JPS57126496A - 5-fluorouracil and its preparation - Google Patents

5-fluorouracil and its preparation

Info

Publication number
JPS57126496A
JPS57126496A JP1101881A JP1101881A JPS57126496A JP S57126496 A JPS57126496 A JP S57126496A JP 1101881 A JP1101881 A JP 1101881A JP 1101881 A JP1101881 A JP 1101881A JP S57126496 A JPS57126496 A JP S57126496A
Authority
JP
Japan
Prior art keywords
glucopyranosyl
acetyl
fluorouracil
formulai
tetra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1101881A
Other languages
Japanese (ja)
Inventor
Masakatsu Ozeki
Kenji Tsujihara
Yoshihisa Arai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP1101881A priority Critical patent/JPS57126496A/en
Publication of JPS57126496A publication Critical patent/JPS57126496A/en
Pending legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by the formulaI(R1 is H or aliphatic acyl).
EXAMPLE: O4-[O-2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl-(1→4)-2,3,6-tri-O-acetyl- β-D-glucopyranosyl]-5-fluorouracil.
USE: An antitumor agent and an agent alleviating leukemia.
PROCESS: A compound{e.g., O-benxzyl-O-[O-2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl-(1→4)-2,3,6-tri-O-acetyl-β-D-glucopyranosyl]-5-fluorouracil, etc.} shown by the formula II (R2 is aliphatic acyl; R3 is a group to be removed by catalytic reduction) is dissolved in a solvent, to which palladium carbon is added, and hydrogen gas is introduced to the solution at room temperature under normal pressure so that catalytic reduction is carried out, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP1101881A 1981-01-27 1981-01-27 5-fluorouracil and its preparation Pending JPS57126496A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1101881A JPS57126496A (en) 1981-01-27 1981-01-27 5-fluorouracil and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1101881A JPS57126496A (en) 1981-01-27 1981-01-27 5-fluorouracil and its preparation

Publications (1)

Publication Number Publication Date
JPS57126496A true JPS57126496A (en) 1982-08-06

Family

ID=11766367

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1101881A Pending JPS57126496A (en) 1981-01-27 1981-01-27 5-fluorouracil and its preparation

Country Status (1)

Country Link
JP (1) JPS57126496A (en)

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