JPS5788125A - Anti-thrombin-heparin complex and manufacture - Google Patents

Anti-thrombin-heparin complex and manufacture

Info

Publication number
JPS5788125A
JPS5788125A JP56153104A JP15310481A JPS5788125A JP S5788125 A JPS5788125 A JP S5788125A JP 56153104 A JP56153104 A JP 56153104A JP 15310481 A JP15310481 A JP 15310481A JP S5788125 A JPS5788125 A JP S5788125A
Authority
JP
Japan
Prior art keywords
thrombin
manufacture
heparin complex
complex
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56153104A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0153650B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Ii Jiyoodan Robaato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Cutter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cutter Laboratories Inc filed Critical Cutter Laboratories Inc
Publication of JPS5788125A publication Critical patent/JPS5788125A/ja
Publication of JPH0153650B2 publication Critical patent/JPH0153650B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP56153104A 1980-09-30 1981-09-29 Anti-thrombin-heparin complex and manufacture Granted JPS5788125A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19217080A 1980-09-30 1980-09-30

Publications (2)

Publication Number Publication Date
JPS5788125A true JPS5788125A (en) 1982-06-01
JPH0153650B2 JPH0153650B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-11-15

Family

ID=22708546

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56153104A Granted JPS5788125A (en) 1980-09-30 1981-09-29 Anti-thrombin-heparin complex and manufacture

Country Status (7)

Country Link
EP (1) EP0048898B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5788125A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE12779T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU553260B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1187074A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3170001D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES505911A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925802A (ja) * 1982-06-10 1984-02-09 カビヴイトラム・アクチエボラ−グ 新規なヘパリン化合物
JP2009503483A (ja) * 2005-07-27 2009-01-29 アバンテイス・フアルマ・エス・アー アンチトロンビンｉｉｉのアフィニティークロマトグラフィーのための方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689323A (en) * 1983-09-26 1987-08-25 Miles Laboratories, Inc. Covalently bound heparin--antithrombin-III complex
EP0209924A1 (en) * 1985-07-12 1987-01-28 Akzo N.V. New anti-trombosis agent based on glycosaminoglycan, process for its preparation, and pharmaceutical compositions
DK148890D0 (da) * 1990-06-19 1990-06-19 Novo Nordisk As Farmaceutisk praeparat
ES2104887T3 (es) * 1991-01-11 1997-10-16 Glaxo Lab Sa Derivados de acridina.
AT405905B (de) * 1997-03-25 1999-12-27 Immuno Ag Neue verwendung von antithrombin iii
ATE377657T1 (de) * 2001-01-26 2007-11-15 Gen Hospital Corp Serpin-arzneistoffe zur behandlung einer hiv- infektion und verfahren zu deren verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6040859B2 (ja) * 1977-07-27 1985-09-12 喜温 三浦 抗血栓性人工医療材料
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925802A (ja) * 1982-06-10 1984-02-09 カビヴイトラム・アクチエボラ−グ 新規なヘパリン化合物
JP2009503483A (ja) * 2005-07-27 2009-01-29 アバンテイス・フアルマ・エス・アー アンチトロンビンｉｉｉのアフィニティークロマトグラフィーのための方法

Also Published As

Publication number Publication date
AU553260B2 (en) 1986-07-10
ATE12779T1 (de) 1985-05-15
ES8302460A1 (es) 1982-12-01
DE3170001D1 (en) 1985-05-23
EP0048898A3 (en) 1982-09-15
JPH0153650B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-11-15
EP0048898A2 (en) 1982-04-07
CA1187074A (en) 1985-05-14
AU7578581A (en) 1982-04-08
EP0048898B1 (en) 1985-04-17
ES505911A0 (es) 1982-12-01

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