JPS59212405A - Antimildew composition - Google Patents

Abstract

PURPOSE:The titled composition that is obtained by adding 2-(4-thiazolyl)-benzimidazole, a long-chain alkyl dimethyl benzyl ammonium salt and an N<alpha>-acyl basic aminoacid ester to a specific solvent, thus being suitable for use in moist places. CONSTITUTION:At least 0.01wt%, preferably more than 0.02wt% of 2-(4-thiazolyl)-benzimidazole, a long-chain alkyl dimethyl benzyl ammonium salt and a lower alkyl salt of an N<alpha>-long chain acyl basic aminoacid, respectively, are added to a solvent containing a water-insoluble high molecular weight compound, preferably a derivative of polyvinyl alcohol to give the objective composition. The solvent for preparing a solution of the water-insoluble high polymer is preferably ethanol. The weight ratio of 2-(4-thia-zolyl)-benzimidazole to the long- chain alkyl dimethyl benzyl ammonium salt is preferred to be 4:1-1:4 in particular.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel antifungal composition that maintains a strong antifungal effect for a long period of time even when wet with water and has excellent storage stability.

In recent years, as the number of houses with highly airtight air conditioning and heating systems has increased, mold has begun to grow not only in relatively humid areas such as bathrooms and kitchens, but also in closets, large bags, etc. , suppression of this has become a major issue from an aesthetic standpoint.

By the way, there are a wide variety of types of mold that occur in normal living environments, and unless all of these types are eliminated, it is impossible to avoid the damage caused by the outbreak of mold.As a household fungicide, it is recommended to use a wide range of molds. There is a need for a substance that can be effective against water and other diseases, and that can maintain its effectiveness for a long period of time even in humid places. and,
Many household fungicides have been known to date, but none of them have a sufficient inhibitory effect on a wide range of molds, their efficacy does not last for a long time, and they are generally used in non-emulsifying types. The loss of effectiveness of this fungicide, dissolved in alcoholic solvents and in liquid form or sprayed using a propellant, is particularly noticeable in humid areas, such as bathrooms,
It is extremely difficult and rare to prevent mold from growing in areas that are likely to get wet, such as kitchens, over a long period of time.

In addition, stability at low temperatures in alcoholic solvents is an essential requirement in order to fully exhibit the antifungal effect.

The present inventors have overcome the shortcomings of conventional fungicides, have completely suppressed the growth of a wide variety of molds that occur in the living environment, and have long-lasting effects even in wet areas. We developed a fungicide composition containing a water-insoluble polymer compound to maintain its effectiveness over a period of time, but it was found that these had poor storage stability at low temperatures when used in alcohol-based solvents. .

Therefore, the present inventors aimed to obtain a composition that exhibits a complete growth-inhibiting effect against mold, maintains its effect for a long period of time even in locations that are easily wetted with water, and has excellent liquid stability. As a result of extensive research, the present invention has been completed. That is, the present invention is based on the present invention, in which 2-(4-thiazolyl)-benzimidazole and long-chain alkyldimethylbenzylammonium are added to a solvent containing a water-insoluble polymer compound. The present invention provides a fungicidal composition comprising a salt and a lower alkyl ester salt of an N"-long chain acyl basic amino acid at a concentration of at least 0.01% by weight, respectively.

Lu2-(
A compound represented by 4--1F-azolyl)-benzimidazole, which is known to exhibit a growth-inhibiting effect on many molds, but alone is not sufficient to completely suppress mold that grows in the home environment. Does not show strong anti-fungal properties.

The long-chain alkyldimethylbenzyl ammonium salt used as the other active ingredient is a compound represented by the general formula (where 几 is an alkyl group having 8 to 22 carbon atoms, and X is a halogen atom), and has antibacterial properties. Although it is known to have anti-fungal properties, it does not show sufficient anti-fungal effects against all the various types of mold that occur in the home environment when used alone.

