JPS5729999B2 - - Google Patents
Info
- Publication number
- JPS5729999B2 JPS5729999B2 JP50117779A JP50117779A JPS5729999B2 JP S5729999 B2 JPS5729999 B2 JP S5729999B2 JP 50117779 A JP50117779 A JP 50117779A JP 50117779 A JP50117779 A JP 50117779A JP S5729999 B2 JPS5729999 B2 JP S5729999B2
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/968—Plasmin, i.e. fibrinolysin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/802—Chromogenic or luminescent peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/930,826 US4275153A (en) | 1978-08-03 | 1978-08-03 | Analytical fluorogenic substrates for proteolytic enzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55500538A JPS55500538A (en:Method) | 1980-08-21 |
| JPS5729999B2 true JPS5729999B2 (en:Method) | 1982-06-25 |
Family
ID=25459832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50117779A Expired JPS5729999B2 (en:Method) | 1978-08-03 | 1979-06-15 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4275153A (en:Method) |
| EP (1) | EP0016800B1 (en:Method) |
| JP (1) | JPS5729999B2 (en:Method) |
| CA (1) | CA1152494A (en:Method) |
| DE (1) | DE2967581D1 (en:Method) |
| IT (1) | IT1117757B (en:Method) |
| NO (1) | NO792553L (en:Method) |
| WO (1) | WO1980000351A1 (en:Method) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012517435A (ja) * | 2009-02-06 | 2012-08-02 | グリフオルス・セラピユーテイクス・インコーポレーテツド | プラスミン活性を決定するための組成物、キットおよび方法 |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2936543A1 (de) * | 1979-09-10 | 1981-04-09 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen |
| CA1161432A (en) * | 1980-02-12 | 1984-01-31 | Lars G. Svendsen | Tripeptide derivatives and their application in assaying enzymes |
| ATE8130T1 (de) * | 1980-08-25 | 1984-07-15 | Kabivitrum Ab | Peptidsubstrate zum bestimmen der proteaseaktivitaet. |
| JPS5856695A (ja) * | 1981-09-28 | 1983-04-04 | Nitto Boseki Co Ltd | 新規なトロンビン測定用基質 |
| EP0078764B1 (de) * | 1981-11-02 | 1986-01-02 | Pentapharm A.G. | Verfahren zur quantitativen Bestimmung von Blutgerinnungsfaktor XII in Humanplasma |
| JPS5925699A (ja) * | 1982-08-03 | 1984-02-09 | Torii Yakuhin Kk | 酵素活性測定方法 |
| US4473639A (en) * | 1982-09-15 | 1984-09-25 | Miles Laboratories, Inc. | Reagent strip test for antithrombin-III |
| CS231228B1 (en) * | 1982-10-01 | 1984-10-15 | Evzen Kasafirek | Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method |
| DE3244030A1 (de) * | 1982-11-27 | 1984-05-30 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
| US4621135A (en) * | 1983-12-08 | 1986-11-04 | Yeda Research & Development Company, Ltd. | Novel THF compositions |
| US4801534A (en) * | 1985-05-28 | 1989-01-31 | Coulter Electronics, Inc. | Water soluble zanthylium derivative substrates |
| US4694070A (en) * | 1985-05-28 | 1987-09-15 | Coulter Electronics, Inc. | Water soluble xanthylium derivatives substrates |
| SE461494B (sv) * | 1986-03-21 | 1990-02-19 | Thorsman & Co Ab | Faestanordning foer en elektrisk kopplingsdosa |
| ATE79635T1 (de) * | 1986-04-01 | 1992-09-15 | Wako Pure Chem Ind Ltd | Peptid-derivate und methode zur messung der wirksamkeit von physiologisch aktiven verbindungen, die dieselben als substraten benuetzen. |
| US5023236A (en) * | 1988-04-07 | 1991-06-11 | Corvas, Inc. | Factor VII/VIIA active site inhibitors |
| US5593967A (en) * | 1990-08-31 | 1997-01-14 | Warner-Lambert Company | Cholecystokinin antagonists, their preparation and therapeutic use |
| US5391705A (en) * | 1991-03-15 | 1995-02-21 | Merrell Dow Pharmaceuticals Inc. | Polyfluorinated tripeptide thrombin inhibitors |
| US5534498A (en) * | 1992-01-30 | 1996-07-09 | Corvas International, Inc. | Trypsin inhibitors |
| US6759384B1 (en) | 1994-04-26 | 2004-07-06 | Aventis Pharmaceuticals Inc. | Factor Xa inhibitors |
| US5849510A (en) * | 1994-04-26 | 1998-12-15 | Selectide Corporation | Factor Xa inhibitors |
| HUT76346A (en) * | 1994-04-26 | 1997-08-28 | Selectide Corp | Factor xa inhibitors |
| US5776720A (en) * | 1995-05-18 | 1998-07-07 | Coulter Corporation | Assay reagent |
| US5871946A (en) * | 1995-05-18 | 1999-02-16 | Coulter Corporation | Method for determining activity of enzymes in metabolically active whole cells |
| US5698411A (en) * | 1995-05-18 | 1997-12-16 | Coulter Corporation | Method for determining activity of enzymes in metabolically active whole cells |
| US5733719A (en) * | 1995-05-18 | 1998-03-31 | Coulter Corporation | Method of making an assay compound |
| US6069232A (en) * | 1995-10-02 | 2000-05-30 | Hoechst Marion Roussel, Inc. | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors |
| GB9525403D0 (en) * | 1995-12-13 | 1996-02-14 | Univ Sunderland | Method for monitoring enzymes |
| US5739354A (en) * | 1996-03-26 | 1998-04-14 | Hoechst Marion Roussel, Inc. | Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide |
| DE10116586B4 (de) * | 2001-04-03 | 2005-07-21 | Stief, Thomas, Dr.med. | Testsystem zur Bestimmung der Hämostaseaktivierung von biologischen Flüssigkeiten |
| WO2010087874A1 (en) * | 2009-01-28 | 2010-08-05 | Anazyme, Llc | Compositions and methods for diagnosis of shock |
| US8338127B2 (en) | 2008-01-31 | 2012-12-25 | Anazyme | Testing a mammal for presence, progression or stage of a shock condition |
| EP2366027B1 (en) * | 2008-11-20 | 2017-01-11 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Rapid fret-based diagnosis of bacterial pathogens |
| EP2189536A1 (en) * | 2008-11-20 | 2010-05-26 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Rapid FRET based anthrax diagnosis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5129998A (en:Method) * | 1974-07-02 | 1976-03-13 | Pentapharm Ag | |
| US4056519A (en) * | 1976-05-10 | 1977-11-01 | Eli Lilly And Company | Substrate for assay of plasmin |
| JPS52146694A (en:Method) * | 1976-05-28 | 1977-12-06 | ||
| US4070245A (en) * | 1975-06-23 | 1978-01-24 | Pentapharm A.G. | Substrate for the quantitative determination of proteolytic enzymes |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862011A (en) * | 1971-08-16 | 1975-01-21 | Robert E Smith | Method for quantitatively determining enzyme concentrations in homogenates |
| SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
| SE380258B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser |
| US4162941A (en) * | 1974-12-05 | 1979-07-31 | Ab Kabi | Method for determining a proteolytic enzyme |
| SE407058B (sv) * | 1974-12-05 | 1979-03-12 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
| US4137225A (en) * | 1975-07-11 | 1979-01-30 | Ab Kabi | Novel chromogenic enzyme substrates |
| SE407571B (sv) * | 1975-07-11 | 1979-04-02 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
| US4169015A (en) * | 1975-07-11 | 1979-09-25 | Ab Kabi | Novel chromogenic thrombin substrates |
| US4167449A (en) * | 1976-07-29 | 1979-09-11 | American Hospital Supply Corporation | Composition and method for determining transferase and protease activity |
| SE437153B (sv) * | 1976-12-01 | 1985-02-11 | Kabi Ab | Specifika kromogena enzymsubstrat for serinproteaser |
| US4215047A (en) * | 1977-06-06 | 1980-07-29 | Ajinomoto Company Incorporated | 7-(Arginylamino)-4-methylcoumarins |
| CA1087075A (en) * | 1977-08-05 | 1980-10-07 | Robert J. Gargiulo | Composition and method for determining transferase and protease activity |
| US4155916A (en) * | 1977-08-29 | 1979-05-22 | Dolbeare Frank A | Fluorescence method for enzyme analysis which couples aromatic amines with aromatic aldehydes |
| SE7801373L (sv) * | 1978-02-07 | 1979-08-08 | Kabi Ab | Lett spjelkbara substrat for kvantifiering av proteaser |
-
1978
- 1978-08-03 US US05/930,826 patent/US4275153A/en not_active Expired - Lifetime
-
1979
- 1979-06-15 JP JP50117779A patent/JPS5729999B2/ja not_active Expired
- 1979-06-15 DE DE7979900842T patent/DE2967581D1/de not_active Expired
- 1979-06-15 WO PCT/US1979/000421 patent/WO1980000351A1/en unknown
- 1979-07-05 CA CA000331214A patent/CA1152494A/en not_active Expired
- 1979-07-31 IT IT49905/79A patent/IT1117757B/it active
- 1979-08-02 NO NO792553A patent/NO792553L/no unknown
-
1980
- 1980-03-11 EP EP79900842A patent/EP0016800B1/en not_active Expired
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5129998A (en:Method) * | 1974-07-02 | 1976-03-13 | Pentapharm Ag | |
| US4070245A (en) * | 1975-06-23 | 1978-01-24 | Pentapharm A.G. | Substrate for the quantitative determination of proteolytic enzymes |
| US4056519A (en) * | 1976-05-10 | 1977-11-01 | Eli Lilly And Company | Substrate for assay of plasmin |
| JPS52146694A (en:Method) * | 1976-05-28 | 1977-12-06 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012517435A (ja) * | 2009-02-06 | 2012-08-02 | グリフオルス・セラピユーテイクス・インコーポレーテツド | プラスミン活性を決定するための組成物、キットおよび方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO792553L (no) | 1980-02-05 |
| EP0016800A1 (en) | 1980-10-15 |
| EP0016800B1 (en) | 1986-03-05 |
| EP0016800A4 (en) | 1981-01-08 |
| US4275153A (en) | 1981-06-23 |
| DE2967581D1 (en) | 1986-04-10 |
| IT7949905A0 (it) | 1979-07-31 |
| IT1117757B (it) | 1986-02-24 |
| WO1980000351A1 (en) | 1980-03-06 |
| CA1152494A (en) | 1983-08-23 |
| JPS55500538A (en:Method) | 1980-08-21 |