JP3207257B2 - Patch - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch, and more particularly to a seal against cracking or housewife eczema, hand eczema, progressive keratoderma dermatosis such as so-called cracks and irritations. The present invention relates to a patch for moisturizing an affected part, protecting a wound and promoting healing by therapy.

[0002]

2. Description of the Related Art Cracks and irritations are said to be diseases that occur when the stratum corneum hardens due to drying due to lack of sebum or moisture, causing the epidermis to lose its flexibility and cracks [Reference: Skin 27 ( 2), 303 (1985)]. At present, various creams containing dl-α-tocopherol acetate having blood circulation promoting and anti-inflammatory effects are commercially available as therapeutic agents for these diseases [Reference: Fragrance Journal 2, 17 (1991)].

[0003] However, these creams are often sticky when applied to the skin and have a poor feeling of use, and often come off the skin upon contact with clothes or the like. In addition, in the case of cracks and nicks due to dry skin due to water work, the cream applied to the skin is washed away by water work, so the medicinal effect is not sufficiently exhibited, and the washed cream adheres to food and dishes. There is a problem that.

[0004] In addition, the cream is not suitable for diseases having a large degree of cracks and cracks, and steroid tape may be used. However, this tape has side effects and habits and is not always a good treatment. There are cases where it cannot be said.

Further, for example, in order to relieve the pain felt when a crack or a crack on the fingertip touches something, an emergency bandage may be applied. There is a problem that the work is uncomfortable and hinders the work. In addition, the first-aid bandage has a problem in that the banding of the bandage is tight and blood circulation to the fingertips is hindered, and the healing is delayed.

[0006]

SUMMARY OF THE INVENTION The present invention has been made to solve the above problems, and an object of the present invention is to physically protect an affected area with a water-impermeable support and to protect the affected area from the inside of the skin. It is an object of the present invention to provide a patch which exhibits excellent healing effects while keeping moisture moist and a drug continuously acting.

[0007]

According to the present invention, there is provided a patch comprising a water-impermeable support having a pressure-sensitive adhesive layer provided on one surface thereof, wherein the pressure-sensitive adhesive layer comprises 80 to 99.5% by weight of the pressure-sensitive adhesive. % And
Vinegar acid retinol, retinol palmitate, biotin,
Pantothenic acid, characterized in that it contains from 20 to 0.5 wt% of at least one or more agents selected from the group consisting of olive Abura及 beauty rice bran.

Hereinafter, the present invention will be described in detail. The components constituting the pressure-sensitive adhesive layer used in the present invention are a pressure-sensitive adhesive and a drug. As the pressure-sensitive adhesive, any of acrylic, rubber, polyurethane and the like can be used. Also,
The type of the pressure-sensitive adhesive may be any of a solvent type, an aqueous type, an emulsion type, a hot melt type, and the like, and is appropriately selected according to the purpose of use, the type of the used drug, and the like.

Specific examples of the base polymer of the pressure-sensitive adhesive include (meth) acrylic acid alkyl ester (co) polymer; styrene-isoprene-styrene block copolymer, styrene-butadiene rubber, polybutene,
Rubber-based polymers such as polyisoprene, butyl rubber, and natural rubber; polyurethane-based polymers.

The monomers capable of forming the (meth) acrylic acid alkyl ester (co) polymer include (meth)
Examples include alkyl acrylates and polymerizable monomers copolymerizable therewith. As the alkyl (meth) acrylate, an alkyl (meth) acrylate having an alkyl group having 1 to 18 carbon atoms is used. For example, methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate 2,2-ethylhexyl (meth) acrylate, dodecyl (meth) acrylate and the like can be used.

Examples of the polymerizable monomer include (meth) acrylic acid, vinylpyrrolidone, diacetone acrylamide, (poly) ethylene glycol (meth) acrylate, polypropylene glycol (meth) acrylate, and 2-hydroxyethyl (meth) acrylate. ) Acrylates, vinyl acetate, styrene and the like.

The alkyl (meth) acrylate (co) polymer can be prepared by any known polymerization method such as solution polymerization and bulk polymerization. If necessary, a tackifier, a liquid rubber, a softener, and the like may be added to the rubber-based pressure-sensitive adhesive.

[0013] As the agent, acetic acid retinol, retinol palmitate, biotin, pantothenic acid, at least one or more selected from the group consisting of olive <br/> Bed Abura及 beauty bran used. However, pantothenic acid is seen containing a pantothenic acid salt, rice bran include rice bran oil and rice bran extract.

[0014]

Retinol acetate and retinol palmitate include, for example, (1) to enhance skin elasticity, (2) to improve dry skin condition, and (3) to regulate epithelial cell growth and activity. (4) It has the effect of increasing the thickness of the dermis and epidermis.

