JPS5839601A - Device for administration of remedy for tree disease - Google Patents

Abstract

PURPOSE:To obtain the titled device capable of releasing the active component slowly to the trunk, and preventing and remedying especially the withering of pine effectively for a long period, by mixing an antimicrobial agent such as benlate, amicar, etc. with a hydrophilic polymer at a specific ratio, and forming the mixture in the form of rod or tablet. CONSTITUTION:The objective device is prepared by mixing 10-60wt% antimicrobial agent such as captan, glyodin, benlate, thiopentazole, amicar, biocide, kasugamycin, griseofulvin, and polyoxin with a hydrophilic polymer (e.g. ethylene-vinyl acetate copolymer having vinyl acetate content of >=15wt%), and forming the mixture in the form of rod or tablet. The device is inserted into a hole bored to the part near the root of the tree trunk to be treated. The hydrophilic resin absorbs water, and the antimicrobial agent is dissolved in the water and released slowly from the formed device into the trunk to exhibit the antimicrobial activity.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a device for administering a therapeutic agent for tree diseases, and more specifically to a device for gradually administering an antimicrobial agent having preventive and therapeutic effects on tree diseases, particularly pine wilt, into the trunk of a tree. .

Traditionally, liquid or powder insecticides have been sprayed on trees to eliminate or kill pests that infect trees, and
Insecticides are sprayed into the soil around the roots of trees, but with this method, the insecticides are quickly washed away by rain, making it impossible to obtain a sufficient effect. Not only is there a risk of contamination of well water and tap water sources, leading to environmental pollution, but it is also inherently inadequate as a treatment method for tree diseases. That is, many tree diseases are caused by filamentous fungi, such as grape powdery mildew (Uncjnulanec).
ator), Zelkova white astringent fungus (U, aceris
D, Q, war'l'ulasnei 1Fuck
), etc., and sooty fungi (Perisp
oriaceae), such as Cladosporiu
It is caused by microorganisms such as the genus m, oera*ocys
Elm Dutch disease (0
, m1m1), especially pine wilt is 0erato
Cystis sp. f) has been found to be an infectious agent. Therefore, tree diseases cannot be fundamentally treated using conventional methods using insecticides.

In view of the above, the inventors of the present invention have conducted extensive research and have found that certain drugs can be used to treat tree diseases, especially secretions. The present invention was developed based on the discovery that in addition to having antibacterial activity against causative microorganisms, by uniformly mixing these with a hydrophilic polymer, the agent can be gradually administered into the tree trunk. be.

The tree disease treatment agent administration device according to the present invention includes at least one antimicrobial agent selected from the group consisting of cabtane, gliosin, benlate, thiobendazole, amical, biocide, kasugamaylene, griseofulvin, and polyoxin. properties, polymer 9
0 to 40% by weight, and is characterized by being shaped into a rod or tablet.

The antimicrobial agent used in the present invention is at least one of the following: pesticides such as cabtan, gliosin, and benlate, fungicides such as thiopendazole, amical, and biocide, and antibiotics such as kasugamaylene, griseofulvin, and polyoxin, and especially benlate, amical, and polyoxin. It is valid. These antimicrobial agents are powders and are generally difficult to gradually administer and absorb into the tree trunk; however, according to the present invention, these antimicrobial agents,
By molding the compound with a hydrophilic polymer and inserting it into a hole previously drilled in the tree trunk, it can be administered into the tree trunk at an appropriate rate. Here, the hydrophilic polymer is preferably a polymer that swells by absorbing more than twice its own volume of water, and in particular, an ethylene-vinyl acetate copolymer with a vinyl acetate content of 15 times Mk or more is preferable. Preferable because of water absorption. The above-mentioned antimicrobial agent is a hydrophilic polymer that gradually dissolves in water absorbed from the tree trunk, and is gradually released from the polymer during tree growth, developing antibacterial activity. To effectively prevent and treat secret knots over a long period of time. In addition, the above ethylene-vinyl acetate copolymer 'gradually dissolves in the terpenoids contained in the resin of the pine tree trunk, and along with this, the antimicrobial agent is gradually released into the tree trunk': into the water pipe. Dissolves and prevents secret knots.

The antimicrobial agent is 1% to 90-40% by weight of the hydrophilic polymer.
0-60 lightning power - suitable to use.

If the amount of the antimicrobial agent is too small relative to the polymer, the therapeutic effect will not be sufficient, whereas if the amount is too large, it will be difficult to form the antimicrobial into a molded product.

