JPS57144978A - Method and apparatus for controlling cultivation of micro-organism - Google Patents
Method and apparatus for controlling cultivation of micro-organismInfo
- Publication number
- JPS57144978A JPS57144978A JP2993181A JP2993181A JPS57144978A JP S57144978 A JPS57144978 A JP S57144978A JP 2993181 A JP2993181 A JP 2993181A JP 2993181 A JP2993181 A JP 2993181A JP S57144978 A JPS57144978 A JP S57144978A
- Authority
- JP
- Japan
- Prior art keywords
- substrate
- supply
- amount
- microbial cells
- signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
PURPOSE: To maintain the supply of the substrate constantly at a desirable state, and to keep the yield of the microbial cell or the product at a high level, by rapidly computing the amount of microbial cells in the cultivation liquid, and controlling the supply of the substrate to the level matched with the computed amount of the microbial cells.
CONSTITUTION: The means 8' for computing the amount of microbial cells computes the partial pressure of carbon dioxide gas in the cultivation tank and the amount of carbon dioxide gas produced by the microorganisms, according to the signals transmitted from the means 6 for determining the pressure in the cultivation tank, the means 5 for determining the flow rate of the exhaust gas, and the means 7 for analyzing the carbon dioxide gas concentration in the exhaust gas. Then, the amount of the microbial cells in the cultivation liquid is computed based on the signal transmitted from the means 9 for setting the numerical value. The means 8" for determining the supply of the substrate transmits the signal to the means 3 for controlling the supply of the substrate according to the computed microbial cell amount, e.g. a signal to increase the supply of the substrate when the supply of the substrate to the microbial cells is lower than the optimum level. The means 3 for controlling the supply of the substrate controls the means 2 for supplying the substrate according to the signal from the means 8".
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2993181A JPS6015306B2 (en) | 1981-03-04 | 1981-03-04 | Microbial culture control method and device |
| KR1019810004438A KR870001649B1 (en) | 1980-11-26 | 1981-11-17 | Micro-organism culture control method and apparatus |
| US06/324,550 US4444882A (en) | 1980-11-26 | 1981-11-24 | Process and apparatus for controlling cultivation of microorganisms |
| DE8181109902T DE3176062D1 (en) | 1980-11-26 | 1981-11-25 | Process and apparatus for controlling cultivation of microorganisms |
| EP81109902A EP0052890B1 (en) | 1980-11-26 | 1981-11-25 | Process and apparatus for controlling cultivation of microorganisms |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2993181A JPS6015306B2 (en) | 1981-03-04 | 1981-03-04 | Microbial culture control method and device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57144978A true JPS57144978A (en) | 1982-09-07 |
| JPS6015306B2 JPS6015306B2 (en) | 1985-04-18 |
Family
ID=12289729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2993181A Expired JPS6015306B2 (en) | 1980-11-26 | 1981-03-04 | Microbial culture control method and device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6015306B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01165368A (en) * | 1987-11-09 | 1989-06-29 | Eastman Kodak Co | Fermentation method of controlled proliferation speed |
| EP1816188A1 (en) * | 2006-02-03 | 2007-08-08 | Hitachi Plant Technologies, Ltd. | Operation controller of culture tank |
| JP2015508658A (en) * | 2012-02-22 | 2015-03-23 | ノボザイムス アクティーゼルスカブ | Advanced fermentation control |
| US11999939B2 (en) | 2017-11-20 | 2024-06-04 | Lonza Ltd | Process and system for propagating cell cultures while preventing lactate accumulation |
-
1981
- 1981-03-04 JP JP2993181A patent/JPS6015306B2/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01165368A (en) * | 1987-11-09 | 1989-06-29 | Eastman Kodak Co | Fermentation method of controlled proliferation speed |
| EP1816188A1 (en) * | 2006-02-03 | 2007-08-08 | Hitachi Plant Technologies, Ltd. | Operation controller of culture tank |
| JP2015508658A (en) * | 2012-02-22 | 2015-03-23 | ノボザイムス アクティーゼルスカブ | Advanced fermentation control |
| US11999939B2 (en) | 2017-11-20 | 2024-06-04 | Lonza Ltd | Process and system for propagating cell cultures while preventing lactate accumulation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6015306B2 (en) | 1985-04-18 |
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