In the present invention, as described above, each of these alone cannot exhibit a satisfactory effect as a household fungicide.
(4-Thiazolyl)-Benzimidashield long-chain alkyldimethylbenzyl ammonium salt and N''-long chain acyl basic amino ridge lower alkyl ester salt are used in combination to provide anti-fungal properties against individual molds. We have succeeded in obtaining a fungicide that synergistically enhances the anti-fungal properties, expands the anti-fungal spectrum, shows excellent effects against a wide variety of molds that occur in the home environment, and has excellent liquid stability. That's what I did.

The long-chain alkyldimethylbenzylammonium salts used in the present invention may be used alone or in combination of two or more -1c. Particularly preferred is benzalkonium chloride.

This 2-(4-thiazolyl)-benzimidazo-# and &
The blending ratio of the fi-furkyldimethylbenzyl ammonium salt is preferably 9:1 to 1:9, particularly preferably 4:1 to 1:4 by weight. Also,
The amount of each of these components used should be at least 0.01% by weight, based on the total composition. In a world where there are so few insects, sufficient antifungal effects cannot be obtained.

Next, water-insoluble polymer compounds include, for example, polyvinyl acetate, partially saponified polyvinyl acetate, formalized polyvinyl alcohol, formalized partially saponified polyvinyl acetate, butyralized polyvinyl alcohol, butyralized partially saponified polyvinyl acetate, ethylene- Saponified products of vinyl acetate copolymer, vinyl acetate-acrylamide copolymer, vinyl acetate-methyl vinyl ether copolymer, saponified product of vinyl chloride-vinyl acetate copolymer, etc. can be used, but vinyl acetate is preferred. homopolymers, copolymers, their saponified products, and their acetalized products. In addition, in view of the relationship with the solvent used to make the target composition into a homogeneous solution, alcohol-soluble ones are advantageous. In the present invention, this polymer compound is
It is used as a solution with a concentration of 0.01% by weight or more, preferably 0.1% by weight or more.

The solvent for preparing this gastric molecular compound solution may be an organic solvent or a mixture of an organic solvent and water. This organic solvent is methanol.

Lower alcohols such as ethanol, propatool, isopropanol, and ethylene glycol.

Lower diols such as propylene glycol.

Lower ketones such as acetone and methyl ethyl ketone are suitable. Particularly suitable in terms of safety and dryness are:
Ethanol, propatool or isopropatool, which are optionally used in combination with water.

Furthermore, the lower alkyl ester of Na-long chain acyl basic amino acid required to stably hold the fungicidal base material in a solution of a water-insoluble polymer compound has the following general formula 2), in which the long chain acyl group is lauroyl, cocoyl, etc. .

or a myristoyl group, particularly preferably a cocoyl group. The basic amino acid component is arginine or lysine, particularly preferably arginine.

In the present invention, the compounding amount is 0.01% by weight or more, preferably 0.02% by weight or more.

General formula 2) I RCO- is a fatty acid residue (C8+ 10+ 12y ta
l 16 ) To prepare the composition of the present invention, a given polymer compound is dissolved in a suitable solvent, and a given amount of 2-
Add (4-thiazolyl)-benzimidazole and long-chain alkyldimethylbenzyl-7sonium salt to form a homogeneous solution.

In this case, there is no particular restriction on the order of addition of the polymer compound, the two active ingredients, and the lower alkyl ester of N''-long-chain acrylic basic amino acid, and they may be added in any order or at the same time. You can also do it.

Since the composition of the present invention has good liquid stability, it can be prepared in any form of use such as application, spraying, or spreading. When the composition of the present invention is applied to the desired location, after drying,
The two active ingredients are immobilized by the polymer compound. Since this polymer compound is water-insoluble, the active ingredient will not be removed even if it gets wet with water, and its strong antifungal effect can be maintained for a long period of time.

