JPS59155260A - 遊離ヘモグロビン分離膜 - Google Patents
遊離ヘモグロビン分離膜Info
- Publication number
- JPS59155260A JPS59155260A JP58028145A JP2814583A JPS59155260A JP S59155260 A JPS59155260 A JP S59155260A JP 58028145 A JP58028145 A JP 58028145A JP 2814583 A JP2814583 A JP 2814583A JP S59155260 A JPS59155260 A JP S59155260A
- Authority
- JP
- Japan
- Prior art keywords
- free hemoglobin
- blood
- membrane
- permeability
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000001554 Hemoglobins Human genes 0.000 title claims description 40
- 108010054147 Hemoglobins Proteins 0.000 title claims description 40
- 239000012528 membrane Substances 0.000 title claims description 40
- 238000000926 separation method Methods 0.000 title claims description 14
- 230000035699 permeability Effects 0.000 claims description 21
- 229920002307 Dextran Polymers 0.000 claims description 12
- 238000002834 transmittance Methods 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 description 27
- 239000008280 blood Substances 0.000 description 27
- 238000001914 filtration Methods 0.000 description 18
- 102000009027 Albumins Human genes 0.000 description 16
- 108010088751 Albumins Proteins 0.000 description 16
- 239000000463 material Substances 0.000 description 13
- 210000002381 plasma Anatomy 0.000 description 12
- 102000004506 Blood Proteins Human genes 0.000 description 7
- 108010017384 Blood Proteins Proteins 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 229920002301 cellulose acetate Polymers 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000012510 hollow fiber Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 206010018910 Haemolysis Diseases 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000007865 diluting Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000005194 fractionation Methods 0.000 description 3
- 229920002239 polyacrylonitrile Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001631 haemodialysis Methods 0.000 description 2
- 238000005534 hematocrit Methods 0.000 description 2
- 230000000322 hemodialysis Effects 0.000 description 2
- 238000002615 hemofiltration Methods 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 description 1
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 1
- 206010018901 Haemoglobinaemia Diseases 0.000 description 1
- 206010022822 Intravascular haemolysis Diseases 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 230000002016 colloidosmotic effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229920005994 diacetyl cellulose Polymers 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 238000002682 general surgery Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 102000018146 globin Human genes 0.000 description 1
- 108060003196 globin Proteins 0.000 description 1
- 201000001505 hemoglobinuria Diseases 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58028145A JPS59155260A (ja) | 1983-02-22 | 1983-02-22 | 遊離ヘモグロビン分離膜 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58028145A JPS59155260A (ja) | 1983-02-22 | 1983-02-22 | 遊離ヘモグロビン分離膜 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59155260A true JPS59155260A (ja) | 1984-09-04 |
| JPH0453548B2 JPH0453548B2 (enrdf_load_stackoverflow) | 1992-08-26 |
Family
ID=12240590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58028145A Granted JPS59155260A (ja) | 1983-02-22 | 1983-02-22 | 遊離ヘモグロビン分離膜 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59155260A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010076624A (ja) * | 2008-09-26 | 2010-04-08 | Toyota Motor Corp | 自動車両制動装置 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5743748A (en) * | 1980-08-28 | 1982-03-11 | Toshirou Wada | Artificial lung device |
-
1983
- 1983-02-22 JP JP58028145A patent/JPS59155260A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5743748A (en) * | 1980-08-28 | 1982-03-11 | Toshirou Wada | Artificial lung device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010076624A (ja) * | 2008-09-26 | 2010-04-08 | Toyota Motor Corp | 自動車両制動装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0453548B2 (enrdf_load_stackoverflow) | 1992-08-26 |
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