temperature of 120 to 150°C, preferably for 60 to 120 minutes, to harden the egg white. At this time, it is preferable to adjust the relative humidity of the heated enclosure air to a total of 30 to 70.11. ＜, Also, the temperature increase rate′? r: 5~] It is preferable to regulate the temperature to 0°C/min.

This hardened egg white strengthens the bubble frame worm.

Next, the molded product is heated to a temperature of 500 to 700°C, preferably for 120 to 180 minutes, to carbonize the egg white. Next, the molded product is placed in an oxygen-containing atmosphere, such as air, at a temperature of 800 to 13
It is heated to 50° C., preferably 850 to 1200° C., to burn off the carbonization and sinter the calcium phosphate compound powder. When heating at this time 1? j1 is generally about 1 to 3 hours.

The gas generated during the above-mentioned egg white curing, egg white carbonization, and carbide combustion escapes out of the porous body, but at this time, a large number of capillary-like void passages are formed, corresponding to the bubbles in the egg white foam. Holes are formed.

The pores communicate with the external space of the body through capillary void passages, and generally, the pores also communicate with each other through capillary void passages.

In the above manufacturing method, ~5 parts by weight of organic fibers having a length of 1 to 5 cm and a diameter of 1 to 30 microns are added to egg white foam based on 100 parts by weight of calcium phosphate compound powder. Can be added and mixed. in this case,
After egg white curing and heating, the molded product is heated to a temperature of 500 to 700℃,
Preferably, heating is performed for 120 to 180 minutes to carbonize the egg white and also carbonize the organic fibers. These carbides are burned off during sintering heating.

The organic fibers in the above method are effective in ensuring the formation of capillary void passageways with a diameter of 1 to 30 microns. Organic fibers are not particularly limited as long as they have a length of 1 to 5 microns and a diameter of 1 to 30 microns and can be completely combusted, but in general, animal fibers such as cat, raccoon dog, mouse, etc. Preferably, these fibers are free of hair, or other natural fibers including silk fibers, cellulose fibers, and organic synthetic fibers such as polyester, polyzolopyrene, polyacid, polyacrylic fibers, and the like.

Another method of producing the porous two-layer mixture of the present invention is to add 20 to 300 parts by weight of a sublimable solid material powder having a particle size of 1 to 600 microns to 100 parts by weight of a calcium phosphate compound. This mixture is press-molded into a desired shape and size, and the molded product is heated to a temperature of 200 to 800°C to remove the sublimable substance by sublimation.
The method includes sintering the calcium phosphate compound powder by heating to a temperature of 00 to 1350°C.

In the above method, the calcium phosphate compound powder is the same as that used in the above method. Further, the sublimable solid material powder is a porous material that forms pores with a desired size of VC1 to 600 microns in the porous body,
There is no particular limitation on the type as long as it sublimates easily at a temperature of 200 to 800°C and leaves substantially no residue. In general, the arranging substances include camphor, chlorine,
2' selected from naphthalene and mixtures of 2a1 or more thereof;

The mixture of the irradiating material powder and the calcium phosphate compound powder is press-molded into the desired size and shape. Although there are no particular limitations on this press molding method, ordinary static pressure press molding methods such as the rubber press method and the C12 method can be used. When the torn molded product is heated to a temperature of 200 to 800°C, preferably for 120 to 180 minutes, the sublimable substance sublimates and escapes, forming pores. At this time, fine powder of the sublimable substance is removed from the pores. Capillary-like void channels communicating with the outside of the porous body are formed by sublimation and escape. ``Capillary-like void spaces communicating between the holes are also formed.

Next, the molded product is heated again at 800 to 1350°C, preferably 8
The calcium phosphate compound powder is sintered by heating to 50 to 1200°C, preferably for 1 to 3 hours.

In the above method, by adjusting the shape and particle size of the sublimable substance powder, the shape and diameter of the pores can be more easily controlled than in the method using strawberry egg white.

In the method using the above sublimable substance powder, 1 to 5 parts by weight of organic fibers having a length of 1 to 5 microns and a diameter of 1 to 30 microns are added and mixed to 100 parts by weight of the calcium phosphate compound powder. You may. If such a mixture is heated to a temperature of 200 to 800°C, preferably for 120 to 180 minutes, the sublimable substances sublimate and escape and the organic fibers are carbonized. Next, by heating to a temperature of 800 to 1350°C, preferably for 1 to 3 hours, the carbide is burned out and the calcium phosphate compound powder is sintered.

In this method, the incorporation of organic fibers is effective in forming capillary-like void channels throughout the article having a diameter of 1 to 30 microns. This organic PJ and fibers are the same as those described above.