Thus, the composition of the present invention comprises 2-(4-thiazolyl)
- By using benzimidazole in combination with a long-chain alkyldimethylbenzyl ammonium salt and a lower alkyl ester salt of a long-chain 7-syl basic amino acid, it has excellent liquid stability during use and has a low concentration. It has a broad anti-fungal spectrum and has a synergistic growth-inhibiting effect against a wide variety of molds.The water-insoluble polymer compound suppresses the elution of active ingredients, making it suitable for household use, especially in humid areas. It is suitable as a fungicide to be applied.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 2-(4-thiazolyl)-benzimidazole (hereinafter referred to as T
(abbreviated as BZ) and benzalkonium chloride (hereinafter referred to as AMB)
(abbreviated as ) and lower alkyl ester salt of Na-long chain acyl basic amino acid, IL alone or in combination were dissolved in ethanol and tested according to JI8-Z-2911r mold resistance test method, 7. An anti-mold test was carried out under the heading ``Testing of paint''. In other words, a filter paper (Toyo Roshi, NO2, 30 liters in diameter) was soaked in the ethanol solution of each sample, pulled out, and left indoors for 2 hours. Place the specified culture medium in a Petri colander at the center of the culture area, sprinkle the test mold spore suspension g, l cc evenly thereon, then cover the Petri colander for 14 days at a temperature of 28°C. Cultured. The culture medium at this time is water IQQQm, glucose 4
09, peptone 11 and agar 25.

In addition, the molds shown below were used as test molds.

Liquid stability was determined by putting it in a 100-glass bottle and storing it at -5"C, and then visually evaluating it after a predetermined period of time. O Evaluation criteria: O: No abnormalities observed △...・・Very slight insoluble matter Aυ×・・・・・・
The results, in which cloudiness or insoluble matter was clearly observed, are shown in Table 1.

Each symbol in the table has the following meaning.

−: No occurrence of mold is observed +: Slight occurrence of mold + Significant occurrence of mold is observed Example 2
0.1% and N''-cocoyl-L-arginine ethyl ester D.L pyrrolidone carboxylate 0.2% dissolved, and TBZ 0.2%, AMB
O, 1%, N”-cocoyl-L-arginine ethyl ester DL pyrrolidone carboxylate 0.2% to PVB (butyralized polyvinyl alcohol) 1.0
% was added and dissolved, and the propellant Freon 12 was further added in a ratio of 259/100 to prepare an aerosol type fungicide. This fungicide was sprayed on areas in the home where mold is likely to grow, and the mold growth status was investigated over a period of 6 months.

At the same time, the stability of the liquid content is also 100f, /
It was placed in a glass bottle, stored at -5°C, and visually evaluated, but no abnormality was observed even after 30 days.

This result is shown in the second light.

, Procedural amendment (method) September 24, 1980 Kazuo Wakasugi, Commissioner of the Patent Office 1, Indication of case Patent Application No. 85789, 1982 2
, Title of the invention: Fungicidal composition 3, Relationship to the 1ffi case Patent applicant: Honjo-chome-3-7-4, Sumida-ku, Tokyo Date of amendment order: August 10, 1982 (shipped) (August 30, 1982) 5. Engraving of the entire text of the specification subject to amendment (no change in content) 6. Contents of amendment as attached.

Claims (1)

[Claims] 1. In a solvent containing a water-insoluble polymer compound, 2-(
A fungicidal composition comprising 4-thiazolyl)-benzimidazole and a long-chain alkyldimethylbenzylammonium salt and a lower alkyl ester salt of an N''-long-chain acyl basic amino acid, each at a concentration of at least 0.01% by weight. 02. The composition according to claim 1, wherein the water-insoluble polymer compound is a polyvinyl alcohol derivative. 3. The long-chain acyl moiety of the lower alkyl ester salt of a N''-long-chain acyl basic amino acid is Composition O according to claim 1, wherein the basic amino acid moiety is arginine or lysine in the lauroyl group, cocoyl group, or myristoyl group.