JPS58148828A - 歯根管処理剤並びに同処理用キツト - Google Patents
歯根管処理剤並びに同処理用キツトInfo
- Publication number
- JPS58148828A JPS58148828A JP57029816A JP2981682A JPS58148828A JP S58148828 A JPS58148828 A JP S58148828A JP 57029816 A JP57029816 A JP 57029816A JP 2981682 A JP2981682 A JP 2981682A JP S58148828 A JPS58148828 A JP S58148828A
- Authority
- JP
- Japan
- Prior art keywords
- agent
- collagenase
- protease
- kit
- kit according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004262 dental pulp cavity Anatomy 0.000 title claims abstract description 20
- 102000029816 Collagenase Human genes 0.000 claims abstract description 37
- 108060005980 Collagenase Proteins 0.000 claims abstract description 37
- 229960002424 collagenase Drugs 0.000 claims abstract description 33
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 32
- 239000004365 Protease Substances 0.000 claims abstract description 27
- 108091005804 Peptidases Proteins 0.000 claims abstract description 23
- 230000000694 effects Effects 0.000 claims abstract description 20
- 102000004190 Enzymes Human genes 0.000 claims abstract description 12
- 108090000790 Enzymes Proteins 0.000 claims abstract description 12
- 229940088598 enzyme Drugs 0.000 claims abstract description 12
- 108090000631 Trypsin Proteins 0.000 claims abstract description 9
- 102000004142 Trypsin Human genes 0.000 claims abstract description 9
- 239000012588 trypsin Substances 0.000 claims abstract description 9
- 239000007853 buffer solution Substances 0.000 claims abstract description 7
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 3
- 229910001425 magnesium ion Inorganic materials 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims abstract description 3
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000007983 Tris buffer Substances 0.000 claims abstract 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims abstract 2
- 102000035195 Peptidases Human genes 0.000 claims description 20
- 235000019419 proteases Nutrition 0.000 claims description 14
- 238000012545 processing Methods 0.000 claims description 10
- 239000000872 buffer Substances 0.000 claims description 9
- 239000012190 activator Substances 0.000 claims description 8
- 239000002131 composite material Substances 0.000 claims description 5
- 239000008363 phosphate buffer Substances 0.000 claims description 5
- 108090000284 Pepsin A Proteins 0.000 claims description 4
- 102000057297 Pepsin A Human genes 0.000 claims description 4
- 229940111202 pepsin Drugs 0.000 claims description 4
- 108090000317 Chymotrypsin Proteins 0.000 claims description 3
- 108090000526 Papain Proteins 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229960002376 chymotrypsin Drugs 0.000 claims description 3
- 229940055729 papain Drugs 0.000 claims description 3
- 235000019834 papain Nutrition 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229960001322 trypsin Drugs 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 241000277331 Salmonidae Species 0.000 claims 1
- 159000000003 magnesium salts Chemical class 0.000 claims 1
- 239000002075 main ingredient Substances 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 12
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 3
- 230000000604 odontoblastic effect Effects 0.000 abstract 1
- 239000008055 phosphate buffer solution Substances 0.000 abstract 1
- 210000004416 odontoblast Anatomy 0.000 description 11
- 102000008186 Collagen Human genes 0.000 description 9
- 108010035532 Collagen Proteins 0.000 description 9
- 229920001436 collagen Polymers 0.000 description 9
- 238000000635 electron micrograph Methods 0.000 description 7
- 239000000835 fiber Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 238000001493 electron microscopy Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 210000004268 dentin Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000723353 Chrysanthemum Species 0.000 description 2
- 235000007516 Chrysanthemum Nutrition 0.000 description 2
- 102000005593 Endopeptidases Human genes 0.000 description 2
- 108010059378 Endopeptidases Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940066758 endopeptidases Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- YJLUBHOZZTYQIP-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)NN=N2 YJLUBHOZZTYQIP-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 241000187254 Actinomadura madurae Species 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 241000606125 Bacteroides Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- 102000005600 Cathepsins Human genes 0.000 description 1
- 108010084457 Cathepsins Proteins 0.000 description 1
- 102000018389 Exopeptidases Human genes 0.000 description 1