When mixing organic fibers or sublimable substance powder with calcium phosphate compound powder, adding a volatile lower alcohol such as methanol or ethanol will make it easier to obtain a homogeneous mixture. control particle size,
It also improves the adhesion between the sublimable substance powder and the organic fibers, thereby promoting the formation of capillary-like void passages communicating with the pores.

Yet another method for producing the porous sesmic material of the present invention is to mix 25 to 380 parts by weight of organic synthetic resin particles e having a particle size of 1 to 600 microns with 100 parts by weight of calcium phosphate compound powder. This mixture is molded into a desired shape and size, and the resulting molded product is heated at 200 to 800°C.
The method includes heating to a temperature of 800 to 1350° C. to thermally decompose and remove the organic synthetic resin particles, and then sintering the calcium phosphate compound powder by heating to a temperature of 800 to 1350° C. in an oxygen-containing atmosphere.

The organic synthetic resin particles having a particle size of 1 to 600 microns used in the above method are effective for forming pores of 1 to 600 microns in a porous body. There is no particular limitation on the type of organic synthetic resin as long as it thermally decomposes at a temperature of 200 to 400°C and escapes from the porous body, but in general, methyl methacrylate, polypropylene, polystyrene, etc. It is selected from thermoplastic synthetic resins, with methyl methacrylate being particularly preferred. Since the organic synthetic resin described above has a certain hardness, the spherical particles will not be deformed or crushed when the particles are mixed with calcium phosphate compound powder or when the mixture is press-molded. Therefore, it is possible to form pores having a size and shape that accurately correspond to the size and shape of the particles used.

The mixture of organic synthetic resin spherical particles and calcium phosphate compound powder is press-molded into a molded article having desired dimensions and shape. There are special limitations on the molding method at this time.
A hydrostatic press molding method for an inverted cone, such as a rubber press method or a C12 method, can be used. The straddled molded product is first heated at a temperature of 200 to 500°C, preferably 30°C.
It is heated at 0 to 350° C. for 120 to 180 minutes to thermally decompose and remove the organic synthetic resin particles, forming corresponding pores and forming capillary void passages extending from the pores.

Next, this molded product was heated to a temperature of 800 to 135% in an oxygen-containing atmosphere.
The calcium phosphate compound powder is sintered by heating at 0°C, preferably 85<) to 1200°C, preferably for 1 to 3 hours. At this time, even if there is a thermal decomposition residue of the organic synthetic resin particles, this is burned off during sintering and heating.

In the method using the organic synthetic resin particles, 100
For every part by weight of calcium phosphate powder, 1 to 1 parts by weight of organic e-fibers having a length of 1 to 5 microns and a diameter of 1 to 30 microns can be added. The types and effects of this organic fiber are the same as described above.

Furthermore, in the method using the organic synthetic resin particles,
2 to 100 parts by weight of calcium phosphate compound powder
An additional 19 parts by weight of sublimable solid material particles having a particle size of 1 to 600 microns can be added. The type of this sublimable substance is the same as described above. In this method, the sublimable material particles have a particle size of 1 to 600 microns and are effective in forming capillary-like void passages.

Furthermore, in the method using the organic synthetic resin particles, for 100 parts by weight of calcium phosphate compound powder,
2~. The length of the guard placement part from 1 to 511III+, and the length from 1 to 511III+
organic fibers with a diameter of 30 microns and 2~-・ri)
s parts of sublimable solid particles having a particle size of 1 to 600 microns may be additionally mixed. The properties and effects of these organic fibers and sublimable solid particles are the same as described above.

Example 1 A mixture of iooy egg white and 32 oleic acid was whipped using an emulsifying mixer, and the liquid level was occasionally sampled by tapping on the surface of a slide glass. Whipping was continued until the minimum bubble size was 3 microns.

In the above egg white foam, 90I synthetic hydroxyapatite (Ca5(PO4)30H, Ca/P atomic piece = 1.67
1 particle size 0.05 to 10 microns) were mixed. This mixture was poured into a frame mold. The molded product was heated to 150°C at a rising rate of 10°C/min in an atmosphere with a relative humidity of 30°C.
The egg white was heated to 180 minutes at this temperature to harden the egg white and form a framework of bubbles. Next, this molding 6
The temperature was gradually increased to 500°C for 120 minutes to carbonize the egg white. Finally, the molded product was heated in air at a temperature of 1000° C. for 1 hour fl, j1 to sinter the hydroxyapatite powder.

The obtained porous body had a porosity of 76, and when it was observed under a microscope, it was found that there were many pores with a pore diameter of 10 to 50 microns, and a large number of capillary-like void passages with a diameter of 12 microns. The pores communicated with the outside and between the pores through the capillary-shaped cavity passage.