Although the device of the present invention is not particularly limited, it can be obtained by kneading an antimicrobial agent with a heated and melted polymer and molding the mixture into a rod shape or tablet shape by extrusion molding, compression molding, or the like. Bulking agents may be used if necessary. The extender is used within a range that does not interfere with the moldability when the antimicrobial agent is molded together with the polymer, and is usually 20 parts by weight or less per 100 parts by weight of the polymer. As the filler, known ones such as walnut flour, tobacco flour, wood flour, clays, talcs, and silicas can be used. In addition, rod-shaped molded products include cylinders and prisms whose cross sections are uniform throughout their length, as well as cylinders and prisms whose tips are conical, warhead-shaped, and pyramid-shaped.
Furthermore, it includes a tapered cylinder whose cross section is gradually reduced in the distal direction, a prismatic cylinder, and a combination thereof, and the tablet-like molded product includes a flat disk shape as well as a spherical shape and an elliptical sphere.

The size of the device of the present invention is appropriately selected, but in the case of a rod-shaped molded product, it usually has a diameter of 5 to 1□s+s and a length of 10 to
In the case of a tablet-shaped product, for example, the thickness is 3
~1011j and a diameter of about 10~2011111 are suitable.

When using the therapeutic agent administration device according to the present invention, an appropriate number of holes are usually drilled near the base of the tree trunk depending on the size of the molded product, and the device is inserted into the holes. The hydrophilic resin absorbs water, the antimicrobial agent is dissolved in this water, and is gradually administered from the molded product into the trunk of the tree, developing antibacterial activity.

Examples of the present invention are listed below, but the present invention is not limited to these.

Example The antimicrobial agent benlate or polyoxin was roll-kneaded into a heat-molten ethylene-vinyl acetate copolymer, pelletized, and then extruded into a rod shape with a diameter of 511@ and a length of 3
Devices 1 to 5 were manufactured by cutting into 0IIlsl. Table 1 shows the antimicrobial content in each device and the vinyl acetate content in the polymer.

Device 6 was obtained by mixing Amicar 48 with a polymer, forming it into a 5 m thick sheet using a hot press at 80° C., and punching this sheet with a punch to form a tablet with a diameter of 10 cm.

Table 1: Amount of antimicrobial agent released per device by immersing each of the above devices in 100 m of distilled water, leaving them in wet coal at 30°C, and replacing the distilled water with fresh water every 24 hours. was measured. As the results are shown in Figure 1, it was confirmed that the antimicrobial agent was sustainedly released in distilled water over a long period of time.

The device is then cut into small pieces and A@perg…US
niger, Penicillium flava
s and oeratocystts sp.

Place it on a Sabouraud medium plate containing each bacterial suspension,
As a result of culturing at 30° C. for 72 hours, the growth inhibition shown in Table 2 was obtained, and it was confirmed that the cells had an effective antibacterial activity against these bacterial cells.

Table 2 In addition, six devices 4 were inserted near the base of the trunk of a pine tree with a diameter of about 20 elm and a height of about 6#I (about 1001), and the buds at the tips of branches at a height of about 2 m above the ground were inserted. A small piece of the new sprout was collected daily and placed on a Sabouraud plate medium supplemented with a cell suspension of Ceratocystis Ip, and incubated at 30°C.
The cells were cultured for 72 hours. As a result, the growth inhibition shown in FIG. 2 was obtained, and it was confirmed that secret knots could be effectively prevented for a long period of time.

[Brief explanation of the drawing]

Fig. gJ1 is a graph showing the sustained release of antimicrobial agents when the device of the present invention is immersed in distilled water, and Fig. IJ2 is a graph showing the 0eratosis of pine shoots to which the device of the present invention is applied.
2 is a graph showing the growth inhibition circle diameter over time of tis sp. Patent Applicant Nitto Electric Industry Co., Ltd. Agent Patent Attorney Itsube Makino "Figure 1

Claims (1)

[Claims] (1) Cabtane, gliodin, benlate, thiopendazole, amical, biocide, and kas are selected from the group consisting of mycin, griseofulvin, and polyoxin (both are a kind of antimicrobial agent with a weight arc of 10 to 60% and a hydrophilic polymer of 90% A device for administering a tree disease treatment agent, characterized in that it is formed into a rod-like or tablet-like shape. The tree disease treatment agent administration device according to claim 1, which is made of a polymer.