JPS59164703A - Antiseptic and antifungal agent - Google Patents

Abstract

PURPOSE:An antiseptic and antifungal agent, containing thiabendazole and another compound as active constituents, capable of exhibiting more improved synergistic effect on antifungal action than in use of each individual chemical, having low toxicity, useful as various compositions or for coating without harming humans and clomestre, animate and is suitable particularly for household use. CONSTITUTION:An antiseptic and antifungal agent containing thiabendazole [2-(4-thiazolyl)benzimidazole] of formula I and one or more of chlorhexidine hydrochloride of formula II, o-phenylphenol of formula III and N,N-dimethyl-N'- phenyl-N'-fluorodichloromethylthiosulfanilide of formula IV as active constituents. The mixing molar ratio between the compound of formula I to the compounds of formulas II-IV is 1:1, and the compounds are dissolved in a suitable solvent and applied to a necessary site or article by a means, e.g. coating, spraying or dipping, etc. or incorporated with a paint and coated to give antifungal effect on the coated surface. The amount of the compounds to be incorporated is preferably 0.1wt% or more total active constituents based on the total weight of the composition.

Description

[Detailed description of the invention] The present invention relates to a preservative and an antifungal agent.

Household or various industrial products, such as organic adhesives,
These materials, products, or It has been conventionally practiced to impart a preservative and anti-mold effect to the surface to be coated. These preservatives and fungicides must not have selective or mild bactericidal or fungicidal effects. In addition, while strong antiseptic and antifungal effects are required, they must also be low in toxicity to humans and livestock.

In order to develop a new antiseptic agent that satisfies these conditions, the present inventors tested and examined a large number of agents, and found that each agent alone does not have sufficient antiseptic and antifungal effects2. Combined use of species compounds. Based on this knowledge, we discovered that the antiseptic and antifungal properties are improved, and that their effects are not selective, and that their effects are so additive that they cannot be predicted from the effects of using each agent alone. The present invention has now been completed.

That is, the preservative and antifungal agent of the present invention is characterized by containing the following components A and B as active ingredients.

(1) Component A 2-(4-thiazolyl)-penzimidazole (2) Component B ・ , − (b) o-phenylphenol (opp) (c) N
, N-dimethyl-N'-phenyl-Nl-fluoro,
Dichloromethylthiosulfanide 2-(4-thiazolyl)-benzimidazole (TR
I) is a compound represented by the structural formula and is known as thiapendazole. This compound has extremely high selectivity and has excellent effects in negative aspects, but it is selective and has weak effects against bacteria, yeast, and algal fungi such as Keka♂ and Kumonoscapi, which are a type of fungi. However, when used alone, these problems could not be completely removed.

The compounds (,1) to (C) used as component (B) are known to be highly safe compounds, but they alone are not effective against many types of mold that occur in the home environment. In the case of 6 unexploded ψJ# which does not show antifungal effect,
゛By using a combination of two compounds that do not exhibit satisfactory effects as preservatives and antifungals on their own, as shown in this □, the antifungal activity against individual molds can be mutually enhanced, and the antifungal effects can be increased. It expands the spectrum and exhibits excellent effects on all of the various forces that occur in the home environment. "The mixing ratio of component A and component B in the preservative aid of the invention is not particularly limited. The mixing ratio is basically 1 mole to 1 mole, and it can be adjusted as desired depending on the purpose. It is appropriate to change the mixing ratio to

The preservative agent of the present invention not only has an excellent preservative and anti-mold effect, but also has extremely low toxicity as shown in Table 1. Therefore, whereas the conventional preservative and fungicidal agent has been considered undesirable for its use due to its strong toxicity, the agent of the present invention is actually It does not cause serious harm to humans or animals in the scene.

