JPS5742633A - Production of blood preparation - Google Patents

Production of blood preparation

Info

Publication number
JPS5742633A
JPS5742633A JP55120140A JP12014080A JPS5742633A JP S5742633 A JPS5742633 A JP S5742633A JP 55120140 A JP55120140 A JP 55120140A JP 12014080 A JP12014080 A JP 12014080A JP S5742633 A JPS5742633 A JP S5742633A
Authority
JP
Japan
Prior art keywords
blood preparation
insoluble
antithrombin
adsorption
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55120140A
Other languages
Japanese (ja)
Other versions
JPS6236494B2 (en
Inventor
Yatsuhiro Kamimura
Yoshiaki Kano
Satoru Funakoshi
Tadakazu Suyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP55120140A priority Critical patent/JPS5742633A/en
Publication of JPS5742633A publication Critical patent/JPS5742633A/en
Publication of JPS6236494B2 publication Critical patent/JPS6236494B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: Water-insoluble antithrombin-III is brought into contact with a blood preparation to remove trace amounts of hypotensive and coagulation-accelerating substances by adsorption in high efficiency, thus producing the objective blood preparation of high safety in high yield.
CONSTITUTION: Water-insoluble antithrombin-III is used and brought into contact with a blood preparation containing hypotensive and coagulation-accelerating substances as contaminants to remove these substances by adsorption. The purity of the starting blood preparation is higher than 40%, preferably higher than 60%. An example of the water-insoluble antithrombin is the reaction product between an insoluble support and antithrombin-III, which is preferably linked to the insoluble support through the carboxyl groups in its molecule. The adsorption is preferably conducted in the presence of a sulfated polysaccharide. The removal rate is higher than 90% and the recovery rate also is higher than 90%.
COPYRIGHT: (C)1982,JPO&Japio
JP55120140A 1980-08-29 1980-08-29 Production of blood preparation Granted JPS5742633A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55120140A JPS5742633A (en) 1980-08-29 1980-08-29 Production of blood preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55120140A JPS5742633A (en) 1980-08-29 1980-08-29 Production of blood preparation

Publications (2)

Publication Number Publication Date
JPS5742633A true JPS5742633A (en) 1982-03-10
JPS6236494B2 JPS6236494B2 (en) 1987-08-07

Family

ID=14778950

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55120140A Granted JPS5742633A (en) 1980-08-29 1980-08-29 Production of blood preparation

Country Status (1)

Country Link
JP (1) JPS5742633A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9534029B2 (en) 2012-10-03 2017-01-03 Csl Behring Ag Method of purifying proteins

Also Published As

Publication number Publication date
JPS6236494B2 (en) 1987-08-07

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