A 1 x 1 x 1 crIT cube was cut out from the above porous molding and its -axial compressive strength was measured, and it was 12 kg.
/cm”.

Example 2 The same operation as in Example 1 was performed, except that 5F polyzolopyrene fibers (length: 5 to 10 microns, diameter = 3 to 10
Micron) was added during the egg white whipping process. The obtained hydroxyano and tight porous material had pores and capillary-like void passages similar to those of Example 2, but many capillary-like passages with a diameter of 5 to 10 microns were observed.

Further, the uniaxial compressive strength of the porous material was 10 kg/crn2.

Example 3 Commercially available pharmacopoeia camphor was crushed and sieved to collect 10 liters of particles with a particle size of 1 to 600 microns.
9 hydroxyapatite powder (same as that described in Example 1) was mixed uniformly. This mixture was pressed under a static pressure of 2 kg/cm 2 with a rubber press molding machine eζ, and left for about 10 minutes to be molded.
℃ for 180 minutes, then heated in air at 1000℃ for 1 hour.

The porous molded product obtained had a porosity of 77 cm and an unconfined compressive strength of 30 kg/cm2. This porous body had a large number of pores of 100 to 500 microns (average about 300 microns) and a large number of capillary-like void passages of 1 to 30 microns in diameter.

Example 4 The same operation as in Example 3 was performed. However, the same polypropylene F & fiber 51 as described in Example 2 - additionally mixed 3
After heating to 50°C, the fibers were further heated to 500°C for 120 minutes to carbonize the fibers.

Among the capillary-like void passages formed in the obtained porous body, many capillary-like passages having a diameter of about 5 to 10 microns were observed.

The resulting porosity has a porosity of 68 cm and a porosity of 28 to 9/Crn”
It had a −axial compressive strength of .

Example 5 True spherical methyl methacrylate particles of 60.9 mm (particle size 30
~300 microns, average particle size approximately 100 microns), and 5
0I hydroxyapatite particles (same as those described in Example 1) and a small amount of methyl alcohol were uniformly mixed while heating.

Before this mixture is sufficiently dry, use a rubber press to
The molded product was statically molded at a pressure of 9/cm" for about 10 minutes. The molded product was heated at a temperature of 350°C for 180 minutes to pyrolyze the methyl methacrylate particles, and then heated to 1000°C in air for 180 minutes.
heated for an hour.

The obtained sintered porous body has a porosity of 70 cm and a porosity of 80k17.
/cm2 and has an unconfined compressive strength of 30 to 300
Numerous true spherical pores with a pore size of microns and a diameter of 2 to 1
It had numerous capillary-like void passageways of 0 microns.

Example 6 The operation money is repeated as in Example 5. However, cat abdominal hair that has been further degreased and degreased with a mixture of methyl methacrylate particles and hydroxyapatite powder (frozen cat abdominal hair cut with a flystat and dried, diameter 2
~10 microns, length approximately 5-10 mm) 21 and heated to 350°C, then heated to 750°C.
The cat hair was carbonized by heating for 20 minutes.

The resulting porous molded product had a porosity of 73 cm and a weight of 90 kg/c.
It showed an unconfined compressive strength of m2. In addition, spherical pores and capillary-like void passages similar to those in Example 5 were observed, but formation of a large number of capillary-like passages having a diameter of 2 to 10 microns was observed.

Example 7 The same operation as in Example 5 was performed. However, the mixture of methyl methacrylate particles and hydroxyapatite powder is further mixed with 3 g of whole methyl alcohol of camphor powder having a particle size of 1 to 600 microns, and before it is completely dried, it is molded with a rubber press, and then After drying by heating at 350°C, the mixture was further heated at 500°C for 120 minutes to sublimate the camphor.

The resulting sintered porous body has a porosity of 65% and 95%! 9
/cm''.

Further, this porous body had spherical pores and capillary-shaped void passages similar to those in Example 5.

Example 8 The same operation as in Example 5 was performed. However, in addition to the mixture of methyl methacrylate particles and hydroxyanogtite powder, cat hair 2II identical to that described in Example 6 and camphor powder 3,9. ! : was added and mixed with methyl alcohol, the mixture was molded in a rubber press, and the molded product was heated at 350°C,
It was further heated at 750° C. for 120 minutes to carbonize the cat hair and sublimate and remove the camphor.

The obtained sintered porous body had a porosity of 76 cm and a porosity of 11 ok.
It exhibited an excellent compressive strength of g/α2.

In addition, spherical pores and capillary-like void passages similar to those in Example 5 were formed, and among them, a large number of capillary-like passages having a diameter of 2 to 10 microns were observed.

