JPS5928973A - Production of syringe filled with drug - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for manufacturing a syringe filled with a medicinal solution in advance.

This type of syringe eliminates the need for transfer work compared to conventional ones that transfer the drug solution from the drug container to the syringe at the time of use. Not only is it superior in that it is not dangerous, but when the chemical solution is extremely expensive, the amount that remains on the drug solution container and the amount that is lost during transfer cannot be ignored. This is extremely effective in avoiding diseconomies. Various methods have been proposed for manufacturing this type of syringe by filling it with a drug solution, which also has the effect of preventing misuse due to transfer of the drug solution.For example, a plan with a gasket inserted from the rear end opening of the syringe barrel After fixing the jar rod and creating a negative pressure inside the syringe barrel, the syringe needle mounting barrel at the tip of the syringe barrel is immersed in the drug solution, and the negative pressure inside the syringe barrel is used to fill the drug solution. There is a way to insert a gasket inside. When using this method, it is possible to fill multiple syringes with drug solution at the same time, but since a vacuum atmosphere must be created before insertion, there may be time constraints and the risk of air leakage. If the work has to be done in a special container, the inner diameter of the syringe barrel is uneven, the insertion position of the plunger rod is uneven, and the uneven shape of the gasket surface is uneven, etc. It is difficult to fill the specified amount of chemical solution into the container.
For this reason, it is necessary to fill the container with one more chemical solution than the predetermined amount, and if the drug solution is expensive, there is an inconvenience that the product cost increases.

The present invention eliminates such conventional drawbacks and provides a complete method for manufacturing a syringe filled with a drug solution that can reliably fill only a predetermined amount of an expensive drug solution. In a method for manufacturing a syringe filled with a drug solution, the syringe barrel is closed and the drug solution is filled from the rear end of the syringe barrel.
- Hold the syringe vertically with the rear end opening of the closed syringe upward, inject the drug solution into the syringe barrel from the rear end opening, and then insert the hollow tube from the rear end of the syringe barrel along the inner surface of the syringe so that the drug solution level Insert the syringe into a position that is slightly further apart to establish communication between the inside of the syringe and the outside of the syringe, and then insert the plunger rod P with a gasket at the tip from the opening at the rear end of the syringe to make the gasket tip hollow. The syringe is characterized by advancing to the tip of the tubule, removing the air in the syringe, and then removing the hollow tubule.

A detailed explanation will be given below with reference to FIGS. 1 and 2 showing an example of the implementation of the present invention. FIG. 1 shows a plunger rod F' (31) having a syringe barrel (1) and a gasket (2) used in the practice of the present invention. Fit the stopper (5) covered with a slotting material to fill and seal the barrel tip (4), aligning the bottom surface (6) 1 of the stopper (5) with the inner surface (7) of the front end of the syringe barrel (1). (8) is a mounting barrel equipped with a syringe needle mounting barrel (9) at the tip, which prevents the drug solution a from entering the barrel tip (4) when filled with the drug solution a, and holds the stopper (5). (1G is a cap).

The plunger rod (3) and the gasket (2) made of soft synthetic resin were screwed together and could be separated.

Next, a detailed description of the present invention for filling the syringe (1) with a drug solution will be given.#! As shown in Figure 2A, hold the syringe barrel (1) with the mounting barrel (8) closed with the stopper (5) vertically with the rear end opening upward, and dispense the drug solution from the rear end opening with the nozzle b of the dispenser. Inject a predetermined amount of a.

At this time, bubbles are often generated on the surface of the drug solution 1 in the syringe barrel +1).

Next, as shown in FIG. 2B, place the holding frame (1a) holding the hollow tube αD in the rear end opening of the syringe barrel (1), aligning the guide hole (11) formed in the groove, and tubule a
Insert the tip of 11 along the inner surface of the syringe barrel (1) to a position slightly away from the surface of the drug solution so as not to contact the air bubbles on the surface of the drug solution 1 in the syringe barrel (1).

Next, as shown in Figure C, insert the plunger rod (3), which has a gasket (2) at its tip, into the syringe barrel (1) through the guide hole of the holding frame (Iz), and insert the gasket (2) into the syringe barrel (1).
After the air in the syringe barrel (1) was expelled through the hollow side Iffa1) while the tip of the syringe was inserted to the tip position of the hollow tubule all, the hollow tubule αD was removed. In the above embodiment, the insertion length of the hollow tube aD is determined by measuring the position of the surface of the drug solution a in the syringe barrel (1), which is determined by the predetermined amount of the drug solution a to be filled into the syringe barrel (1), Adjustment was made in advance so that when the hollow tube 09 was inserted, the holding frame α would be locked to the rear end of the injection # (1) and would not be inserted beyond the new position. In addition, the insertion position of the O plunger rod (3) with the gasket (2) is such that the protrusion I formed at the rear end of the plunger rod (3) is inserted into the edge α9 provided around the holding frame O guide hole α4. The gasket (2) was locked to prevent the distal end surface of the gasket (2) from being inserted beyond the distal end of the hollow tube (11).

As mentioned above, if the position of the hollow capillary αυ is not slightly released, air bubbles and liquids will overflow through the hollow capillary Ut due to the insertion of the gasket (2), and the chemical solution a will Due to capillary action on the outer surface of the hollow side GL (Ll), it enters between the gasket (2) and the inner surface of the syringe barrel αJ, and not only is it impossible to fill the syringe barrel (1) with a predetermined amount of drug solution a. When the drug la infiltrates up to the circumference m of the gasket (2), it is impossible to distinguish it from leakage caused by the gasket (2).

As is clear from the above explanation, when the present invention is used, the syringe is held vertically with the rear end opening of the syringe closed with a stopper facing upward, and after the drug solution is injected into the syringe, the hollow thin tube is inserted from the rear end of the syringe. Insert the drug solution along its inner surface until it is slightly separated from the inside of the syringe barrel to communicate between the inside and outside of the syringe barrel, then insert the plunger rod with a gasket at the tip, and move the plunger rod until the gasket tip reaches the tip of the hollow tube. Since the air in the syringe barrel is removed, the drug solution will not enter the overflowing gasket surface during this air venting operation, and the prescribed amount of drug V can be reliably filled, even with expensive drug solutions. The present invention has the effect of providing a method for manufacturing a syringe filled with a drug solution, which can be filled without waste and thus reduce the cost of the product.

[Brief explanation of drawings]

1 and 2 show an example of the implementation of the present invention. FIG. 1 is a partially cutaway plan view of a syringe barrel and a plunger rod with a gasket used in the embodiment, and FIG. FIG. 3 is a diagram showing a manufacturing process using the syringe shown in the figure. (1)...Syringe barrel (2)...Gasket (3)...Plunger eye (8)...Needle attachment part tL])...Hollow thin tube a...Outside drug solution 2 given name

Claims (1)

[Claims] 1. In a method for manufacturing a syringe filled with a drug solution, in which the syringe with which the syringe needle is attached at the tip of the syringe is closed and the drug solution is filled from the rear end of the syringe, the syringe with the syringe attached is closed with a stopper. Hold the syringe vertically with the rear end opening upward, inject the drug solution into the syringe barrel from the rear end opening, and then insert the hollow tube from the rear end of the syringe barrel along its inner surface until it is slightly away from the drug solution level. The inside of the syringe and the outside of the syringe are communicated and fixed, and then a plunger rod with a gasket at the tip is inserted from the rear end opening of the syringe, and the gasket tip is advanced to the position of the tip of the hollow tube to enter the syringe. 1. A method for manufacturing a syringe filled with a drug solution, the method comprising: removing air after removing the hollow tube.