JPS5798250A - O-substituted pyroracemic acid oxim, manufacture and therapeutic medicine containing same for diabetes, primary diabetes, fat accumulating disease and atherosclerosis - Google Patents
O-substituted pyroracemic acid oxim, manufacture and therapeutic medicine containing same for diabetes, primary diabetes, fat accumulating disease and atherosclerosisInfo
- Publication number
- JPS5798250A JPS5798250A JP56150828A JP15082881A JPS5798250A JP S5798250 A JPS5798250 A JP S5798250A JP 56150828 A JP56150828 A JP 56150828A JP 15082881 A JP15082881 A JP 15082881A JP S5798250 A JPS5798250 A JP S5798250A
- Authority
- JP
- Japan
- Prior art keywords
- radical
- substituted
- diabetes
- nitrile
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010012601 diabetes mellitus Diseases 0.000 title 2
- 201000001320 Atherosclerosis Diseases 0.000 title 1
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical class CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 cinnamyloxy, phenylamino Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000002825 nitriles Chemical class 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- BNJMRELGMDUDDB-UHFFFAOYSA-N $l^{1}-sulfanylbenzene Chemical compound [S]C1=CC=CC=C1 BNJMRELGMDUDDB-UHFFFAOYSA-N 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- MVGBKLTYYAYYGY-UHFFFAOYSA-N pyruvic oxime Chemical class ON=C(C)C(O)=O MVGBKLTYYAYYGY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803036281 DE3036281A1 (de) | 1980-09-26 | 1980-09-26 | 0-substituierte brenztraubensaeureoxime, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5798250A true JPS5798250A (en) | 1982-06-18 |
| JPH0226625B2 JPH0226625B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-06-12 |
Family
ID=6112892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56150828A Granted JPS5798250A (en) | 1980-09-26 | 1981-09-25 | O-substituted pyroracemic acid oxim, manufacture and therapeutic medicine containing same for diabetes, primary diabetes, fat accumulating disease and atherosclerosis |
Country Status (14)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3208330A1 (de) * | 1982-03-09 | 1983-09-15 | Basf Ag, 6700 Ludwigshafen | Alpha-oximinoessigsaeurederivate, ihre herstellung und ihre verwendung zur herstellung von fungizid wirksamen verbindungen |
| US4584014A (en) * | 1984-07-02 | 1986-04-22 | Rohm And Haas Company | Ethylideneaminooxyacetic acids and esters |
| WO1986000522A1 (en) * | 1984-07-17 | 1986-01-30 | Boehringer Mannheim Gmbh | UTILIZATION OF alpha-CETOCARBONIC ACID HYDRAZONES AND OXINES FOR TREATING CARDIAC OR CIRCULATORY DISEASES |
| DE3528753A1 (de) * | 1985-08-10 | 1987-02-19 | Bayer Ag | Substituierte pyrazolin-5-one |
| US4740524A (en) * | 1986-05-16 | 1988-04-26 | Rohm And Haas Company | Alpha-halopyruvate oxime |
| DE3838310A1 (de) * | 1988-11-11 | 1990-05-23 | Basf Ag | Hydroxylaminderivate |
| AU620974B2 (en) * | 1989-03-31 | 1992-02-27 | Sumitomo Chemical Company, Limited | Pyrazole oxime derivatives, production of same and method of controlling extremely harmful pests |
| JPH03190141A (ja) * | 1989-12-12 | 1991-08-20 | Samsung Electron Devices Co Ltd | 平板ディスプレー用薄膜トランジスタ及びその製造方法 |
| DE4204206A1 (de) * | 1992-02-13 | 1993-08-19 | Basf Ag | Mischungen aus optisch aktiven cyclohexenonoximethern, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als herbizide |
| US5393921A (en) * | 1993-07-07 | 1995-02-28 | The Gillette Company | Process for synthesizing O-substituted oxime compounds and conversion to the corresponding O-substituted hydroxylamine |
| ES2083324B1 (es) * | 1993-11-12 | 1996-12-16 | Univ Cordoba | Procedimiento de obtencion de nitrilos a partir de alfa-cetoacidos. |
| US5570072A (en) * | 1995-01-03 | 1996-10-29 | Siemens Stromberg-Carlson | Method of establishing a relay contact arrangement |