In the present invention, the pressure-sensitive adhesive layer may contain, if necessary, other than the above-mentioned agents, for example, non-steroidal anti-inflammatory agents such as acetylsalicylic acid, flurbiprofen, ibuprofen; squalane, glycol salicylate, hyaluronic acid, etc. Moisturizers; other active ingredients such as antihistamines, anti-inflammatory agents, anti-inflammatory analgesics, antibiotics, and antibacterial agents may be used alone or in combination of two or more.

In the present invention, if the amount of the drug in the pressure-sensitive adhesive layer is small, sufficient medicinal effect cannot be obtained, and if the amount is large, oily bleeding occurs in the pressure-sensitive adhesive layer.
It is contained at a ratio of 0% by weight, preferably 1 to 10% by weight.

The pressure-sensitive adhesive layer has a thickness of 20 to 200.
μm is preferable, and the drug is uniformly dispersed in the pressure-sensitive adhesive layer.

The support used in the present invention is water-impermeable, for example, polyethylene; polystyrene; polyamide; polybutadiene; polybutene; polypropylene; polyisoprene; silicone resin; plasticized polyvinyl chloride; Vinyl chloride resins such as vinyl chloride and plasticized (vinyl acetate-vinyl chloride copolymer); ethylene resins such as ethylene-vinyl acetate copolymer, ethylene-vinyl chloride copolymer, ethylene-methyl methacrylate copolymer Copolymer; alkyl (meth) acrylate (co) polymer; styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, styrene-ethylene-butadiene-styrene block copolymer, styrene -Butadiene rubber, cellulose acetate One such as ethyl cellulose or 2
A synthetic resin film having at least one kind as a base polymer is preferably used. In addition, these synthetic resin films may be used alone, or two or more kinds may be used by laminating them.

The thickness of the support is preferably from 20 to 200 μm, more preferably from 40 to 100 μm.

When the load at the time of 50% elongation is small, the support becomes difficult to attach because the stiffness is lost. When the load at the time of 50% elongation is large, the support cannot follow the movement when applied to the joint. Since the skin is pulled, peeled or floated, and tightly wound when wrapped around a finger, 200 to 90 mm per 15 mm width
0 g is preferred.

As a support, 5% at 50% elongation is used.
It is preferable to use a resin having a residual stress ratio of 90% or less after 60 seconds or a residual stress ratio of 75% or less after 60 seconds after elongation at 50% because it is flexible and does not tighten.

In the present invention, the load per 15 mm width at 50% elongation is measured by the following method.
That is, a rectangular sample of 15 × 40 mm was stretched at a rate of 100 mm / min using a tensile tester until the sample length became 60 mm (elongation rate: 50%), and the load at that time was measured. % The load at the time of elongation.

The above-mentioned residual stress ratio is a value calculated by the following equation. Residual stress (%) = (B / A) × 100 where A is the load (g / 15 m
m), and B is the load (g / 15 mm) when the support is stretched by 50% and left as it is for t seconds.

In the patch of the present invention, in order to maximize the sealing effect and the pharmacological effect, a non-water-permeable support is used, and its moisture permeability (JIS Z0208 Adhesive Tape / Adhesive Sheet Test Method) The value measured in conformity with the formula (1) is smaller, the sealing effect is obtained, but skin irritation such as rash due to stuffiness is caused, and the sealing effect is reduced as the size becomes larger.
It is preferably in the range of 0~600g / m ² · 24hr, and more preferably from 150~400g / m ² · 24hr.

The patch of the present invention can be obtained by applying and drying a solution or dispersion containing, for example, an adhesive, a drug, and if necessary, other medicinal ingredients and an absorption aid to a support. Can be As a solvent for the solution or dispersion, an organic solvent or water is used. Instead of using the above solution or dispersion, a method of heating and melting a mixture of an adhesive and a drug and applying the mixture on a support can also be adopted. Further, a method is also used in which the solution, dispersion or melt is coated on a release paper and dried, and then transferred to the support in close contact with the support.

The above-mentioned release paper is used for the purpose of protecting the pressure-sensitive adhesive layer. For example, a film obtained by performing a silicone release treatment on one side such as a polyethylene terephthalate film, a polyethylene-coated high-quality paper, a polyolefin-coated glassine paper, a polypropylene film, or the like is used. The thickness is usually preferably 500 μm or less, more preferably 20 to 200 μm.

The shape of the patch of the present invention can be arbitrarily selected, such as a sheet, a band, a patch, and a roll.