Example 9 The porous bodies obtained in each of Examples 1 to 8 were
．． 5α, cut into a cylindrical shape with a length of 1 cm), and filled into a defect created by surgery on the femur of a Peagle dog. Two weeks later, when the tubes were cut open and observed, significant induction of new bone was observed in the spherical cavities in each case. Also, 2
After ~3 months, the development of new bone from the outer periphery to the inside of the porous body was observed, and the so-called return-over proceeded smoothly, and phenomena such as abnormal growth of colladan fiber cells and hardening of the tissue were observed. I couldn't.

Effects of the Invention The porous ceramic material of the present invention has pores having a pore diameter of 1 to 600 microns, preferably 3 to 300 microns, and 1 to 3
The capillary-like void passage has a diameter of 0 microns, preferably 1 to 20 μm, and since this capillary-like void passage can function as a biofilter, its abnormal development due to the invasion of collagen fibers is prevented. It inhibits the hardening of bone tissue due to the catalytic action of collagen fibers, inhibits the induction of new growth, makes it difficult for bone-destructive cells to enter the capillary cavity passageway, and prevents the hardening of the collagen fibers themselves due to abnormal development of collagen fibers. , bone cells, last living cells,
Only red blood cells, body fluids, etc. can selectively pass through. Further, pores having a specific pore diameter can promote activation of bone cells and preliminary cells at the cellular level.

Therefore, by using the porous η ceramic material of the present invention, it is possible to promote the induction of new bone and promote bone return-over while maintaining good compatibility with living organisms.

Further, in the porous ceramic material of the present invention, the spherical pores are communicated with each other through a capillary-like void passage, and further, the spherical pores and the external space of the porous body of the present invention are communicated with each other through a capillary-like void passage. (lj',
The feature of the present invention is that the porous body of the present invention is composed of all combinations of spherical pores, capillary-like void passages, and the inner space of the porous body of the present invention. In the present invention, the capillary-like void passage is 1 to 30μ, preferably 1 to 2
Since the passages are extremely small (0μ), they work effectively in inducing new bone formation.More specifically, when the porous ceramic material of the present invention is buried in existing bone, the particle size of the pores and The pores are large enough for collagen fibers to enter the pores, although the shape of the feathers is incompletely controlled. Due to the abnormal development and hardening of the collagen, there is a concern that inflammation may occur around the implanted area. Since the diameter of the caries is extremely small, 1 to 30 μm, preferably 1 to 20 μm, it is difficult for the collagen fibers to enter the capillary-like cavity passages, preventing the collagen fibers from hardening and hardening, and is effective in inducing new bone formation. Last living cell,
Because only red blood cell fluid can selectively pass through, very soft bones (same structure as natural bones of humans and animals, with a bony structure in the center and hardened bone around the center) are initially formed, which gradually becomes softer. Bone organization toward the outside is possible. Therefore, it is possible to create a natural bone of a deceased person or animal with exactly the same structure, that is, the center of the bone is in the shape of a bony bone, and the outer periphery is a structured bone with increased bone density.
It is possible to create strong new bone with the same structure as natural bone, which is completely different from conventional hardened bone or apatite bone. This is because when the porous ceramic material of the present invention is implanted into existing bone, the bone of the present invention is eaten away and disappears, and in its place, new bone with the same structure as natural bone is induced, which is completely non-toxic and strong even for a long period of time. Flexible bones are formed. As mentioned above, the porous ceramic material of the structure of the present invention has such a structure that a very soft bone is first formed, and something corresponding to a bone pancreas is first formed.This is the same as natural bone, and this As the bone tissue moves outward and the bone density increases, flexible and strong bones are formed, just like the natural bones of humans and animals.

Alternatively, the porous ceramic material of the present invention consisting of capillary-like void passages and spherical pores can be used for the above-mentioned biomaterials (IC).
, it can also be used as electronic materials for LSI, media materials for genetic engineering, etc.

Patent Applicant: Sumitomo Cement Co., Ltd. Patent Attorney: Akira Aoki, Patent Attorney: Kazuyuki Nishidate, Patent Attorney: Akira Yamaguchi, Procedural Amendment (White Breath) October C, 1980, Manabu Shiga, Commissioner of the Japan Patent Office] , Indication of the case Patent Application No. 124087 of 1982 2. Name of the invention Porous ceramic material 3. Person making the amendment Relationship to the case Patent applicant name Sumitomo Cement Co., Ltd. (Tato Tsukishi) 4. Address of the agent Address: 8-10 Toranomon-chome, Minato-ku, Tokyo 105 (2 others) 5. Subject of amendment A. ``Claims'' column in specification store, ``Detailed description of the invention'' column in specification 6. Contents of the amendment A. Attached document entry 9 (1) Page 11, line 14 of the specification, “Shite,” and 1
Add the following between the "missing part" and "missing part".

