JPS5928973A - Production of syringe filled with drug - Google Patents
Production of syringe filled with drugInfo
- Publication number
- JPS5928973A JPS5928973A JP57136843A JP13684382A JPS5928973A JP S5928973 A JPS5928973 A JP S5928973A JP 57136843 A JP57136843 A JP 57136843A JP 13684382 A JP13684382 A JP 13684382A JP S5928973 A JPS5928973 A JP S5928973A
- Authority
- JP
- Japan
- Prior art keywords
- syringe
- drug solution
- rear end
- gasket
- tip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明は、予め薬液を充填した注射筒の製造方法に関す
る。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for manufacturing a syringe filled with a medicinal solution in advance.
この種の注射筒は従来の薬液容器から使用時に注射筒へ
薬液を移し替える式のものに比べて移し替えの作業を不
用とし、その際の細菌による汚染やガラスやゴムの細片
の混入の危険がない点で優れているばかりでなく、薬液
が極めて高価な場合には薬液容器に付着して残存する量
、また移し替えの際に失われる量を無視することができ
ず、このような不経済を避けるために極めて有効である
。薬液の移し替えに起因する誤用を防止する効果もあり
この種の注射筒に薬液を充填して製造する方法は種々提
案されており、例えば、注射筒の後端開口から挿入した
ガスケットを有するプランジャーロッドを固定し、注射
筒中を負圧にした後、注射筒の先端の注射針装着筒を薬
液に浸漬して、この注射筒中の負圧を利用して薬液を充
填する方法や真空室の中でガスケットを挿入したりする
方法がある。この方法によるときは注射筒への薬液充填
が同時に多数本に亘って行うことができるが真空の雰囲
気をつくってから挿入しなければならないため、時間的
な制約を受けたり気f1¥7c保ち得る特殊な容器内で
作業しなければならず、また注射筒の内径にパラつきが
あp、またプランジャーロッドの挿入位置が不統一であ
る場合、更にガスケット表面の凹凸形状の不統一等によ
り正確に所定量の薬液を充填することが困難でToり、
このため所定量よ1多目の薬液を充填しなければならず
、薬液が高価な場合には製品コストを上昇させる不都合
がある。This type of syringe eliminates the need for transfer work compared to conventional ones that transfer the drug solution from the drug container to the syringe at the time of use. Not only is it superior in that it is not dangerous, but when the chemical solution is extremely expensive, the amount that remains on the drug solution container and the amount that is lost during transfer cannot be ignored. This is extremely effective in avoiding diseconomies. Various methods have been proposed for manufacturing this type of syringe by filling it with a drug solution, which also has the effect of preventing misuse due to transfer of the drug solution.For example, a plan with a gasket inserted from the rear end opening of the syringe barrel After fixing the jar rod and creating a negative pressure inside the syringe barrel, the syringe needle mounting barrel at the tip of the syringe barrel is immersed in the drug solution, and the negative pressure inside the syringe barrel is used to fill the drug solution. There is a way to insert a gasket inside. When using this method, it is possible to fill multiple syringes with drug solution at the same time, but since a vacuum atmosphere must be created before insertion, there may be time constraints and the risk of air leakage. If the work has to be done in a special container, the inner diameter of the syringe barrel is uneven, the insertion position of the plunger rod is uneven, and the uneven shape of the gasket surface is uneven, etc. It is difficult to fill the specified amount of chemical solution into the container.
For this reason, it is necessary to fill the container with one more chemical solution than the predetermined amount, and if the drug solution is expensive, there is an inconvenience that the product cost increases.
本発明はかかる従来の欠点を解消し、高価な薬液を所定
量のみ確実に充填することができる薬液充填済みの注射
筒の製造方法全提供するもので、注射筒先端の注射針の
装着筒を閉塞し、該注射筒の後端から薬液を充填する式
の薬液充填済みの注射筒の製造方法において、装着筒t
−aで閉塞した注射筒の後端開口を上方として垂直に保
持し、該後端開口から薬液を注射筒中に注入し、次いで
中空細管を注射筒の後端からその内面に沿わせて薬液面
より僅かに離れる位置まテ挿入して注射筒内と注射筒外
とを連通させて固定し、次いでガスケットを先端に備え
たプランジャーロツPを注射筒の後端開口から挿入しガ
スケット先端を中空細管先端の位置まで進入させ注射筒
中の空気をシト除した彼、中空細管を抜去することを特
徴とする。The present invention eliminates such conventional drawbacks and provides a complete method for manufacturing a syringe filled with a drug solution that can reliably fill only a predetermined amount of an expensive drug solution. In a method for manufacturing a syringe filled with a drug solution, the syringe barrel is closed and the drug solution is filled from the rear end of the syringe barrel.
