JPS57209218A - Antithrombotic - Google Patents

Antithrombotic

Info

Publication number
JPS57209218A
JPS57209218A JP9489081A JP9489081A JPS57209218A JP S57209218 A JPS57209218 A JP S57209218A JP 9489081 A JP9489081 A JP 9489081A JP 9489081 A JP9489081 A JP 9489081A JP S57209218 A JPS57209218 A JP S57209218A
Authority
JP
Japan
Prior art keywords
antithrombotic
methylallyltrisulfide
active ingredient
garlic
coagulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9489081A
Other languages
Japanese (ja)
Inventor
Toyohiko Ariga
Susumu Oshiba
Terumi Tamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIHON ARUKON KK
NIPPON ARUKON KK
Original Assignee
NIHON ARUKON KK
NIPPON ARUKON KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIHON ARUKON KK, NIPPON ARUKON KK filed Critical NIHON ARUKON KK
Priority to JP9489081A priority Critical patent/JPS57209218A/en
Publication of JPS57209218A publication Critical patent/JPS57209218A/en
Pending legal-status Critical Current

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: An antithrombotic that contains methylallyltrisulfied, a component in garlic oil, as an active ingredient, thus showning strong inhibition of blood platelet coagulation, especially its secondary coagulation, with a small amount and having reduced acute toxicity.
CONSTITUTION: Methylallyltrisulfide of the formula is used as an active ingredient to prepare an antithrombotic. The methylallyltrisulfide is sparated from naturally occurring garlic or the like and purified or prepared by heating a mixture of diallyldisulfide and dimethylsulfide-sulfur in the presence of di-n- butylamine under reflux and purifying the reaction product. It shows good remedial effect for blood vessel diseases such as arterioscrelosis, diabetic retinopathy or renopathy.
COPYRIGHT: (C)1982,JPO&Japio
JP9489081A 1981-06-19 1981-06-19 Antithrombotic Pending JPS57209218A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9489081A JPS57209218A (en) 1981-06-19 1981-06-19 Antithrombotic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9489081A JPS57209218A (en) 1981-06-19 1981-06-19 Antithrombotic

Publications (1)

Publication Number Publication Date
JPS57209218A true JPS57209218A (en) 1982-12-22

Family

ID=14122631

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9489081A Pending JPS57209218A (en) 1981-06-19 1981-06-19 Antithrombotic

Country Status (1)

Country Link
JP (1) JPS57209218A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550193A1 (en) * 1983-08-05 1985-02-08 Sal Fine Chemicals Internation Inclusion complexes of methyl and allyl trisulphide with cyclodextrins, process for preparing them and pharmaceutical compositions containing them
JPS61215328A (en) * 1985-03-20 1986-09-25 Susumu Oshiba Antithrombotic agent
EP0464521A2 (en) * 1990-06-22 1992-01-08 Wakunaga Seiyaku Kabushiki Kaisha Polysulfide compounds and lipid peroxidation inhibitor containing the polysulfide compounds as active ingredient
US5231114A (en) * 1990-06-22 1993-07-27 Wakunaga Seiyaku Kabushiki Kaisha Polysulfides compounds and lipid peroxidation inhibitor containing the polysulfide compounds as active ingredient

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550193A1 (en) * 1983-08-05 1985-02-08 Sal Fine Chemicals Internation Inclusion complexes of methyl and allyl trisulphide with cyclodextrins, process for preparing them and pharmaceutical compositions containing them
JPS61215328A (en) * 1985-03-20 1986-09-25 Susumu Oshiba Antithrombotic agent
EP0464521A2 (en) * 1990-06-22 1992-01-08 Wakunaga Seiyaku Kabushiki Kaisha Polysulfide compounds and lipid peroxidation inhibitor containing the polysulfide compounds as active ingredient
US5231114A (en) * 1990-06-22 1993-07-27 Wakunaga Seiyaku Kabushiki Kaisha Polysulfides compounds and lipid peroxidation inhibitor containing the polysulfide compounds as active ingredient

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