JPS5726687A - N6-((2-hydroxypropyl)aryl)adenosine - Google Patents

N6-((2-hydroxypropyl)aryl)adenosine

Info

Publication number
JPS5726687A
JPS5726687A JP8876481A JP8876481A JPS5726687A JP S5726687 A JPS5726687 A JP S5726687A JP 8876481 A JP8876481 A JP 8876481A JP 8876481 A JP8876481 A JP 8876481A JP S5726687 A JPS5726687 A JP S5726687A
Authority
JP
Japan
Prior art keywords
adenosine
hydroxypropyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8876481A
Other languages
English (en)
Inventor
Hamiruton Robaato
Hendaason Richiyaado
Pitsuzere Baanetsuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of JPS5726687A publication Critical patent/JPS5726687A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP8876481A 1980-06-09 1981-06-09 N6-((2-hydroxypropyl)aryl)adenosine Pending JPS5726687A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/157,693 US4388308A (en) 1980-06-09 1980-06-09 N6 -[(2-Hydroxypropyl)aryl]adenosines

Publications (1)

Publication Number Publication Date
JPS5726687A true JPS5726687A (en) 1982-02-12

Family

ID=22564866

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8876481A Pending JPS5726687A (en) 1980-06-09 1981-06-09 N6-((2-hydroxypropyl)aryl)adenosine

Country Status (6)

Country Link
US (1) US4388308A (ja)
JP (1) JPS5726687A (ja)
CA (1) CA1179333A (ja)
DE (1) DE3122814A1 (ja)
FR (1) FR2483930A1 (ja)
GB (1) GB2077726B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
US4501735A (en) * 1983-12-05 1985-02-26 Warner-Lambert Company N6-(1- and 2-benzocycloalkyl) adenosines
US4616003A (en) * 1984-10-26 1986-10-07 Warner-Lambert Company N6 -dihydroxypropyladenosines
US4626526A (en) * 1984-10-26 1986-12-02 Warner-Lambert Company (S)-N6 -2-hydroxypropyladenosines
FR2574798B1 (fr) * 1984-12-13 1987-11-20 Cepbepe Nouvelle adenosine substituee en n6 et medicament la contenant comme principe actif
WO1988002258A1 (en) * 1986-10-06 1988-04-07 The University Of Virginia Alumni Patents Foundati Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
US5066655A (en) * 1987-04-24 1991-11-19 Whitby Research, Inc. N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5565566A (en) * 1987-04-24 1996-10-15 Discovery Therapeutics, Inc. N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US4992535A (en) * 1988-10-26 1991-02-12 G. D. Searle & Co. Methods of making novel R and S diastereomers of N6 -[(2-hydroxypropyl)aryl]adenosines
US5032584A (en) * 1988-10-26 1991-07-16 G. D. Searle & Co. S-diastereomer of an n6 -((2-hydroxypropyl)aryl)adenosine and its medicinal uses
US5030624A (en) * 1988-10-26 1991-07-09 G. D. Searle & Co. R-diastereomer of an N6 -[(2-hydroxypropyl)aryl]adenosine and its medicinal uses
US5391739A (en) * 1989-03-29 1995-02-21 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
ZA902280B (en) * 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor agents
US5064947A (en) * 1989-03-29 1991-11-12 Merrell Dow Pharmaceuticals Inc. Selective adenosine reseptor compounds
US8703104B2 (en) * 2007-10-25 2014-04-22 Ecolab Usa Inc Use of metal astringents for the treatment of hairy heel warts

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128629C (ja) * 1966-05-07
DE1795761A1 (de) * 1966-05-07 1974-11-21 Boehringer Mannheim Gmbh Adenosin-derivate und verfahren zu ihrer herstellung
DE2338705A1 (de) * 1973-07-31 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
US4138562A (en) * 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
IT1164735B (it) * 1978-10-13 1987-04-15 Wellcome Found Derivati adenosinici e procedimento per la loro preparazione
US4340730A (en) * 1980-06-09 1982-07-20 G. D. Searle & Co. N6 -Substituted adenosines
US4315000A (en) * 1980-07-07 1982-02-09 Warner-Lambert Company β-D-Arabinofuranosylimidazo(4,5-c)pyridine compounds and methods for their production

Also Published As

Publication number Publication date
FR2483930A1 (fr) 1981-12-11
DE3122814A1 (de) 1982-04-01
CA1179333A (en) 1984-12-11
GB2077726A (en) 1981-12-23
FR2483930B1 (ja) 1984-05-18
GB2077726B (en) 1984-09-26
US4388308A (en) 1983-06-14

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