JPS57126496A - 5-fluorouracil and its preparation - Google Patents
5-fluorouracil and its preparationInfo
- Publication number
- JPS57126496A JPS57126496A JP1101881A JP1101881A JPS57126496A JP S57126496 A JPS57126496 A JP S57126496A JP 1101881 A JP1101881 A JP 1101881A JP 1101881 A JP1101881 A JP 1101881A JP S57126496 A JPS57126496 A JP S57126496A
- Authority
- JP
- Japan
- Prior art keywords
- glucopyranosyl
- acetyl
- fluorouracil
- formulai
- tetra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound shown by the formulaI(R1 is H or aliphatic acyl).
EXAMPLE: O4-[O-2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl-(1→4)-2,3,6-tri-O-acetyl- β-D-glucopyranosyl]-5-fluorouracil.
USE: An antitumor agent and an agent alleviating leukemia.
PROCESS: A compound{e.g., O-benxzyl-O-[O-2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl-(1→4)-2,3,6-tri-O-acetyl-β-D-glucopyranosyl]-5-fluorouracil, etc.} shown by the formula II (R2 is aliphatic acyl; R3 is a group to be removed by catalytic reduction) is dissolved in a solvent, to which palladium carbon is added, and hydrogen gas is introduced to the solution at room temperature under normal pressure so that catalytic reduction is carried out, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1101881A JPS57126496A (en) | 1981-01-27 | 1981-01-27 | 5-fluorouracil and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1101881A JPS57126496A (en) | 1981-01-27 | 1981-01-27 | 5-fluorouracil and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57126496A true JPS57126496A (en) | 1982-08-06 |
Family
ID=11766367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1101881A Pending JPS57126496A (en) | 1981-01-27 | 1981-01-27 | 5-fluorouracil and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57126496A (en) |
-
1981
- 1981-01-27 JP JP1101881A patent/JPS57126496A/en active Pending
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