[0029]

The patch of the present invention uses a water-impermeable support, and the above-mentioned drug is contained in an adhesive layer formed on the support, whereby the support physically protects the affected area, It moisturizes from the inside of the skin and at the same time suppresses inflammation of the affected area by the drug acting continuously, so that it exerts a synergistic healing effect on symptoms such as crack eczema, so-called cracks and irritations.

[0030]

Embodiments of the present invention will be described below. Example 1 [Preparation of Acrylic Adhesive] 302 parts by weight of 2-ethylhexyl acrylate and 98 parts by weight of vinylpyrrolidone were charged into a separable flask, and the initial polymerization monomer concentration was 8%.
70.6 parts by weight of ethyl acetate was added so as to be 5% by weight to obtain a solution. This solution was heated to 60 ° C. under a nitrogen atmosphere, and a solution prepared by dissolving 1 part by weight of lauroyl peroxide as a polymerization initiator in 100 ml of ethyl acetate was added little by little sequentially, and the polymerization reaction was carried out for 32 hours. Ethyl acetate was added to a concentration of 25% by weight, and then uniformly mixed with a dissolver to obtain an acrylic pressure-sensitive adhesive solution.

[Preparation of a drug-containing pressure-sensitive adhesive solution] A drug-containing pressure-sensitive adhesive solution was prepared by dissolving 2 parts by weight of dl-α-tocopherol acetate as a drug in 392 parts by weight of the acrylic pressure-sensitive adhesive solution.

[Preparation of Patch] After the above-mentioned drug-containing pressure-sensitive adhesive solution was coated on a release paper obtained by subjecting a polyethylene terephthalate film having a thickness of 40 μm to silicone release treatment, 6
After drying at 0 ° C. for 30 minutes, a drug-containing pressure-sensitive adhesive layer having a thickness of 40 μm was formed. The adhesive layer was transferred to a 50 μm-thick non-plasticized polyvinyl chloride support to prepare a patch.

[Measurement of Physical Properties of Support] (1) Measurement of Load at 50% Elongation The support used above was cut into a strip of 15 × 80 mm to form a sample, which was left at 23 ° C. and 50% relative humidity. rear,
The distance between the gauges of the sample was 40 mm and the tensile tester (Orie)
ntec Tensilon UCT-500) at a speed of 100 mm / min, 60 mm (50% elongation)
The measurement results are shown in Table 1 with the load at that time taken as the load at 50% elongation.

(2) Measurement of Residual Stress The support was allowed to stand for 60 seconds or more at an elongation of 50%, and the change in load was recorded on a chart paper during this time, and the change was measured at 50%.
Loads at 5 seconds and 60 seconds after the elongation were read, and the residual stress ratio (%) was calculated. The results are shown in Table 1.

[Measurement of moisture permeability of patch] JIS Z02
The moisture permeability of the patch was measured in accordance with No.37, and the results are shown in Table 1.

[Evaluation of the functionality of the patch]
It was cut into a size of × 60 mm and attached to the joint of a finger, and the stickiness was evaluated for sensory properties. The evaluation was performed by six people, and the average was shown in Table 1.
It was shown to. The functional evaluation of the patch was performed for three items (a) to (c), and was determined based on the following criteria. (A) Feeling of sticking: ○ indicates that the skin did not stick when bent, and did not peel, and X indicates that the skin stuck when bent and peeled. (B) Ease of sticking: A sample having a certain degree of stiffness and easy to stick was evaluated as ○, and a sample having no stiffness and wrinkling when applied was evaluated as ×. (C) Tightening: When there was no tightness when wound around the finger, it was evaluated as ○, and when tightly wound around the finger, X was evaluated.

[Evaluation of the efficacy of the patch] The patch prepared above was applied to the affected area (10 persons) of a person with fissure eczema such as cracks and rags for 2 to 5 days and the symptoms were observed.
Table 1 shows the ratio (%) of those judged as “healed”, “better” and “slightly better” among the ten subjects as effective rates.

Example 2 368 parts by weight of the acrylic pressure-sensitive adhesive solution prepared in Example 1 was used as a drug for acetic acid d.
A patch was prepared in the same manner as in Example 1, except that 8 parts by weight of l-α-tocopherol was dissolved to prepare a drug-containing pressure-sensitive adhesive solution, and the physical properties of the support were measured in the same manner as in Example 1. The patch was evaluated for moisture permeability, sensory evaluation and drug efficacy, and the results are shown in Table 1.

Example 3 340 parts by weight of the acrylic pressure-sensitive adhesive solution prepared in Example 1 was added to the acetic acid d as a drug.
A patch was prepared in the same manner as in Example 1 except that 15 parts by weight of l-α-tocopherol was dissolved to prepare a drug-containing pressure-sensitive adhesive solution, and the physical properties of the support were measured in the same manner as in Example 1. The patch was evaluated for moisture permeability, sensory evaluation and drug efficacy, and the results are shown in Table 1.

