JPS5681600A - Methylated prostaglandin derivative - Google Patents

Methylated prostaglandin derivative

Info

Publication number
JPS5681600A
JPS5681600A JP15835479A JP15835479A JPS5681600A JP S5681600 A JPS5681600 A JP S5681600A JP 15835479 A JP15835479 A JP 15835479A JP 15835479 A JP15835479 A JP 15835479A JP S5681600 A JPS5681600 A JP S5681600A
Authority
JP
Japan
Prior art keywords
formula
methylated
group
methylated prostaglandin
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15835479A
Other languages
Japanese (ja)
Other versions
JPS611033B2 (en
Inventor
Satoshi Enomoto
Yoshiro Asano
Fumio Tamura
Hiromitsu Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Priority to JP15835479A priority Critical patent/JPS5681600A/en
Priority to US06/153,415 priority patent/US4318908A/en
Priority to IN181/MAS/80A priority patent/IN151356B/en
Priority to AU64215/80A priority patent/AU537762B2/en
Priority to ZA00807161A priority patent/ZA807161B/en
Priority to AT80107209T priority patent/ATE11283T1/en
Priority to EP80107209A priority patent/EP0030299B1/en
Priority to DE8080107209T priority patent/DE3069990D1/en
Priority to DK516880A priority patent/DK160830C/en
Priority to CA000366198A priority patent/CA1159821A/en
Publication of JPS5681600A publication Critical patent/JPS5681600A/en
Publication of JPS611033B2 publication Critical patent/JPS611033B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

NEW MATERIAL:A methylated prostaglandin derivative expressed by formula I, II or III [St is formula IV (R is H, acetyl, propionyl, benzoyl, etc.), etc.; R1 is H, acetyl, propionyl, butyryl or benzoyl].
EXAMPLE: 3-Hydroxy-1,3,5(10)-estratriene-17β-oxycarbonylmethyl 16, 16-dimethyl- 11α, 15α-dihydroxy-9-oxo-5(cis)-13(trans)-prostadienoate.
USE: An inducer for abortion and laber of pregnant mammals, a fertility improver of female mammals, an estrus adjusting contraceptive agent and an emmenagogue agent having a stimulating and activating action on contraction of uterine walls.
PROCESS: Estradiol and a methylated prostaglandin are converted into an ester of formula V (B is group after removal of OH group at the 17-position; X is halogen; n is 1, 2 or 3), if necessary with an introducing and binding agent. The halogen in the ester is then reacted with the carboxylic acid group of a methylated prostaglandin.
COPYRIGHT: (C)1981,JPO&Japio
JP15835479A 1979-12-06 1979-12-06 Methylated prostaglandin derivative Granted JPS5681600A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP15835479A JPS5681600A (en) 1979-12-06 1979-12-06 Methylated prostaglandin derivative
US06/153,415 US4318908A (en) 1979-12-06 1980-05-27 Methylated prostaglandin derivatives
IN181/MAS/80A IN151356B (en) 1979-12-06 1980-10-01
AU64215/80A AU537762B2 (en) 1979-12-06 1980-11-10 Prostaglandin esters of steroids
ZA00807161A ZA807161B (en) 1979-12-06 1980-11-18 Methylated prostaglandin derivatives
AT80107209T ATE11283T1 (en) 1979-12-06 1980-11-19 STEROID ESTERS OF METHYLATED PROSTAGLANDIN DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS.
EP80107209A EP0030299B1 (en) 1979-12-06 1980-11-19 Steroid esters of methylated prostaglandin derivatives and their pharmaceutical compositions
DE8080107209T DE3069990D1 (en) 1979-12-06 1980-11-19 Steroid esters of methylated prostaglandin derivatives and their pharmaceutical compositions
DK516880A DK160830C (en) 1979-12-06 1980-12-03 METHYLERED PROSTAGLANDIN STEROID HORMOND DERIVATIVES AND ABORTIVE AGENTS CONTAINING SAME
CA000366198A CA1159821A (en) 1979-12-06 1980-12-05 Methylated prostaglandin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15835479A JPS5681600A (en) 1979-12-06 1979-12-06 Methylated prostaglandin derivative

Publications (2)

Publication Number Publication Date
JPS5681600A true JPS5681600A (en) 1981-07-03
JPS611033B2 JPS611033B2 (en) 1986-01-13

Family

ID=15669818

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15835479A Granted JPS5681600A (en) 1979-12-06 1979-12-06 Methylated prostaglandin derivative

Country Status (3)

Country Link
JP (1) JPS5681600A (en)
IN (1) IN151356B (en)
ZA (1) ZA807161B (en)

Also Published As

Publication number Publication date
IN151356B (en) 1983-04-02
JPS611033B2 (en) 1986-01-13
ZA807161B (en) 1981-11-25

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