- Hold the syringe vertically with the rear end opening of the closed syringe upward, inject the drug solution into the syringe barrel from the rear end opening, and then insert the hollow tube from the rear end of the syringe barrel along the inner surface of the syringe so that the drug solution level Insert the syringe into a position that is slightly further apart to establish communication between the inside of the syringe and the outside of the syringe, and then insert the plunger rod P with a gasket at the tip from the opening at the rear end of the syringe to make the gasket tip hollow. The syringe is characterized by advancing to the tip of the tubule, removing the air in the syringe, and then removing the hollow tubule.
本発明の実施の一例を示す第1図及び第2図に従って詳
説すれば次の通りである。第1図は、本発明の実施に使
用する注射筒(1)及びガスケット(2)を有するプラ
ンジャーロツF′(31を示す。注射筒(1)はその先
端の筒先部(4)に該筒先部(4)を充填密封するノぞ
ツキング材でおる栓(5)を嵌着し、該栓(5)の底面
(6)1−注射筒(1)の前端内面(7)と一致させ薬
液aを充填した際に薬液aが筒先部(4)に侵入しない
ようにした、(8)は先端に注射針装着筒(9)を備え
た装着筒で、前記栓(5)を保持して筒先部(4)に固
着されている。(1Gはキャップである。A detailed explanation will be given below with reference to FIGS. 1 and 2 showing an example of the implementation of the present invention. FIG. 1 shows a plunger rod F' (31) having a syringe barrel (1) and a gasket (2) used in the practice of the present invention. Fit the stopper (5) covered with a slotting material to fill and seal the barrel tip (4), aligning the bottom surface (6) 1 of the stopper (5) with the inner surface (7) of the front end of the syringe barrel (1). (8) is a mounting barrel equipped with a syringe needle mounting barrel (9) at the tip, which prevents the drug solution a from entering the barrel tip (4) when filled with the drug solution a, and holds the stopper (5). (1G is a cap).
プランジャーロッド(3)と軟質合成樹脂などのガスケ
ット(2)とは螺着されており分離日夜とした。The plunger rod (3) and the gasket (2) made of soft synthetic resin were screwed together and could be separated.
次に前記注射筒(1)に薬液at充填する本発明の詳細
な説明すると、#!2図A示の如く栓(5)により装着
筒(8)を閉塞した注射筒(1)を後端開口を上方にし
て喬直に保持し、後端開口から分注器のノズルbによっ
て薬液aの所定量を注入する。Next, a detailed description of the present invention for filling the syringe (1) with a drug solution will be given.#! As shown in Figure 2A, hold the syringe barrel (1) with the mounting barrel (8) closed with the stopper (5) vertically with the rear end opening upward, and dispense the drug solution from the rear end opening with the nozzle b of the dispenser. Inject a predetermined amount of a.
この際注射筒+1)中の薬液1表面には気泡が生じる場
合が多い。At this time, bubbles are often generated on the surface of the drug solution 1 in the syringe barrel +1).
次いで第2図B示の如く中空細管αDを保持した保持枠
(1aを注射筒(1)の後端開口に、その溝に形成した
案内孔(11を一致させて載置すると共に井背・細管a
11の先端を注射筒(1)中の薬液1表面の気泡に接触
しないように薬液の表面から僅かに離れる位置まで注射
筒(1)内面に沿わせて挿入する。Next, as shown in FIG. 2B, place the holding frame (1a) holding the hollow tube αD in the rear end opening of the syringe barrel (1), aligning the guide hole (11) formed in the groove, and tubule a
Insert the tip of 11 along the inner surface of the syringe barrel (1) to a position slightly away from the surface of the drug solution so as not to contact the air bubbles on the surface of the drug solution 1 in the syringe barrel (1).
