JPH0665073A - Plaster - Google Patents

Abstract

PURPOSE:To provide a plaster capable of physically protecting a diseased part with a water-impermeable substrate, moistening the skin from inside and giving continuous action of the drug component to exhibit excellent curing effect. CONSTITUTION:The plaster has a tacky adhesive layer formed on one surface of a water-impermeable substrate. The tacky adhesive layer contains 80-99.5wt.% of a tacky adhesive and 20-0.5wt.% of at least one kind of drug selected from dl-alpha-tocopherol acetate, retinol acetate, retinol palmitate, biotin, pantothenic acid, olive oil, aloe and rice bran.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch, and in particular, it seals against skin diseases such as crack eruption or housewife eczema, hand eczema, progressive keratoderma ergosum, so-called cracks and cracks. The present invention relates to a patch for moisturizing an affected area and protecting a wound by therapy to promote healing.

[0002]

2. Description of the Related Art Cracks and cracks are said to be a disease caused by hardening of the stratum corneum due to drying due to lack of sebum and water, resulting in loss of flexibility and cracking of the epidermis [Reference: Skin 27 ( 2), 303 (1985)]. At present, various therapeutic creams containing dl-α-tocopherol acetate having blood circulation promoting and anti-inflammatory effects are commercially available as therapeutic agents for these diseases [Reference: Fragrance Journal 2, 17 (1991)].

However, these creams are often sticky when applied to the skin and have a bad feeling in use, or are often released from the skin by contact with clothes or the like. Also, in the case of cracks or cracks caused by dry skin due to water work etc., the cream applied to the skin will be washed away by water work, so the medicinal effect will not be exerted sufficiently, and further, the washed out cream will adhere to food and tableware. There is a problem of doing.

The above-mentioned cream is not suitable for diseases with a large degree of cracks and cracks, and a steroid tape is sometimes used. However, this tape has side effects and habits, and is not always a good treatment method. There are cases where it cannot be said.

[0005] Furthermore, for example, in order to relieve the pain felt when the fingertip cracks or cracks touch something, an emergency adhesive bandage may be applied. When the adhesive bandage is applied to the fingertip or knuckle, it may be peeled off. There is a problem that it is uncomfortable and interferes with the work. In addition, the first-aid bandage has a problem in that the wound becomes tight and blood circulation to the fingertip is obstructed, and healing is delayed.

[0006]

SUMMARY OF THE INVENTION The present invention has been made to solve the above problems, and its purpose is to physically protect an affected area with a water-impermeable support and to protect the affected area from the inside of the skin. An object of the present invention is to provide a patch that moisturizes and continuously acts on a drug to exhibit an excellent healing effect.

[0007]

The patch of the present invention is a patch in which a pressure-sensitive adhesive layer is provided on one surface of a water-impermeable support, and the pressure-sensitive adhesive layer is 80 to 99.5 wt. %When,
20 to 0.5% by weight of at least one drug selected from the group consisting of dl-α tocopherol acetate, retinol acetate, retinol palmitate, biotin, pantothenic acid, olive oil, aloe, and rice bran. To do.

The present invention will be described in detail below. The components constituting the pressure-sensitive adhesive layer used in the present invention are a pressure-sensitive adhesive and a drug. As the pressure-sensitive adhesive, any of acrylic, rubber, polyurethane and the like can be used. Also,
The type of the pressure-sensitive adhesive may be solvent-based, water-based, emulsion-based, hot-melt-based, or the like, and is appropriately selected according to the purpose of use and the type of drug used.

Specific examples of the base polymer of the pressure-sensitive adhesive include (meth) acrylic acid alkyl ester (co) polymers; styrene-isoprene-styrene block copolymers, styrene-butadiene rubber, polybutene,
Examples include rubber-based polymers such as polyisoprene, butyl rubber and natural rubber; and polyurethane-based polymers.