| US5594400A (en) * | 1995-01-03 | 1997-01-14 | Siemens Stromberg-Carlson | Reed relay |
| JP2007535398A (ja) | 2004-04-22 | 2007-12-06 | シーメンス ウォーター テクノロジース コーポレイション | 有機物質を消化するためのメンブレンバイオリアクタおよび処理槽を含む濾過装置ならびに廃液処理方法 |
| US7563363B2 (en) | 2005-10-05 | 2009-07-21 | Siemens Water Technologies Corp. | System for treating wastewater |
| US7455765B2 (en) | 2006-01-25 | 2008-11-25 | Siemens Water Technologies Corp. | Wastewater treatment system and method |
| CN112812035B (zh) * | 2021-02-01 | 2022-07-12 | 闽江学院 | 一种氟代乙醛-氧-芳基肟类化合物及其合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2470083A (en) * | 1946-04-03 | 1949-05-17 | Walter H Hartung | Ethers of oximino acid chlorides |
| US3104258A (en) | 1958-09-25 | 1963-09-17 | Fmc Corp | Novel synthesis of amino acids |
| CH511662A (de) | 1970-07-16 | 1971-08-31 | Fischer Ag Georg | Schnellwechseleinrichtung für Aufspannvorrichtung an Drehmaschinen |
| BE791214A (fr) * | 1972-05-08 | 1973-05-10 | Glaxo Lab Ltd | Procede de preparation d'isomeres de derives d'acide hydroxyiminoacetique etherifie purs |
| US4060686A (en) | 1973-12-21 | 1977-11-29 | Janice Bradshaw | Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group |
| US4052194A (en) | 1974-01-24 | 1977-10-04 | Merrill Wilcox | Oxime abscission agents |
| JPS606354B2 (ja) | 1976-03-30 | 1985-02-18 | 藤沢薬品工業株式会社 | ジ置換アルコキシベンゼン誘導体およびその塩類 |
| DE2739380A1 (de) | 1977-09-01 | 1979-03-08 | Boehringer Mannheim Gmbh | N-substituierte 2-hydrazono-propionsaeure-derivate, verfahren zur herstellung derselben und arzneimittel, die diese enthalten |
| DE2837863A1 (de) | 1978-09-04 | 1980-03-13 | Ciba Geigy Ag | Oxim-derivate zum schutz von pflanzenkulturen |
| DE3031842A1 (de) | 1980-08-23 | 1982-04-08 | Boehringer Mannheim Gmbh, 6800 Mannheim | N-substituierte brenztraubensaeurehydrazone, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
-
1980
- 1980-09-26 DE DE19803036281 patent/DE3036281A1/de not_active Withdrawn
-
1981
- 1981-09-08 US US06/300,076 patent/US4425360A/en not_active Expired - Fee Related
- 1981-09-19 DE DE8181107441T patent/DE3167634D1/de not_active Expired
- 1981-09-19 EP EP81107441A patent/EP0048911B1/de not_active Expired
- 1981-09-19 AT AT81107441T patent/ATE10622T1/de not_active IP Right Cessation
- 1981-09-21 CS CS816933A patent/CS228907B2/cs unknown
- 1981-09-21 SU SU3336185A patent/SU1279526A3/ru active
- 1981-09-21 IL IL63894A patent/IL63894A0/xx not_active IP Right Cessation
- 1981-09-21 HU HU812726A patent/HU184967B/hu not_active IP Right Cessation
- 1981-09-21 ES ES505672A patent/ES8205762A1/es not_active Expired
- 1981-09-23 DD DD81233511A patent/DD201781A5/de not_active IP Right Cessation
- 1981-09-24 CA CA000386602A patent/CA1242199A/en not_active Expired
- 1981-09-25 JP JP56150828A patent/JPS5798250A/ja active Granted
-
1982
- 1982-06-08 SU SU823449247A patent/SU1217252A3/ru active
-
1987
- 1987-11-24 SG SG1024/87A patent/SG102487G/en unknown
-
1991
- 1991-11-28 HK HK948/91A patent/HK94891A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU1217252A3 (ru) | 1986-03-07 |
| JPH0226625B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-06-12 |
| EP0048911A3 (en) | 1982-09-29 |
| ES505672A0 (es) | 1982-08-16 |
| HU184967B (en) | 1984-11-28 |
| IL63894A0 (en) | 1981-12-31 |
| DE3167634D1 (en) | 1985-01-17 |
| SU1279526A1 (ru) | 1986-12-23 |
| SG102487G (en) | 1989-01-27 |
| HK94891A (en) | 1991-12-06 |
| ES8205762A1 (es) | 1982-08-16 |
| ATE10622T1 (de) | 1984-12-15 |
| CS228907B2 (en) | 1984-05-14 |
| EP0048911B1 (de) | 1984-12-05 |
| US4425360A (en) | 1984-01-10 |
| EP0048911A2 (de) | 1982-04-07 |
| CA1242199A (en) | 1988-09-20 |
| SU1279526A3 (ru) | 1986-12-23 |
| DE3036281A1 (de) | 1982-05-13 |
| DD201781A5 (de) | 1983-08-10 |
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