JPS5919528B2 - How to remove flame-causing substances from the patch - Google Patents

Description

[Detailed description of the invention] The present invention relates to a method for removing inflammatory substances from a patch.

Patches are widely used by the general public to treat stiffness, neuralgia, bruises, sprains, muscle pain, etc., and to protect wounds, but people with sensitive skin may develop skin irritations while using them. In many cases, we had no choice but to abandon the use of the adhesive patch.

Until now, many attempts have been made to remove inflammation-causing substances from the ingredients in plasters, but since it is difficult to limit inflammation-causing substances to a single ingredient, it is a low-irritant product that can be used safely even by people with sensitive skin. A sex patch has not yet been obtained.

The present inventors have demonstrated that inflammatory substances in the plaster of the patch migrate into the skin through a thin layer of skin fluid formed between the patch and the skin, causing a rash. Focusing on this, they succeeded in removing the inflammation-causing substance by washing the patch with a hydrophilic solvent, and completed the present invention.

The present invention relates to a method for removing inflammatory substances from a patch, which comprises washing the patch with a hydrophilic solvent.

In carrying out the present invention, the patch coated with the plaster is placed in a bath filled with a hydrophilic solvent for an appropriate period of time, preferably at 0.
．． The sample is immersed for 5 to 30 minutes, and if necessary, the elution of the inflammatory substance is promoted by stirring the hydrophilic solvent, shaking the patch, or emitting ultrasonic waves.

Hydrophilic solvents used in the present invention include water, electrolyte aqueous solutions, lower alcohols, lower fatty acids, hydrophilic organic solvents such as acetone, and their aqueous solutions, and are easily volatile from the viewpoint of workability and economical efficiency. It is preferable to use methanol, ethanol, acetone, a mixture thereof, or an aqueous solution thereof.

The patch from which the inflammatory substances have been eluted and washed is taken out of the tank and dried to form a product.

As a result of a patch test, the patch of the present invention caused extremely less rash than an untreated product, and as a result of an adhesion test, it was found to have no inferiority in adhesive strength compared to an untreated product.

Next, the present invention will be explained with reference to Examples and Test Examples.

Example 1 Commercially available adhesive tape (Blenderm Tape manufactured by Sumitomo 3M Co., Ltd.), which is a polyethylene tape coated with a polyacrylic acid ester adhesive.

Hereinafter, it will be referred to as A tape.

) and (Note) A prototype tape (
Hereinafter, it will be referred to as B tape.

) was cut into 80i pieces, immersed in a tank containing water 11, subjected to ultrasonic waves, and subjected to four types of treatment for 0.5 minutes, 1 minute, 5 minutes, and 10 minutes, and air-dried for 6 hours after treatment.

Example 2 80i of tape A and tape B were each cut, immersed in a tank containing 11 methanol for 0.5 minutes, 1 minute, 5 minutes, and 10 minutes, respectively, and air-dried for 3 hours after treatment.

Test Example 1 Nototsuchi Test The presence or absence of rash was investigated using the following patch test using 20 healthy adult males as subjects. 3 Tapes A and B treated for 1 minute in Examples 1 and 2 and their Samples were prepared by cutting out untreated A tape and B tape, which were control products, into a circle with a diameter of 2.5 cm. These six samples were made into a set, and each set was randomly placed on the forearm on both ventricular sides of each subject. Apply for 5 hours, peel off 2 hours later and 2 hours later
Four hours later, the number of people who developed a rash was counted.

The results are shown in Table 1.

Test Example 2 Adhesive Strength Test The following adhesive strength test was conducted on the A tape and B tape treated in Examples 1 and 2, and the untreated A tape and B tape as control products, to determine the adhesive strength with and without treatment. We investigated the differences.

(1) Lightly press the tip of your finger against the adhesive surface of the adhesive tape that is the finger touch test specimen.
Differences in adhesive strength were investigated based on the force required to pull apart.

No difference was observed between Tape A and Tape B compared to the control product due to differences in processing agent or processing time.

(2) Adhesive tape, which is a 180° peel test specimen, has a width of 1 crrL and a length of 10 cIr.
Glue the L-cut piece to a Bakelite plate, and make 850
After pressure bonding with roller I, 30cIr with tensile tester.
Peeling resistance value (g/crrL) when pulled at a speed of L/min
) was measured.

The results are shown in Table 2.

No significant difference was observed between Tape A and Tape B compared to the control product due to differences in processing agent or processing time.

Claims (1)

[Claims] 1. A method for removing inflammatory substances from a patch, which comprises washing the patch with a hydrophilic solvent.