JPS5754166A - 88azaa16 166jifuruorupurosutanoido - Google Patents

88azaa16 166jifuruorupurosutanoido

Info

Publication number
JPS5754166A
JPS5754166A JP56124205A JP12420581A JPS5754166A JP S5754166 A JPS5754166 A JP S5754166A JP 56124205 A JP56124205 A JP 56124205A JP 12420581 A JP12420581 A JP 12420581A JP S5754166 A JPS5754166 A JP S5754166A
Authority
JP
Japan
Prior art keywords
88azaa16
stereo
active
prostanoids
aza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56124205A
Other languages
English (en)
Inventor
Meriru Sukuraibunaa Richaado
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of JPS5754166A publication Critical patent/JPS5754166A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP56124205A 1980-08-11 1981-08-10 88azaa16 166jifuruorupurosutanoido Pending JPS5754166A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/176,784 US4320136A (en) 1980-08-11 1980-08-11 8-Aza-16,16-difluoroprostanoids

Publications (1)

Publication Number Publication Date
JPS5754166A true JPS5754166A (en) 1982-03-31

Family

ID=22645804

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56124205A Pending JPS5754166A (en) 1980-08-11 1981-08-10 88azaa16 166jifuruorupurosutanoido

Country Status (7)

Country Link
US (1) US4320136A (ja)
EP (1) EP0046082B1 (ja)
JP (1) JPS5754166A (ja)
AT (1) ATE13667T1 (ja)
CA (1) CA1161447A (ja)
DE (1) DE3170838D1 (ja)
DK (1) DK352281A (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024647A1 (fr) * 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine
JP2012111767A (ja) * 2001-07-23 2012-06-14 Ono Pharmaceut Co Ltd Ｅｐ４アゴニストを有効成分とする骨量低下疾患の治療剤

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4530933A (en) * 1982-12-27 1985-07-23 E. I. Du Pont De Nemours And Company 8-Aza-13-thiaprostanoids and a method of use thereof as anti-ulcer agents
US4456613A (en) * 1982-12-27 1984-06-26 E. I. Du Pont De Nemours And Company 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
DK1339678T3 (da) * 2000-11-27 2008-02-04 Pfizer Prod Inc Selektive agonister til EP4-receptor til behandling af osteoporose
JP2004521954A (ja) 2001-07-16 2004-07-22 エフ．ホフマン−ラ　ロシュ　アーゲー Ｅｐ４受容体作用薬としてのプロスタグランジン類似体
MXPA04000454A (es) * 2001-07-16 2004-03-18 Hoffmann La Roche Derivados de 2-pirrolidona como agonistas de prostanoides.
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
RU2311409C2 (ru) * 2003-01-10 2007-11-27 Ф.Хоффманн-Ля Рош Аг Производные 2-пиперидона в качестве агонистов простагландина
US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US20080058375A1 (en) * 2004-01-08 2008-03-06 Elworthy Todd R 2-Piperidone derivatives as prostaglandin antagonists
CA2738045C (en) * 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
NZ704171A (en) 2012-07-19 2017-10-27 Cayman Chemical Co Inc Difluorolactam compositions for ep4-mediated osteo related diseases and conditions
CA2903314C (en) 2013-03-15 2023-02-14 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
EP3235817B1 (en) 2013-03-15 2018-12-12 Cayman Chemical Company, Incorporated Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
WO2014144610A1 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
CA2910398A1 (en) 2013-07-19 2015-01-22 Cayman Chemical Company, Inc. Methods, systems, and compositions for promoting bone growth
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
CA2988523A1 (en) 2015-06-12 2016-12-15 Simon Fraser University Amide-linked ep4 agonist-bisphosphonate compounds and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873566A (en) * 1973-02-28 1975-03-25 Du Pont 3-Pyrazolidinones and pyrazolidines
US3962293A (en) * 1973-07-20 1976-06-08 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin F1
US3969378A (en) * 1973-07-20 1976-07-13 The Upjohn Company 16-Fluoro prostaglandin A2 analogs
US3974192A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin B1 analogs
US3974190A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin A1 analogs
US3974193A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin B2 analogs
US3974191A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin F1 analogs
US3969376A (en) * 1973-07-20 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin E1 analogs
US3974189A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin E2 analogs
US4187381A (en) * 1973-08-06 1980-02-05 Hoffmann-La Roche Inc. 16-Substituted prostaglandins
US4017534A (en) * 1974-06-03 1977-04-12 American Cyanamid Company 16-Fluoro-11-deoxy-13-dihydro-prostaglandin
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
US3969379A (en) * 1975-02-21 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin A1 analogs
US3969381A (en) * 1975-02-21 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin B1 analogs
US3969380A (en) * 1975-02-21 1976-07-13 The Upjohn Company 16-Fluoro prostaglandin F2 analogs
US3969377A (en) * 1975-02-21 1976-07-13 The Upjohn Company 16-Fluoro prostaglandin E1 analogs
US4113873A (en) * 1975-04-26 1978-09-12 Tanabe Seiyaku Co. Ltd. 8-azaprostanoic acid derivatives
US4003911A (en) * 1975-09-26 1977-01-18 E. I. Du Pont De Nemours And Company Selected 3-pyrrolidinones and 2,4-pyrrolidindiones
US4032533A (en) * 1976-02-19 1977-06-28 E. I. Du Pont De Nemours And Company 3,4-disubstituted-1,3,4-thiadiazoline-2,5-diones
IL49325A (en) * 1976-03-31 1979-11-30 Labaz 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
DE2619638A1 (de) 1976-05-04 1977-11-17 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung
US4177346A (en) * 1976-08-06 1979-12-04 Pfizer Inc. 1,5-Disubstituted-2-pyrrolidones
US4211876A (en) * 1979-06-13 1980-07-08 E. I. Du Pont De Nemours And Company 3-Pyrazolidinone carboxamides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024647A1 (fr) * 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine
JP2012111767A (ja) * 2001-07-23 2012-06-14 Ono Pharmaceut Co Ltd Ｅｐ４アゴニストを有効成分とする骨量低下疾患の治療剤

Also Published As

Publication number Publication date
EP0046082B1 (en) 1985-06-05
US4320136A (en) 1982-03-16
CA1161447A (en) 1984-01-31
ATE13667T1 (de) 1985-06-15
DK352281A (da) 1982-02-12
EP0046082A3 (en) 1982-03-03
DE3170838D1 (en) 1985-07-11
EP0046082A2 (en) 1982-02-17

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