JPS5794290A - Method for producing interferon - Google Patents
Method for producing interferonInfo
- Publication number
- JPS5794290A JPS5794290A JP55169103A JP16910380A JPS5794290A JP S5794290 A JPS5794290 A JP S5794290A JP 55169103 A JP55169103 A JP 55169103A JP 16910380 A JP16910380 A JP 16910380A JP S5794290 A JPS5794290 A JP S5794290A
- Authority
- JP
- Japan
- Prior art keywords
- interferon
- carrier
- micro
- cells
- proliferated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE: To produce interferon having high titir, stably, by treating animal cells attached to and proliferated on micro-carrier with a solution containing glucocorticoid.
CONSTITUTION: Seed cells such as diploid cells are inoculated in a medium containing suspended micro-carrier and if necessary a proper concentration of blood serum, and cultured at a proper temperature under slow stirring. The surface of the micro-carrier is covered almost completely with the proliferated cells within about severalW10 days. Glucocorticoid (e.g. hydrocortisone) of concentration of usually 0.01W100μM is added to the medium suspended with the micro-carrier having attached and proliferated cells 72W6 hours before addition of an interferon-inducing agent. Thereafter, the interferon-inducing treatment is carried out by superinduction method or UV method. An interferon having high titer can be obtained stably by this process.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55169103A JPS5794290A (en) | 1980-12-02 | 1980-12-02 | Method for producing interferon |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55169103A JPS5794290A (en) | 1980-12-02 | 1980-12-02 | Method for producing interferon |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5794290A true JPS5794290A (en) | 1982-06-11 |
JPH0123119B2 JPH0123119B2 (en) | 1989-05-01 |
Family
ID=15880355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55169103A Granted JPS5794290A (en) | 1980-12-02 | 1980-12-02 | Method for producing interferon |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5794290A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59179074A (en) * | 1983-03-30 | 1984-10-11 | Toray Ind Inc | Cultivation of cell |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5568296A (en) * | 1978-05-17 | 1980-05-22 | Thomae Gmbh Dr K | Production of interferon |
-
1980
- 1980-12-02 JP JP55169103A patent/JPS5794290A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5568296A (en) * | 1978-05-17 | 1980-05-22 | Thomae Gmbh Dr K | Production of interferon |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59179074A (en) * | 1983-03-30 | 1984-10-11 | Toray Ind Inc | Cultivation of cell |
JPH0314425B2 (en) * | 1983-03-30 | 1991-02-26 | Toray Industries |
Also Published As
Publication number | Publication date |
---|---|
JPH0123119B2 (en) | 1989-05-01 |
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