- 108010091443 Exopeptidases Proteins 0.000 description 1
- 108090000270 Ficain Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001638 boron Chemical class 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- YQDHCCVUYCIGSW-LBPRGKRZSA-N ethyl (2s)-2-benzamido-5-(diaminomethylideneamino)pentanoate Chemical compound NC(=N)NCCC[C@@H](C(=O)OCC)NC(=O)C1=CC=CC=C1 YQDHCCVUYCIGSW-LBPRGKRZSA-N 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 235000019836 ficin Nutrition 0.000 description 1
- POTUGHMKJGOKRI-UHFFFAOYSA-N ficin Chemical compound FI=CI=N POTUGHMKJGOKRI-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 239000012173 sealing wax Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dental Preparations (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57029816A JPS58148828A (ja) | 1982-02-27 | 1982-02-27 | 歯根管処理剤並びに同処理用キツト |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57029816A JPS58148828A (ja) | 1982-02-27 | 1982-02-27 | 歯根管処理剤並びに同処理用キツト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58148828A true JPS58148828A (ja) | 1983-09-05 |
| JPH0357084B2 JPH0357084B2 (https=) | 1991-08-30 |
Family
ID=12286539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57029816A Granted JPS58148828A (ja) | 1982-02-27 | 1982-02-27 | 歯根管処理剤並びに同処理用キツト |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58148828A (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006501225A (ja) * | 2002-08-15 | 2006-01-12 | スリーエム エスペ アーゲー | 酵素含有組成物、かかる組成物を製造する方法およびその使用 |
| WO2008121019A1 (ru) * | 2007-03-29 | 2008-10-09 | Obschestvo S Ogranishennoi Otvetstvennostu 'farmving' | Средство противогистаминного антиаллергического действия и способ его получения |
| US8246951B2 (en) | 2004-05-24 | 2012-08-21 | 3M Deutschland Gmbh | Collagenolytic active enzyme containing compositions, and their use in the dental field |
| WO2017170996A1 (ja) * | 2016-03-31 | 2017-10-05 | 国立研究開発法人国立長寿医療研究センター | 歯科用前処理材及び歯組織再生キット |
| CN111148536A (zh) * | 2017-09-29 | 2020-05-12 | 国立研究开发法人国立长寿医疗研究中心 | 非细胞根管填料以及非细胞牙体组织再生促进试剂盒 |
-
1982
- 1982-02-27 JP JP57029816A patent/JPS58148828A/ja active Granted
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006501225A (ja) * | 2002-08-15 | 2006-01-12 | スリーエム エスペ アーゲー | 酵素含有組成物、かかる組成物を製造する方法およびその使用 |
| JP2010090164A (ja) * | 2002-08-15 | 2010-04-22 | 3M Espe Ag | 酵素含有組成物、かかる組成物を製造する方法およびその使用 |
| US9050332B2 (en) | 2002-08-15 | 2015-06-09 | 3M Innovative Properties Company | Enzyme containing composition, process of producing said composition and its use |
| US8246951B2 (en) | 2004-05-24 | 2012-08-21 | 3M Deutschland Gmbh | Collagenolytic active enzyme containing compositions, and their use in the dental field |
| WO2008121019A1 (ru) * | 2007-03-29 | 2008-10-09 | Obschestvo S Ogranishennoi Otvetstvennostu 'farmving' | Средство противогистаминного антиаллергического действия и способ его получения |
| EA017351B1 (ru) * | 2007-03-29 | 2012-11-30 | Общество С Ограниченной Ответственностью "Фармвинг" | Средство противогистаминного антиаллергического действия и способ его получения |
| US8569489B2 (en) | 2007-03-29 | 2013-10-29 | A.B. Intelpharm Limited | 7-[4-(Benzhydrylpiperazinyl-1)butyl]-3-methylxanthine and its salts with organic or inorganic acids possessing antihistaminic and antiallergenic activity |
| CN109152866A (zh) * | 2016-03-31 | 2019-01-04 | 国立研究开发法人国立长寿医疗研究中心 | 牙科用前处理材料及牙组织再生试剂盒 |
| WO2017170996A1 (ja) * | 2016-03-31 | 2017-10-05 | 国立研究開発法人国立長寿医療研究センター | 歯科用前処理材及び歯組織再生キット |
| JPWO2017170996A1 (ja) * | 2016-03-31 | 2019-02-14 | 国立研究開発法人国立長寿医療研究センター | 歯科用前処理材及び歯組織再生キット |
| EP3446723A4 (en) * | 2016-03-31 | 2019-10-16 | National Center for Geriatrics and Gerontology | DENTAL TREATMENT MATERIAL AND DENTAL HANDLING KIT |
| US10668134B2 (en) | 2016-03-31 | 2020-06-02 | National Center For Geriatrics And Gerontology | Dental pretreatment material and dental tissue regeneration kit |
| EP3721916A1 (en) * | 2016-03-31 | 2020-10-14 | National Center for Geriatrics and Gerontology | Dental pretreatment material and dental tissue regeneration kit |
| JP2021072925A (ja) * | 2016-03-31 | 2021-05-13 | エア・ウォーター株式会社 | 根管充填材 |
| CN113827486A (zh) * | 2016-03-31 | 2021-12-24 | 国立研究开发法人国立长寿医疗研究中心 | 根管填充材料及牙组织再生试剂盒 |
| US20220401528A1 (en) * | 2016-03-31 | 2022-12-22 | National Center For Geriatrics And Gerontology | Dental pretreatment material and dental tissue regeneration kit |
| CN111148536A (zh) * | 2017-09-29 | 2020-05-12 | 国立研究开发法人国立长寿医疗研究中心 | 非细胞根管填料以及非细胞牙体组织再生促进试剂盒 |
| CN111148536B (zh) * | 2017-09-29 | 2021-12-28 | 兴和株式会社 | 非细胞根管填料以及非细胞牙体组织再生促进试剂盒 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0357084B2 (https=) | 1991-08-30 |
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