JPS5683472A - Preparation of 3-acyl-1-substituted indole derivative - Google Patents

Preparation of 3-acyl-1-substituted indole derivative

Info

Publication number
JPS5683472A
JPS5683472A JP16031179A JP16031179A JPS5683472A JP S5683472 A JPS5683472 A JP S5683472A JP 16031179 A JP16031179 A JP 16031179A JP 16031179 A JP16031179 A JP 16031179A JP S5683472 A JPS5683472 A JP S5683472A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
indole derivative
substituted indole
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16031179A
Other languages
Japanese (ja)
Other versions
JPS6230987B2 (en
Inventor
Takeo Oba
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Akira Otsu
Tatsuyuki Naritomo
Seiji Kurozumi
Takeshi Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP16031179A priority Critical patent/JPS5683472A/en
Publication of JPS5683472A publication Critical patent/JPS5683472A/en
Publication of JPS6230987B2 publication Critical patent/JPS6230987B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PURPOSE:To obtain the titled useful compound having improved inhibitory action on platelet aggregation in high yield and efficiently, by condensing a 1-substituted indole derivative with a carboxylic acid anhydride in the presence of hydriodic acid as a catalyst. CONSTITUTION:A 1-substituted indole derivative of formula I [R1 and R6 are H or lower alkyl; R2, R3, R4 and R5 are H, OH, halogen, lower alkoxyl and alkanoyloxy, etc.; however, R2 and R3, R3 and R4, R4 and R5 together form methylene and ethylenedioxy; n is 0 or an integer 1-5; X is formula II (R7 is H or lower alkyl; R8 is lower alkyl, etc.) or formula III (R9 is lower alkoxyl, etc.) is condensed with a carboxylic acid anhydride of formula IV (phi is aromatic, hetero cyclic, alicyclic group, etc.) in the presence of hydriodic acid at 80-150 deg.C for 1- 6hr, and if necessary hydrolyzed to give the aimed compound of formula V [X' is formula VI (R8' is H, lower alkyl, etc.), etc.]. USE:Prevention of infarction in cardiovascular systems, etc.
JP16031179A 1979-12-12 1979-12-12 Preparation of 3-acyl-1-substituted indole derivative Granted JPS5683472A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16031179A JPS5683472A (en) 1979-12-12 1979-12-12 Preparation of 3-acyl-1-substituted indole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16031179A JPS5683472A (en) 1979-12-12 1979-12-12 Preparation of 3-acyl-1-substituted indole derivative

Publications (2)

Publication Number Publication Date
JPS5683472A true JPS5683472A (en) 1981-07-08
JPS6230987B2 JPS6230987B2 (en) 1987-07-06

Family

ID=15712206

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16031179A Granted JPS5683472A (en) 1979-12-12 1979-12-12 Preparation of 3-acyl-1-substituted indole derivative

Country Status (1)

Country Link
JP (1) JPS5683472A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6072861A (en) * 1983-09-28 1985-04-24 Nippon Zoki Pharmaceut Co Ltd Novel acylindole derivative and medicinal composition containing the same
JPS6147462A (en) * 1984-08-11 1986-03-07 Nippon Zoki Pharmaceut Co Ltd Novel acylindole derivative and blood platelet agglutination inhibitor containing said compound as active constituent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU277794A1 (en) * А. П. Терентьев, М. А. Володина , В. Г. Мишина METHOD OF OBTAINING 1-ALKYL-2-METHYL (PHENYL) -3-ACETYL-
US3399198A (en) * 1962-09-07 1968-08-27 Merck & Co Inc 1-pyrimidinoyl-and 1-imidazoloyl-3-haloacetyl indoles
JPS4843740A (en) * 1971-10-07 1973-06-23

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU277794A1 (en) * А. П. Терентьев, М. А. Володина , В. Г. Мишина METHOD OF OBTAINING 1-ALKYL-2-METHYL (PHENYL) -3-ACETYL-
US3399198A (en) * 1962-09-07 1968-08-27 Merck & Co Inc 1-pyrimidinoyl-and 1-imidazoloyl-3-haloacetyl indoles
JPS4843740A (en) * 1971-10-07 1973-06-23

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6072861A (en) * 1983-09-28 1985-04-24 Nippon Zoki Pharmaceut Co Ltd Novel acylindole derivative and medicinal composition containing the same
JPS6147462A (en) * 1984-08-11 1986-03-07 Nippon Zoki Pharmaceut Co Ltd Novel acylindole derivative and blood platelet agglutination inhibitor containing said compound as active constituent

Also Published As

Publication number Publication date
JPS6230987B2 (en) 1987-07-06

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