JPS57500382A - - Google Patents

Info

Publication number
JPS57500382A
JPS57500382A JP50088681A JP50088681A JPS57500382A JP S57500382 A JPS57500382 A JP S57500382A JP 50088681 A JP50088681 A JP 50088681A JP 50088681 A JP50088681 A JP 50088681A JP S57500382 A JPS57500382 A JP S57500382A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP50088681A
Other versions
JPH0686385B2 (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/116,186 external-priority patent/US4287180A/en
Priority claimed from US06/116,187 external-priority patent/US4286056A/en
Application filed filed Critical
Publication of JPS57500382A publication Critical patent/JPS57500382A/ja
Publication of JPH0686385B2 publication Critical patent/JPH0686385B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
JP56500886A 1980-01-28 1981-01-02 活性プロトロンビン複合体組成物およびその製造方法 Expired - Lifetime JPH0686385B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US116187 1980-01-28
US06/116,186 US4287180A (en) 1980-01-28 1980-01-28 Method for treating blood clotting factor inhibitors
US06/116,187 US4286056A (en) 1980-01-28 1980-01-28 Method for making therapeutic enzyme compositions
US116186 1980-01-28
PCT/US1981/000003 WO1981002105A1 (en) 1980-01-28 1981-01-02 Therapeutic compositions & methods for manufacture and use

Related Child Applications (4)

Application Number Title Priority Date Filing Date
JP6123152A Division JPH07145074A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123153A Division JPH07145075A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123150A Division JPH07145072A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123151A Division JPH07145073A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物

Publications (2)

Publication Number Publication Date
JPS57500382A true JPS57500382A (ja) 1982-03-04
JPH0686385B2 JPH0686385B2 (ja) 1994-11-02

Family

ID=26813964

Family Applications (5)

Application Number Title Priority Date Filing Date
JP56500886A Expired - Lifetime JPH0686385B2 (ja) 1980-01-28 1981-01-02 活性プロトロンビン複合体組成物およびその製造方法
JP6123151A Pending JPH07145073A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123152A Pending JPH07145074A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123153A Pending JPH07145075A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123150A Pending JPH07145072A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP6123151A Pending JPH07145073A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123152A Pending JPH07145074A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123153A Pending JPH07145075A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物
JP6123150A Pending JPH07145072A (ja) 1980-01-28 1994-05-12 血液凝固因子阻害因子処置のための水性組成物

Country Status (7)

Country Link
EP (1) EP0044343B1 (ja)
JP (5) JPH0686385B2 (ja)
CA (1) CA1176563A (ja)
DE (1) DE3165600D1 (ja)
DK (1) DK427281A (ja)
IT (1) IT1141963B (ja)
WO (1) WO1981002105A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT368883B (de) * 1980-07-22 1982-11-25 Immuno Ag Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
JPH0780783B2 (ja) * 1985-11-26 1995-08-30 ノボ ノルディスク アクティーゼルスカブ 出血障害の治療のための第▲ＶＩＩ▼ａ因子を含有する治療組成物
DE4430205A1 (de) * 1994-08-26 1996-02-29 Behringwerke Ag Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
AUPN436995A0 (en) * 1995-07-24 1995-08-17 Csl Limited Method for the production of thrombin
DE19531637A1 (de) * 1995-08-28 1997-03-06 Immuno Ag Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung
CA2285935C (en) 1997-04-08 2011-01-18 Baxter Aktiengesellschaft An immunotolerant prothrombin complex preparation
AT407484B (de) 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
JP4676585B2 (ja) 1999-12-24 2011-04-27 一般財団法人化学及血清療法研究所 血液凝固異常に基づく疾患の治療・予防用医薬組成物
JP2004517950A (ja) * 2001-02-05 2004-06-17 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチド及び第ｖｉｉｉ因子ポリペプチドの組合された使用
RS20050051A (en) 2002-07-23 2007-06-04 Bio-Products & Bio Engineering Ag., Pharmaceutical active ingredient preparation and medicaments that contain thrombin or have a thrombin-generating capacity
DE50311422D1 (de) * 2002-07-23 2009-05-28 Bio & Bio Licensing Sa Thrombingenerierfähige und thrombinhaltige pharmazeutische wirkstoffzubereitungen und arzneimittel
JP2007055899A (ja) * 2003-10-27 2007-03-08 Chemo Sero Therapeut Res Inst 血液凝固第ｘ因子を主剤とする血液凝固異常に基づく疾患の治療・予防用医薬組成物
AU2011313505B2 (en) * 2010-10-06 2015-09-17 Medimmune Limited Factor II and fibrinogen for treatment of haemostatic disorders
RU2559576C1 (ru) * 2014-06-09 2015-08-10 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения РФ Способ получения вирусбезопасного полного протромбинового комплекса

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA920947A (en) * 1968-10-02 1973-02-13 Y. C. Hew Howard Prothrombin complex
US3717708A (en) * 1968-10-24 1973-02-20 Cutter Lab Blood coagulation complex
US3560475A (en) * 1969-06-19 1971-02-02 Baxter Laboratories Inc Prothrombin complex prepared by precipitation with polyethylene glycol
US4170590A (en) * 1974-12-14 1979-10-09 Biotest-Serum-Institut Gmbh Ion exchanger treatment of citrate-stabilized plasma
DE2550011C2 (de) * 1975-11-07 1982-11-25 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines antihämophilen Mittels
AT350726B (de) * 1976-08-30 1979-06-11 Immuno Ag Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma
DE2902158A1 (de) * 1979-01-20 1980-07-31 Biotest Serum Institut Gmbh Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen
FR2472390A1 (fr) * 1979-05-04 1981-07-03 Merieux Inst Procede de preparation de concentres de complexe prothrombinique hautement purifies, et concentres obtenus
JPH0686385A (ja) * 1992-08-31 1994-03-25 Matsushita Electric Ind Co Ltd 動電型スピーカ

Also Published As

Publication number Publication date
JPH07145073A (ja) 1995-06-06
EP0044343A4 (en) 1982-06-10
EP0044343B1 (en) 1984-08-22
CA1176563A (en) 1984-10-23
EP0044343A1 (en) 1982-01-27
JPH07145072A (ja) 1995-06-06
DE3165600D1 (en) 1984-09-27
JPH0686385B2 (ja) 1994-11-02
IT1141963B (it) 1986-10-08
JPH07145074A (ja) 1995-06-06
JPH07145075A (ja) 1995-06-06
WO1981002105A1 (en) 1981-08-06
DK427281A (da) 1981-09-25

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