JPS5748985A - Novel mitomycin derivative - Google Patents

Novel mitomycin derivative

Info

Publication number
JPS5748985A
JPS5748985A JP55124052A JP12405280A JPS5748985A JP S5748985 A JPS5748985 A JP S5748985A JP 55124052 A JP55124052 A JP 55124052A JP 12405280 A JP12405280 A JP 12405280A JP S5748985 A JPS5748985 A JP S5748985A
Authority
JP
Japan
Prior art keywords
solvent
formula
compound
methyl bromoacetate
excessive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55124052A
Other languages
Japanese (ja)
Other versions
JPS6237632B2 (en
Inventor
Kimikatsu Shirahata
Kazumichi Kono
Yutaka Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP55124052A priority Critical patent/JPS5748985A/en
Publication of JPS5748985A publication Critical patent/JPS5748985A/en
Publication of JPS6237632B2 publication Critical patent/JPS6237632B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I [R1 is alkoxy, substituted carbamoyloxy; R2 is CH2R3(R3 is H, alkyl, alkoxycarbonyl, acyloxy), acyl].
EXAMPLE: 1a-N-Methoxycarbonylmethylmitomycin A.
USE: Antibiotic or antitumor agent.
PREPARATION: For example, mitomycin A of formula II is dissolved in a solvent such as dimethylformamide, combined with methyl bromoacetate and potassium cabonate and they are stirred under a flow of nitrogen at room temperature. After the completion of the reaction, excessive potassium carbonate in the reaction mixture is filtered off and excessive methyl bromoacetate and the solvent are distilled off. The residue is subjected to silica-gel chromatography using chloroform-methanol mixed solvent as a developing solvent to effect purification, thereby the compound of formula I is obtained.
COPYRIGHT: (C)1982,JPO&Japio
JP55124052A 1980-09-09 1980-09-09 Novel mitomycin derivative Granted JPS5748985A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55124052A JPS5748985A (en) 1980-09-09 1980-09-09 Novel mitomycin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55124052A JPS5748985A (en) 1980-09-09 1980-09-09 Novel mitomycin derivative

Publications (2)

Publication Number Publication Date
JPS5748985A true JPS5748985A (en) 1982-03-20
JPS6237632B2 JPS6237632B2 (en) 1987-08-13

Family

ID=14875779

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55124052A Granted JPS5748985A (en) 1980-09-09 1980-09-09 Novel mitomycin derivative

Country Status (1)

Country Link
JP (1) JPS5748985A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6168489A (en) * 1984-09-04 1986-04-08 ユニヴアシテイ　パテンツ，インコーポレイテツド Novel hexasubstituted mitomycin analogue

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6168489A (en) * 1984-09-04 1986-04-08 ユニヴアシテイ　パテンツ，インコーポレイテツド Novel hexasubstituted mitomycin analogue

Also Published As

Publication number Publication date
JPS6237632B2 (en) 1987-08-13

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