JPS5813524B2 - External parts for animals - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an external member in the form of a sheet, tape or strip for use on animals for testing or treatment.

When testing the transdermal drug dosage, skin irritation, adhesion, etc. of a therapeutic system member having a drug-containing adhesive layer using animals such as rats, guinea pigs, rabbits, monkeys, and dogs; When treating diseases in animals such as cats, horses, and cows using therapeutic components that have a drug-containing adhesive layer, these animals may feel discomfort due to the attachment of the component to their body surfaces, and may bite with their mouths. There are problems in that accurate test data cannot be obtained and the diseased area does not heal because it is removed or eaten.

One way to solve this problem has been to cover the area with a net-like bandage or a cover made of metal or synthetic resin, but these wrapping operations are complicated and , did not have sufficient removal prevention effect.

As a result of extensive research into methods for preventing the removal of such externally used members, the present inventors found that the problem could be solved by imparting gustatory repellency to the supporting member, and thus led to the present invention.

That is, the present invention provides an external member for animals, which is composed of an adhesive layer and a support member supporting the layer, and the member is endowed with taste repellent ability.

The adhesive layer may contain a therapeutically useful drug.

Drugs useful for treatment include two types of drugs, one of which is drugs that are applied to the human body, and the other is the drug that is applied to animals. It is used to measure various properties such as skin irritation, adhesiveness, etc.

Another drug is a drug useful in treating animals.

The adhesive substance used to form the adhesive layer is not particularly limited, and those that are irritating to skin are generally excluded.

Preferred examples are as follows.

One of them is roptyl (meth)acrylate, hexyl (meth)acrylate, 2-ethylbutyl (meth)acrylate, inoctyl (meth)acrylate, (meth)acrylate.
(meth)acrylic acid esters such as 2-ethylhexyl acrylate, decyl (meth)acrylate, dodecyl (meth)acrylate, and tridecyl (meth)acrylate, and (meth)acrylic acid copolymerizable with the esters; itaconic acid, maleic acid, maleic anhydride, maleic anhydride,
Copolymers with functional monomers such as hydroxyethyl acrylate, hydroxypropyl acrylate, acrylamide, dimethylacrylamide, methylaminoethyl methacrylate, methoxyethyl (meth)acrylate and/or vinyl monomers such as acrylonitrile and vinyl acetate. An alkali-based composition is shown on the side.

Other examples include rubber-based viscous compositions containing rubber such as silicone rubber, polyisoprene rubber, polyisoptylene rubber, styrene-butadiene (or isoprene)-styrene block copolymer rubber, acrylic rubber, natural rubber, etc. vinyl polymers such as polyvinyl ether, polyvinyl alcohol, polyvinyl acetate, polyvinyl pyrrolidone, etc., or cellulose derivatives, polyurethane elastomers, polybutadiene elastomers, polyester elastomers, etc. Examples include a viscous composition as a component.

These compositions can use crosslinking agents or crosslinking means to balance cohesive and adhesive properties.

Supporting members that support the adhesive layer include films, metal foils, nonwoven fabrics, woven fabrics, knitted fabrics, paper, felt, and leather made of cellophane, cellulose acetate, polyester, polyhinyl chloride, polyolefin, polyurethane, polyacrylic, etc. (including synthetic leather), rubber and/or synthetic resin foamed films or sheets, laminated films or sheets made of two or more of these, and compositions thereof.

To impart taste repellent ability to these supporting members, a substance having repellent ability is blended in advance and made into a film, or
This can easily be done by foaming, but it may also be impregnated and/or coated to impart repellency.

The substances with taste repellency used in the practice of the present invention have low toxicity and do not affect the pharmacological effect, and include, for example, oriental orchard, spruce, rhubarb, aloe, acacia japonica, orientalis, orientalis. Bitter substances such as
Examples include pungent substances such as chili pepper extract and astringent substances such as tannic acid.

These taste-based repellent substances are selected and used depending on the type of animal, and the amount of compounding, impregnation, or coating depends on the repellent effect the substance has on the animal to which it is applied. It is determined.

For example, in a compounding system, it is preferable to use about 0.1 to 20% by weight; too much is not preferable because the properties of the resulting film or foam deteriorate and it becomes expensive.

In the external member for animals of the present invention, since the support member is given taste repellent ability, the external member attached for testing or treatment will not be removed by chewing in the mouth or eaten. Therefore, it has the characteristics that accurate test data can be obtained and that the diseased area can be reliably treated.

The features of the present invention are as follows.

Example 1 One side of a 12 μm thick polyester film was coated with adhesive obtained by polymerizing 2-ethylhexyl acrylate: hydroxyethyl acrylate = 9:1 (weight ratio) in ethyl acetate using azobisizoptylnitrile. Substance (solid content 2
5% by weight) was applied and dried so that the thickness after drying was 50 μm.

Next, on the other side of the film, assembly was mixed in an amount of 10% by weight based on the solid content of the polyacrylic acid ester emulsion, and the mixture was coated and dried to a thickness of 5 μm after drying. The external member for animals of the invention was obtained.

Next, in order to evaluate the properties of the member, the abdominal hair of 10 rats was removed, and a sample holding the reagent body was pasted on the center of the adhesive layer surface of the member (width 1 cm, length 3 cm). .

Observation after 24 hours showed that the sample was slightly chewed, but no peeling was observed.

For comparison, we observed samples to which no repellency had been imparted, and found that 8 out of 10 had been completely peeled off, and 2 had more than half of their peeled off.

Example 2 Polyvinyl chloride resin dioctyl phthalate: Aloe =
A blend of 100:45:15 (weight ratio) is calendered to obtain a polyvinyl chloride film with a repellency of 100 μm.

A natural rubber adhesive substance was applied to one side of this film to obtain an external member for animals.

Next, in order to evaluate the properties of the material, the material was used as a tape-like wrapping material on the paws of dogs whose paws had been provided with trauma treatment material, and a repellent effect due to its bitter taste was observed.

However, the type that does not contain aloe vera is about 2 ounces after wrapping.
It was eaten up by time.

Example 3 A polyurethane foam sheet (10 times foamed) with a thickness of 1 mm was immersed in a bath of 10% ethyl alcohol solution of chili pepper extract and dried.

A block copolymer adhesive substance containing methyl salicylate and l-menthol in a ratio of 1:1 (weight ratio) is formed on one side of this sheet to a thickness of 300 μm, and the external animal member of the present invention is prepared. I got it.

Next, in order to evaluate the properties of this material, we made a 10cm x 10cm sample and applied it to the foot of a racehorse to treat inflammation in the foot.After 24 hours, an anti-inflammatory effect was observed, and the sample No peeling was observed.

For comparison, a sample not impregnated with chili pepper extract showed only a slight anti-inflammatory effect and also peeled off.

Claims (1)

[Claims] 1. An external member for animals, consisting of an adhesive layer and a support member supporting the layer, the member being provided with taste repellent ability.