JPS5943448B2 - Cosmetics containing pigmented powder of Sikon extract pigment - Google Patents

Description

[Detailed Description of the Invention] The present invention relates to a "purple root" plant of the family Trifoliaceae: Lit-ho
sperm erythrorhizon 5ie
bold et Zucc-arini (Litho
sperm official Linde
var.

erythrorhi zon Maxi mowi
The present invention relates to the application of a pigment component extract contained in the roots of C. c.sub.z) to new cosmetics.

Shikon is one of the representative herbal medicines listed in ``Nichishu,'' and has also been used as a dye since ancient times, and is known as ``Shikonzome.''

The pigment component extracted from Shikon is usually obtained as a red color, and the extract is extracted using an organic solvent such as benzene, ether, chloroform, acetone, or alcohol as the extraction solvent.

The pigment component of the extract extracted from Shikonin is mainly composed of Shikonin and Shikonin derivatives, and has the characteristic that it exhibits a red color in weakly acidic to neutral conditions, and changes to the original purple color of Shikonin at a pH of around 8.

Therefore, when adding Sicon extract to general skin cosmetics or external ointments, the pH of the usual product should be 4 to 4.
Since it is finished at a pH of about 7, it took on a red color in this pH range.

Therefore, in order to obtain the beautiful purple color unique to Shicon in the normal pH range for cosmetics, the present inventors developed a combination of Shicon extract (Shikon derivative), a chelate of aluminum, and protein (albumin). The extract "Unpublished Patent Publication No. 1983-94432" was developed.

However, since this extract is water-soluble, it has been difficult to add it to the base of oil-based cosmetics and external ointments.

Therefore, in order to improve this drawback, the present inventor made various studies and, as a result, used extracted powder of silk fibroin and keratin obtained from the hair and feathers of livestock animals, and added it to an aluminum salt solution. By soaking the powder in water and further adding Sicon extract to fix it on the above-mentioned protein, we succeeded in obtaining a pigmented powder exhibiting an extremely excellent purple color tone.

This material is easily dispersed in oil, has less fading due to sunlight, and is extremely easy to handle.

EXAMPLES Below, in order to further describe the present invention in detail, examples will be shown and described more specifically.

Example 1: Production method using silk fibroin powder Part 5 While stirring aluminum acetate aqueous solution 51,
Powder mainly composed of fibroin (protein) obtained from 1 kg of silk was added, stirred well to disperse it, left overnight, and filtered to remove silk protein powder using suction filtration.
Wash with 0TLl of water.

Next, 20 g of Shikon extract (concentrated soft extract containing mainly Shikonin and Shikonin derivatives) was dissolved again in 200 ml of ether, 21 mL of ethanol was added thereto, and 50 to 6
The previously obtained aluminum acetate-fixed silk protein powder is added to a solution of 0° C. hot water 41, and left for 90 minutes on a 60-70° C. water bath with occasional stirring.

Next, it was taken out of the hot water bath and left to stand at room temperature for two days and nights, thereby completing the fixation of the pigment component to the silk protein powder.Next, the precipitate resulting from the standing was dehydrated by suction filtration, and ethanol was added. 51 for 60 minutes, and then filtered with suction to remove the precipitate.

The precipitate separated by filtration was air-dried overnight and then heated at 80±5℃ for 6 hours.
After drying under reduced pressure for a period of time, a pigmented powder of purple shikon extracted pigment is obtained.

Example 2: Production method using keratin powder obtained from animal hair or feathers While stirring an aqueous aluminum chloride solution 61, 1k
Add powder mainly composed of keratin (protein) obtained from sheep's wool, chicken, duck, etc., stir well to disperse, leave overnight, and then filter with suction to obtain protein mainly composed of keratin. The powder is filtered off and washed with approx. 157 g of water.

Next, 5 g of Shikon extract (concentrated soft extract obtained by extracting Shikon with ethanol and containing mainly Shikonin and Shikonin derivatives) was dissolved again in ethanol 21, and then heated with 50-60°C water. The previously obtained aluminum acetate-fixed keratin protein powder is added to the solution to which No. 41 has been added, and the mixture is left for 60 minutes on a water bath at 60 to 70° C. with occasional stirring.

Next, it is taken out from the hot water bath and left to stand at room temperature for two days and nights to complete the fixation of the pigment component to the keratin protein powder, and then the precipitate resulting from the standing is dehydrated by suction filtration. After immersing it in ethanol 51 for 30 minutes, it is filtered with suction to remove the precipitate.