The monomer capable of forming the above-mentioned (meth) acrylic acid alkyl ester (co) polymer is (meth)
Examples thereof include alkyl acrylates and polymerizable monomers copolymerizable therewith. As the (meth) acrylic acid alkyl ester, a (meth) acrylic acid alkyl ester having an alkyl group having 1 to 18 carbon atoms is used, and examples thereof include methyl (meth) acrylate, ethyl (meth) acrylate, and butyl (meth) acrylate. 2-Ethylhexyl (meth) acrylate, dodecyl (meth) acrylate and the like can be used.

Examples of the above-mentioned polymerizable monomer include (meth) acrylic acid, vinylpyrrolidone, diacetone acrylamide, (poly) ethylene glycol (meth) acrylate, polypropylene glycol (meth) acrylate and 2-hydroxyethyl (meth). ) Acrylate, vinyl acetate, styrene and the like.

The (meth) acrylic acid alkyl ester (co) polymer can be prepared by any known polymerization method such as solution polymerization and bulk polymerization. If necessary, a tackifier, a liquid rubber, a softening agent, etc. may be added to the rubber-based pressure-sensitive adhesive.

The above-mentioned agents include dl-α-tocopherol acetate, retinol acetate, retinol palmitate,
At least one selected from the group consisting of biotin, pantothenic acid, olive oil, aloe and rice bran is used. However, pantothenic acid includes pantothenate, aloe includes aloe extract and aero powder, and rice bran includes rice bran oil and rice bran extract.

Among the above-mentioned agents, dl-α-tocopherol acetate is added to, for example, a blood circulation action and an anti-inflammatory action, and
(1) increase moisture retention from the inside of the skin, (2) smooth the skin, (3) suppress lipid peroxidation, (4) help wound healing, (5) protect cell membrane, ( 6) It has an action of suppressing the decomposition of vitamin A, and is widely used in external preparations for skin, cosmetics and the like.

Retinol acetate and retinol palmitate, for example, (1) enhance the elasticity of the skin, (2) improve the condition of dry skin, (3) regulate the growth and activity of epithelial cells. (4) There is an action such as increasing the thickness of the dermis and the epidermis.

In the present invention, the pressure-sensitive adhesive layer contains, in addition to the above-mentioned agents, non-steroidal anti-inflammatory agents such as acetylsalicylic acid, flurbiprofen and ibuprofen; squalane, glycol salicylate, hyaluronic acid and the like, if necessary. Other moisturizing agents; other medicinal ingredients such as antihistamines, sedatives, anti-inflammatory analgesics, antibiotics and antibacterial agents may be used alone or in combination of two or more kinds.

In the present invention, when the amount of the drug in the pressure-sensitive adhesive layer is small, sufficient medicinal effect cannot be obtained, and when the amount is large, oiliness is generated in the pressure-sensitive adhesive layer.
The content is 0% by weight, and preferably 1 to 10% by weight.

The thickness of the pressure-sensitive adhesive layer is 20 to 200.
μm is preferable, and the drug is uniformly dispersed in this adhesive layer.

The support used in the present invention is a water-impermeable material, for example, polyethylene; polystyrene; polyamide; polybutadiene; polybutene; polypropylene; polyisoprene; silicone resin; plasticized polyvinyl chloride, polyurethane plasticized poly. Vinyl chloride resin such as vinyl chloride, plasticized (vinyl acetate-vinyl chloride copolymer); ethylene-based resin such as ethylene-vinyl acetate copolymer, ethylene-vinyl chloride copolymer, ethylene-methyl methacrylate copolymer Copolymer; (meth) acrylic acid alkyl ester (co) polymer; styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, styrene-ethylene-butadiene-styrene block copolymer, styrene -Butadiene rubber, cellulose acetate One such as ethyl cellulose or 2
A synthetic resin film containing at least one kind of base polymer is preferably used. Further, these synthetic resin films may be used alone or in combination of two or more kinds.

The thickness of the support is preferably 20 to 200 μm, more preferably 40 to 100 μm.