(Left below) 5- The undiscovered and listed preservatives and antifungal agents in Table 1 provide antiseptic and antifungal effects.
It can be blended into the desired composition, and applied to the required locations by dissolving it in an appropriate solvent and applying it, spraying, dipping, etc.
It can also be applied with the product number or mixed with paint etc. to give the coated surface 6 and anti-mildew effect.The amount to be added is based on the total amount of component A and component B relative to the total amount of the composition from the point of view of effectiveness. 4
ci, the amount per lid is preferably 6-ti or more. Suitable solvents are organic solvents,
Or a mixed solvent of an organic solvent and water. The organic solvents to be removed include lower alcohols such as methanol, ethanol, furonol, and isopropanol, lower diols such as ethylene glycol, col 1, and pro♂gelicol, and lower ketones such as acetone and methyl ethyl ketone. type is appropriate. Among organic solvents, ethanol, propanol, and isopronosol are particularly suitable in terms of safety and drying properties, and these can be used in combination with water if necessary. As is clear from the above, the preservative and fungicide of the present invention has low toxicity and excellent antifungal effect, and is suitable as a preservative and antifungal agent for yuzu compositions and coatings, and is particularly useful as a household preservative. Suitable as a fungicide. , -5! Example g2 Compositions La to 1c were obtained by mixing and dissolving the compositions (unit: parts) shown in the table.

These compositions are used after being diluted with water or an organic solvent depending on the cost.

The composition shown in Table 2 (sg3) is mixed and dissolved to form composition 2.
1-2c were obtained. .

゛ (hereinafter referred to as margin)・ , □ , ゛, Table 3 g4 The composition shown in Table 3 was mixed and ground with an atomizer or an agent 1 to obtain a powdered □ assembled product 3-3C. .

(Margin below) 9- No. 4 Table 5. .

' Wettable powder compositions 4a to 4C were obtained by mixing and pulverizing the compositions shown in Table '5. □ ゛ ・Table 5 10 - Dissolve component A and component B with the composition shown in Table 6, add 16 parts of LP0 to this, and prepare aerosol compositions 5a to 5.
I got c.

Regarding the preservative and anti-mold compositions of the present invention obtained as shown in Table 6 above, a preservative and anti-mold test was carried out using, as controls, those without the addition of component A, those without the addition of component B, and those without the addition of chemicals. I did it.

Test Example 1 (Preservation test of glue solution) 15 parts of glue and water (remainder) were placed in f 200 II/flask, and 1 m of composition was added to 0.4 part 9 Composition 2a was added to 0.4 part
1 part of 5 m of the Part 1 composition was added to each, heated while stirring, and cooled to obtain a glue solution. As a comparative example, component A (T'DI) or component B (C! HO
) alone and a glue solution with the same composition without the addition of drugs were prepared, each of these enteric coated/1v8 was placed in a polyethylene bag in a thermostatic chamber at 30"C, and after 7 and 14 days, it was The increase in the number of bacteria in the glue solution was measured by the agar dilution method.The results are shown in Table 7.

Table 7 Test Example 2 (Preservative test of casein solution) Using 15 parts of casein instead of glue, composition 1 was used as a drug.
0.4 part of ~0.6 part of composition 2b.

A casein solution preservation test was conducted in the same manner as in Test Example 1 except that Composition 5b was used, and the results are shown in Table 8.

Table 8 Test Example 3 (Preservation test of starch paste) Using 15 parts of wheat starch instead of glue, -13 di-starch paste was prepared, and Composition 1c was added as a drug to 0.
．． A starch liquid preservative test was carried out in the same manner as in Test Example 1 except that 4 parts, 0.6 parts of 9 composition 2c, and 1 part of 9 composition 5c were used, and the results are shown in Table 9.

Table 9 EM Example 4 (Anti-mold test of emulsion paint! #L) 99.6 parts of ♂yl acetate thread emulsion paint and the above composition 3m, 3b, 3c, 4a, 4b
A coating material was prepared by adding 0.4 parts of each of 4c and 4c. As comparative examples, paints containing only component A or component B, and paints with the same composition without the addition of chemicals were manufactured by Wll.

The mold resistance test was conducted using JI8-Z-2911r mold resistance test method, 7. The test was carried out in accordance with the section ``Paint Test''. The results are shown in Table 10.

(Margin below) Table 10

Claims (1)

[Claims] L(A) 2-(4-thiazolyl)benzimidazole and (B) at least one of chlorhexidine hydrochloride, 0-phenylphenol and N,N-dimethyl-N'-phenyl-N'-fluorodichloromethylthiosulfanide.
A preservative and antifungal agent characterized by containing seeds as an active ingredient.