The filtered precipitate is air-dried overnight and then dried under reduced pressure at 60±5° C. for 6 hours to obtain a reddish-purple pigmented powder of Sikon extract pigment.

The protein pigments made from Shicon pigments obtained in Examples 1 and 2 are not simply dried in a mixed state of both (the pigment derived from Shicon and the protein), but also the protein pigments obtained by Shicon pigments are mixed into the protein powder used. It is also different from the one in the adsorbed state.

This is clearly shown in the stability in the elution test shown in Table 2 and the optical external absorption spectra shown in Figures 1 to 4, which clearly shows that both substances are in a bonded state, and therefore stable. It was assumed that her sex had improved.

In other words, considering the features of the pigment powders according to Examples 1 and 2 from the structural and manufacturing process standpoints, as shown in FIG. Next, (2) a shikonin derivative (pigment component) is produced in the order in which it is fixed on the protein.

As a result, it can be said that a stable pigmented powder could be obtained.

That is, the pigmented powders obtained in Examples 1 and 2 contain fibroin, keratin, etc., which are the raw materials for their production.
Aluminum is fixed through the histidine residues of the animal-derived protein powder, and the pigment component shikonin and its derivatives contained in the shikonin extract undergo chelation bonding, which makes it highly resistant to water and alcohol. An insoluble reactant can be obtained, and as a result, a stable pigment can be obtained.

For the aqueous solutions of aluminum salts shown in the Examples, when obtaining a purple color, it is preferable to use 3-6 salts such as aluminum acetate and aluminum chloride.

In this case, if the concentration of the aluminum salt is greatly excessive, the shikonin derivative component tends to stick to the animal protein powder.

If you want to get even more reddish-purple color, use aluminum salt 0.5~
It is preferable to use an aqueous solution of about 2%.

Additionally, in Examples 1 and 2, unfixed aluminum was completely washed with water, and if this washing was incomplete, the aluminum and the dye component were chelate bonded after the operation of adding the dye component of Shicon. For this reason, it becomes insoluble and there is a risk that it will simply be mixed into the animal protein powder used, so it is desirable to take sufficient care in washing with water.

In Examples 1 and 2, extracts obtained by extraction with ether and ethanol were used as the Citrus extract, but the Citrus extract need not be particularly limited, and any of the extracts extracted using the above-mentioned known solvents can be used.

In other words, it can be controlled by the amount of soft extract of Citrus chinensis used. For example, when manufacturing according to the manufacturing method of Examples 1 and 2, it is preferable to use the amount shown in the table below (Table 1).

- The silk fibroin powder used as the protein powder is commercially available, and is usually prepared by defatting silk fibers and grinding them into a fine powder using a pulverizer.

- Protein powders obtained from the hair or feathers of domestic animals include, for example, powders made by defatting wool or chicken feathers, freezing them at about -180°C using liquid nitrogen, and pulverizing them. In the latter case, it is preferable to use a powder that has been pulverized under instantaneous high pressure at high temperature and further pulverized.

In addition, the hair or feathers used themselves have colored pigments,
For example, for raw wool and hair, it is best to degrease and decolorize it and then grind it into a fine powder using one of the above methods. Keratin powder or chicken feather keratin powder may be used.

Now, when using the pigmented powder of Sikon extracted pigment obtained by the method shown in Examples 1 and 2 in cosmetics, there are the following advantages.

1) When used in water-based products, the stability against light is improved compared to products in which shikonin and its derivatives are simply dissolved.

2) It can also be used in products that do not contain coloring solvents such as alcohol.

3) Since it is insoluble in water and various solvents, when a product containing this pigment is applied to the face, there is no elution of the pigment caused by moisture such as sweat, and makeup is less likely to come off.

Table 2 above shows the test results regarding the absence of elution of the pigment as a pigmented powder. This is a look at the elution of the dye.

In other words, as shown in Table 2, in the pigment cosmetic powder obtained in the example, the pigment does not elute again.

On the other hand, in the case of conventional Shikon extract alone or in the form of a simple mixed powder, it is eluted into the formulation in a solvent often used in cosmetics, and the eluted pigment is not purple but red. present.

Next, the application of the purple pigmented powder according to the present invention to cosmetics will be described based on Examples.