次いでli2図C示の如く保持枠(Izの案内孔−を介
して先端にガスケット(2)を備えたプランジャーロッ
ド(3)t−注射筒(1)中へ挿入しガスケット(2)
の先端が中空細管allの先端位置まで挿入しつつ注射
筒(1)中の空気を中空側Iffa1)を介して排除し
た後に、中空細管αDを抜去した。前記実施例にあって
は中空細管aDの挿入長さは、注射筒(1)へ充填する
薬液aの所定量によって決定される注射筒(1)中の薬
液aの表面の位置音測定し、中空細管09を挿入した際
に保持枠α諺が注射# (1)の後端に係止して新宅位
置以上に挿入されないように予め調整した。またガスケ
ット(2)付Oプランジャーロッド(3)の挿入位置は
プランジャーロッド(3)の後端に形成した突片Iが保
持枠部O案内孔α四の周囲に設けた縁部α9に係止して
ガスケット(2)の先端面が中空細管(11)の先端以
上の挿入されないようにした。Next, as shown in Figure C, insert the plunger rod (3), which has a gasket (2) at its tip, into the syringe barrel (1) through the guide hole of the holding frame (Iz), and insert the gasket (2) into the syringe barrel (1).
After the air in the syringe barrel (1) was expelled through the hollow side Iffa1) while the tip of the syringe was inserted to the tip position of the hollow tubule all, the hollow tubule αD was removed. In the above embodiment, the insertion length of the hollow tube aD is determined by measuring the position of the surface of the drug solution a in the syringe barrel (1), which is determined by the predetermined amount of the drug solution a to be filled into the syringe barrel (1), Adjustment was made in advance so that when the hollow tube 09 was inserted, the holding frame α would be locked to the rear end of the injection # (1) and would not be inserted beyond the new position. In addition, the insertion position of the O plunger rod (3) with the gasket (2) is such that the protrusion I formed at the rear end of the plunger rod (3) is inserted into the edge α9 provided around the holding frame O guide hole α4. The gasket (2) was locked to prevent the distal end surface of the gasket (2) from being inserted beyond the distal end of the hollow tube (11).
以上の如く、中空細管αυの位置會充横された薬液龜の
嵌置エク僅かに離さないと、ガスケット(2)の挿入に
よって気泡や菓ikaが中空細管Ut通じて溢流し、ま
た薬液aが中空側gl(Ll)の外面における毛細管現
象によってガスケット(2)と注射筒αJの内面との間
に浸入し、所定量の薬液aを注射筒(1)に充填するこ
とが出来ないばかりか、ガスケット(2)の周mまで薬
laが浸入すゐときはガスケット(2)の論断における
漏洩と区別することができなぐなる。As mentioned above, if the position of the hollow capillary αυ is not slightly released, air bubbles and liquids will overflow through the hollow capillary Ut due to the insertion of the gasket (2), and the chemical solution a will Due to capillary action on the outer surface of the hollow side GL (Ll), it enters between the gasket (2) and the inner surface of the syringe barrel αJ, and not only is it impossible to fill the syringe barrel (1) with a predetermined amount of drug solution a. When the drug la infiltrates up to the circumference m of the gasket (2), it is impossible to distinguish it from leakage caused by the gasket (2).
以上の説明から明らかなように本考案によるときは、栓
で閉塞した注射筒の後端開口を上方として垂直に保持し
て薬液を注射筒中に注入した後、中空細管を注射筒の後
端からその内面に沿わせて薬液面工多僅かに離れる位置
まで挿入し注射筒内外を連通した後、ガスケットを先端
に備えたプランジャーロッドを挿入し、ガスケット先端
が中空細管の先端位置まで進入させて注射筒中の空気を
排除するので、この空気抜き操作中に薬液が溢流した夛
ガスケット局面に進入することがなく確実に所定量の薬
V、を充填することができるので高価な薬液にあっても
無駄なく充填することができ従って、製品のコストダウ
ンを図ることができる薬液充填済みの注射筒の製造方法
を提供するの効果がある。As is clear from the above explanation, when the present invention is used, the syringe is held vertically with the rear end opening of the syringe closed with a stopper facing upward, and after the drug solution is injected into the syringe, the hollow thin tube is inserted from the rear end of the syringe. Insert the drug solution along its inner surface until it is slightly separated from the inside of the syringe barrel to communicate between the inside and outside of the syringe barrel, then insert the plunger rod with a gasket at the tip, and move the plunger rod until the gasket tip reaches the tip of the hollow tube. Since the air in the syringe barrel is removed, the drug solution will not enter the overflowing gasket surface during this air venting operation, and the prescribed amount of drug V can be reliably filled, even with expensive drug solutions. The present invention has the effect of providing a method for manufacturing a syringe filled with a drug solution, which can be filled without waste and thus reduce the cost of the product.
