JPS57116074A - Novel camptothecin derivative and its preparation - Google Patents
Novel camptothecin derivative and its preparationInfo
- Publication number
- JPS57116074A JPS57116074A JP114781A JP114781A JPS57116074A JP S57116074 A JPS57116074 A JP S57116074A JP 114781 A JP114781 A JP 114781A JP 114781 A JP114781 A JP 114781A JP S57116074 A JPS57116074 A JP S57116074A
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- aralkyl
- alkenyl
- compound
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP114781A JPS57116074A (en) | 1981-01-09 | 1981-01-09 | Novel camptothecin derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP114781A JPS57116074A (en) | 1981-01-09 | 1981-01-09 | Novel camptothecin derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57116074A true JPS57116074A (en) | 1982-07-19 |
| JPS6247190B2 JPS6247190B2 (enrdf_load_stackoverflow) | 1987-10-06 |
Family
ID=11493323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP114781A Granted JPS57116074A (en) | 1981-01-09 | 1981-01-09 | Novel camptothecin derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57116074A (enrdf_load_stackoverflow) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| WO1994011376A1 (en) * | 1992-07-23 | 1994-05-26 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues and methods of preparation thereof |
| US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
| WO1997046564A1 (en) * | 1996-06-05 | 1997-12-11 | Dr. Reddy's Research Foundation | Novel water-soluble analogues of 20(s)-camptothecin |
| US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
| US6562834B2 (en) | 2000-10-27 | 2003-05-13 | Aventis Pharma S. A. | Combination comprising camptothecin and a stilbene derivative for the treatment of cancer |
| US6664242B2 (en) | 2000-02-28 | 2003-12-16 | Aventis Pharma S.A. | Composition and method comprising CPT-11 and a pyrimidine derivative for the treatment of cancer |
| US6716983B2 (en) | 1996-10-30 | 2004-04-06 | Tanabe Seiyaku Co., Ltd. | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| US6960596B2 (en) | 2000-03-17 | 2005-11-01 | Aventis Pharma S.A. | Composition comprising camptothecin or a comptothecin derivative and a platin derivative for the treatment of cancer |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63164287U (enrdf_load_stackoverflow) * | 1987-04-16 | 1988-10-26 |
-
1981
- 1981-01-09 JP JP114781A patent/JPS57116074A/ja active Granted
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| WO1994011376A1 (en) * | 1992-07-23 | 1994-05-26 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues and methods of preparation thereof |
| US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
| WO1997046564A1 (en) * | 1996-06-05 | 1997-12-11 | Dr. Reddy's Research Foundation | Novel water-soluble analogues of 20(s)-camptothecin |
| CN1102932C (zh) * | 1996-06-05 | 2003-03-12 | 雷迪博士研究基金会 | 20(s)－喜树碱的水溶性类似物，制备方法和用途 |
| US6716983B2 (en) | 1996-10-30 | 2004-04-06 | Tanabe Seiyaku Co., Ltd. | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| US7060832B2 (en) | 1996-10-30 | 2006-06-13 | Tanabe Seiyaku Co., Ltd. | Nitrogen-containing fused heterocyclic carboxylic acids having an absolute configuration of “R” |
| US6664242B2 (en) | 2000-02-28 | 2003-12-16 | Aventis Pharma S.A. | Composition and method comprising CPT-11 and a pyrimidine derivative for the treatment of cancer |
| US6960596B2 (en) | 2000-03-17 | 2005-11-01 | Aventis Pharma S.A. | Composition comprising camptothecin or a comptothecin derivative and a platin derivative for the treatment of cancer |
| US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
| US6562834B2 (en) | 2000-10-27 | 2003-05-13 | Aventis Pharma S. A. | Combination comprising camptothecin and a stilbene derivative for the treatment of cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6247190B2 (enrdf_load_stackoverflow) | 1987-10-06 |
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