As the above-mentioned support, when the load at 50% extension is small, it becomes stiff and it is difficult to attach, and when the load at 50% extension is large, it cannot follow the movement when it is attached to a joint, 200-90 per 15mm width, since the skin may become tight, peeling or floating may occur, and tightening may occur when wrapped around a finger.
0 g is preferred.

As the support, 5% at 50% elongation is used.
It is preferable to use a material having a stress residual ratio after 90 seconds of 90% or less or a stress residual ratio after elongation of 50% of 75% of 75% or less because it is flexible and does not have winding tightness.

In the present invention, the load per 15 mm width at the time of 50% elongation is measured by the following method.
That is, using a tensile tester, a 15 × 40 mm strip-shaped sample is stretched at a speed of 100 mm / min until the sample length reaches 60 mm (elongation rate 50%), and the load at that time is measured to obtain 50. % The load when stretched.

The stress residual rate is a value calculated by the following equation. Residual stress rate (%) = (B / A) × 100 where A is the load (g / 15 m) when the support is stretched 50%.
m), and B is the load (g / 15 mm) when the support is stretched by 50% and left standing for t seconds.

In the patch of the present invention, in order to maximize the sealing effect and the pharmacological effect, a non-water permeable support is used, but its moisture permeability (JIS Z0208 adhesive tape / adhesive sheet test method) The value measured in accordance with (4) has a sealing effect when it is small, but it causes skin irritation such as rash due to stuffiness, and when it is large, the sealing effect decreases, so 6
The range of 0 to 600 g / m ² · 24 hr is preferable, and the range of 150 to 400 g / m ² · 24 hr is more preferable.

The patch of the present invention is obtained, for example, by applying a solution or dispersion containing an adhesive, a drug, and if necessary, other medicinal components, absorption aids, etc. onto a support and drying it. To be An organic solvent or water is used as the solvent of the solution or dispersion. Further, instead of using the above-mentioned solution or dispersion, a method of heating and melting a mixture of an adhesive, a drug and the like and applying this on a support can also be adopted. Further, a method may be used in which the above-mentioned solution, dispersion or melt is applied on a release paper and dried, and this is brought into close contact with a support and transferred.

The above-mentioned release paper is used for the purpose of protecting the pressure-sensitive adhesive layer, and for example, a polyethylene terephthalate film, polyethylene-coated high-quality paper, polyolefin-coated glassine paper, polypropylene film, or the like with a silicone release treatment on one side is used. The thickness is usually preferably 500 μm or less, and more preferably 20 to 200 μm.

The patch of the present invention may have any shape such as a sheet, a strip, a patch and a roll.

[0029]

The patch of the present invention uses a water-impermeable support, and the above-mentioned drug is contained in the pressure-sensitive adhesive layer formed on the support, whereby the support physically protects the affected area, While moisturizing from the inside of the skin, the drug acts continuously to suppress inflammation in the affected area, and thus exerts a synergistic healing effect on symptoms such as cracked eczema, so-called cracks and cracks.

[0030]

EXAMPLES Examples of the present invention will be described below. (Example 1) [Preparation of acrylic pressure-sensitive adhesive] 302 parts by weight of 2-ethylhexyl acrylate and 98 parts by weight of vinylpyrrolidone were charged in a separable flask, and the initial polymerization monomer concentration was 8
A solution was obtained by adding 70.6 parts by weight of ethyl acetate to a concentration of 5% by weight. This solution was heated to 60 ° C. under a nitrogen atmosphere, and 1 part by weight of lauroyl peroxide as a polymerization initiator was dissolved in 100 ml of ethyl acetate, and the solution was added little by little to carry out a polymerization reaction for 32 hours. Ethyl acetate was added so as to have a concentration of 25% by weight, and then uniformly mixed with a dissolver to obtain an acrylic pressure-sensitive adhesive solution.

[Preparation of Drug-Containing Pressure-Sensitive Adhesive Solution] A drug-containing pressure-sensitive adhesive solution was prepared by dissolving 2 parts by weight of dl-α-tocopherol acetate as a drug in 392 parts by weight of the acrylic pressure-sensitive adhesive solution.