"By controlling the bone regeneration rate, bone resorption over time is controlled, and
Correct m or less to 1.

(3) On page 16, line 3, “30-120” was changed to “20
~300''.

(4) Page 16, line 5, [1 to 5mmJ to '5mm
Correct J below.

(5) Page 16, line 8, l-300~500” (:
Correct J to 200-800℃J.

(6) Line 8 of the 17th line, 11~5mm1' 5
Correct to "mm or less".

(7) Same page 18, line 14, rl~5mmJ '5
Correct to "mm or less".

(8) On page 21, line 14, correct "rlQ~300 microns" to "r3~300 microns" by +fit.

(9) On page 22, line 15, "1O~300 microns" is corrected to "3~300 microns J."

00) Page 24, line 9, [can be promoted. '' should be corrected as follows.

Accelerating T, and abnormally excessive bone erosion (bone resorption) by predicting from the initial regeneration speed the activation of bone-destructive cells that occurs when bone regenerates after bone tissue turnover is completed. can be controlled.

The capillary void passage of the present invention is formed by (1) a passage formed by combustion of machine fibers and (2) a gas generated by combustion and sublimation of egg white, sublimable solid material powder, organic synthetic resin particles, etc. It is a passage. Among these, passages formed by combustion of organic fibers are preferred because the diameter can be well controlled. (11) In the first and second lines of page 27, "1 μ" is corrected to "1 micron".

(12) On page 28, line 12, "carbonization" is corrected to "carbide."

(13) Page 29, line 4 and line 13, (-1~
5+nmJ are respectively corrected to ``5 mm or less''.

(14) Page 32, line 1, [1-5mmJ to '5m
Correct m and below J.

(15) Page 35, lines 5 and 19, [1-5
Correct mmJ by 5 mm or less.

(1G) On page 36, between lines 4 and 5, do the following by 11 people.

The fiber length of the organic fiber used in the present invention is 5 mm or less, but the lower limit is not particularly determined, and is about 1 micron, which is corrected to 3 to 10 microns.

(18) Same page 40, line 8, ``About 5-10 mm 1 is corrected to ``about 5-10 microns.''

(19) On page 41, line 4, replace "95" with '160 J
Correct to.

(20) On page 43, line 13, it says “promote”.
amended to "promote and control bone resorption over time that occurs by controlling the rate of bone regeneration."

(21) On page 45, lines 2 to 4, delete [(same structure as the natural bones of humans and animals, with a bone in the center and hardened bone around it).

(22) On page 45, line 5, the following is added between "is." and "therefore."

"Then, it has the same structure as the natural bones of humans and animals, with a bony structure in the center and hardened bone around it.

(23) In the 14th line of page 45, the word "induced" is replaced with "induced," and the activation of bone-destructive cells that occurs when bone regenerates after bone tissue turnover is completed. It is possible to control abnormal bone erosion (bone resorption) by predicting the initial regeneration rate of the part and correct it.

7. List of Attached Documents Amended Claims 1 copy 2. Claims ■ Comprising a sintered porous body of a calcium phosphate compound, the porous body having a capillary shape extending in the shape of a large number of passages. A void and a large number of voids having a pore diameter of 1 to 600 microns are formed, and the capillary void passage has a diameter of 1 to 30 microns.
A porous material having a size in the range of microns, wherein at least the pores and the external space of the porous body communicate with each other through at least a part of the plurality of capillary-like pore passages. ceramic material.

2. The ceramic material according to claim 1, wherein the atomic ratio of calcium to phosphorus in the calcium phosphate compound is within the range of 1.30 to 1.80.

3. The ceramic material according to claim 1, wherein the calcium phosphate compound is hydroxyapatite.

4. The ceramic material according to claim 1, wherein the pore diameter is within the range of 3 to 300 microns.

5. The ceramic material according to claim 1, wherein the diameter of the capillary void passage is within the range of 1 to 20 microns.

6. The porous body has a porosity of 40% to 90%.
A ceramic material according to claim 1.

7. The ceramic material according to claim 1, wherein a portion of the plurality of capillary void passages communicates with each other the plurality of pores.

8. Whisk 100 parts by weight of egg white to form a large number of bubbles with a pore size of 1 to 600 microns, and form an egg white foam of 30 to 120 parts by weight.
It is mixed with parts by weight of calcium phosphate compound powder, and molded by pouring this mixture into a mold having a desired shape and size,
The shaped mixture was heated to a temperature of 120-150°C to harden the albumen, then heated to a temperature of 500-700°C to carbonize the albumen, and then heated to a temperature of 500-700°C to carbonize the albumen, and then heated in an oxygen-containing atmosphere for 8
9. A method for producing a porous ceramic material, which comprises heating to a temperature of 00°C to 1350°C to burn off the carbide and sinter the calcium phosphate compound powder.9. 9. The method according to claim 8, wherein the egg white curing heating step is performed in an atmosphere having a relative humidity of 30 to 70% at a temperature increase rate of 5 to b minutes.

10. The calcium phosphate compound powder is 0.05 to 1O
9. The method of claim 8, wherein the particle size is in the micron range.

11. Whisk 100 parts by weight of egg white to form a large number of bubbles with a pore size of 1 to 600 microns.
~120% phosphoric acid 11 compound powder and 1~5
Parts by weight of organic fibers having a length of 5 mm or less and a diameter of 1 to 30 microns are mixed, the mixture is molded into a desired shape, and the molded mixture is heated to a temperature of 120 to 150 °C. Harden the egg whites, then heat to 500-700°
C to carbonize the albumen and fibers, and then heat to a temperature of 800 to 1350C in an oxygen-containing atmosphere to burn off the carbide and sinter the calcium phosphate compound powder. A method for producing a porous ceramic material, characterized in that:

J2. 12. The method according to claim 11, wherein the organic fibers are animal fibers, silk fibers, cellulose fibers and/or synthetic fibers.

14. Mix 20 to 300 parts by weight of a sublimable solid substance powder with a particle size of 1 to 600 microns with 100 parts by weight of calcium phosphate compound powder, press-form this mixture into the desired shape and size, and The molded product is heated to a temperature of 300 to 500°C to sublimate and remove the sublimable substance, and then 8
A method for producing a porous ceramic material, characterized in that the @acid calcium compound powder is sintered by heating to a temperature of 00 to 1350°C.

15. The calcium phosphate compound powder is 0.05 to 10
15. The method of claim 14 having a particle size of microns.

16. The sublimable solid substance is selected from camphor, camphor, naphthazine, and a mixture of two or more thereof.
A method according to claim 14.

17. 20 to 300 parts by weight of sublimable solid material powder having a particle size of 1 to 600 microns and 1 to 5 parts by weight of organic fibers having a length of 5 mm or less and a diameter of 1 to 30 microns. The mixture is press-molded into a desired shape and size, and the molded product is heated to a temperature of 200 to 800°C to sublimate and remove the sublimable substance, and to remove the sublimable substance from the machine fiber. 1. A method for producing a porous ceramic material, which comprises carbonizing and then heating in an oxygen-containing atmosphere at a temperature of 800 to 1350° C. to burn off the carbide and sinter the calcium phosphate compound powder.

18. The method of claim 17, wherein the organic fibers are animal fibers, silk fibers, cellulose fibers, and/or organic synthetic fibers.

20.25 to 380 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microns are mixed with 100 parts by weight of calcium phosphate compound powder, and this mixture is pressed into a desired shape and size. The molded product obtained by molding was heated to 200 to 8
The organic synthetic resin particles are removed by heating to a temperature of 00°C, and then heated to a temperature of 800 to 135°C in an oxygen-containing atmosphere.
A method for producing a porous ceramic material, comprising sintering the calcium phosphate compound powder by heating to a temperature of 0°C.

Sato, the calcium phosphate compound powder has a content of 0.05 to 10
21. The method of claim 20 having a particle size of microns.

Reciprocally, the particle size of the organic synthetic resin spherical particles is 10 to 30
21. The method of claim 20 in the range of 0 microns.

Normally, the organic synthetic resin is polymethyl methacrylate,
21. The method according to claim 20, wherein the material is at least one selected from polypropylene and polystyrene.

25 to 380 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microliters, and 1 to 5 parts by weight of 5
Organic fibers having a length of mm or less and a diameter of 1 to 30 microns are mixed with 100 parts by weight of calcium phosphate compound powder, the resulting mixture is press-molded into a desired shape, and the resulting molded product is The synthetic resin is thermally decomposed and the organic fibers are carbonized by heating to a temperature of 200 to 800°C, and then heated to a temperature of 800 to 135°C in an oxygen-containing atmosphere.
A method for producing a porous ceramic material, comprising heating to a temperature of 0° C. to burn off the carbide and sinter the calcium phosphate compound powder.

25. The method according to claim 24, wherein the organic fibers are selected from animal fibers, silk fibers, cellulose fibers and/or organic synthetic fibers.

the method of.

-η1. 12. The method according to claim 11, wherein the particle size of the organic synthetic resin particles is within the range of 10 to 300 microns.

28.25 to 380 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microns;
sublimable solid material particles having a particle size of 600 microns are mixed with 100 parts by weight of calcium phosphate compound powder,
The obtained mixture is press-molded into a desired shape and size, and the obtained molded product is heated to a temperature of 200 to 800 ° C. to remove the synthetic resin particles by thermal decomposition and remove the sublimable material particles by sublimation, Then 800-13 in an oxygen-containing atmosphere
A method for producing a porous ceramic material, characterized in that the calcium phosphate compound powder is sintered by heating to a temperature of 50°C.

The method according to claim 1, wherein the sublimable substance is selected from camphor, camphor, naphthalene, and a mixture of two of these.

29. The method according to claim 28, wherein the particle size of the organic synthetic resin particles is within the range of 10 to 300 microns.

31.25 to 380 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microns;
sublimable solid material particles having a particle size of 600 microns;
1 to 5 parts by weight of organic fibers having a length of 5 mm JJ, -F and a diameter of 1 to 30 microns are mixed with ]00 parts by weight of calcium phosphate compound powder, and the resulting mixture is
Press molded into desired shape and size, and the resulting molded product was
The organic synthetic resin particles are removed by thermal decomposition by heating to a temperature of ~800°C, the sublimable material particles are removed by sublimation, and the organic fibers are carbonized, and then heated to a temperature of 800°C in an oxygen-containing atmosphere.
A method for producing a porous ceramic material, comprising heating to a temperature of ~1350°C to burn off the carbide and sinter the calcium phosphate compound powder.

32. The particle size of the organic synthetic resin spherical particles is 10 to 300.
32. The method of claim 31 in the micron range.

33. The method of claim 31, wherein the organic fibers have a length of 1 micron to 5 mm.

Claims (1)

[Scope of Claims] 1. A sintered porous body of a calcium phosphate compound, the porous body having a large number of tubular voids extending in the form of passages, and a large number of pores with diameters of 1 to 600 microns. pores are formed, and the diameter of the capillary-like void passage is within the range of 1 to 30 microns, and at least the space between the pores and the external space of the porous body is A porous ceramic material characterized in that the porous ceramic material is connected by at least a portion of the capillary-like void channels. 2. The ceramic material according to claim 1, wherein the atomic ratio of calcium to phosphorus in the calcium phosphate compound is within the range of 1.30 to 1.80. 3. The ceramic material according to claim 1, wherein the calcium phosphate compound is hydroxyanoyatite. 4. The ceramic material according to claim 1, wherein the pore diameter of the pores Mij is within the range of 3 to 300 microns. 5. The ceramic material according to claim 1, wherein the diameter of the capillary void passage is within the range of 1 to 20 microns. 6. The porous body has a porosity of 40% to 90%.
The ceramic material according to claim 1, wherein a part of the plurality of capillary void passages communicates the plurality of pores with each other. 8. Whisk 100 parts by weight of egg white to form a large number of bubbles with a pore size of 1 to 600 microns, and form an egg white foam of 30 to 120 parts by weight.
It is mixed with parts by weight of calcium phosphate compound powder, and molded by pouring this mixture into a mold having a desired shape and size,
The shaped mixture is heated to a temperature of 120-150°C to harden the albumen, then heated to a temperature of 500-7GO°C to carbonize the albumen, and then heated to a temperature of 80°C in an oxygen-containing atmosphere.
A method for producing a porous ceramic material, comprising heating to a temperature of 0° C. to 1350° C. to burn off the carbide and sinter the calcium phosphate compound powder. 9. The method according to claim 8, wherein the egg white curing and heating step is carried out at a temperature increase rate of 5 to oc/min in an atmosphere having a relative humidity of 30 to 70%. 10, the calcium phosphate compound powder is 0.05 to 10
9. The method of claim 8 having a particle size of microns. 11. Whisk 100 parts by weight of egg white to form a large number of bubbles with a pore size of 1 to 600 microns.
~120 parts by weight of phosphorus weight lucium compound powder and 1 to 5 parts by weight of organic fibers having a length of 1 to 5 microns and a diameter of 1 to 30 microns are mixed, and this mixture is molded into a desired shape and size. , the shaped mixture is heated to a temperature of 120-150°C to harden the albumen, then heated to a temperature of 500-700°C to carbonize the albumen and fibers, and then heated in an oxygen-containing atmosphere. A method for producing a porous ceramic Hamura, comprising heating to a temperature of 800° C. to 13,500° C. to burn off the carbide and sinter the calcium phosphate compound powder. 12. Claim 6, wherein the organic fiber is an animal fiber, a silk fiber, a cellulose fiber, and/or an organic synthetic fiber.
The method described in Section 9 of Section 4. 13. 20 to 300 parts by weight of a sublimable solid material powder having a particle size of 1 to 600 microns is mixed with OO parts by weight of a calcium phosphate compound powder, and the mixture is press-molded into a desired shape and size, 300 to 500 pieces of this molded product
Production of a porous ceramic material, characterized in that the sublimable substance is sublimated and removed by heating to a temperature of 800 to 1350 °C, and then the calcium phosphate compound powder is sintered by heating to a temperature of 800 to 1350 °C. Method. 14. The calcium phosphate compound powder has a content of 0.05 to 10
14. The method of claim 13 having a particle size of microns. 15. The sublimable solid substance is selected from camphor, camphor, naphthalene, and a mixture of two or more thereof.
The method according to claim 13. Organic fibers having a fiber length and a diameter of 1 to 30 microns are mixed with 1003 parts of calcium phosphate compound powder, this mixture is press-molded into the desired shape, and the molded product is heated to a temperature of 200-800°C. Heat to sublimate and remove the sublimable substance and carbonize the organic fibers, and then heat in an oxygen-containing atmosphere to a temperature of 800 to 1350°C to burn and remove the carbide and remove the calcium phosphate compound powder. A method for manufacturing a porous ceramic material, the entire feature of which is sintering. 17. The organic fiber is animal #1! 17. The method according to claim 16, wherein the fiber is fiber, silk fiber, cellulose fiber, and/or organic synthetic fiber. 18.25 to 380 parts by weight of organic synthetic resin particles K having a particle size of 1 to 600 microns are mixed with 100 parts by weight of calcium phosphate compound powder, and this mixture is press-molded into a desired shape and size. molded product i, 200-8
The organic synthetic resin particles are removed by thermal decomposition by heating to a temperature of 00°C, and then heated to a temperature of 800 to 1350°C in an oxygen-containing atmosphere.
1. A method for producing a porous ceramic material, comprising sintering the calcium phosphate compound powder by heating to a temperature of . 19. The calcium phosphate compound powder is 005-1O
19. The method of claim 18 having a particle size of microns. 20 The particle size of the organic synthetic resin spherical particles is 10 to 30
19. The method of claim 18 in the range of 0 microns. 21. The method according to claim 18, wherein the organic synthetic resin is at least one selected from polymethyl methacrylate, polypropylene, and polystyrene. 22.25 to 380 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microns and 1 to 5 parts by weight of 1
An organic fiber having a length of 5 to 30 microns and a diameter of 1 to 30 microns is mixed with 100 parts by weight of calcium phosphate compound powder, and the resulting mixture is press-molded into a desired shape and size, resulting in a molded product. 'f: heated to a temperature of 200 to 800°C to thermally decompose and remove the synthetic resin and carbonize the organic fiber, and then heated to a temperature of 800 to 135°C in an oxygen-containing atmosphere.
A method for producing a porous ceramic material, comprising heating to a temperature of 0° C. to burn off the carbide and sinter the calcium phosphate compound powder. 23. The method according to claim 21, wherein the organic fibers are selected from animal fibers, silk fibers, cellulose fibers and/or traditional synthetic fibers. 24. The method according to claim 22, wherein the particle size of the organic synthetic resin particles is within the range of 10 to 300 microns. 25.25 to 380 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microns;
sublimable solid material particles having a particle size of 00 microns; i;
The resulting mixture is press-molded into a desired shape and size, and the resulting molded product is heated to a temperature of 200 to 800°C to thermally decompose and remove the synthetic resin particles. At the same time, the sublimable material particles are removed by sublimation, and then the particles of 800 to 135
A method for producing a porous ceramic material, which comprises heating to a temperature of 0° C. to sinter the calcium phosphate compound powder. 26. The sublimable substance is camphor, camphor, naphthalene,
and a mixture of two or more thereof. 27. The method according to claim 25, wherein the particle size of the organic synthetic resin particles is within the range of 10 to 300 microns. 28.25 to 380 parts by weight of organic synthetic resin particles having a particle size of 1 to 600 microns;
sublimable solid material particles having a particle size of 600 microns;
1 to 5 parts by weight of organic fibers having a length of 1 to 5 and a diameter of 1 to 30 microns are mixed with 100 parts by weight of calcium phosphate compound powder, and the resulting mixture is pressed into the desired shape and size. The molded product obtained by molding is 200 to 800
℃ to thermally decompose and remove the organic synthetic resin particles, sublimate and remove the sublimable material particles, and carbonize the organic fibers, and then heat to
A method for producing a porous ceramic material, which comprises heating to a temperature of 0.degree. C. to burn off the carbide and sinter the calcium phosphate compound powder. 29. The particle size of the organic synthetic resin spherical particles is 10 to 300.
29. The method of claim m 28 in the micron range.