JPS57179164A - Preparation of imidazole derivative - Google Patents
Preparation of imidazole derivativeInfo
- Publication number
- JPS57179164A JPS57179164A JP6402781A JP6402781A JPS57179164A JP S57179164 A JPS57179164 A JP S57179164A JP 6402781 A JP6402781 A JP 6402781A JP 6402781 A JP6402781 A JP 6402781A JP S57179164 A JPS57179164 A JP S57179164A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- imidazole
- novel compound
- formula
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain an imidazole derivative having improved antifungal activity in high yield, by reacting a novel compound wit imidazole as raw materials under basic conditions to carry out the isolation of the reaction product very easily and efficiently.
CONSTITUTION: A compound of formulaI[X is halogen or organic sulfonic acid residue of the formula OSO2R (R is alkyl or aryl)](a novel compound) is reacted with imidazole in the presence of a basic substance, e.g. NaOH, or the imidazole is previously prepared as a sodium or potassium salt, and reacted with the novel compound of formulaIto give the aimed compound of formula II. The reaction is preferably carried out in the presence of a heterogeneous two-phase solvent and a phase transfer catalyst. The nitrate salt of the compound of formula II is used for medical applications. The novel compound of formulaIis easily obtained from 2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethanol by the conventional method.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6402781A JPS57179164A (en) | 1981-04-30 | 1981-04-30 | Preparation of imidazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6402781A JPS57179164A (en) | 1981-04-30 | 1981-04-30 | Preparation of imidazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57179164A true JPS57179164A (en) | 1982-11-04 |
Family
ID=13246240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6402781A Pending JPS57179164A (en) | 1981-04-30 | 1981-04-30 | Preparation of imidazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57179164A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108329266A (en) * | 2018-03-27 | 2018-07-27 | 宁波百思佳医药科技有限公司 | A kind of Miconazole crystal form and its preparation method and application |
JP2019535795A (en) * | 2016-11-28 | 2019-12-12 | セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited | Compositions and methods for the treatment of oral infections |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5182273A (en) * | 1974-11-19 | 1976-07-19 | Janssen Pharmaceutica Nv | 11* beetaa ariiru * echiru 1hh imidazoorueeteruoyobi sonosanfukaenno seizohoho |
-
1981
- 1981-04-30 JP JP6402781A patent/JPS57179164A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5182273A (en) * | 1974-11-19 | 1976-07-19 | Janssen Pharmaceutica Nv | 11* beetaa ariiru * echiru 1hh imidazoorueeteruoyobi sonosanfukaenno seizohoho |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019535795A (en) * | 2016-11-28 | 2019-12-12 | セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited | Compositions and methods for the treatment of oral infections |
CN108329266A (en) * | 2018-03-27 | 2018-07-27 | 宁波百思佳医药科技有限公司 | A kind of Miconazole crystal form and its preparation method and application |
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