JPS57203090A - Organogermanium compound and its preparation - Google Patents
Organogermanium compound and its preparationInfo
- Publication number
- JPS57203090A JPS57203090A JP56087558A JP8755881A JPS57203090A JP S57203090 A JPS57203090 A JP S57203090A JP 56087558 A JP56087558 A JP 56087558A JP 8755881 A JP8755881 A JP 8755881A JP S57203090 A JPS57203090 A JP S57203090A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- preparation
- formulai
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Organogermanium compound Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- NLIJOIUVZBYQRS-UHFFFAOYSA-N 3-trichlorogermylpropanoic acid Chemical compound OC(=O)CC[Ge](Cl)(Cl)Cl NLIJOIUVZBYQRS-UHFFFAOYSA-N 0.000 abstract 1
- QJPXCEZHYSIWRD-UHFFFAOYSA-N C(C)[Ge](S)(S)S Chemical class C(C)[Ge](S)(S)S QJPXCEZHYSIWRD-UHFFFAOYSA-N 0.000 abstract 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- GIEAINOVPLDQPT-UHFFFAOYSA-N ethylgermanium Chemical compound CC[Ge] GIEAINOVPLDQPT-UHFFFAOYSA-N 0.000 abstract 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- VLZFWMHRXCHTLY-UHFFFAOYSA-N trichloro(ethyl)germane Chemical class CC[Ge](Cl)(Cl)Cl VLZFWMHRXCHTLY-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formulaI[A, B are H, lower alkyl; Z is COOH, CN, CONH2, CHO, COOR (R is lower alkyl)].
EXAMPLE: 2-Carboxyethyltrichlorogermanium.
USE: Hypotensor or antitumor agent: it is low-toxicity and quite free from side- effects.
PREPARATION: The reaction of ethyltrichlorogermanium derivative of formula II with hydrogen sulfide is conducted in the presence of a base such as pyridine under anhydrous conditions to give ethyltrimercaptogermanium derivative of formula III. Then, the compound of formula III is subjected to intermolecular dehydrosulfurization to give the compound of formulaI. The compound of formulaIhas a basic structure of ethylgermanium sesquisulfide where the compound of formula II and sulfur atoms bond at a 2:3 ratio.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56087558A JPS5935916B2 (en) | 1981-06-09 | 1981-06-09 | Organic germanium compound and its manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56087558A JPS5935916B2 (en) | 1981-06-09 | 1981-06-09 | Organic germanium compound and its manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57203090A true JPS57203090A (en) | 1982-12-13 |
| JPS5935916B2 JPS5935916B2 (en) | 1984-08-31 |
Family
ID=13918312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56087558A Expired JPS5935916B2 (en) | 1981-06-09 | 1981-06-09 | Organic germanium compound and its manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5935916B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3425404A1 (en) * | 1983-07-11 | 1985-01-31 | Asai Germanium Research Institute, Tokio/Tokyo | ANTINEOPLASTIC |
| JPS62142189A (en) * | 1986-12-12 | 1987-06-25 | Asai Gerumaniumu Kenkyusho:Kk | Organogermanium compound |
| US4681960A (en) * | 1983-07-01 | 1987-07-21 | Asai Germanium Research Institute | Organogermanium compound |
| US4720564A (en) * | 1984-04-25 | 1988-01-19 | Asai Germanium Research Institute | Antioxidant organogermanium compound |
| US4822817A (en) * | 1986-06-18 | 1989-04-18 | Asai Germanium Research Institute | Remedy for bone disease |
-
1981
- 1981-06-09 JP JP56087558A patent/JPS5935916B2/en not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681960A (en) * | 1983-07-01 | 1987-07-21 | Asai Germanium Research Institute | Organogermanium compound |
| US4748187A (en) * | 1983-07-01 | 1988-05-31 | Asai Germanium Research Institute | Opioid peptide-degrading enzyme inhibitor with a germanium compound |
| DE3425404A1 (en) * | 1983-07-11 | 1985-01-31 | Asai Germanium Research Institute, Tokio/Tokyo | ANTINEOPLASTIC |
| DE3425404C2 (en) * | 1983-07-11 | 1987-03-05 | Asai Germanium Research Institute, Tokio/Tokyo | Use of germanium sesquisulphides as antineoplastic agent |
| US4720564A (en) * | 1984-04-25 | 1988-01-19 | Asai Germanium Research Institute | Antioxidant organogermanium compound |
| US5071873A (en) * | 1984-04-25 | 1991-12-10 | Asai Germanium Research Institute | Antioxidant |
| US4822817A (en) * | 1986-06-18 | 1989-04-18 | Asai Germanium Research Institute | Remedy for bone disease |
| JPS62142189A (en) * | 1986-12-12 | 1987-06-25 | Asai Gerumaniumu Kenkyusho:Kk | Organogermanium compound |
| JPH0348200B2 (en) * | 1986-12-12 | 1991-07-23 | Asai Germanium Res Inst |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5935916B2 (en) | 1984-08-31 |
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