JPS5759852A - Urea derivative - Google Patents

Urea derivative

Info

Publication number
JPS5759852A
JPS5759852A JP13700580A JP13700580A JPS5759852A JP S5759852 A JPS5759852 A JP S5759852A JP 13700580 A JP13700580 A JP 13700580A JP 13700580 A JP13700580 A JP 13700580A JP S5759852 A JPS5759852 A JP S5759852A
Authority
JP
Japan
Prior art keywords
expressed
alkyl
formulai
lower alkyl
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13700580A
Other languages
Japanese (ja)
Other versions
JPH0147461B2 (en
Inventor
Kanji Noda
Akira Nakagawa
Toshiharu Motomura
Satoru Miyata
Toshitaka Inoue
Hiroyuki Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP13700580A priority Critical patent/JPS5759852A/en
Publication of JPS5759852A publication Critical patent/JPS5759852A/en
Publication of JPH0147461B2 publication Critical patent/JPH0147461B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A urea derivative expressed by formulaI[R is H or lower alkyl. X is O or S; A is alkyl, unsaturated alkyl, cycloalkyl, aryl, aralkyl or -(CH2)n COOR' (R' is lower alkyl; n is an integer 1W8)].
EXAMPLE: N-(trans-4-Carboxycyclohexylmethyl)-N'-cyclohexylurea.
USE: A medicine having anticomplementary action, preventing agent and remedy for allergic diseases, e.g. nephritis, hheumatism, collagen diseases of autoimmune diseases, having antiplasminic, antitumor, antiulcer and antithrombotic actions.
PROCESS: A 4-aminomethylcyclohexanecarboxylic acid expressed by formula II or an ester derivative thereof is reacted with an isocyanate or thiocyanate derivative expressed by formula III in a solvent, e.g. tetrahydrofuran or dioxane, to give the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP13700580A 1980-09-29 1980-09-29 Urea derivative Granted JPS5759852A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13700580A JPS5759852A (en) 1980-09-29 1980-09-29 Urea derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13700580A JPS5759852A (en) 1980-09-29 1980-09-29 Urea derivative

Publications (2)

Publication Number Publication Date
JPS5759852A true JPS5759852A (en) 1982-04-10
JPH0147461B2 JPH0147461B2 (en) 1989-10-13

Family

ID=15188571

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13700580A Granted JPS5759852A (en) 1980-09-29 1980-09-29 Urea derivative

Country Status (1)

Country Link
JP (1) JPS5759852A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107214A2 (en) * 1982-09-02 1984-05-02 Duphar International Research B.V Pharmaceutical compositions containing benzoyl-phenyl ureas with anti-tumour activity
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
CN104529832A (en) * 2014-11-18 2015-04-22 江苏泰仓农化有限公司 Production technology of N-cyclohexylurea

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103896812A (en) * 2014-04-16 2014-07-02 厦门大学 N,N'-dicyclohexyl-N-higher fatty acid ureide analogs and pharmaceutical application thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107214A2 (en) * 1982-09-02 1984-05-02 Duphar International Research B.V Pharmaceutical compositions containing benzoyl-phenyl ureas with anti-tumour activity
EP0585130A2 (en) * 1992-08-27 1994-03-02 Shiseido Company Limited External preparation for skin containing a depigmentation agent
EP0585130A3 (en) * 1992-08-27 1994-06-08 Shiseido Co Ltd External preparation for skin containing a depigmentation agent
US5690914A (en) * 1992-08-27 1997-11-25 Shiseido Co., Ltd External preparation for skin
CN104529832A (en) * 2014-11-18 2015-04-22 江苏泰仓农化有限公司 Production technology of N-cyclohexylurea

Also Published As

Publication number Publication date
JPH0147461B2 (en) 1989-10-13

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