JPS5683472A - Preparation of 3-acyl-1-substituted indole derivative - Google Patents
Preparation of 3-acyl-1-substituted indole derivativeInfo
- Publication number
- JPS5683472A JPS5683472A JP16031179A JP16031179A JPS5683472A JP S5683472 A JPS5683472 A JP S5683472A JP 16031179 A JP16031179 A JP 16031179A JP 16031179 A JP16031179 A JP 16031179A JP S5683472 A JPS5683472 A JP S5683472A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lower alkyl
- indole derivative
- substituted indole
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
PURPOSE:To obtain the titled useful compound having improved inhibitory action on platelet aggregation in high yield and efficiently, by condensing a 1-substituted indole derivative with a carboxylic acid anhydride in the presence of hydriodic acid as a catalyst. CONSTITUTION:A 1-substituted indole derivative of formula I [R1 and R6 are H or lower alkyl; R2, R3, R4 and R5 are H, OH, halogen, lower alkoxyl and alkanoyloxy, etc.; however, R2 and R3, R3 and R4, R4 and R5 together form methylene and ethylenedioxy; n is 0 or an integer 1-5; X is formula II (R7 is H or lower alkyl; R8 is lower alkyl, etc.) or formula III (R9 is lower alkoxyl, etc.) is condensed with a carboxylic acid anhydride of formula IV (phi is aromatic, hetero cyclic, alicyclic group, etc.) in the presence of hydriodic acid at 80-150 deg.C for 1- 6hr, and if necessary hydrolyzed to give the aimed compound of formula V [X' is formula VI (R8' is H, lower alkyl, etc.), etc.]. USE:Prevention of infarction in cardiovascular systems, etc.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16031179A JPS5683472A (en) | 1979-12-12 | 1979-12-12 | Preparation of 3-acyl-1-substituted indole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16031179A JPS5683472A (en) | 1979-12-12 | 1979-12-12 | Preparation of 3-acyl-1-substituted indole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5683472A true JPS5683472A (en) | 1981-07-08 |
JPS6230987B2 JPS6230987B2 (en) | 1987-07-06 |
Family
ID=15712206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16031179A Granted JPS5683472A (en) | 1979-12-12 | 1979-12-12 | Preparation of 3-acyl-1-substituted indole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5683472A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6072861A (en) * | 1983-09-28 | 1985-04-24 | Nippon Zoki Pharmaceut Co Ltd | Novel acylindole derivative and medicinal composition containing the same |
JPS6147462A (en) * | 1984-08-11 | 1986-03-07 | Nippon Zoki Pharmaceut Co Ltd | Novel acylindole derivative and blood platelet agglutination inhibitor containing said compound as active constituent |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU277794A1 (en) * | А. П. Терентьев, М. А. Володина , В. Г. Мишина | METHOD OF OBTAINING 1-ALKYL-2-METHYL (PHENYL) -3-ACETYL- | ||
US3399198A (en) * | 1962-09-07 | 1968-08-27 | Merck & Co Inc | 1-pyrimidinoyl-and 1-imidazoloyl-3-haloacetyl indoles |
JPS4843740A (en) * | 1971-10-07 | 1973-06-23 |
-
1979
- 1979-12-12 JP JP16031179A patent/JPS5683472A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU277794A1 (en) * | А. П. Терентьев, М. А. Володина , В. Г. Мишина | METHOD OF OBTAINING 1-ALKYL-2-METHYL (PHENYL) -3-ACETYL- | ||
US3399198A (en) * | 1962-09-07 | 1968-08-27 | Merck & Co Inc | 1-pyrimidinoyl-and 1-imidazoloyl-3-haloacetyl indoles |
JPS4843740A (en) * | 1971-10-07 | 1973-06-23 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6072861A (en) * | 1983-09-28 | 1985-04-24 | Nippon Zoki Pharmaceut Co Ltd | Novel acylindole derivative and medicinal composition containing the same |
JPS6147462A (en) * | 1984-08-11 | 1986-03-07 | Nippon Zoki Pharmaceut Co Ltd | Novel acylindole derivative and blood platelet agglutination inhibitor containing said compound as active constituent |
Also Published As
Publication number | Publication date |
---|---|
JPS6230987B2 (en) | 1987-07-06 |
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