[Preparation of adhesive patch] After applying the above-mentioned drug-containing pressure-sensitive adhesive solution onto a release paper, which is a silicone terephthalate film having a thickness of 40 μm and subjected to a silicone release treatment,
It was dried at 0 ° C. for 30 minutes to form a drug-containing pressure-sensitive adhesive layer having a thickness of 40 μm. The adhesive layer was transferred to a 50 μm thick non-plasticized polyvinyl chloride support to prepare a patch.

[Measurement of Physical Properties of Support] (1) Load Measurement at 50% Elongation The support used above was cut into a strip of 15 × 80 mm to prepare a sample, which was left at 23 ° C. and 50% relative humidity. rear,
A 40 mm distance between the gauge marks of the sample
ntec Tensilon UCT-500), 60 mm at a speed of 100 mm / min (extension rate 50%)
The measurement results are shown in Table 1 with the load at that time taken as the load at 50% elongation.

(2) Measurement of residual stress rate The above-mentioned support was left for 60 seconds or longer in a state where the elongation rate was 50%, and the change in load was recorded on the chart paper during this period to obtain 50%.
The loads after 5 seconds and 60 seconds from the stretched state were read to calculate the stress residual rate (%), and the results are shown in Table 1.

[Measurement of moisture permeability of patch] JIS Z02
According to 37, the water vapor permeability of the patch was measured, and the results are shown in Table 1.

[Evaluation of Functionality of Patch]
It cut | disconnected to 60 mm and it stuck to the joint part of a finger | toe, and the sensory evaluation of sticking property was performed. Evaluation was performed by 6 people, and the average is shown in Table 1.
It was shown to. The functional evaluation of the patch was carried out on the three items (a) to (c), and judged based on the following criteria. (A) Sticking sensation: One in which the skin did not bulge and did not peel when bent was rated as ◯, and one in which the skin bulged and peeled when bent was rated as x. (B) Ease of sticking: One having a certain degree of elasticity and easy to stick to was marked with ◯, and one having no waist and causing wrinkles when sticking was marked with x. (C) Tightness of winding: A material which is not tightly wound even when wound around a finger is marked with ◯, and a material which is tightly wound around a finger is marked with x.

[Evaluation of drug efficacy of patch] The patch prepared above was applied to the affected part of a person (10 people) having a cracked eczema disease such as a crack or a crack for 2 to 5 days, and the symptoms were observed.
The ratio (%) of those judged to be “healed”, “improved” and “slightly improved” out of 10 is shown in Table 1 as the effective rate.

Example 2 With respect to 368 parts by weight of the acrylic adhesive solution prepared in Example 1, acetic acid d was used as a drug.
A patch was prepared in the same manner as in Example 1 except that 8 parts by weight of l-α tocopherol was dissolved to prepare a drug-containing adhesive solution, and the physical properties of the support were measured in the same manner as in Example 1. The moisture permeability of the patch, the sensory evaluation and the drug efficacy evaluation were performed, and the results are shown in Table 1.

(Example 3) Acetic acid d was added as a drug to 340 parts by weight of the acrylic adhesive solution prepared in Example 1.
A patch was prepared in the same manner as in Example 1 except that 15 parts by weight of l-α tocopherol was dissolved to prepare a drug-containing adhesive solution, and the physical properties of the support were measured in the same manner as in Example 1. The moisture permeability of the patch, the sensory evaluation and the drug efficacy evaluation were performed, and the results are shown in Table 1.

Example 4 As a support, the thickness is 50 μm.
Example 1 except that the porous polyethylene of Example 1 was used.
After preparing the patch in the same manner as in 1., the physical properties of the support, the moisture permeability of the patch, the functional evaluation and the drug efficacy evaluation were carried out in the same manner as in Example 1, and the results are shown in Table 1.