Example 4 As a support, a thickness of 50 μm
Example 1 except that the porous polyethylene of Example 1 was used.
After preparing a patch in the same manner as in Example 1, measurement of the physical properties of the support, moisture permeability of the patch, evaluation of the functionality, and evaluation of the medicinal effect were performed in the same manner as in Example 1. The results are shown in Table 1.

Example 5 As an acrylic pressure-sensitive adhesive, 196 parts by weight of methacrylic acid-n-butyl acrylate copolymer (trade name "Primal N-580", manufactured by Nippon Acrylic Co., Ltd., solid content: 50% by weight) A patch was prepared in the same manner as in Example 1 except that 2 parts by weight of dl-α-tocopherol acetate was dissolved to prepare a drug-containing adhesive solution. Physical property measurement,
The patch was evaluated for moisture permeability, sensory evaluation and drug efficacy, and the results are shown in Table 1.

Example 6 100 parts by weight of a styrene-isoprene-styrene block copolymer (trade name “Califlex” manufactured by Shell Chemical Co., Ltd.), 100 parts by weight of hydrogenated rosin, and 70 parts by weight of liquid paraffin were mixed with toluene / It was uniformly dissolved in a cyclohexane mixed solvent (weight ratio 1: 1) to prepare an adhesive solution having a solid content of 25% by weight. After uniformly dissolving 2 parts by weight of dl-α-tocopherol acetate in 392 parts by weight of this adhesive solution, an adhesive layer was formed in the same manner as in Example 1 and transferred to a 50 μm-thick porous polyethylene film. To prepare a patch. For this patch, the measurement of the physical properties of the support, the moisture permeability of the patch, the evaluation of the functionality, and the evaluation of the medicinal effect were carried out in the same manner as in Example 1, and the results are shown in Table 1.

(Examples 7 to 13) Except that 8 parts by weight of the drugs shown in Table 1 were dissolved in 368 parts by weight of the acrylic pressure-sensitive adhesive solution prepared in Example 1 to prepare a drug-containing pressure-sensitive adhesive solution. Prepared a patch in the same manner as in Example 1, and measured the physical properties of the support, evaluated the moisture permeability of the patch, evaluated the functionality, and evaluated the efficacy in the same manner as in Example 1. The results are shown in Table 1. Indicated.

Comparative Example 1 The same procedure as in Example 1 was carried out except that a patch was prepared without adding a drug to the acrylic pressure-sensitive adhesive solution prepared in Example 1.
The patch was evaluated for moisture permeability, sensory evaluation and drug efficacy, and the results are shown in Table 1. (Comparative Example 2) Except that 300 parts by weight of the acrylic pressure-sensitive adhesive solution prepared in Example 1 was dissolved in 25 parts by weight of dl-α-tocopherol acetate to prepare a drug-containing pressure-sensitive adhesive solution. Prepare a patch in the same manner as in 1,
In the same manner as in Example 1, the physical properties of the support, the moisture permeability of the patch, the evaluation of the functionality, and the evaluation of the drug effect were evaluated.
It was shown to. In the patch obtained above, oil bleeding from the pressure-sensitive adhesive layer was observed. (Comparative Example 3) A commercially available cream containing dl-α-tocopherol acetate for cracks and irrigations (trade name “Winterborne” manufactured by Nichibo Pharmaceutical Co., Ltd.) was applied to the affected area, and the efficacy was evaluated. The results are shown in Table 1. It was shown to.

[0045]

[Table 1]

[0046]

The patch of the present invention uses a water-impermeable support and contains an agent in an adhesive layer formed on the support, whereby the support physically protects the affected area, Since it moisturizes from the inside of the skin and the drug continuously acts to suppress inflammation of the affected area, it exerts an excellent synergistic healing effect on fissure eczema such as cracks and irritations.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ identification code FI A61K 35/78 A61K 35/78 CU (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 31 / 22,31 / 23,31 / 195 A61K 31 / 4188,31 / 355 A61K 35 / 78,9 / 70

Claims (1)

(57) [Claims] 1. A patch comprising a pressure-sensitive adhesive layer provided on one side of a water-impermeable support, wherein the pressure-sensitive adhesive layer comprises
And 99.5 wt%, acetic acid retinol, retinol palmitate, biotin, pantothenic acid, at least one or more agents selected from the group consisting of olive Abura及 beauty bran 2
A patch characterized by containing 0 to 0.5% by weight.