JPS5735570A - Alpha-amino-beta-hydroxybutyryl-l-hystidine and its preparation - Google Patents
Alpha-amino-beta-hydroxybutyryl-l-hystidine and its preparationInfo
- Publication number
- JPS5735570A JPS5735570A JP11137180A JP11137180A JPS5735570A JP S5735570 A JPS5735570 A JP S5735570A JP 11137180 A JP11137180 A JP 11137180A JP 11137180 A JP11137180 A JP 11137180A JP S5735570 A JPS5735570 A JP S5735570A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- formula
- hystidine
- preparation
- protecting groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- WHBMMWSBFZVSSR-UHFFFAOYSA-N R3HBA Natural products CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N THREONINE Chemical compound CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 t-butoxycarbonyl group Chemical group 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The compound of formula I.
USE: Anti-inflammatory, antiulcerative, granulation accelerator.
PREPARATION: α-Amino-β-hydroxybutanoic acid of formula II and L-hystidine are protected with proper protecting groups which are used in peptide synthesis respectively and made to react, then the protecting groups are removed from the reaction product to give the compound of formula I. The optically active D- or L-isomer of formula II is obtained by protecting the amino group of DL-γ-amino- β-hydroxybutanoic acid with t-butoxycarbonyl group, making an optically active base acting on the product to form a mixture of diastereomer salts, subjecting the mixture to fractional crystallization and removing the protecting groups.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11137180A JPS5735570A (en) | 1980-08-12 | 1980-08-12 | Alpha-amino-beta-hydroxybutyryl-l-hystidine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11137180A JPS5735570A (en) | 1980-08-12 | 1980-08-12 | Alpha-amino-beta-hydroxybutyryl-l-hystidine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5735570A true JPS5735570A (en) | 1982-02-26 |
Family
ID=14559492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11137180A Pending JPS5735570A (en) | 1980-08-12 | 1980-08-12 | Alpha-amino-beta-hydroxybutyryl-l-hystidine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5735570A (en) |
-
1980
- 1980-08-12 JP JP11137180A patent/JPS5735570A/en active Pending
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