第1図及び第2図は本発明の実施の一例を示すもので第
1図はその実施例に使用する注射筒及びガスケット付プ
ランジャーロッドの一部截除平面図、第2図は篤1図の
注射筒を用いた製造工程を示す線図である。
(1)・・・注射筒 (2)・・・ガスケッ
ト(3)・・・プランジャー目ツド(8)・・・注射針
装着部tL])・・・中空細管 a・・・薬液
外2名1 and 2 show an example of the implementation of the present invention. FIG. 1 is a partially cutaway plan view of a syringe barrel and a plunger rod with a gasket used in the embodiment, and FIG. FIG. 3 is a diagram showing a manufacturing process using the syringe shown in the figure. (1)...Syringe barrel (2)...Gasket (3)...Plunger eye (8)...Needle attachment part tL])...Hollow thin tube a...Outside drug solution 2 given name
Claims (1)
の後端から薬液を充填する式の薬液充填済みの注射筒の
製造方法において、装着筒を栓で閉寒した注射筒の後端
開口を上方として垂直に保持し、該後端開口から薬液を
注射筒中に注入し、次いで中空細管を注射筒の後端から
その内面に沿わせて薬液面より僅かに離ねる位置まで挿
入して注射筒内と注射筒外とを連通させて固定し、次い
でガスケットを先端に備えたプランジャーロッドを注射
筒の後端開口から挿入しガスケット先端を中空細管先端
の位置まで進入させ注射筒中の空気を排除した後、中空
細管を抜去することを特徴とする薬液充填済みの注射筒
の製造方法。1. In a method for manufacturing a syringe filled with a drug solution, in which the syringe with which the syringe needle is attached at the tip of the syringe is closed and the drug solution is filled from the rear end of the syringe, the syringe with the syringe attached is closed with a stopper. Hold the syringe vertically with the rear end opening upward, inject the drug solution into the syringe barrel from the rear end opening, and then insert the hollow tube from the rear end of the syringe barrel along its inner surface until it is slightly away from the drug solution level. The inside of the syringe and the outside of the syringe are communicated and fixed, and then a plunger rod with a gasket at the tip is inserted from the rear end opening of the syringe, and the gasket tip is advanced to the position of the tip of the hollow tube to enter the syringe. 1. A method for manufacturing a syringe filled with a drug solution, the method comprising: removing air after removing the hollow tube.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57136843A JPS5928973A (en) | 1982-08-07 | 1982-08-07 | Production of syringe filled with drug |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57136843A JPS5928973A (en) | 1982-08-07 | 1982-08-07 | Production of syringe filled with drug |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5928973A true JPS5928973A (en) | 1984-02-15 |
JPH0155027B2 JPH0155027B2 (en) | 1989-11-22 |
Family
ID=15184801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP57136843A Granted JPS5928973A (en) | 1982-08-07 | 1982-08-07 | Production of syringe filled with drug |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5928973A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62194866A (en) * | 1985-12-20 | 1987-08-27 | マリンクロッド・メディカル・インコーポレイテッド | Production of sterilized pre-packed plastic syringe |
US4840265A (en) * | 1986-08-29 | 1989-06-20 | Kabushiki Kaisha Maki Seisakusho | Object distributing and supplying method and apparatus |
JP2008212213A (en) * | 2007-02-28 | 2008-09-18 | Hisamitsu Pharmaceut Co Inc | Vacuum capper |
-
1982
- 1982-08-07 JP JP57136843A patent/JPS5928973A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62194866A (en) * | 1985-12-20 | 1987-08-27 | マリンクロッド・メディカル・インコーポレイテッド | Production of sterilized pre-packed plastic syringe |
JPH0634827B2 (en) * | 1985-12-20 | 1994-05-11 | マリンクロッド・メディカル・インコーポレイテッド | Pre-filled sterile plastic syringe and method of manufacturing the same |
US4840265A (en) * | 1986-08-29 | 1989-06-20 | Kabushiki Kaisha Maki Seisakusho | Object distributing and supplying method and apparatus |
JP2008212213A (en) * | 2007-02-28 | 2008-09-18 | Hisamitsu Pharmaceut Co Inc | Vacuum capper |
Also Published As
Publication number | Publication date |
---|---|
JPH0155027B2 (en) | 1989-11-22 |
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