JPS57176913A - Condurango glycoside, its preparation and antitumor agent consisting of the same - Google Patents

Condurango glycoside, its preparation and antitumor agent consisting of the same

Info

Publication number
JPS57176913A
JPS57176913A JP56047554A JP4755481A JPS57176913A JP S57176913 A JPS57176913 A JP S57176913A JP 56047554 A JP56047554 A JP 56047554A JP 4755481 A JP4755481 A JP 4755481A JP S57176913 A JPS57176913 A JP S57176913A
Authority
JP
Japan
Prior art keywords
extract
methanol
condurango
glycoside
resultant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56047554A
Other languages
Japanese (ja)
Other versions
JPH0234957B2 (en
Inventor
Hiroshi Mihashi
Denichi Mizuno
Koji Hayashi
Shigeru Abe
Muneaki Takase
Toshiharu Narita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Priority to JP56047554A priority Critical patent/JPH0234957B2/en
Priority to PCT/JP1982/000088 priority patent/WO1982003396A1/en
Publication of JPS57176913A publication Critical patent/JPS57176913A/en
Publication of JPH0234957B2 publication Critical patent/JPH0234957B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

NEW MATERIAL:A condurango glycoside. Properties: White amorphous solid. Molecular weight: 1163 (by the field desorption mass spectrum). Elementary analysis: C, 59.24; H, 7.52. Melting point 160W167°C. Specific rotarory power: [α]D20 -25.4° (C=0.35 in methanol). Color reactions: Positive to the Keller -Kiliani reaction, etc. Neutral. Soluble in water, methanol, etc. and insoluble in pentane, n-hexane, et. etc.
USE: An antitumor agent.
PROCESS: A condurango, e.g. a bark thereof, is extracted with an organic solvent, e.g. methanol, or a mixture thereof to give an extract, which is then concentrated to dryness under reduced pressure. The resultant residue is then mixed with a chlorinated hydrocarbon other than CCl4 to afford and extract, which is then passed through an open column and concentrated under reduced pressure to dryness. The resultant solid is then pulverized to give a brown powdery extract. The resultant extract is subjected to the high-speed liquid chromatography to fractionate and isolate the aimed condurange glycoside.
COPYRIGHT: (C)1982,JPO&Japio
JP56047554A 1981-03-31 1981-03-31 KONZURANGOHAITOTAI * SONOSEIZOHOHOOYOBISOREKARANARUKOSHUYOZAI Expired - Lifetime JPH0234957B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP56047554A JPH0234957B2 (en) 1981-03-31 1981-03-31 KONZURANGOHAITOTAI * SONOSEIZOHOHOOYOBISOREKARANARUKOSHUYOZAI
PCT/JP1982/000088 WO1982003396A1 (en) 1981-03-31 1982-03-30 Novel cundurango glycoside compounds,process for their preparation,their use as antitumor agent,and composition containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56047554A JPH0234957B2 (en) 1981-03-31 1981-03-31 KONZURANGOHAITOTAI * SONOSEIZOHOHOOYOBISOREKARANARUKOSHUYOZAI

Publications (2)

Publication Number Publication Date
JPS57176913A true JPS57176913A (en) 1982-10-30
JPH0234957B2 JPH0234957B2 (en) 1990-08-07

Family

ID=12778387

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56047554A Expired - Lifetime JPH0234957B2 (en) 1981-03-31 1981-03-31 KONZURANGOHAITOTAI * SONOSEIZOHOHOOYOBISOREKARANARUKOSHUYOZAI

Country Status (1)

Country Link
JP (1) JPH0234957B2 (en)

Also Published As

Publication number Publication date
JPH0234957B2 (en) 1990-08-07

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