JPS5686153A - Mercaptoacylldisubstituteddproline derivative and relative compounds - Google Patents
Mercaptoacylldisubstituteddproline derivative and relative compoundsInfo
- Publication number
- JPS5686153A JPS5686153A JP14887080A JP14887080A JPS5686153A JP S5686153 A JPS5686153 A JP S5686153A JP 14887080 A JP14887080 A JP 14887080A JP 14887080 A JP14887080 A JP 14887080A JP S5686153 A JPS5686153 A JP S5686153A
- Authority
- JP
- Japan
- Prior art keywords
- mercaptoacylldisubstituteddproline
- derivative
- relative compounds
- compounds
- relative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/086,905 US4291040A (en) | 1979-10-22 | 1979-10-22 | Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63319343A Division JPH01287068A (ja) | 1979-10-22 | 1988-12-16 | 4,4―ジ置換プロリンまたは4―モノ置換デヒドロプロリン誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5686153A true JPS5686153A (en) | 1981-07-13 |
JPH0132821B2 JPH0132821B2 (ja) | 1989-07-10 |
Family
ID=22201670
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14887080A Granted JPS5686153A (en) | 1979-10-22 | 1980-10-22 | Mercaptoacylldisubstituteddproline derivative and relative compounds |
JP63319343A Granted JPH01287068A (ja) | 1979-10-22 | 1988-12-16 | 4,4―ジ置換プロリンまたは4―モノ置換デヒドロプロリン誘導体 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63319343A Granted JPH01287068A (ja) | 1979-10-22 | 1988-12-16 | 4,4―ジ置換プロリンまたは4―モノ置換デヒドロプロリン誘導体 |
Country Status (7)
Country | Link |
---|---|
US (1) | US4291040A (ja) |
JP (2) | JPS5686153A (ja) |
CA (1) | CA1161049A (ja) |
DE (1) | DE3039889A1 (ja) |
FR (1) | FR2467845A1 (ja) |
GB (3) | GB2061933B (ja) |
IT (1) | IT1128613B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61251657A (ja) * | 1984-09-12 | 1986-11-08 | ユ−エスヴイ− フア−マシユ−テイカル コ−ポレ−シヨン | 抗高血圧性誘導体類 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA794723B (en) * | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
US4356182A (en) * | 1979-10-22 | 1982-10-26 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
US4692458A (en) * | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
US4390695A (en) * | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4456761A (en) * | 1981-02-02 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 4-Substituted dehydroprolines |
CA1258853A (en) * | 1982-04-30 | 1989-08-29 | Rudiger D. Haugwitz | Substituted 4-phenoxy prolines |
US4851514A (en) * | 1987-05-01 | 1989-07-25 | E. R. Squibb & Sons, Inc. | Process for preparing a compound useful in preparing ace inhibitors and intermediate produced thereby |
DE3844978B4 (de) * | 1987-05-01 | 2004-09-02 | E.R. Squibb & Sons, Inc. | Verfahren zur Herstellung von (cis)-4-Hydroxy-4-phenyl-L-prolin-Derivaten |
DE3814663C2 (de) * | 1987-05-01 | 1999-12-02 | Squibb & Sons Inc | Triphenyler, Verfahren zu seiner Herstellung sowie dessen Verwendung |
DE19913699A1 (de) * | 1999-03-26 | 2000-09-28 | Basf Ag | Verfahren zur Herstellung von 3,4-Dihydroprolinen und 3,4-Dehydropiperidinen |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
US4091024A (en) * | 1976-12-03 | 1978-05-23 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
US4116962A (en) * | 1976-12-03 | 1978-09-26 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
US4129566A (en) * | 1978-02-15 | 1978-12-12 | E. R. Squibb & Sons, Inc. | Derivatives of dehydrocyclicimino acids |
US4108886A (en) * | 1977-03-11 | 1978-08-22 | E. R. Squibb & Sons, Inc. | Thiopropanoylamino acid derivatives |
IT7851510A0 (it) * | 1977-10-28 | 1978-10-16 | Sandoz Ag | Ammidi di amminoacidi ciclici loro preparazione e loro applicazione quali medicamenti |
US4154935A (en) * | 1978-02-21 | 1979-05-15 | E. R. Squibb & Sons, Inc. | Halogen substituted mercaptoacylamino acids |
CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
NL7809120A (nl) * | 1978-09-07 | 1980-03-11 | Oce Andeno B V Grubbenvorsterw | Werkwijze voor de bereiding van proline-derivaten. |
CA1132985A (en) * | 1978-12-22 | 1982-10-05 | John Krapcho | Ketal and thioketal derivatives of mercaptoacyl prolines |
US4288368A (en) * | 1979-07-30 | 1981-09-08 | E. R. Squibb & Sons, Inc. | Dithioacylproline derivatives |
-
1979
- 1979-10-22 US US06/086,905 patent/US4291040A/en not_active Expired - Lifetime
-
1980
- 1980-10-03 CA CA000361545A patent/CA1161049A/en not_active Expired
- 1980-10-20 IT IT49946/80A patent/IT1128613B/it active
- 1980-10-21 GB GB8033961A patent/GB2061933B/en not_active Expired
- 1980-10-22 DE DE19803039889 patent/DE3039889A1/de not_active Ceased
- 1980-10-22 JP JP14887080A patent/JPS5686153A/ja active Granted
- 1980-10-22 FR FR8022613A patent/FR2467845A1/fr active Granted
-
1983
- 1983-01-13 GB GB08300908A patent/GB2122605B/en not_active Expired
- 1983-01-13 GB GB08300909A patent/GB2115807B/en not_active Expired
-
1988
- 1988-12-16 JP JP63319343A patent/JPH01287068A/ja active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61251657A (ja) * | 1984-09-12 | 1986-11-08 | ユ−エスヴイ− フア−マシユ−テイカル コ−ポレ−シヨン | 抗高血圧性誘導体類 |
Also Published As
Publication number | Publication date |
---|---|
CA1161049A (en) | 1984-01-24 |
FR2467845B1 (ja) | 1983-08-26 |
US4291040A (en) | 1981-09-22 |
GB2122605B (en) | 1984-06-13 |
GB2122605A (en) | 1984-01-18 |
JPH0316343B2 (ja) | 1991-03-05 |
GB8300908D0 (en) | 1983-02-16 |
GB2115807A (en) | 1983-09-14 |
IT8049946A0 (it) | 1980-10-20 |
IT1128613B (it) | 1986-05-28 |
GB2061933A (en) | 1981-05-20 |
JPH0132821B2 (ja) | 1989-07-10 |
GB2115807B (en) | 1984-02-08 |
GB2061933B (en) | 1983-08-24 |
FR2467845A1 (fr) | 1981-04-30 |
JPH01287068A (ja) | 1989-11-17 |
DE3039889A1 (de) | 1981-04-30 |
GB8300909D0 (en) | 1983-02-16 |
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