JPS5681600A - Methylated prostaglandin derivative - Google Patents
Methylated prostaglandin derivativeInfo
- Publication number
- JPS5681600A JPS5681600A JP15835479A JP15835479A JPS5681600A JP S5681600 A JPS5681600 A JP S5681600A JP 15835479 A JP15835479 A JP 15835479A JP 15835479 A JP15835479 A JP 15835479A JP S5681600 A JPS5681600 A JP S5681600A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- methylated
- group
- methylated prostaglandin
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:A methylated prostaglandin derivative expressed by formula I, II or III [St is formula IV (R is H, acetyl, propionyl, benzoyl, etc.), etc.; R1 is H, acetyl, propionyl, butyryl or benzoyl].
EXAMPLE: 3-Hydroxy-1,3,5(10)-estratriene-17β-oxycarbonylmethyl 16, 16-dimethyl- 11α, 15α-dihydroxy-9-oxo-5(cis)-13(trans)-prostadienoate.
USE: An inducer for abortion and laber of pregnant mammals, a fertility improver of female mammals, an estrus adjusting contraceptive agent and an emmenagogue agent having a stimulating and activating action on contraction of uterine walls.
PROCESS: Estradiol and a methylated prostaglandin are converted into an ester of formula V (B is group after removal of OH group at the 17-position; X is halogen; n is 1, 2 or 3), if necessary with an introducing and binding agent. The halogen in the ester is then reacted with the carboxylic acid group of a methylated prostaglandin.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15835479A JPS5681600A (en) | 1979-12-06 | 1979-12-06 | Methylated prostaglandin derivative |
US06/153,415 US4318908A (en) | 1979-12-06 | 1980-05-27 | Methylated prostaglandin derivatives |
IN181/MAS/80A IN151356B (en) | 1979-12-06 | 1980-10-01 | |
AU64215/80A AU537762B2 (en) | 1979-12-06 | 1980-11-10 | Prostaglandin esters of steroids |
ZA00807161A ZA807161B (en) | 1979-12-06 | 1980-11-18 | Methylated prostaglandin derivatives |
AT80107209T ATE11283T1 (en) | 1979-12-06 | 1980-11-19 | STEROID ESTERS OF METHYLATED PROSTAGLANDIN DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS. |
EP80107209A EP0030299B1 (en) | 1979-12-06 | 1980-11-19 | Steroid esters of methylated prostaglandin derivatives and their pharmaceutical compositions |
DE8080107209T DE3069990D1 (en) | 1979-12-06 | 1980-11-19 | Steroid esters of methylated prostaglandin derivatives and their pharmaceutical compositions |
DK516880A DK160830C (en) | 1979-12-06 | 1980-12-03 | METHYLERED PROSTAGLANDIN STEROID HORMOND DERIVATIVES AND ABORTIVE AGENTS CONTAINING SAME |
CA000366198A CA1159821A (en) | 1979-12-06 | 1980-12-05 | Methylated prostaglandin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15835479A JPS5681600A (en) | 1979-12-06 | 1979-12-06 | Methylated prostaglandin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5681600A true JPS5681600A (en) | 1981-07-03 |
JPS611033B2 JPS611033B2 (en) | 1986-01-13 |
Family
ID=15669818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15835479A Granted JPS5681600A (en) | 1979-12-06 | 1979-12-06 | Methylated prostaglandin derivative |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS5681600A (en) |
IN (1) | IN151356B (en) |
ZA (1) | ZA807161B (en) |
-
1979
- 1979-12-06 JP JP15835479A patent/JPS5681600A/en active Granted
-
1980
- 1980-10-01 IN IN181/MAS/80A patent/IN151356B/en unknown
- 1980-11-18 ZA ZA00807161A patent/ZA807161B/en unknown
Also Published As
Publication number | Publication date |
---|---|
IN151356B (en) | 1983-04-02 |
JPS611033B2 (en) | 1986-01-13 |
ZA807161B (en) | 1981-11-25 |
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