JPS57171938A - Preparation of optically active naphthylpropionic acid ester - Google Patents
Preparation of optically active naphthylpropionic acid esterInfo
- Publication number
- JPS57171938A JPS57171938A JP56056731A JP5673181A JPS57171938A JP S57171938 A JPS57171938 A JP S57171938A JP 56056731 A JP56056731 A JP 56056731A JP 5673181 A JP5673181 A JP 5673181A JP S57171938 A JPS57171938 A JP S57171938A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- ester
- crystallization
- resolution
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 naphthylpropionic acid ester Chemical class 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 abstract 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 238000002425 crystallisation Methods 0.000 abstract 3
- 230000008025 crystallization Effects 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56056731A JPS57171938A (en) | 1981-04-15 | 1981-04-15 | Preparation of optically active naphthylpropionic acid ester |
US06/367,044 US4417070A (en) | 1981-04-15 | 1982-04-09 | Process for preparing an optical active ester of naphthylpropionic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56056731A JPS57171938A (en) | 1981-04-15 | 1981-04-15 | Preparation of optically active naphthylpropionic acid ester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57171938A true JPS57171938A (en) | 1982-10-22 |
JPS6213942B2 JPS6213942B2 (en, 2012) | 1987-03-30 |
Family
ID=13035647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56056731A Granted JPS57171938A (en) | 1981-04-15 | 1981-04-15 | Preparation of optically active naphthylpropionic acid ester |
Country Status (2)
Country | Link |
---|---|
US (1) | US4417070A (en, 2012) |
JP (1) | JPS57171938A (en, 2012) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4983758A (en) * | 1987-12-03 | 1991-01-08 | Sumitomo Chemical Company, Limited | Process for producing an optically active α-isopropyl-p-chlorophenylacetic acid |
JP2002193895A (ja) * | 2000-12-27 | 2002-07-10 | Daicel Chem Ind Ltd | 環式骨格を有する3−アクリロイルオキシプロピオン酸エステル誘導体、及びアクリル酸エステル混合物 |
US9242681B2 (en) | 2010-03-30 | 2016-01-26 | Kubota Corporation | Cabin system |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4594442A (en) * | 1983-05-02 | 1986-06-10 | Hoffman-La Roche Inc. | Naphthalenyloxy substituted carboxylic acids |
DE3621835A1 (de) * | 1986-06-28 | 1988-01-07 | Hoechst Ag | Verfahren zur racemisierung optisch aktiver (alpha)-phenoxypropionsaeure und deren derivate |
IT1222013B (it) * | 1987-07-10 | 1990-08-31 | Chimica Profarmaco Spa Ind | Processo di risoluzione ottica di acido 2 (6 metossi 2 naftil) propionico |
US5191112A (en) * | 1989-10-17 | 1993-03-02 | Nissan Chemical Industries, Ltd. | Process for optical resolution of (±)-2-(3-benzoyl)-phenylpropionic acid |
US5189208A (en) * | 1991-07-01 | 1993-02-23 | Ethyl Corporation | Ibuprofen resolution |
US5196575A (en) * | 1992-02-19 | 1993-03-23 | Hoechst Celanese Corp. | Supercritical separation of isomers of functional organic compounds at moderate conditions |
JP2012516874A (ja) | 2009-02-06 | 2012-07-26 | ディーエスエム アイピー アセッツ ビー.ブイ. | キラルなα−アリールプロピオン酸誘導体の合成方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3980699A (en) * | 1971-11-04 | 1976-09-14 | Syntex Corporation | 2-Naphthyl acetic acid derivatives |
US3975432A (en) * | 1972-03-16 | 1976-08-17 | Syntex Corporation | Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid |
US3803245A (en) * | 1972-05-11 | 1974-04-09 | Syntex Corp | Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid,and intermediate therefor |
-
1981
- 1981-04-15 JP JP56056731A patent/JPS57171938A/ja active Granted
-
1982
- 1982-04-09 US US06/367,044 patent/US4417070A/en not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4983758A (en) * | 1987-12-03 | 1991-01-08 | Sumitomo Chemical Company, Limited | Process for producing an optically active α-isopropyl-p-chlorophenylacetic acid |
JP2002193895A (ja) * | 2000-12-27 | 2002-07-10 | Daicel Chem Ind Ltd | 環式骨格を有する3−アクリロイルオキシプロピオン酸エステル誘導体、及びアクリル酸エステル混合物 |
US9242681B2 (en) | 2010-03-30 | 2016-01-26 | Kubota Corporation | Cabin system |
Also Published As
Publication number | Publication date |
---|---|
US4417070A (en) | 1983-11-22 |
JPS6213942B2 (en, 2012) | 1987-03-30 |
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