JPS57179164A - Preparation of imidazole derivative - Google Patents

Preparation of imidazole derivative

Info

Publication number
JPS57179164A
JPS57179164A JP6402781A JP6402781A JPS57179164A JP S57179164 A JPS57179164 A JP S57179164A JP 6402781 A JP6402781 A JP 6402781A JP 6402781 A JP6402781 A JP 6402781A JP S57179164 A JPS57179164 A JP S57179164A
Authority
JP
Japan
Prior art keywords
compound
imidazole
novel compound
formula
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6402781A
Other languages
Japanese (ja)
Inventor
Yoshihiro Hasegawa
Saburo Sugai
Tokuji Okazaki
Mitsuya Akaboshi
Shiro Ikegami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OOTA SEIYAKU KK
OTA SEIYAKU KK
Original Assignee
OOTA SEIYAKU KK
OTA SEIYAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OOTA SEIYAKU KK, OTA SEIYAKU KK filed Critical OOTA SEIYAKU KK
Priority to JP6402781A priority Critical patent/JPS57179164A/en
Publication of JPS57179164A publication Critical patent/JPS57179164A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain an imidazole derivative having improved antifungal activity in high yield, by reacting a novel compound wit imidazole as raw materials under basic conditions to carry out the isolation of the reaction product very easily and efficiently.
CONSTITUTION: A compound of formulaI[X is halogen or organic sulfonic acid residue of the formula OSO2R (R is alkyl or aryl)](a novel compound) is reacted with imidazole in the presence of a basic substance, e.g. NaOH, or the imidazole is previously prepared as a sodium or potassium salt, and reacted with the novel compound of formulaIto give the aimed compound of formula II. The reaction is preferably carried out in the presence of a heterogeneous two-phase solvent and a phase transfer catalyst. The nitrate salt of the compound of formula II is used for medical applications. The novel compound of formulaIis easily obtained from 2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethanol by the conventional method.
COPYRIGHT: (C)1982,JPO&Japio
JP6402781A 1981-04-30 1981-04-30 Preparation of imidazole derivative Pending JPS57179164A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6402781A JPS57179164A (en) 1981-04-30 1981-04-30 Preparation of imidazole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6402781A JPS57179164A (en) 1981-04-30 1981-04-30 Preparation of imidazole derivative

Publications (1)

Publication Number Publication Date
JPS57179164A true JPS57179164A (en) 1982-11-04

Family

ID=13246240

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6402781A Pending JPS57179164A (en) 1981-04-30 1981-04-30 Preparation of imidazole derivative

Country Status (1)

Country Link
JP (1) JPS57179164A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108329266A (en) * 2018-03-27 2018-07-27 宁波百思佳医药科技有限公司 A kind of Miconazole crystal form and its preparation method and application
JP2019535795A (en) * 2016-11-28 2019-12-12 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ Compositions and methods for the treatment of oral infections

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5182273A (en) * 1974-11-19 1976-07-19 Janssen Pharmaceutica Nv 11* beetaa ariiru * echiru 1hh imidazoorueeteruoyobi sonosanfukaenno seizohoho

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5182273A (en) * 1974-11-19 1976-07-19 Janssen Pharmaceutica Nv 11* beetaa ariiru * echiru 1hh imidazoorueeteruoyobi sonosanfukaenno seizohoho

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019535795A (en) * 2016-11-28 2019-12-12 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ Compositions and methods for the treatment of oral infections
CN108329266A (en) * 2018-03-27 2018-07-27 宁波百思佳医药科技有限公司 A kind of Miconazole crystal form and its preparation method and application

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