JPS5759852A - Urea derivative - Google Patents
Urea derivativeInfo
- Publication number
- JPS5759852A JPS5759852A JP13700580A JP13700580A JPS5759852A JP S5759852 A JPS5759852 A JP S5759852A JP 13700580 A JP13700580 A JP 13700580A JP 13700580 A JP13700580 A JP 13700580A JP S5759852 A JPS5759852 A JP S5759852A
- Authority
- JP
- Japan
- Prior art keywords
- expressed
- alkyl
- formulai
- lower alkyl
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A urea derivative expressed by formulaI[R is H or lower alkyl. X is O or S; A is alkyl, unsaturated alkyl, cycloalkyl, aryl, aralkyl or -(CH2)n COOR' (R' is lower alkyl; n is an integer 1W8)].
EXAMPLE: N-(trans-4-Carboxycyclohexylmethyl)-N'-cyclohexylurea.
USE: A medicine having anticomplementary action, preventing agent and remedy for allergic diseases, e.g. nephritis, hheumatism, collagen diseases of autoimmune diseases, having antiplasminic, antitumor, antiulcer and antithrombotic actions.
PROCESS: A 4-aminomethylcyclohexanecarboxylic acid expressed by formula II or an ester derivative thereof is reacted with an isocyanate or thiocyanate derivative expressed by formula III in a solvent, e.g. tetrahydrofuran or dioxane, to give the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13700580A JPS5759852A (en) | 1980-09-29 | 1980-09-29 | Urea derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13700580A JPS5759852A (en) | 1980-09-29 | 1980-09-29 | Urea derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5759852A true JPS5759852A (en) | 1982-04-10 |
JPH0147461B2 JPH0147461B2 (en) | 1989-10-13 |
Family
ID=15188571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13700580A Granted JPS5759852A (en) | 1980-09-29 | 1980-09-29 | Urea derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5759852A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0107214A2 (en) * | 1982-09-02 | 1984-05-02 | Duphar International Research B.V | Pharmaceutical compositions containing benzoyl-phenyl ureas with anti-tumour activity |
EP0585130A2 (en) * | 1992-08-27 | 1994-03-02 | Shiseido Company Limited | External preparation for skin containing a depigmentation agent |
CN104529832A (en) * | 2014-11-18 | 2015-04-22 | 江苏泰仓农化有限公司 | Production technology of N-cyclohexylurea |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103896812A (en) * | 2014-04-16 | 2014-07-02 | 厦门大学 | N,N'-dicyclohexyl-N-higher fatty acid ureide analogs and pharmaceutical application thereof |
-
1980
- 1980-09-29 JP JP13700580A patent/JPS5759852A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0107214A2 (en) * | 1982-09-02 | 1984-05-02 | Duphar International Research B.V | Pharmaceutical compositions containing benzoyl-phenyl ureas with anti-tumour activity |
EP0585130A2 (en) * | 1992-08-27 | 1994-03-02 | Shiseido Company Limited | External preparation for skin containing a depigmentation agent |
EP0585130A3 (en) * | 1992-08-27 | 1994-06-08 | Shiseido Co Ltd | External preparation for skin containing a depigmentation agent |
US5690914A (en) * | 1992-08-27 | 1997-11-25 | Shiseido Co., Ltd | External preparation for skin |
CN104529832A (en) * | 2014-11-18 | 2015-04-22 | 江苏泰仓农化有限公司 | Production technology of N-cyclohexylurea |
Also Published As
Publication number | Publication date |
---|---|
JPH0147461B2 (en) | 1989-10-13 |
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