Example 3. : Oily cream stearic acid ・・・・・・・・・・・・・・・・・・
・・・・・・ s, o % beeswax ・・・・・・
・・・・・・・・・・・・・・・・・・10.0 Liquid paraffin・・・・・・・・・・・・・・・・・・・・・
・・・30.0 Safflower oil ・・・・・・・・・・・・
・・・・・・・・・・・・・・・ 7.0 Lecithin
・・・・・・・・・・・・・・・・・・・・・・・・
0.5 Nonionic surfactant・・・・・・・・・・・・
・・・・・・ 2.0 Propylene glycol・・・・・・
・・・・・・・・・ 5.0 Pigmented powder obtained in Example 1 ・・・・・・・・・ 1.0 Antioxidant ・・・・・・
・・・・・・・・・・・・・・・・・・Appropriate amount of preservative and fungicide ・・・・・・・・・・・・・・・・・・・・・・・・
・〃Fragrance・・・・・・・・・・・・・・・・
·······〃purified water ···········
36.5 (Production method) Melt and mix stearic acid, beeswax, liquid paraffin, flower oil, lecithin, and antioxidant, and keep warm at 80°C.

Next, the pigmented powder containing the pigment component of Sicon obtained in Example 1 was kneaded in advance with propylene glycol, added to a nonionic surfactant and dispersed, and then added to the oil phase kept at 80°C to emulsify. I do.

After emulsification, flavoring is added and the product is rapidly cooled to room temperature and then filled into containers.

Example 3: Blushing talc 4 songs 45.0
% carrion ・・・・・・・・・・・・・・・・・・
・・・・・・15.0 Magnesium carbonate・・・・・・
・・・・・・・・・・・・・・・ 5.0 Zinc stearate ・・・・・・・・・・・・・・・・・・ 5
．． 0Titanium dioxide ・・・・・・・・・・・・・・・
・10.0 Pigmented powder obtained in Example 2
・20,0 fragrance ・・・・・・・・・・・・・・・
・・・・・・・・・Appropriate amount (manufacturing) Pigmented powder containing talc, kaolin, magnesium carbonate, zinc stearate, titanium dioxide, and the pigment components of the shicon obtained in Example 2 was mixed with a stirring crusher. Add a small amount of alcohol, grind and mix, add fragrance, and mold into a product.

Example: Gel lotion glycerin ・・・・・・・・・・・・・・・・・・
・・・・・・ 2.0 Propylene glycol・・・・
・・・・・・・・・・・・ 4.0 Carboxy vinyl polymer ・・・・・・ 0.3 Pigmented powder obtained in Example 1 ・・・・・・ 0.4 Nonionic interface Activator...
・・・・・・・・・・・・・・・ 0.5 ethanol
・・・・・・・・・・・・・・・・・・・・・・・・
7.0 Preservative disinfectant ・・・・・・・・・
Appropriate amount of fragrance ・・・・・・・・・・・・・・・・・・
・・・・・・〃Purified water ・・・・・・・・・・・・・・・
85.8 The pigmented powder obtained in Example 1 using the pigment component of Shicon is kneaded with glycerin and propylene glycol, and added to an aqueous solution of carboxyvinyl polymer.

Next, add preservatives, sterilizers, non-iodine surfactants, and fragrances in advance.
Add the solution dissolved in ethanol, disperse it evenly, and then fill it into a container to make the product.

[Brief explanation of the drawing]

Figures 1 to 4 show patterns of optical external absorption spectra (barium bromide method). FIG. 1 shows the pigmented powder obtained in Example 1. Figure 2 shows a powder simply mixed with silk fibroin protein powder and shikon extract (soft extract). Figure 3 shows silk fibroin protein powder. Figure 4 shows Shikon extract (soft extract). Figure 5 is a schematic diagram of the pigmented powder according to Example 1 or 2, and the number 1.2 in the figure indicates the order of reaction (bonding) in the manufacturing process. The residue is a histidine group. A1 is aluminum, R of shikonin chelate bonded to A1 is -H, -CO-CH-(CH) 2. −
CO-CH=(CH3)2. -CO-CH2-CO-C
H2-C= C(CH3)2゜H3

Claims (1)

[Claims] 1 Protein powder mainly composed of fibroin obtained by defatting silk fibers and then pulverizing, or protein powder mainly composed of keratin obtained by defatting and pulverizing the hair or feathers of domestic animals, in an aluminum salt solution. After soaking in water, unfixed aluminum salts were removed, and then Shikone and its derivatives, which are pigment components extracted from purple roots, were added, and the mixture was soaked in a water bath at 60 to 70°C with occasional stirring.
After being allowed to stand for 2 days and nights at room temperature, the resulting precipitate was dehydrated and taken out, immersed in ethanol, filtered with suction to take out the precipitate, air-dried, and then dried under reduced pressure. Cosmetics containing pigmented powder of pigment extracted from Sicon.