JPS57128683A - Production of optically active pantolactone - Google Patents
Production of optically active pantolactoneInfo
- Publication number
- JPS57128683A JPS57128683A JP1524081A JP1524081A JPS57128683A JP S57128683 A JPS57128683 A JP S57128683A JP 1524081 A JP1524081 A JP 1524081A JP 1524081 A JP1524081 A JP 1524081A JP S57128683 A JPS57128683 A JP S57128683A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- salt
- pantoic acid
- pantoic
- fractionated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: A mineral acid salt of optically active aminoalcohol, which is readily synthesized and used as a resolving reagent, is added to an alkali metal salt of DL-pantoic acid and the formed salt is fractionated by crystallization, decomposed and converted into the lactone, thus producing the titled substance used as an intermediate of drugs in high yield.
CONSTITUTION: An alkali such as sodium hydroxide is made to act on DL-pantolactone to form an alkali metal salt of DL-pantoic acid and a mineral acid salt of optically active aminoalcohol of the formula (R is methyl, isopropyl, isobutyl) is made to act on the above pantoic acid as a resolving reagent by less than 1mol, preferably 0.5W0.8mol/mol of the DL-pantoic acid salt to prepare its diastereomer. The resultant dastereomer is fractionated by crystallization and decomposed to give an optically active pantoic acid, which is lactonized to produce the objective lactone.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1524081A JPS57128683A (en) | 1981-02-03 | 1981-02-03 | Production of optically active pantolactone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1524081A JPS57128683A (en) | 1981-02-03 | 1981-02-03 | Production of optically active pantolactone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57128683A true JPS57128683A (en) | 1982-08-10 |
JPS647992B2 JPS647992B2 (en) | 1989-02-10 |
Family
ID=11883332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1524081A Granted JPS57128683A (en) | 1981-02-03 | 1981-02-03 | Production of optically active pantolactone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57128683A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110734415A (en) * | 2019-11-28 | 2020-01-31 | 安徽泰格生物科技有限公司 | Aqueous solution crystallization method of D-pantoic acid lactone |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0355900U (en) * | 1989-10-05 | 1991-05-29 |
-
1981
- 1981-02-03 JP JP1524081A patent/JPS57128683A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110734415A (en) * | 2019-11-28 | 2020-01-31 | 安徽泰格生物科技有限公司 | Aqueous solution crystallization method of D-pantoic acid lactone |
CN110734415B (en) * | 2019-11-28 | 2021-09-17 | 安徽泰格生物科技有限公司 | Aqueous solution crystallization method of D-pantolactone |
Also Published As
Publication number | Publication date |
---|---|
JPS647992B2 (en) | 1989-02-10 |
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