(Example 5) As an acrylic adhesive, 196 parts by weight of methacrylic acid-acrylic acid-n-butyl copolymer (manufactured by Nippon Acrylic Co., Ltd., trade name "Primal N-580", solid content 50% by weight). After preparing a patch in the same manner as in Example 1 except that 2 parts by weight of dl-α-tocopherol acetate was dissolved to prepare a drug-containing pressure-sensitive adhesive solution, a support was prepared in the same manner as in Example 1. Physical property measurement,
The moisture permeability, the sensory evaluation and the drug efficacy evaluation of the patch were conducted, and the results are shown in Table 1.

(Example 6) 100 parts by weight of a styrene-isoprene-styrene block copolymer (trade name "Califlex" manufactured by Shell Chemical Co., Ltd.), 100 parts by weight of hydrogenated rosin and 70 parts by weight of liquid paraffin were mixed with toluene / It was uniformly dissolved in a cyclohexane mixed solvent (weight ratio 1: 1) to prepare an adhesive solution having a solid content of 25% by weight. After uniformly dissolving 2 parts by weight of dl-α-tocopherol acetate in 392 parts by weight of this adhesive solution, an adhesive layer was formed in the same manner as in Example 1 and transferred to a porous polyethylene film having a thickness of 50 μm. To prepare a patch. With respect to this patch, in the same manner as in Example 1, the physical properties of the support, the moisture permeability of the patch, the functional evaluation and the drug efficacy evaluation were carried out, and the results are shown in Table 1.

(Examples 7 to 13) 8 parts by weight of the drug shown in Table 1 was dissolved in 368 parts by weight of the acrylic pressure-sensitive adhesive solution prepared in Example 1 to prepare a drug-containing adhesive solution. Was prepared in the same manner as in Example 1, and in the same manner as in Example 1, the physical properties of the support, the moisture permeability of the patch, the sensory evaluation and the drug efficacy evaluation were carried out, and the results are shown in Table 1. Indicated.

Comparative Example 1 The physical properties of the support were measured in the same manner as in Example 1 except that the patch was prepared without adding a drug to the acrylic pressure-sensitive adhesive solution prepared in Example 1.
The moisture permeability, the sensory evaluation and the drug efficacy evaluation of the patch were conducted, and the results are shown in Table 1. (Comparative Example 2) Example 3 except that 25 parts by weight of dl-α tocopherol acetate acetate was dissolved in 300 parts by weight of the acrylic adhesive solution prepared in Example 1 to prepare a drug-containing adhesive solution. Prepare a patch in the same manner as in 1,
In the same manner as in Example 1, the physical properties of the support, the moisture permeability of the patch, the functional evaluation and the medicinal effect evaluation were performed, and the results are shown in Table 1.
It was shown to. The patch obtained as described above was found to be oily from the adhesive layer. (Comparative Example 3) Commercially available cream containing dl-α tocopherol acetate for cracks and cracks (manufactured by Nihon Yakuhin Co., Ltd., trade name "Winterborne") was applied to the affected area, and drug efficacy was evaluated. The results are shown in Table 1. It was shown to.

[0045]

[Table 1]

[0046]

EFFECTS OF THE INVENTION The patch of the present invention uses a water-impermeable support, and by containing a drug in the adhesive layer formed on the support, the support physically protects the affected area, It moisturizes from the inside of the skin, and since the drug continuously acts to suppress inflammation of the affected area, it exhibits an excellent synergistic healing effect against cracked eczema such as cracks and cracks.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display location A61K 31/40 9360-4C

Claims (1)

[Claims] 1. A patch having a pressure-sensitive adhesive layer provided on one surface of a water-impermeable support, wherein the pressure-sensitive adhesive layer comprises pressure-sensitive adhesives 80-9.
9.5% by weight and 20 to 0.5% by weight of at least one drug selected from the group consisting of dl-α-tocopherol acetate, retinol acetate, retinol palmitate, biotin, pantothenic acid, olive oil, aloe and rice bran. An adhesive patch containing: