JPS5750964A - Preparation of 10-hydroxy-4-benzazonine derivative - Google Patents

Preparation of 10-hydroxy-4-benzazonine derivative

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Publication number
JPS5750964A
JPS5750964A JP12557980A JP12557980A JPS5750964A JP S5750964 A JPS5750964 A JP S5750964A JP 12557980 A JP12557980 A JP 12557980A JP 12557980 A JP12557980 A JP 12557980A JP S5750964 A JPS5750964 A JP S5750964A
Authority
JP
Japan
Prior art keywords
formula
compound
benzazonine
reducing
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12557980A
Other languages
Japanese (ja)
Inventor
Ichihiro Hayashi
Osamu Futsukaichi
Yoshio Miyamura
Keiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Iyakuhin Kogyo Co Ltd
Original Assignee
Nihon Iyakuhin Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Iyakuhin Kogyo Co Ltd filed Critical Nihon Iyakuhin Kogyo Co Ltd
Priority to JP12557980A priority Critical patent/JPS5750964A/en
Publication of JPS5750964A publication Critical patent/JPS5750964A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To prepare the titled compound having excellent pharmacological activities such as analgesic activity, etc., easily, economically, in high yield, with simple procedure, by reducing a 4-benzazonine-7-one derivative having a specific group at the 10-position.
CONSTITUTION: The objective compound of formula III is prepared either by reducing the compound of formula I (R is H, or a group eliminable by recuction, e.g. group of formula II, COCH3, COOC2H5, etc.; R' is H or CH3), e.g. 10-benzyloxy- 1,4-dimethyl-2,3,4,5-tetrahydro-1,6-methano-1H-4-benzazonine-7( 6H )-one, with hydrogen activated by a catalyst comprising Pd which may be supported on a carrier, in a solvent such as acetic acid, pref. adding an acid such as hydrochloric acid to the system, at 50W80°C under atmospheric pressure, or by reducing the compound of formula I in a lower alcohol solvent with a complex metal hydride e.g. NaBH4, pref. adding an aqueous solution of alkali hydroxide to the system, at room temperature for 2W4hr.
COPYRIGHT: (C)1982,JPO&Japio
JP12557980A 1980-09-10 1980-09-10 Preparation of 10-hydroxy-4-benzazonine derivative Pending JPS5750964A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12557980A JPS5750964A (en) 1980-09-10 1980-09-10 Preparation of 10-hydroxy-4-benzazonine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12557980A JPS5750964A (en) 1980-09-10 1980-09-10 Preparation of 10-hydroxy-4-benzazonine derivative

Publications (1)

Publication Number Publication Date
JPS5750964A true JPS5750964A (en) 1982-03-25

Family

ID=14913669

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12557980A Pending JPS5750964A (en) 1980-09-10 1980-09-10 Preparation of 10-hydroxy-4-benzazonine derivative

Country Status (1)

Country Link
JP (1) JPS5750964A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108530241A (en) * 2018-04-04 2018-09-14 武汉大学 A kind of preparation method of Benzocyclodirivative and Eptazocine with benzyl position quaternary carbon center
CN110563605A (en) * 2018-06-05 2019-12-13 上海医药工业研究院 Intermediate for preparing eptazocine hydrobromide and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50100073A (en) * 1974-01-14 1975-08-08

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50100073A (en) * 1974-01-14 1975-08-08

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108530241A (en) * 2018-04-04 2018-09-14 武汉大学 A kind of preparation method of Benzocyclodirivative and Eptazocine with benzyl position quaternary carbon center
CN110563605A (en) * 2018-06-05 2019-12-13 上海医药工业研究院 Intermediate for preparing eptazocine hydrobromide and preparation method thereof

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