JPS57176913A - Condurango glycoside, its preparation and antitumor agent consisting of the same - Google Patents
Condurango glycoside, its preparation and antitumor agent consisting of the sameInfo
- Publication number
- JPS57176913A JPS57176913A JP56047554A JP4755481A JPS57176913A JP S57176913 A JPS57176913 A JP S57176913A JP 56047554 A JP56047554 A JP 56047554A JP 4755481 A JP4755481 A JP 4755481A JP S57176913 A JPS57176913 A JP S57176913A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- methanol
- condurango
- glycoside
- resultant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:A condurango glycoside. Properties: White amorphous solid. Molecular weight: 1163 (by the field desorption mass spectrum). Elementary analysis: C, 59.24; H, 7.52. Melting point 160W167°C. Specific rotarory power: [α]D20 -25.4° (C=0.35 in methanol). Color reactions: Positive to the Keller -Kiliani reaction, etc. Neutral. Soluble in water, methanol, etc. and insoluble in pentane, n-hexane, et. etc.
USE: An antitumor agent.
PROCESS: A condurango, e.g. a bark thereof, is extracted with an organic solvent, e.g. methanol, or a mixture thereof to give an extract, which is then concentrated to dryness under reduced pressure. The resultant residue is then mixed with a chlorinated hydrocarbon other than CCl4 to afford and extract, which is then passed through an open column and concentrated under reduced pressure to dryness. The resultant solid is then pulverized to give a brown powdery extract. The resultant extract is subjected to the high-speed liquid chromatography to fractionate and isolate the aimed condurange glycoside.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56047554A JPH0234957B2 (en) | 1981-03-31 | 1981-03-31 | KONZURANGOHAITOTAI * SONOSEIZOHOHOOYOBISOREKARANARUKOSHUYOZAI |
PCT/JP1982/000088 WO1982003396A1 (en) | 1981-03-31 | 1982-03-30 | Novel cundurango glycoside compounds,process for their preparation,their use as antitumor agent,and composition containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56047554A JPH0234957B2 (en) | 1981-03-31 | 1981-03-31 | KONZURANGOHAITOTAI * SONOSEIZOHOHOOYOBISOREKARANARUKOSHUYOZAI |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57176913A true JPS57176913A (en) | 1982-10-30 |
JPH0234957B2 JPH0234957B2 (en) | 1990-08-07 |
Family
ID=12778387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56047554A Expired - Lifetime JPH0234957B2 (en) | 1981-03-31 | 1981-03-31 | KONZURANGOHAITOTAI * SONOSEIZOHOHOOYOBISOREKARANARUKOSHUYOZAI |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0234957B2 (en) |
-
1981
- 1981-03-31 JP JP56047554A patent/JPH0234957B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH0234957B2 (en) | 1990-08-07 |
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